Putative inositol 5'-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

synaptojanin (N-terminal domain), putative

Species:

Leishmania major

UniProt:

Q4QFI4_LEIMA

TriTrypDb:

LmjF.14.1490 , LMJLV39_140022800 , LMJSD75_140022500

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.427
CLV_C14_Caspase3-7	459	463	PF00656	0.343
CLV_C14_Caspase3-7	522	526	PF00656	0.437
CLV_C14_Caspase3-7	815	819	PF00656	0.609
CLV_NRD_NRD_1	627	629	PF00675	0.422
CLV_NRD_NRD_1	636	638	PF00675	0.401
CLV_NRD_NRD_1	695	697	PF00675	0.446
CLV_PCSK_KEX2_1	695	697	PF00082	0.477
CLV_PCSK_KEX2_1	74	76	PF00082	0.582
CLV_PCSK_KEX2_1	834	836	PF00082	0.636
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.582
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.636
CLV_PCSK_SKI1_1	401	405	PF00082	0.315
CLV_PCSK_SKI1_1	478	482	PF00082	0.549
CLV_PCSK_SKI1_1	835	839	PF00082	0.588
CLV_Separin_Metazoa	348	352	PF03568	0.346
CLV_Separin_Metazoa	475	479	PF03568	0.310
DEG_APCC_DBOX_1	400	408	PF00400	0.346
DEG_APCC_DBOX_1	636	644	PF00400	0.421
DEG_Nend_UBRbox_3	1	3	PF02207	0.686
DEG_SPOP_SBC_1	441	445	PF00917	0.461
DEG_SPOP_SBC_1	727	731	PF00917	0.410
DOC_CDC14_PxL_1	121	129	PF14671	0.457
DOC_CKS1_1	56	61	PF01111	0.735
DOC_CYCLIN_RxL_1	93	104	PF00134	0.456
DOC_CYCLIN_yClb5_NLxxxL_5	494	503	PF00134	0.259
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.335
DOC_CYCLIN_yCln2_LP_2	663	669	PF00134	0.351
DOC_MAPK_DCC_7	36	45	PF00069	0.575
DOC_MAPK_DCC_7	570	580	PF00069	0.404
DOC_MAPK_gen_1	16	23	PF00069	0.395
DOC_MAPK_gen_1	36	45	PF00069	0.378
DOC_MAPK_gen_1	637	647	PF00069	0.367
DOC_MAPK_gen_1	768	777	PF00069	0.537
DOC_MAPK_gen_1	789	799	PF00069	0.344
DOC_MAPK_MEF2A_6	259	268	PF00069	0.380
DOC_MAPK_MEF2A_6	36	45	PF00069	0.630
DOC_MAPK_MEF2A_6	638	647	PF00069	0.364
DOC_MAPK_MEF2A_6	701	708	PF00069	0.419
DOC_PP1_RVXF_1	715	722	PF00149	0.579
DOC_PP1_RVXF_1	94	101	PF00149	0.496
DOC_PP2B_LxvP_1	679	682	PF13499	0.391
DOC_PP4_FxxP_1	167	170	PF00568	0.346
DOC_PP4_FxxP_1	211	214	PF00568	0.392
DOC_USP7_MATH_1	10	14	PF00917	0.667
DOC_USP7_MATH_1	117	121	PF00917	0.429
DOC_USP7_MATH_1	220	224	PF00917	0.397
DOC_USP7_MATH_1	241	245	PF00917	0.378
DOC_USP7_MATH_1	419	423	PF00917	0.425
DOC_USP7_MATH_1	455	459	PF00917	0.540
DOC_USP7_MATH_1	460	464	PF00917	0.502
DOC_USP7_MATH_1	519	523	PF00917	0.516
DOC_USP7_MATH_1	713	717	PF00917	0.493
DOC_USP7_MATH_1	798	802	PF00917	0.362
DOC_USP7_MATH_1	816	820	PF00917	0.638
DOC_WW_Pin1_4	175	180	PF00397	0.380
DOC_WW_Pin1_4	2	7	PF00397	0.680
DOC_WW_Pin1_4	523	528	PF00397	0.553
DOC_WW_Pin1_4	55	60	PF00397	0.644
DOC_WW_Pin1_4	656	661	PF00397	0.497
DOC_WW_Pin1_4	761	766	PF00397	0.800
LIG_14-3-3_CanoR_1	254	259	PF00244	0.420
LIG_14-3-3_CanoR_1	315	319	PF00244	0.229
LIG_14-3-3_CanoR_1	351	357	PF00244	0.344
LIG_14-3-3_CanoR_1	408	414	PF00244	0.323
LIG_14-3-3_CanoR_1	478	486	PF00244	0.467
LIG_14-3-3_CanoR_1	65	73	PF00244	0.568
LIG_14-3-3_CanoR_1	835	841	PF00244	0.607
LIG_Actin_WH2_2	626	643	PF00022	0.439
LIG_Actin_WH2_2	819	836	PF00022	0.676
LIG_BIR_III_2	52	56	PF00653	0.604
LIG_BIR_III_2	757	761	PF00653	0.570
LIG_BRCT_BRCA1_1	449	453	PF00533	0.424
LIG_BRCT_BRCA1_1	658	662	PF00533	0.375
LIG_BRCT_BRCA1_1	96	100	PF00533	0.495
LIG_Clathr_ClatBox_1	425	429	PF01394	0.302
LIG_Clathr_ClatBox_1	48	52	PF01394	0.564
LIG_CSL_BTD_1	163	166	PF09270	0.427
LIG_CtBP_PxDLS_1	219	223	PF00389	0.420
LIG_FHA_1	143	149	PF00498	0.380
LIG_FHA_1	160	166	PF00498	0.219
LIG_FHA_1	178	184	PF00498	0.302
LIG_FHA_1	320	326	PF00498	0.302
LIG_FHA_1	330	336	PF00498	0.302
LIG_FHA_1	513	519	PF00498	0.502
LIG_FHA_1	685	691	PF00498	0.534
LIG_FHA_1	720	726	PF00498	0.470
LIG_FHA_1	767	773	PF00498	0.443
LIG_FHA_2	255	261	PF00498	0.427
LIG_FHA_2	443	449	PF00498	0.386
LIG_FHA_2	457	463	PF00498	0.467
LIG_FHA_2	563	569	PF00498	0.450
LIG_FHA_2	58	64	PF00498	0.599
LIG_FHA_2	684	690	PF00498	0.474
LIG_FHA_2	728	734	PF00498	0.483
LIG_FHA_2	813	819	PF00498	0.584
LIG_GSK3_LRP6_1	55	60	PF00069	0.551
LIG_HCF-1_HBM_1	295	298	PF13415	0.302
LIG_Integrin_RGD_1	651	653	PF01839	0.328
LIG_LIR_Gen_1	103	111	PF02991	0.412
LIG_LIR_Gen_1	134	144	PF02991	0.361
LIG_LIR_Gen_1	295	302	PF02991	0.302
LIG_LIR_Gen_1	355	364	PF02991	0.315
LIG_LIR_Gen_1	429	437	PF02991	0.364
LIG_LIR_Gen_1	483	491	PF02991	0.411
LIG_LIR_Nem_3	103	108	PF02991	0.407
LIG_LIR_Nem_3	119	124	PF02991	0.399
LIG_LIR_Nem_3	134	140	PF02991	0.252
LIG_LIR_Nem_3	162	167	PF02991	0.304
LIG_LIR_Nem_3	187	191	PF02991	0.266
LIG_LIR_Nem_3	295	301	PF02991	0.302
LIG_LIR_Nem_3	429	433	PF02991	0.340
LIG_LIR_Nem_3	483	488	PF02991	0.403
LIG_LIR_Nem_3	653	658	PF02991	0.507
LIG_LYPXL_yS_3	124	127	PF13949	0.403
LIG_PCNA_yPIPBox_3	473	487	PF02747	0.286
LIG_Pex14_2	357	361	PF04695	0.321
LIG_Pex14_2	562	566	PF04695	0.421
LIG_Pex14_2	630	634	PF04695	0.416
LIG_PTAP_UEV_1	58	63	PF05743	0.531
LIG_SH2_CRK	809	813	PF00017	0.408
LIG_SH2_GRB2like	598	601	PF00017	0.402
LIG_SH2_NCK_1	544	548	PF00017	0.665
LIG_SH2_PTP2	137	140	PF00017	0.380
LIG_SH2_SRC	298	301	PF00017	0.302
LIG_SH2_SRC	809	812	PF00017	0.442
LIG_SH2_STAP1	199	203	PF00017	0.346
LIG_SH2_STAP1	298	302	PF00017	0.302
LIG_SH2_STAP1	544	548	PF00017	0.683
LIG_SH2_STAP1	598	602	PF00017	0.361
LIG_SH2_STAP1	669	673	PF00017	0.516
LIG_SH2_STAT3	811	814	PF00017	0.374
LIG_SH2_STAT5	137	140	PF00017	0.338
LIG_SH2_STAT5	281	284	PF00017	0.302
LIG_SH2_STAT5	29	32	PF00017	0.472
LIG_SH2_STAT5	300	303	PF00017	0.302
LIG_SH2_STAT5	356	359	PF00017	0.320
LIG_SH2_STAT5	598	601	PF00017	0.414
LIG_SH2_STAT5	669	672	PF00017	0.472
LIG_SH2_STAT5	796	799	PF00017	0.486
LIG_SH3_3	145	151	PF00018	0.427
LIG_SH3_3	202	208	PF00018	0.428
LIG_SH3_3	29	35	PF00018	0.406
LIG_SH3_3	524	530	PF00018	0.484
LIG_SH3_3	53	59	PF00018	0.682
LIG_SH3_3	555	561	PF00018	0.597
LIG_SH3_3	802	808	PF00018	0.449
LIG_SUMO_SIM_anti_2	422	427	PF11976	0.383
LIG_SUMO_SIM_anti_2	769	776	PF11976	0.427
LIG_SUMO_SIM_par_1	721	726	PF11976	0.500
LIG_TRAF2_1	120	123	PF00917	0.479
LIG_TRAF2_1	534	537	PF00917	0.540
LIG_TRAF2_1	750	753	PF00917	0.573
LIG_TRAF2_2	64	69	PF00917	0.616
LIG_TRFH_1	662	666	PF08558	0.473
LIG_TYR_ITIM	27	32	PF00017	0.487
LIG_UBA3_1	30	38	PF00899	0.455
LIG_UBA3_1	360	365	PF00899	0.411
LIG_UBA3_1	387	393	PF00899	0.324
LIG_WRC_WIRS_1	118	123	PF05994	0.451
LIG_WW_3	765	769	PF00397	0.644
MOD_CDK_SPxxK_3	175	182	PF00069	0.380
MOD_CDK_SPxxK_3	2	9	PF00069	0.637
MOD_CDK_SPxxK_3	761	768	PF00069	0.671
MOD_CK1_1	235	241	PF00069	0.463
MOD_CK1_1	336	342	PF00069	0.331
MOD_CK1_1	463	469	PF00069	0.452
MOD_CK1_1	726	732	PF00069	0.655
MOD_CK2_1	104	110	PF00069	0.410
MOD_CK2_1	117	123	PF00069	0.398
MOD_CK2_1	331	337	PF00069	0.302
MOD_CK2_1	442	448	PF00069	0.356
MOD_CK2_1	562	568	PF00069	0.385
MOD_CK2_1	683	689	PF00069	0.487
MOD_CK2_1	727	733	PF00069	0.555
MOD_GlcNHglycan	234	237	PF01048	0.392
MOD_GlcNHglycan	352	355	PF01048	0.452
MOD_GlcNHglycan	393	396	PF01048	0.414
MOD_GlcNHglycan	551	554	PF01048	0.606
MOD_GlcNHglycan	600	603	PF01048	0.366
MOD_GlcNHglycan	725	728	PF01048	0.489
MOD_GlcNHglycan	822	825	PF01048	0.541
MOD_GlcNHglycan	90	93	PF01048	0.507
MOD_GSK3_1	100	107	PF00069	0.480
MOD_GSK3_1	155	162	PF00069	0.357
MOD_GSK3_1	220	227	PF00069	0.405
MOD_GSK3_1	237	244	PF00069	0.241
MOD_GSK3_1	307	314	PF00069	0.429
MOD_GSK3_1	325	332	PF00069	0.255
MOD_GSK3_1	336	343	PF00069	0.263
MOD_GSK3_1	456	463	PF00069	0.511
MOD_GSK3_1	490	497	PF00069	0.365
MOD_GSK3_1	519	526	PF00069	0.514
MOD_GSK3_1	719	726	PF00069	0.446
MOD_GSK3_1	737	744	PF00069	0.617
MOD_GSK3_1	812	819	PF00069	0.531
MOD_N-GLC_1	683	688	PF02516	0.436
MOD_N-GLC_1	761	766	PF02516	0.679
MOD_N-GLC_1	88	93	PF02516	0.562
MOD_N-GLC_2	802	804	PF02516	0.417
MOD_NEK2_1	139	144	PF00069	0.327
MOD_NEK2_1	319	324	PF00069	0.305
MOD_NEK2_1	331	336	PF00069	0.313
MOD_NEK2_1	350	355	PF00069	0.215
MOD_NEK2_1	369	374	PF00069	0.240
MOD_NEK2_1	453	458	PF00069	0.437
MOD_NEK2_1	494	499	PF00069	0.344
MOD_NEK2_1	506	511	PF00069	0.313
MOD_NEK2_1	512	517	PF00069	0.363
MOD_NEK2_1	562	567	PF00069	0.433
MOD_NEK2_1	596	601	PF00069	0.424
MOD_NEK2_1	719	724	PF00069	0.444
MOD_NEK2_1	737	742	PF00069	0.572
MOD_NEK2_1	94	99	PF00069	0.546
MOD_OFUCOSY	217	224	PF10250	0.245
MOD_PIKK_1	10	16	PF00454	0.733
MOD_PIKK_1	326	332	PF00454	0.338
MOD_PIKK_1	478	484	PF00454	0.482
MOD_PIKK_1	512	518	PF00454	0.451
MOD_PIKK_1	623	629	PF00454	0.406
MOD_PIKK_1	667	673	PF00454	0.489
MOD_PK_1	74	80	PF00069	0.442
MOD_PKA_1	74	80	PF00069	0.696
MOD_PKA_2	270	276	PF00069	0.414
MOD_PKA_2	314	320	PF00069	0.311
MOD_PKA_2	350	356	PF00069	0.380
MOD_PKA_2	407	413	PF00069	0.322
MOD_PKA_2	64	70	PF00069	0.689
MOD_PKA_2	74	80	PF00069	0.637
MOD_Plk_1	224	230	PF00069	0.356
MOD_Plk_1	447	453	PF00069	0.390
MOD_Plk_2-3	104	110	PF00069	0.413
MOD_Plk_4	241	247	PF00069	0.315
MOD_Plk_4	314	320	PF00069	0.302
MOD_Plk_4	336	342	PF00069	0.257
MOD_Plk_4	352	358	PF00069	0.304
MOD_Plk_4	442	448	PF00069	0.359
MOD_Plk_4	460	466	PF00069	0.407
MOD_Plk_4	836	842	PF00069	0.602
MOD_ProDKin_1	175	181	PF00069	0.380
MOD_ProDKin_1	2	8	PF00069	0.679
MOD_ProDKin_1	523	529	PF00069	0.546
MOD_ProDKin_1	55	61	PF00069	0.645
MOD_ProDKin_1	656	662	PF00069	0.490
MOD_ProDKin_1	761	767	PF00069	0.797
MOD_SUMO_for_1	758	761	PF00179	0.567
MOD_SUMO_rev_2	631	640	PF00179	0.406
MOD_SUMO_rev_2	752	760	PF00179	0.550
MOD_SUMO_rev_2	817	822	PF00179	0.465
TRG_DiLeu_BaEn_1	475	480	PF01217	0.418
TRG_DiLeu_BaEn_1	715	720	PF01217	0.448
TRG_DiLeu_BaLyEn_6	786	791	PF01217	0.301
TRG_DiLeu_LyEn_5	475	480	PF01217	0.311
TRG_ENDOCYTIC_2	124	127	PF00928	0.373
TRG_ENDOCYTIC_2	137	140	PF00928	0.240
TRG_ENDOCYTIC_2	29	32	PF00928	0.474
TRG_ENDOCYTIC_2	298	301	PF00928	0.302
TRG_ENDOCYTIC_2	796	799	PF00928	0.452
TRG_ER_diArg_1	182	185	PF00400	0.302
TRG_ER_diArg_1	694	696	PF00400	0.454
TRG_NES_CRM1_1	424	436	PF08389	0.302
TRG_NLS_Bipartite_1	628	642	PF00514	0.509
TRG_NLS_MonoExtN_4	637	642	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	789	793	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T7	Leptomonas seymouri	72%	99%
A0A1X0NNZ9	Trypanosomatidae	49%	100%
A0A3Q8I9X9	Leishmania donovani	91%	100%
A0A3R7LN11	Trypanosoma rangeli	47%	100%
A4H7W9	Leishmania braziliensis	75%	100%
A4HW96	Leishmania infantum	91%	100%
C9ZSR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9APZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5AVZ2	Trypanosoma cruzi	47%	100%