Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFH7_LEIMA

TriTrypDb:

LmjF.15.0070 , LMJLV39_150005700 , LMJSD75_150005800

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.544
CLV_C14_Caspase3-7	93	97	PF00656	0.504
CLV_NRD_NRD_1	183	185	PF00675	0.671
CLV_NRD_NRD_1	284	286	PF00675	0.536
CLV_NRD_NRD_1	34	36	PF00675	0.460
CLV_NRD_NRD_1	354	356	PF00675	0.498
CLV_NRD_NRD_1	426	428	PF00675	0.460
CLV_PCSK_FUR_1	181	185	PF00082	0.627
CLV_PCSK_KEX2_1	183	185	PF00082	0.632
CLV_PCSK_KEX2_1	284	286	PF00082	0.552
CLV_PCSK_KEX2_1	34	36	PF00082	0.460
CLV_PCSK_KEX2_1	354	356	PF00082	0.498
CLV_PCSK_KEX2_1	426	428	PF00082	0.460
CLV_PCSK_PC7_1	350	356	PF00082	0.473
CLV_PCSK_SKI1_1	300	304	PF00082	0.624
DOC_CYCLIN_RxL_1	390	401	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.557
DOC_MAPK_gen_1	354	361	PF00069	0.506
DOC_USP7_MATH_1	165	169	PF00917	0.644
DOC_USP7_MATH_1	172	176	PF00917	0.677
DOC_USP7_MATH_1	190	194	PF00917	0.493
DOC_USP7_MATH_1	198	202	PF00917	0.796
DOC_USP7_MATH_1	2	6	PF00917	0.570
DOC_USP7_MATH_1	237	241	PF00917	0.609
DOC_USP7_MATH_1	461	465	PF00917	0.651
DOC_WW_Pin1_4	144	149	PF00397	0.619
DOC_WW_Pin1_4	161	166	PF00397	0.518
DOC_WW_Pin1_4	168	173	PF00397	0.559
DOC_WW_Pin1_4	210	215	PF00397	0.619
DOC_WW_Pin1_4	443	448	PF00397	0.481
DOC_WW_Pin1_4	449	454	PF00397	0.570
LIG_14-3-3_CanoR_1	224	233	PF00244	0.613
LIG_14-3-3_CanoR_1	236	242	PF00244	0.502
LIG_14-3-3_CanoR_1	34	42	PF00244	0.476
LIG_14-3-3_CanoR_1	43	49	PF00244	0.406
LIG_14-3-3_CanoR_1	68	77	PF00244	0.726
LIG_eIF4E_1	443	449	PF01652	0.464
LIG_FHA_1	14	20	PF00498	0.495
LIG_FHA_1	215	221	PF00498	0.581
LIG_FHA_1	225	231	PF00498	0.523
LIG_FHA_1	256	262	PF00498	0.506
LIG_FHA_1	305	311	PF00498	0.546
LIG_FHA_1	319	325	PF00498	0.404
LIG_FHA_1	444	450	PF00498	0.410
LIG_FHA_2	240	246	PF00498	0.552
LIG_FHA_2	27	33	PF00498	0.430
LIG_FHA_2	318	324	PF00498	0.404
LIG_FHA_2	71	77	PF00498	0.628
LIG_FHA_2	91	97	PF00498	0.447
LIG_LIR_Gen_1	419	429	PF02991	0.407
LIG_LIR_Gen_1	90	95	PF02991	0.517
LIG_LIR_Nem_3	419	425	PF02991	0.509
LIG_LIR_Nem_3	90	94	PF02991	0.519
LIG_RPA_C_Fungi	350	362	PF08784	0.587
LIG_SH2_NCK_1	48	52	PF00017	0.410
LIG_SH2_STAP1	102	106	PF00017	0.497
LIG_SH2_STAT5	266	269	PF00017	0.493
LIG_SH2_STAT5	44	47	PF00017	0.538
LIG_SH3_2	231	236	PF14604	0.484
LIG_SH3_3	109	115	PF00018	0.569
LIG_SH3_3	142	148	PF00018	0.621
LIG_SH3_3	179	185	PF00018	0.733
LIG_SH3_3	228	234	PF00018	0.505
LIG_SH3_3	410	416	PF00018	0.546
LIG_SH3_3	64	70	PF00018	0.643
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.504
LIG_SUMO_SIM_par_1	444	452	PF11976	0.502
LIG_TRAF2_1	385	388	PF00917	0.605
LIG_TRAF2_1	398	401	PF00917	0.457
LIG_TRAF2_1	83	86	PF00917	0.641
LIG_WRC_WIRS_1	88	93	PF05994	0.461
MOD_CK1_1	164	170	PF00069	0.649
MOD_CK1_1	193	199	PF00069	0.630
MOD_CK1_1	223	229	PF00069	0.571
MOD_CK1_1	244	250	PF00069	0.612
MOD_CK1_1	46	52	PF00069	0.528
MOD_CK2_1	123	129	PF00069	0.658
MOD_CK2_1	144	150	PF00069	0.618
MOD_CK2_1	239	245	PF00069	0.565
MOD_CK2_1	341	347	PF00069	0.477
MOD_CK2_1	461	467	PF00069	0.625
MOD_GlcNHglycan	108	111	PF01048	0.542
MOD_GlcNHglycan	159	162	PF01048	0.647
MOD_GlcNHglycan	200	203	PF01048	0.598
MOD_GlcNHglycan	254	258	PF01048	0.535
MOD_GlcNHglycan	422	425	PF01048	0.534
MOD_GlcNHglycan	49	52	PF01048	0.522
MOD_GSK3_1	13	20	PF00069	0.489
MOD_GSK3_1	152	159	PF00069	0.681
MOD_GSK3_1	161	168	PF00069	0.622
MOD_GSK3_1	172	179	PF00069	0.655
MOD_GSK3_1	190	197	PF00069	0.567
MOD_GSK3_1	210	217	PF00069	0.543
MOD_GSK3_1	219	226	PF00069	0.717
MOD_GSK3_1	237	244	PF00069	0.698
MOD_GSK3_1	374	381	PF00069	0.480
MOD_GSK3_1	43	50	PF00069	0.490
MOD_GSK3_1	439	446	PF00069	0.512
MOD_NEK2_1	13	18	PF00069	0.521
MOD_NEK2_1	219	224	PF00069	0.579
MOD_PIKK_1	176	182	PF00454	0.628
MOD_PKA_1	34	40	PF00069	0.441
MOD_PKA_2	191	197	PF00069	0.721
MOD_PKA_2	208	214	PF00069	0.539
MOD_PKA_2	223	229	PF00069	0.597
MOD_PKA_2	317	323	PF00069	0.449
MOD_PKA_2	34	40	PF00069	0.485
MOD_PKA_2	374	380	PF00069	0.537
MOD_Plk_1	244	250	PF00069	0.507
MOD_Plk_2-3	123	129	PF00069	0.641
MOD_Plk_2-3	98	104	PF00069	0.482
MOD_Plk_4	87	93	PF00069	0.462
MOD_ProDKin_1	144	150	PF00069	0.618
MOD_ProDKin_1	161	167	PF00069	0.518
MOD_ProDKin_1	168	174	PF00069	0.560
MOD_ProDKin_1	210	216	PF00069	0.619
MOD_ProDKin_1	443	449	PF00069	0.489
MOD_SUMO_for_1	7	10	PF00179	0.506
TRG_DiLeu_BaEn_3	86	92	PF01217	0.486
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.514
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.462
TRG_ER_diArg_1	181	184	PF00400	0.684
TRG_ER_diArg_1	284	286	PF00400	0.469
TRG_ER_diArg_1	33	35	PF00400	0.452
TRG_ER_diArg_1	425	427	PF00400	0.463
TRG_ER_diArg_1	66	69	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C4	Leptomonas seymouri	41%	87%
A0A3Q8IIJ0	Leishmania donovani	89%	100%
A0A422NS55	Trypanosoma rangeli	30%	78%
A4H7X7	Leishmania braziliensis	65%	100%
A4HWA4	Leishmania infantum	89%	100%
E9AQ04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%