LeishMANIAdb
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Putative glutathione-S-transferase/glutaredoxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glutathione-S-transferase/glutaredoxin
Gene product:
glutathione-S-transferase/glutaredoxin, putative
Species:
Leishmania major
UniProt:
Q4QFI5_LEIMA
TriTrypDb:
LmjF.14.1480 , LMJLV39_140022700 , LMJSD75_140022400
Length:
311

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 16
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0016020 membrane 2 10
GO:0020023 kinetoplast 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QFI5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI5

Function

Biological processes
Term Name Level Count
GO:0001516 prostaglandin biosynthetic process 8 4
GO:0006082 organic acid metabolic process 3 4
GO:0006629 lipid metabolic process 3 4
GO:0006631 fatty acid metabolic process 4 4
GO:0006633 fatty acid biosynthetic process 5 4
GO:0006636 unsaturated fatty acid biosynthetic process 6 4
GO:0006690 icosanoid metabolic process 6 4
GO:0006692 prostanoid metabolic process 6 4
GO:0006693 prostaglandin metabolic process 7 4
GO:0008152 metabolic process 1 4
GO:0008610 lipid biosynthetic process 4 4
GO:0009058 biosynthetic process 2 4
GO:0009987 cellular process 1 4
GO:0016053 organic acid biosynthetic process 4 4
GO:0019752 carboxylic acid metabolic process 5 4
GO:0032787 monocarboxylic acid metabolic process 6 4
GO:0033559 unsaturated fatty acid metabolic process 5 4
GO:0043436 oxoacid metabolic process 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044255 cellular lipid metabolic process 3 4
GO:0044281 small molecule metabolic process 2 4
GO:0044283 small molecule biosynthetic process 3 4
GO:0046394 carboxylic acid biosynthetic process 5 4
GO:0046456 icosanoid biosynthetic process 6 4
GO:0046457 prostanoid biosynthetic process 7 4
GO:0071704 organic substance metabolic process 2 4
GO:0072330 monocarboxylic acid biosynthetic process 6 4
GO:1901576 organic substance biosynthetic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0015035 protein-disulfide reductase activity 3 14
GO:0015036 disulfide oxidoreductase activity 4 14
GO:0016491 oxidoreductase activity 2 14
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 14
GO:0016740 transferase activity 2 13
GO:0016853 isomerase activity 2 12
GO:0016860 intramolecular oxidoreductase activity 3 12
GO:0050220 prostaglandin-E synthase activity 4 12
GO:0097573 obsolete glutathione oxidoreductase activity 4 14
GO:0140096 catalytic activity, acting on a protein 2 14
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor 4 5
GO:0019153 protein-disulfide reductase (glutathione) activity 4 5
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 1
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 1
GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 187 191 PF00656 0.328
CLV_NRD_NRD_1 265 267 PF00675 0.498
CLV_NRD_NRD_1 32 34 PF00675 0.506
CLV_NRD_NRD_1 8 10 PF00675 0.362
CLV_PCSK_KEX2_1 32 34 PF00082 0.515
CLV_PCSK_SKI1_1 169 173 PF00082 0.461
CLV_PCSK_SKI1_1 200 204 PF00082 0.481
CLV_PCSK_SKI1_1 222 226 PF00082 0.520
CLV_PCSK_SKI1_1 38 42 PF00082 0.601
CLV_PCSK_SKI1_1 85 89 PF00082 0.415
CLV_PCSK_SKI1_1 9 13 PF00082 0.257
DEG_Nend_Nbox_1 1 3 PF02207 0.661
DOC_CDC14_PxL_1 113 121 PF14671 0.251
DOC_MAPK_gen_1 114 121 PF00069 0.216
DOC_MAPK_gen_1 266 273 PF00069 0.389
DOC_MAPK_MEF2A_6 114 121 PF00069 0.223
DOC_MAPK_MEF2A_6 65 72 PF00069 0.296
DOC_USP7_MATH_1 163 167 PF00917 0.279
DOC_USP7_UBL2_3 200 204 PF12436 0.279
LIG_14-3-3_CanoR_1 164 168 PF00244 0.267
LIG_14-3-3_CanoR_1 169 174 PF00244 0.208
LIG_14-3-3_CanoR_1 245 252 PF00244 0.380
LIG_14-3-3_CanoR_1 38 45 PF00244 0.304
LIG_14-3-3_CanoR_1 74 79 PF00244 0.223
LIG_APCC_ABBAyCdc20_2 236 242 PF00400 0.304
LIG_Clathr_ClatBox_1 270 274 PF01394 0.345
LIG_EH1_1 211 219 PF00400 0.244
LIG_FHA_1 273 279 PF00498 0.269
LIG_FHA_2 138 144 PF00498 0.359
LIG_FHA_2 50 56 PF00498 0.411
LIG_GBD_Chelix_1 137 145 PF00786 0.529
LIG_LIR_Gen_1 43 51 PF02991 0.319
LIG_LIR_Gen_1 89 98 PF02991 0.260
LIG_LIR_Nem_3 110 116 PF02991 0.218
LIG_LIR_Nem_3 274 279 PF02991 0.261
LIG_LIR_Nem_3 55 61 PF02991 0.393
LIG_LIR_Nem_3 89 93 PF02991 0.257
LIG_PTB_Apo_2 196 203 PF02174 0.294
LIG_SH2_CRK 113 117 PF00017 0.200
LIG_SH2_CRK 276 280 PF00017 0.263
LIG_SH2_CRK 90 94 PF00017 0.201
LIG_SH2_GRB2like 197 200 PF00017 0.315
LIG_SH2_NCK_1 90 94 PF00017 0.250
LIG_SH2_SRC 188 191 PF00017 0.333
LIG_SH2_STAP1 197 201 PF00017 0.321
LIG_SH2_STAT5 130 133 PF00017 0.303
LIG_SH2_STAT5 188 191 PF00017 0.307
LIG_SH2_STAT5 212 215 PF00017 0.291
LIG_SH2_STAT5 27 30 PF00017 0.437
LIG_SH2_STAT5 75 78 PF00017 0.273
LIG_SH3_3 215 221 PF00018 0.315
LIG_SUMO_SIM_par_1 269 275 PF11976 0.346
LIG_TYR_ITIM 88 93 PF00017 0.237
MOD_CK1_1 191 197 PF00069 0.322
MOD_CK2_1 137 143 PF00069 0.349
MOD_CMANNOS 159 162 PF00535 0.458
MOD_Cter_Amidation 264 267 PF01082 0.577
MOD_GSK3_1 158 165 PF00069 0.355
MOD_GSK3_1 184 191 PF00069 0.328
MOD_N-GLC_1 175 180 PF02516 0.468
MOD_N-GLC_1 36 41 PF02516 0.507
MOD_NEK2_1 108 113 PF00069 0.345
MOD_NEK2_1 12 17 PF00069 0.278
MOD_NEK2_1 131 136 PF00069 0.315
MOD_NEK2_1 175 180 PF00069 0.287
MOD_NEK2_1 216 221 PF00069 0.305
MOD_NEK2_2 25 30 PF00069 0.321
MOD_NEK2_2 80 85 PF00069 0.319
MOD_PIKK_1 131 137 PF00454 0.271
MOD_PIKK_1 292 298 PF00454 0.372
MOD_PKA_2 163 169 PF00069 0.266
MOD_PKA_2 244 250 PF00069 0.389
MOD_PKA_2 3 9 PF00069 0.699
MOD_PKA_2 73 79 PF00069 0.228
MOD_Plk_1 175 181 PF00069 0.272
MOD_Plk_1 36 42 PF00069 0.395
MOD_Plk_4 108 114 PF00069 0.297
MOD_Plk_4 163 169 PF00069 0.326
MOD_Plk_4 184 190 PF00069 0.344
MOD_Plk_4 25 31 PF00069 0.289
MOD_SUMO_for_1 104 107 PF00179 0.220
MOD_SUMO_for_1 151 154 PF00179 0.399
MOD_SUMO_rev_2 249 256 PF00179 0.391
TRG_DiLeu_BaLyEn_6 65 70 PF01217 0.372
TRG_ENDOCYTIC_2 113 116 PF00928 0.236
TRG_ENDOCYTIC_2 186 189 PF00928 0.289
TRG_ENDOCYTIC_2 276 279 PF00928 0.260
TRG_ENDOCYTIC_2 288 291 PF00928 0.278
TRG_ENDOCYTIC_2 90 93 PF00928 0.243
TRG_ER_diArg_1 32 35 PF00400 0.319
TRG_NLS_MonoCore_2 256 261 PF00514 0.329
TRG_NLS_MonoExtN_4 254 261 PF00514 0.423
TRG_Pf-PMV_PEXEL_1 32 36 PF00026 0.490

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HS46 Leptomonas seymouri 73% 100%
A0A0N1ILY8 Leptomonas seymouri 23% 80%
A0A0S4IXT4 Bodo saltans 56% 95%
A0A0S4JV60 Bodo saltans 30% 93%
A0A1X0NND6 Trypanosomatidae 57% 99%
A0A1X0NTT0 Trypanosomatidae 31% 93%
A0A3S7WT83 Leishmania donovani 97% 100%
A0A3S7WZV5 Leishmania donovani 25% 78%
A0A422MZ79 Trypanosoma rangeli 27% 92%
A0A422N3R5 Trypanosoma rangeli 56% 100%
A4H7W8 Leishmania braziliensis 88% 100%
A4HF09 Leishmania braziliensis 27% 78%
A4HW95 Leishmania infantum 97% 100%
A4I288 Leishmania infantum 25% 78%
C9ZRQ5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 91%
C9ZSR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9APZ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9AYD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 78%
Q4Q940 Leishmania major 25% 100%
Q66LN0 Bos taurus 26% 84%
Q7ZUC7 Danio rerio 26% 82%
Q8BWM0 Mus musculus 26% 81%
Q9H7Z7 Homo sapiens 26% 82%
Q9N0A4 Macaca fascicularis 26% 82%
V5AYZ4 Trypanosoma cruzi 29% 92%
V5DC17 Trypanosoma cruzi 57% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS