Lysine decarboxylase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Possible lysine decarboxylase, putative

Species:

Leishmania major

UniProt:

Q4QFI0_LEIMA

TriTrypDb:

LmjF.15.0040 , LMJLV39_150005300 , LMJSD75_150005300

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.463
CLV_NRD_NRD_1	231	233	PF00675	0.230
CLV_PCSK_KEX2_1	170	172	PF00082	0.461
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.461
CLV_PCSK_SKI1_1	75	79	PF00082	0.440
DOC_CYCLIN_RxL_1	217	225	PF00134	0.446
DOC_MAPK_DCC_7	263	273	PF00069	0.450
DOC_MAPK_gen_1	170	177	PF00069	0.413
DOC_MAPK_gen_1	263	273	PF00069	0.463
DOC_MAPK_MEF2A_6	266	275	PF00069	0.440
DOC_MIT_MIM_1	166	175	PF04212	0.453
DOC_PP1_RVXF_1	218	225	PF00149	0.446
DOC_PP4_FxxP_1	52	55	PF00568	0.372
DOC_USP7_UBL2_3	263	267	PF12436	0.505
DOC_WW_Pin1_4	154	159	PF00397	0.598
DOC_WW_Pin1_4	23	28	PF00397	0.479
DOC_WW_Pin1_4	325	330	PF00397	0.514
DOC_WW_Pin1_4	8	13	PF00397	0.622
LIG_14-3-3_CanoR_1	5	13	PF00244	0.662
LIG_14-3-3_CanoR_1	65	69	PF00244	0.323
LIG_14-3-3_CanoR_1	75	82	PF00244	0.316
LIG_Actin_WH2_2	249	265	PF00022	0.439
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BRCT_BRCA1_1	206	210	PF00533	0.439
LIG_BRCT_BRCA1_1	302	306	PF00533	0.463
LIG_deltaCOP1_diTrp_1	279	287	PF00928	0.530
LIG_FHA_1	217	223	PF00498	0.463
LIG_FHA_1	24	30	PF00498	0.505
LIG_FHA_1	263	269	PF00498	0.439
LIG_FHA_1	64	70	PF00498	0.325
LIG_FHA_2	155	161	PF00498	0.516
LIG_FHA_2	250	256	PF00498	0.430
LIG_FHA_2	83	89	PF00498	0.383
LIG_HP1_1	272	276	PF01393	0.450
LIG_LIR_Apic_2	51	55	PF02991	0.367
LIG_LIR_Gen_1	225	234	PF02991	0.440
LIG_LIR_Gen_1	254	262	PF02991	0.430
LIG_LIR_Gen_1	279	289	PF02991	0.430
LIG_LIR_Gen_1	319	329	PF02991	0.493
LIG_LIR_LC3C_4	174	177	PF02991	0.380
LIG_LIR_Nem_3	146	150	PF02991	0.402
LIG_LIR_Nem_3	152	156	PF02991	0.420
LIG_LIR_Nem_3	225	229	PF02991	0.433
LIG_LIR_Nem_3	254	260	PF02991	0.439
LIG_LIR_Nem_3	279	284	PF02991	0.444
LIG_LIR_Nem_3	319	324	PF02991	0.491
LIG_MAD2	47	55	PF02301	0.370
LIG_Pex14_2	226	230	PF04695	0.431
LIG_PTB_Apo_2	31	38	PF02174	0.409
LIG_REV1ctd_RIR_1	227	237	PF16727	0.430
LIG_SH2_CRK	293	297	PF00017	0.539
LIG_SH2_CRK	321	325	PF00017	0.516
LIG_SH2_STAP1	238	242	PF00017	0.430
LIG_SH2_STAP1	82	86	PF00017	0.457
LIG_SH2_STAT5	13	16	PF00017	0.527
LIG_SH2_STAT5	153	156	PF00017	0.453
LIG_SH2_STAT5	228	231	PF00017	0.488
LIG_SH3_1	266	272	PF00018	0.450
LIG_SH3_3	241	247	PF00018	0.481
LIG_SH3_3	266	272	PF00018	0.430
LIG_TRAF2_1	297	300	PF00917	0.444
LIG_TRAF2_1	309	312	PF00917	0.396
LIG_TRFH_1	154	158	PF08558	0.608
LIG_UBA3_1	256	263	PF00899	0.445
LIG_WRC_WIRS_1	144	149	PF05994	0.460
MOD_CDK_SPxxK_3	23	30	PF00069	0.481
MOD_CK1_1	73	79	PF00069	0.449
MOD_CK2_1	133	139	PF00069	0.485
MOD_CK2_1	249	255	PF00069	0.430
MOD_CK2_1	294	300	PF00069	0.430
MOD_CK2_1	306	312	PF00069	0.430
MOD_GlcNHglycan	18	23	PF01048	0.538
MOD_GlcNHglycan	308	311	PF01048	0.278
MOD_GlcNHglycan	41	44	PF01048	0.482
MOD_GlcNHglycan	72	75	PF01048	0.340
MOD_GSK3_1	258	265	PF00069	0.439
MOD_GSK3_1	300	307	PF00069	0.539
MOD_GSK3_1	323	330	PF00069	0.403
MOD_GSK3_1	4	11	PF00069	0.709
MOD_GSK3_1	94	101	PF00069	0.520
MOD_NEK2_1	112	117	PF00069	0.436
MOD_NEK2_1	175	180	PF00069	0.329
MOD_NEK2_1	204	209	PF00069	0.449
MOD_NEK2_1	236	241	PF00069	0.450
MOD_NEK2_1	262	267	PF00069	0.439
MOD_NEK2_1	280	285	PF00069	0.439
MOD_NEK2_1	37	42	PF00069	0.455
MOD_NEK2_1	63	68	PF00069	0.450
MOD_NEK2_1	70	75	PF00069	0.277
MOD_PIKK_1	112	118	PF00454	0.403
MOD_PIKK_1	133	139	PF00454	0.352
MOD_PIKK_1	294	300	PF00454	0.480
MOD_PIKK_1	75	81	PF00454	0.425
MOD_PKA_2	4	10	PF00069	0.562
MOD_PKA_2	64	70	PF00069	0.310
MOD_Plk_1	82	88	PF00069	0.472
MOD_Plk_4	280	286	PF00069	0.427
MOD_Plk_4	300	306	PF00069	0.460
MOD_Plk_4	64	70	PF00069	0.297
MOD_ProDKin_1	154	160	PF00069	0.603
MOD_ProDKin_1	23	29	PF00069	0.473
MOD_ProDKin_1	325	331	PF00069	0.529
MOD_ProDKin_1	8	14	PF00069	0.618
TRG_DiLeu_BaEn_1	255	260	PF01217	0.431
TRG_DiLeu_BaEn_1	300	305	PF01217	0.539
TRG_ENDOCYTIC_2	153	156	PF00928	0.521
TRG_ENDOCYTIC_2	293	296	PF00928	0.539
TRG_ENDOCYTIC_2	32	35	PF00928	0.458
TRG_ENDOCYTIC_2	321	324	PF00928	0.494
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M2	Leptomonas seymouri	72%	100%
A0A0S4J0W4	Bodo saltans	42%	100%
A0A0S4KLV2	Bodo saltans	57%	98%
A0A1X0NU32	Trypanosomatidae	60%	100%
A0A3Q8IC52	Leishmania donovani	97%	100%
A0A422MT26	Trypanosoma rangeli	61%	100%
A4H7X4	Leishmania braziliensis	79%	100%
A4HWA1	Leishmania infantum	97%	100%
C9ZNT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AQ01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5AWJ3	Trypanosoma cruzi	60%	88%