Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFH6_LEIMA

TriTrypDb:

LmjF.15.0080 , LMJLV39_150005800 , LMJSD75_150005900

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFH6

PDB structure(s): 7ane_p

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.649
CLV_NRD_NRD_1	118	120	PF00675	0.418
CLV_NRD_NRD_1	133	135	PF00675	0.465
CLV_NRD_NRD_1	2	4	PF00675	0.584
CLV_NRD_NRD_1	99	101	PF00675	0.428
CLV_PCSK_KEX2_1	144	146	PF00082	0.503
CLV_PCSK_KEX2_1	158	160	PF00082	0.349
CLV_PCSK_KEX2_1	2	4	PF00082	0.584
CLV_PCSK_KEX2_1	311	313	PF00082	0.781
CLV_PCSK_KEX2_1	35	37	PF00082	0.424
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.503
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.349
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.705
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.416
CLV_PCSK_SKI1_1	144	148	PF00082	0.385
CLV_PCSK_SKI1_1	178	182	PF00082	0.425
CLV_PCSK_SKI1_1	91	95	PF00082	0.423
DEG_APCC_DBOX_1	118	126	PF00400	0.395
DEG_Nend_UBRbox_1	1	4	PF02207	0.578
DOC_CKS1_1	194	199	PF01111	0.461
DOC_PP4_FxxP_1	45	48	PF00568	0.426
DOC_PP4_MxPP_1	57	60	PF00568	0.426
DOC_USP7_MATH_1	99	103	PF00917	0.440
DOC_USP7_UBL2_3	169	173	PF12436	0.580
DOC_WW_Pin1_4	193	198	PF00397	0.459
DOC_WW_Pin1_4	258	263	PF00397	0.671
DOC_WW_Pin1_4	296	301	PF00397	0.522
DOC_WW_Pin1_4	310	315	PF00397	0.549
LIG_14-3-3_CanoR_1	103	113	PF00244	0.431
LIG_14-3-3_CanoR_1	2	12	PF00244	0.582
LIG_APCC_ABBA_1	147	152	PF00400	0.539
LIG_deltaCOP1_diTrp_1	22	31	PF00928	0.432
LIG_deltaCOP1_diTrp_1	50	58	PF00928	0.432
LIG_FHA_1	223	229	PF00498	0.676
LIG_FHA_1	82	88	PF00498	0.511
LIG_FHA_2	21	27	PF00498	0.518
LIG_FHA_2	225	231	PF00498	0.703
LIG_FHA_2	251	257	PF00498	0.649
LIG_FHA_2	267	273	PF00498	0.560
LIG_FHA_2	78	84	PF00498	0.500
LIG_LIR_Apic_2	43	49	PF02991	0.422
LIG_LIR_Apic_2	6	12	PF02991	0.577
LIG_LIR_Gen_1	171	182	PF02991	0.441
LIG_LIR_Gen_1	29	37	PF02991	0.418
LIG_LIR_Gen_1	50	60	PF02991	0.432
LIG_LIR_Gen_1	83	94	PF02991	0.370
LIG_LIR_Nem_3	126	132	PF02991	0.399
LIG_LIR_Nem_3	29	34	PF02991	0.562
LIG_LIR_Nem_3	50	55	PF02991	0.399
LIG_LIR_Nem_3	83	89	PF02991	0.392
LIG_NRBOX	246	252	PF00104	0.679
LIG_Pex14_1	24	28	PF04695	0.435
LIG_Pex14_1	51	55	PF04695	0.399
LIG_SH2_CRK	9	13	PF00017	0.523
LIG_SH2_GRB2like	112	115	PF00017	0.432
LIG_SH2_PTP2	46	49	PF00017	0.408
LIG_SH2_SRC	46	49	PF00017	0.408
LIG_SH2_STAT5	174	177	PF00017	0.547
LIG_SH2_STAT5	295	298	PF00017	0.519
LIG_SH2_STAT5	46	49	PF00017	0.407
LIG_SH2_STAT5	86	89	PF00017	0.536
LIG_SH3_3	73	79	PF00018	0.580
LIG_TYR_ITSM	82	89	PF00017	0.388
LIG_UBA3_1	183	192	PF00899	0.588
MOD_CDK_SPxxK_3	310	317	PF00069	0.795
MOD_CK1_1	224	230	PF00069	0.615
MOD_CK1_1	243	249	PF00069	0.598
MOD_CK1_1	260	266	PF00069	0.605
MOD_CK1_1	77	83	PF00069	0.484
MOD_CK2_1	173	179	PF00069	0.444
MOD_CK2_1	20	26	PF00069	0.512
MOD_CK2_1	243	249	PF00069	0.645
MOD_CK2_1	266	272	PF00069	0.643
MOD_GlcNHglycan	170	173	PF01048	0.479
MOD_GlcNHglycan	242	245	PF01048	0.583
MOD_GSK3_1	217	224	PF00069	0.544
MOD_GSK3_1	258	265	PF00069	0.592
MOD_GSK3_1	266	273	PF00069	0.513
MOD_GSK3_1	289	296	PF00069	0.559
MOD_GSK3_1	77	84	PF00069	0.518
MOD_N-GLC_1	74	79	PF02516	0.493
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	257	262	PF00069	0.723
MOD_NEK2_1	286	291	PF00069	0.605
MOD_NEK2_1	40	45	PF00069	0.443
MOD_NEK2_2	266	271	PF00069	0.579
MOD_PIKK_1	185	191	PF00454	0.584
MOD_PIKK_1	77	83	PF00454	0.484
MOD_PKA_1	2	8	PF00069	0.615
MOD_PKA_2	1	7	PF00069	0.587
MOD_PKA_2	222	228	PF00069	0.629
MOD_PKA_2	99	105	PF00069	0.428
MOD_Plk_1	152	158	PF00069	0.470
MOD_Plk_1	178	184	PF00069	0.409
MOD_Plk_1	67	73	PF00069	0.478
MOD_Plk_2-3	85	91	PF00069	0.575
MOD_Plk_4	178	184	PF00069	0.410
MOD_Plk_4	198	204	PF00069	0.496
MOD_ProDKin_1	193	199	PF00069	0.459
MOD_ProDKin_1	258	264	PF00069	0.663
MOD_ProDKin_1	296	302	PF00069	0.525
MOD_ProDKin_1	310	316	PF00069	0.549
MOD_SUMO_rev_2	131	137	PF00179	0.343
MOD_SUMO_rev_2	166	171	PF00179	0.446
TRG_DiLeu_BaEn_1	179	184	PF01217	0.577
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.539
TRG_ENDOCYTIC_2	112	115	PF00928	0.432
TRG_ENDOCYTIC_2	129	132	PF00928	0.403
TRG_ENDOCYTIC_2	151	154	PF00928	0.398
TRG_ENDOCYTIC_2	174	177	PF00928	0.560
TRG_ENDOCYTIC_2	52	55	PF00928	0.398
TRG_ENDOCYTIC_2	86	89	PF00928	0.381
TRG_ER_diArg_1	1	3	PF00400	0.592
TRG_ER_diLys_1	317	321	PF00400	0.552
TRG_NLS_Bipartite_1	144	161	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM8	Leptomonas seymouri	77%	100%
A0A0S4KJ11	Bodo saltans	56%	94%
A0A1X0NU97	Trypanosomatidae	64%	100%
A0A3S5H6T6	Leishmania donovani	97%	100%
A0A422NSE6	Trypanosoma rangeli	64%	100%
A4H7X8	Leishmania braziliensis	86%	100%
A4HWA5	Leishmania infantum	97%	100%
C9ZNU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AQ05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DCQ2	Trypanosoma cruzi	67%	100%