Nucleotid_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFI2_LEIMA

TriTrypDb:

LmjF.15.0020 , LMJLV39_150005100 , LMJSD75_150005100

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QFI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.436
CLV_NRD_NRD_1	477	479	PF00675	0.688
CLV_NRD_NRD_1	578	580	PF00675	0.593
CLV_NRD_NRD_1	92	94	PF00675	0.632
CLV_PCSK_FUR_1	409	413	PF00082	0.581
CLV_PCSK_FUR_1	49	53	PF00082	0.379
CLV_PCSK_KEX2_1	411	413	PF00082	0.617
CLV_PCSK_KEX2_1	476	478	PF00082	0.636
CLV_PCSK_KEX2_1	51	53	PF00082	0.298
CLV_PCSK_KEX2_1	560	562	PF00082	0.612
CLV_PCSK_KEX2_1	578	580	PF00082	0.525
CLV_PCSK_KEX2_1	92	94	PF00082	0.586
CLV_PCSK_KEX2_1	98	100	PF00082	0.570
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.580
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.295
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.654
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.582
CLV_PCSK_SKI1_1	12	16	PF00082	0.329
CLV_PCSK_SKI1_1	20	24	PF00082	0.324
CLV_PCSK_SKI1_1	345	349	PF00082	0.625
CLV_PCSK_SKI1_1	401	405	PF00082	0.583
CLV_PCSK_SKI1_1	451	455	PF00082	0.469
CLV_PCSK_SKI1_1	51	55	PF00082	0.319
CLV_PCSK_SKI1_1	579	583	PF00082	0.586
CLV_PCSK_SKI1_1	93	97	PF00082	0.606
CLV_Separin_Metazoa	89	93	PF03568	0.346
DEG_APCC_DBOX_1	33	41	PF00400	0.624
DEG_APCC_DBOX_1	477	485	PF00400	0.448
DOC_CKS1_1	357	362	PF01111	0.443
DOC_CKS1_1	512	517	PF01111	0.447
DOC_CYCLIN_RxL_1	49	56	PF00134	0.504
DOC_MAPK_DCC_7	265	275	PF00069	0.334
DOC_MAPK_gen_1	263	270	PF00069	0.318
DOC_MAPK_gen_1	31	40	PF00069	0.567
DOC_MAPK_gen_1	448	458	PF00069	0.308
DOC_MAPK_gen_1	49	59	PF00069	0.422
DOC_MAPK_gen_1	490	497	PF00069	0.424
DOC_MAPK_MEF2A_6	196	204	PF00069	0.332
DOC_MAPK_MEF2A_6	263	270	PF00069	0.306
DOC_MAPK_MEF2A_6	451	460	PF00069	0.323
DOC_PP1_RVXF_1	138	144	PF00149	0.389
DOC_PP4_FxxP_1	313	316	PF00568	0.382
DOC_PP4_FxxP_1	454	457	PF00568	0.318
DOC_PP4_FxxP_1	497	500	PF00568	0.412
DOC_PP4_FxxP_1	512	515	PF00568	0.368
DOC_USP7_MATH_1	320	324	PF00917	0.427
DOC_USP7_MATH_1	506	510	PF00917	0.450
DOC_USP7_MATH_1	556	560	PF00917	0.453
DOC_USP7_MATH_1	577	581	PF00917	0.418
DOC_USP7_MATH_1	616	620	PF00917	0.316
DOC_USP7_MATH_1	65	69	PF00917	0.273
DOC_USP7_MATH_1	73	77	PF00917	0.493
DOC_WW_Pin1_4	223	228	PF00397	0.381
DOC_WW_Pin1_4	256	261	PF00397	0.395
DOC_WW_Pin1_4	312	317	PF00397	0.442
DOC_WW_Pin1_4	356	361	PF00397	0.512
DOC_WW_Pin1_4	511	516	PF00397	0.454
DOC_WW_Pin1_4	612	617	PF00397	0.391
LIG_14-3-3_CanoR_1	18	23	PF00244	0.592
LIG_14-3-3_CanoR_1	308	314	PF00244	0.470
LIG_14-3-3_CanoR_1	525	530	PF00244	0.425
LIG_14-3-3_CanoR_1	539	546	PF00244	0.326
LIG_14-3-3_CanoR_1	578	582	PF00244	0.482
LIG_14-3-3_CanoR_1	82	91	PF00244	0.397
LIG_BRCT_BRCA1_1	427	431	PF00533	0.324
LIG_BRCT_BRCA1_1	508	512	PF00533	0.406
LIG_BRCT_BRCA1_1	55	59	PF00533	0.251
LIG_Clathr_ClatBox_1	460	464	PF01394	0.372
LIG_deltaCOP1_diTrp_1	151	154	PF00928	0.336
LIG_EH1_1	297	305	PF00400	0.265
LIG_eIF4E_1	298	304	PF01652	0.337
LIG_EVH1_2	271	275	PF00568	0.316
LIG_FHA_1	129	135	PF00498	0.402
LIG_FHA_1	257	263	PF00498	0.399
LIG_FHA_1	299	305	PF00498	0.333
LIG_FHA_1	346	352	PF00498	0.449
LIG_FHA_1	470	476	PF00498	0.393
LIG_FHA_1	512	518	PF00498	0.433
LIG_FHA_2	209	215	PF00498	0.410
LIG_FHA_2	347	353	PF00498	0.448
LIG_FHA_2	357	363	PF00498	0.372
LIG_FHA_2	496	502	PF00498	0.452
LIG_FHA_2	587	593	PF00498	0.347
LIG_Integrin_RGD_1	107	109	PF01839	0.626
LIG_LIR_Apic_2	280	286	PF02991	0.367
LIG_LIR_Apic_2	312	316	PF02991	0.377
LIG_LIR_Apic_2	452	457	PF02991	0.388
LIG_LIR_Apic_2	494	500	PF02991	0.401
LIG_LIR_Apic_2	509	515	PF02991	0.372
LIG_LIR_Gen_1	151	162	PF02991	0.324
LIG_LIR_Gen_1	174	183	PF02991	0.393
LIG_LIR_Gen_1	288	299	PF02991	0.364
LIG_LIR_Gen_1	551	557	PF02991	0.352
LIG_LIR_Gen_1	56	66	PF02991	0.396
LIG_LIR_Nem_3	151	157	PF02991	0.328
LIG_LIR_Nem_3	174	180	PF02991	0.401
LIG_LIR_Nem_3	184	189	PF02991	0.384
LIG_LIR_Nem_3	288	294	PF02991	0.381
LIG_LIR_Nem_3	325	330	PF02991	0.456
LIG_LIR_Nem_3	493	499	PF02991	0.490
LIG_LIR_Nem_3	551	555	PF02991	0.359
LIG_LIR_Nem_3	56	62	PF02991	0.396
LIG_LIR_Nem_3	580	584	PF02991	0.321
LIG_MYND_1	260	264	PF01753	0.364
LIG_NRBOX	3	9	PF00104	0.555
LIG_PCNA_PIPBox_1	118	127	PF02747	0.367
LIG_Pex14_1	570	574	PF04695	0.338
LIG_Pex14_2	218	222	PF04695	0.466
LIG_Pex14_2	55	59	PF04695	0.353
LIG_Pex14_2	571	575	PF04695	0.342
LIG_Rb_LxCxE_1	597	615	PF01857	0.262
LIG_SH2_CRK	19	23	PF00017	0.537
LIG_SH2_CRK	283	287	PF00017	0.361
LIG_SH2_CRK	330	334	PF00017	0.411
LIG_SH2_GRB2like	379	382	PF00017	0.328
LIG_SH2_GRB2like	83	86	PF00017	0.366
LIG_SH2_NCK_1	225	229	PF00017	0.328
LIG_SH2_SRC	379	382	PF00017	0.328
LIG_SH2_SRC	83	86	PF00017	0.415
LIG_SH2_STAP1	177	181	PF00017	0.335
LIG_SH2_STAP1	183	187	PF00017	0.297
LIG_SH2_STAP1	427	431	PF00017	0.324
LIG_SH2_STAT3	124	127	PF00017	0.370
LIG_SH2_STAT3	282	285	PF00017	0.342
LIG_SH2_STAT5	124	127	PF00017	0.424
LIG_SH2_STAT5	186	189	PF00017	0.382
LIG_SH2_STAT5	298	301	PF00017	0.436
LIG_SH2_STAT5	379	382	PF00017	0.328
LIG_SH2_STAT5	488	491	PF00017	0.503
LIG_SH2_STAT5	564	567	PF00017	0.340
LIG_SH2_STAT5	574	577	PF00017	0.298
LIG_SH2_STAT5	83	86	PF00017	0.572
LIG_SH3_3	265	271	PF00018	0.380
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.239
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.386
LIG_SUMO_SIM_par_1	197	207	PF11976	0.375
LIG_SUMO_SIM_par_1	459	464	PF11976	0.311
LIG_SUMO_SIM_par_1	62	68	PF11976	0.402
LIG_TRAF2_1	26	29	PF00917	0.530
LIG_WRC_WIRS_1	549	554	PF05994	0.350
LIG_WW_3	522	526	PF00397	0.371
MOD_CDK_SPxxK_3	256	263	PF00069	0.350
MOD_CDK_SPxxK_3	356	363	PF00069	0.449
MOD_CK1_1	147	153	PF00069	0.339
MOD_CK1_1	175	181	PF00069	0.347
MOD_CK1_1	226	232	PF00069	0.361
MOD_CK1_1	312	318	PF00069	0.427
MOD_CK1_1	419	425	PF00069	0.263
MOD_CK1_1	486	492	PF00069	0.430
MOD_CK1_1	535	541	PF00069	0.393
MOD_CK2_1	346	352	PF00069	0.450
MOD_CK2_1	83	89	PF00069	0.376
MOD_CMANNOS	570	573	PF00535	0.553
MOD_Cter_Amidation	96	99	PF01082	0.570
MOD_GlcNHglycan	249	252	PF01048	0.567
MOD_GlcNHglycan	508	511	PF01048	0.623
MOD_GlcNHglycan	540	543	PF01048	0.624
MOD_GlcNHglycan	67	70	PF01048	0.468
MOD_GSK3_1	128	135	PF00069	0.373
MOD_GSK3_1	252	259	PF00069	0.441
MOD_GSK3_1	36	43	PF00069	0.578
MOD_GSK3_1	482	489	PF00069	0.412
MOD_GSK3_1	534	541	PF00069	0.420
MOD_GSK3_1	582	589	PF00069	0.372
MOD_GSK3_1	612	619	PF00069	0.367
MOD_N-GLC_1	128	133	PF02516	0.598
MOD_N-GLC_1	147	152	PF02516	0.442
MOD_N-GLC_1	532	537	PF02516	0.542
MOD_N-GLC_1	600	605	PF02516	0.627
MOD_NEK2_1	117	122	PF00069	0.349
MOD_NEK2_1	252	257	PF00069	0.378
MOD_NEK2_1	346	351	PF00069	0.448
MOD_NEK2_1	384	389	PF00069	0.367
MOD_NEK2_1	438	443	PF00069	0.346
MOD_NEK2_1	469	474	PF00069	0.493
MOD_NEK2_1	527	532	PF00069	0.446
MOD_NEK2_1	53	58	PF00069	0.366
MOD_NEK2_1	64	69	PF00069	0.385
MOD_NEK2_1	7	12	PF00069	0.644
MOD_NEK2_2	172	177	PF00069	0.272
MOD_NEK2_2	577	582	PF00069	0.327
MOD_OFUCOSY	155	161	PF10250	0.522
MOD_PIKK_1	123	129	PF00454	0.348
MOD_PK_1	18	24	PF00069	0.538
MOD_PK_1	525	531	PF00069	0.366
MOD_PKA_2	166	172	PF00069	0.398
MOD_PKA_2	320	326	PF00069	0.439
MOD_PKA_2	538	544	PF00069	0.410
MOD_PKA_2	577	583	PF00069	0.471
MOD_PKA_2	8	14	PF00069	0.641
MOD_PKB_1	16	24	PF00069	0.535
MOD_Plk_1	150	156	PF00069	0.332
MOD_Plk_1	416	422	PF00069	0.315
MOD_Plk_1	600	606	PF00069	0.412
MOD_Plk_4	166	172	PF00069	0.420
MOD_Plk_4	309	315	PF00069	0.404
MOD_Plk_4	416	422	PF00069	0.332
MOD_Plk_4	483	489	PF00069	0.539
MOD_Plk_4	527	533	PF00069	0.449
MOD_Plk_4	548	554	PF00069	0.354
MOD_Plk_4	586	592	PF00069	0.359
MOD_ProDKin_1	223	229	PF00069	0.384
MOD_ProDKin_1	256	262	PF00069	0.402
MOD_ProDKin_1	312	318	PF00069	0.444
MOD_ProDKin_1	356	362	PF00069	0.507
MOD_ProDKin_1	511	517	PF00069	0.452
MOD_ProDKin_1	612	618	PF00069	0.376
MOD_SUMO_for_1	410	413	PF00179	0.406
MOD_SUMO_for_1	594	597	PF00179	0.298
TRG_DiLeu_BaEn_2	351	357	PF01217	0.445
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.405
TRG_ENDOCYTIC_2	177	180	PF00928	0.388
TRG_ENDOCYTIC_2	19	22	PF00928	0.574
TRG_ENDOCYTIC_2	330	333	PF00928	0.424
TRG_ENDOCYTIC_2	427	430	PF00928	0.322
TRG_ER_diArg_1	15	18	PF00400	0.697
TRG_ER_diArg_1	475	478	PF00400	0.416
TRG_ER_diArg_1	91	93	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	33%	97%
A0A3Q8ID98	Leishmania donovani	91%	100%
A0A3Q8IM92	Leishmania donovani	33%	93%
A4H7X2	Leishmania braziliensis	75%	100%
A4HLI8	Leishmania braziliensis	32%	96%
A4HLJ0	Leishmania braziliensis	31%	96%
A4HLJ2	Leishmania braziliensis	30%	100%
A4HW99	Leishmania infantum	91%	100%
A4I8Z8	Leishmania infantum	33%	93%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	93%
Q4Q457	Leishmania major	33%	100%