Lysine decarboxylase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Possible lysine decarboxylase, putative

Species:

Leishmania major

UniProt:

Q4QFI0_LEIMA

TriTrypDb:

LmjF.15.0040 , LMJLV39_150005300 , LMJSD75_150005300

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QFI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI0

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.463
CLV_NRD_NRD_1	231	233	PF00675	0.230
CLV_PCSK_KEX2_1	170	172	PF00082	0.461
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.461
CLV_PCSK_SKI1_1	75	79	PF00082	0.440
DOC_CYCLIN_RxL_1	217	225	PF00134	0.446
DOC_MAPK_DCC_7	263	273	PF00069	0.450
DOC_MAPK_gen_1	170	177	PF00069	0.413
DOC_MAPK_gen_1	263	273	PF00069	0.463
DOC_MAPK_MEF2A_6	266	275	PF00069	0.440

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M2	Leptomonas seymouri	72%	100%
A0A0S4J0W4	Bodo saltans	42%	100%
A0A0S4KLV2	Bodo saltans	57%	98%
A0A1X0NU32	Trypanosomatidae	60%	100%
A0A3Q8IC52	Leishmania donovani	97%	100%
A0A422MT26	Trypanosoma rangeli	61%	100%
A4H7X4	Leishmania braziliensis	79%	100%
A4HWA1	Leishmania infantum	97%	100%
C9ZNT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AQ01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%

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