Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFH3_LEIMA

TriTrypDb:

LmjF.15.0110 , LMJLV39_150006100 , LMJSD75_150006200

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QFH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.559
CLV_NRD_NRD_1	224	226	PF00675	0.582
CLV_NRD_NRD_1	231	233	PF00675	0.649
CLV_NRD_NRD_1	257	259	PF00675	0.397
CLV_NRD_NRD_1	387	389	PF00675	0.452
CLV_NRD_NRD_1	759	761	PF00675	0.438
CLV_NRD_NRD_1	777	779	PF00675	0.539
CLV_PCSK_FUR_1	385	389	PF00082	0.475
CLV_PCSK_KEX2_1	108	110	PF00082	0.670
CLV_PCSK_KEX2_1	257	259	PF00082	0.395
CLV_PCSK_KEX2_1	387	389	PF00082	0.421
CLV_PCSK_KEX2_1	692	694	PF00082	0.651
CLV_PCSK_KEX2_1	759	761	PF00082	0.438
CLV_PCSK_KEX2_1	777	779	PF00082	0.539
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.560
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.651
CLV_PCSK_SKI1_1	20	24	PF00082	0.440
CLV_PCSK_SKI1_1	232	236	PF00082	0.715
CLV_PCSK_SKI1_1	354	358	PF00082	0.641
CLV_PCSK_SKI1_1	388	392	PF00082	0.434
CLV_PCSK_SKI1_1	576	580	PF00082	0.480
CLV_PCSK_SKI1_1	616	620	PF00082	0.370
CLV_Separin_Metazoa	774	778	PF03568	0.540
DEG_APCC_DBOX_1	306	314	PF00400	0.426
DEG_APCC_DBOX_1	615	623	PF00400	0.381
DEG_COP1_1	329	340	PF00400	0.491
DEG_MDM2_SWIB_1	295	302	PF02201	0.483
DEG_Nend_UBRbox_1	1	4	PF02207	0.699
DEG_SCF_FBW7_1	555	562	PF00400	0.466
DEG_SCF_FBW7_1	577	583	PF00400	0.351
DEG_SCF_TRCP1_1	205	211	PF00400	0.570
DOC_CKS1_1	380	385	PF01111	0.480
DOC_CKS1_1	577	582	PF01111	0.400
DOC_CYCLIN_RxL_1	613	620	PF00134	0.437
DOC_MAPK_HePTP_8	635	647	PF00069	0.418
DOC_MAPK_MEF2A_6	638	647	PF00069	0.485
DOC_PP1_RVXF_1	416	423	PF00149	0.412
DOC_PP1_RVXF_1	552	558	PF00149	0.507
DOC_PP2B_LxvP_1	511	514	PF13499	0.382
DOC_PP4_FxxP_1	393	396	PF00568	0.419
DOC_PP4_FxxP_1	735	738	PF00568	0.593
DOC_USP7_MATH_1	140	144	PF00917	0.443
DOC_USP7_MATH_1	160	164	PF00917	0.250
DOC_USP7_MATH_1	27	31	PF00917	0.468
DOC_USP7_MATH_1	356	360	PF00917	0.662
DOC_USP7_MATH_1	364	368	PF00917	0.602
DOC_USP7_MATH_1	547	551	PF00917	0.467
DOC_USP7_MATH_1	580	584	PF00917	0.477
DOC_USP7_MATH_1	596	600	PF00917	0.290
DOC_USP7_MATH_1	705	709	PF00917	0.531
DOC_USP7_MATH_1	782	786	PF00917	0.518
DOC_USP7_UBL2_3	686	690	PF12436	0.675
DOC_WW_Pin1_4	354	359	PF00397	0.694
DOC_WW_Pin1_4	379	384	PF00397	0.526
DOC_WW_Pin1_4	426	431	PF00397	0.401
DOC_WW_Pin1_4	450	455	PF00397	0.377
DOC_WW_Pin1_4	543	548	PF00397	0.495
DOC_WW_Pin1_4	555	560	PF00397	0.398
DOC_WW_Pin1_4	568	573	PF00397	0.311
DOC_WW_Pin1_4	576	581	PF00397	0.348
DOC_WW_Pin1_4	671	676	PF00397	0.669
DOC_WW_Pin1_4	677	682	PF00397	0.662
DOC_WW_Pin1_4	734	739	PF00397	0.606
DOC_WW_Pin1_4	90	95	PF00397	0.643
LIG_14-3-3_CanoR_1	167	175	PF00244	0.406
LIG_14-3-3_CanoR_1	323	329	PF00244	0.571
LIG_14-3-3_CanoR_1	616	622	PF00244	0.463
LIG_Actin_WH2_2	271	289	PF00022	0.418
LIG_Actin_WH2_2	310	325	PF00022	0.582
LIG_Actin_WH2_2	754	772	PF00022	0.409
LIG_BRCT_BRCA1_1	533	537	PF00533	0.483
LIG_BRCT_BRCA1_1	627	631	PF00533	0.333
LIG_CaM_IQ_9	711	727	PF13499	0.407
LIG_CtBP_PxDLS_1	482	486	PF00389	0.516
LIG_deltaCOP1_diTrp_1	296	299	PF00928	0.390
LIG_deltaCOP1_diTrp_1	494	497	PF00928	0.449
LIG_FHA_1	188	194	PF00498	0.441
LIG_FHA_1	209	215	PF00498	0.591
LIG_FHA_1	395	401	PF00498	0.494
LIG_FHA_1	464	470	PF00498	0.440
LIG_FHA_1	486	492	PF00498	0.573
LIG_FHA_1	506	512	PF00498	0.339
LIG_FHA_1	544	550	PF00498	0.404
LIG_FHA_1	589	595	PF00498	0.400
LIG_FHA_1	613	619	PF00498	0.477
LIG_FHA_1	712	718	PF00498	0.558
LIG_FHA_1	763	769	PF00498	0.517
LIG_FHA_1	84	90	PF00498	0.733
LIG_FHA_2	112	118	PF00498	0.642
LIG_FHA_2	237	243	PF00498	0.700
LIG_FHA_2	478	484	PF00498	0.433
LIG_FHA_2	502	508	PF00498	0.432
LIG_LIR_Gen_1	148	158	PF02991	0.432
LIG_LIR_Gen_1	266	275	PF02991	0.526
LIG_LIR_Gen_1	296	304	PF02991	0.368
LIG_LIR_Gen_1	327	336	PF02991	0.483
LIG_LIR_Gen_1	453	464	PF02991	0.407
LIG_LIR_Gen_1	531	540	PF02991	0.529
LIG_LIR_Gen_1	591	596	PF02991	0.333
LIG_LIR_Nem_3	113	119	PF02991	0.503
LIG_LIR_Nem_3	148	153	PF02991	0.489
LIG_LIR_Nem_3	296	302	PF02991	0.370
LIG_LIR_Nem_3	327	331	PF02991	0.479
LIG_LIR_Nem_3	389	393	PF02991	0.383
LIG_LIR_Nem_3	429	435	PF02991	0.333
LIG_LIR_Nem_3	453	459	PF02991	0.386
LIG_LIR_Nem_3	531	536	PF02991	0.585
LIG_LIR_Nem_3	542	548	PF02991	0.376
LIG_LIR_Nem_3	644	649	PF02991	0.334
LIG_LIR_Nem_3	785	790	PF02991	0.510
LIG_MYND_1	426	430	PF01753	0.400
LIG_Pex14_2	295	299	PF04695	0.451
LIG_SH2_CRK	533	537	PF00017	0.589
LIG_SH2_NCK_1	116	120	PF00017	0.482
LIG_SH2_NCK_1	328	332	PF00017	0.480
LIG_SH2_NCK_1	533	537	PF00017	0.483
LIG_SH2_PTP2	519	522	PF00017	0.448
LIG_SH2_SRC	116	119	PF00017	0.426
LIG_SH2_STAP1	533	537	PF00017	0.598
LIG_SH2_STAP1	551	555	PF00017	0.475
LIG_SH2_STAP1	62	66	PF00017	0.556
LIG_SH2_STAT3	435	438	PF00017	0.471
LIG_SH2_STAT5	309	312	PF00017	0.310
LIG_SH2_STAT5	398	401	PF00017	0.410
LIG_SH2_STAT5	456	459	PF00017	0.363
LIG_SH2_STAT5	519	522	PF00017	0.364
LIG_SH2_STAT5	569	572	PF00017	0.426
LIG_SH2_STAT5	65	68	PF00017	0.517
LIG_SH2_STAT5	786	789	PF00017	0.508
LIG_SH3_2	380	385	PF14604	0.480
LIG_SH3_2	405	410	PF14604	0.442
LIG_SH3_3	190	196	PF00018	0.480
LIG_SH3_3	209	215	PF00018	0.463
LIG_SH3_3	240	246	PF00018	0.546
LIG_SH3_3	332	338	PF00018	0.577
LIG_SH3_3	377	383	PF00018	0.593
LIG_SH3_3	402	408	PF00018	0.518
LIG_SH3_3	560	566	PF00018	0.418
LIG_SH3_3	620	626	PF00018	0.309
LIG_SH3_3	740	746	PF00018	0.521
LIG_Sin3_3	409	416	PF02671	0.442
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.588
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.542
LIG_SUMO_SIM_par_1	250	256	PF11976	0.484
LIG_SUMO_SIM_par_1	300	305	PF11976	0.404
LIG_SUMO_SIM_par_1	309	314	PF11976	0.243
LIG_SUMO_SIM_par_1	85	90	PF11976	0.493
LIG_TRAF2_1	290	293	PF00917	0.476
LIG_TYR_ITSM	112	119	PF00017	0.513
LIG_WRC_WIRS_1	456	461	PF05994	0.494
MOD_CDK_SPxK_1	379	385	PF00069	0.487
MOD_CDK_SPxK_1	671	677	PF00069	0.495
MOD_CDK_SPxxK_3	677	684	PF00069	0.515
MOD_CDK_SPxxK_3	90	97	PF00069	0.556
MOD_CK1_1	145	151	PF00069	0.602
MOD_CK1_1	187	193	PF00069	0.551
MOD_CK1_1	29	35	PF00069	0.502
MOD_CK1_1	324	330	PF00069	0.626
MOD_CK1_1	359	365	PF00069	0.671
MOD_CK1_1	441	447	PF00069	0.465
MOD_CK1_1	455	461	PF00069	0.411
MOD_CK1_1	503	509	PF00069	0.530
MOD_CK2_1	236	242	PF00069	0.663
MOD_CK2_1	38	44	PF00069	0.540
MOD_CK2_1	462	468	PF00069	0.528
MOD_CK2_1	477	483	PF00069	0.337
MOD_CK2_1	701	707	PF00069	0.580
MOD_Cter_Amidation	106	109	PF01082	0.743
MOD_DYRK1A_RPxSP_1	677	681	PF00069	0.493
MOD_GlcNHglycan	149	153	PF01048	0.559
MOD_GlcNHglycan	204	208	PF01048	0.686
MOD_GlcNHglycan	215	218	PF01048	0.641
MOD_GlcNHglycan	312	316	PF01048	0.377
MOD_GlcNHglycan	323	326	PF01048	0.467
MOD_GlcNHglycan	366	369	PF01048	0.673
MOD_GlcNHglycan	4	7	PF01048	0.585
MOD_GlcNHglycan	450	453	PF01048	0.508
MOD_GlcNHglycan	533	536	PF01048	0.602
MOD_GlcNHglycan	627	630	PF01048	0.433
MOD_GlcNHglycan	638	641	PF01048	0.378
MOD_GlcNHglycan	694	698	PF01048	0.662
MOD_GlcNHglycan	703	706	PF01048	0.538
MOD_GSK3_1	162	169	PF00069	0.395
MOD_GSK3_1	187	194	PF00069	0.531
MOD_GSK3_1	203	210	PF00069	0.550
MOD_GSK3_1	22	29	PF00069	0.689
MOD_GSK3_1	311	318	PF00069	0.537
MOD_GSK3_1	326	333	PF00069	0.653
MOD_GSK3_1	354	361	PF00069	0.620
MOD_GSK3_1	444	451	PF00069	0.413
MOD_GSK3_1	501	508	PF00069	0.393
MOD_GSK3_1	531	538	PF00069	0.505
MOD_GSK3_1	543	550	PF00069	0.381
MOD_GSK3_1	555	562	PF00069	0.600
MOD_GSK3_1	576	583	PF00069	0.445
MOD_GSK3_1	671	678	PF00069	0.647
MOD_GSK3_1	701	708	PF00069	0.487
MOD_LATS_1	498	504	PF00433	0.417
MOD_NEK2_1	162	167	PF00069	0.480
MOD_NEK2_1	191	196	PF00069	0.527
MOD_NEK2_1	271	276	PF00069	0.399
MOD_NEK2_1	295	300	PF00069	0.426
MOD_NEK2_1	31	36	PF00069	0.533
MOD_NEK2_1	399	404	PF00069	0.319
MOD_NEK2_1	412	417	PF00069	0.396
MOD_NEK2_1	448	453	PF00069	0.502
MOD_NEK2_1	485	490	PF00069	0.590
MOD_NEK2_1	509	514	PF00069	0.427
MOD_NEK2_1	89	94	PF00069	0.694
MOD_NEK2_2	38	43	PF00069	0.586
MOD_OFUCOSY	593	598	PF10250	0.393
MOD_PIKK_1	168	174	PF00454	0.368
MOD_PIKK_1	356	362	PF00454	0.815
MOD_PIKK_1	483	489	PF00454	0.507
MOD_PIKK_1	580	586	PF00454	0.426
MOD_PIKK_1	657	663	PF00454	0.604
MOD_PIKK_1	705	711	PF00454	0.578
MOD_PIKK_1	95	101	PF00454	0.604
MOD_PKA_2	166	172	PF00069	0.403
MOD_PKA_2	74	80	PF00069	0.597
MOD_Plk_1	112	118	PF00069	0.563
MOD_Plk_1	148	154	PF00069	0.511
MOD_Plk_1	295	301	PF00069	0.476
MOD_Plk_1	752	758	PF00069	0.481
MOD_Plk_4	31	37	PF00069	0.592
MOD_Plk_4	38	44	PF00069	0.466
MOD_Plk_4	394	400	PF00069	0.408
MOD_Plk_4	452	458	PF00069	0.498
MOD_Plk_4	617	623	PF00069	0.437
MOD_Plk_4	782	788	PF00069	0.481
MOD_ProDKin_1	354	360	PF00069	0.694
MOD_ProDKin_1	379	385	PF00069	0.524
MOD_ProDKin_1	426	432	PF00069	0.399
MOD_ProDKin_1	450	456	PF00069	0.376
MOD_ProDKin_1	543	549	PF00069	0.487
MOD_ProDKin_1	555	561	PF00069	0.406
MOD_ProDKin_1	568	574	PF00069	0.307
MOD_ProDKin_1	576	582	PF00069	0.350
MOD_ProDKin_1	671	677	PF00069	0.670
MOD_ProDKin_1	734	740	PF00069	0.602
MOD_ProDKin_1	90	96	PF00069	0.641
TRG_DiLeu_BaEn_1	374	379	PF01217	0.655
TRG_DiLeu_BaEn_2	730	736	PF01217	0.525
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.530
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.402
TRG_ENDOCYTIC_2	116	119	PF00928	0.474
TRG_ENDOCYTIC_2	182	185	PF00928	0.295
TRG_ENDOCYTIC_2	268	271	PF00928	0.364
TRG_ENDOCYTIC_2	328	331	PF00928	0.481
TRG_ENDOCYTIC_2	434	437	PF00928	0.477
TRG_ENDOCYTIC_2	456	459	PF00928	0.374
TRG_ENDOCYTIC_2	518	521	PF00928	0.328
TRG_ENDOCYTIC_2	533	536	PF00928	0.481
TRG_ER_diArg_1	385	388	PF00400	0.462
TRG_ER_diArg_1	424	427	PF00400	0.356
TRG_ER_diArg_1	758	760	PF00400	0.449
TRG_ER_diArg_1	776	778	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR8	Leptomonas seymouri	48%	98%
A0A0S4KHH2	Bodo saltans	30%	92%
A0A1X0NTL8	Trypanosomatidae	40%	100%
A0A3Q8IA12	Leishmania donovani	93%	100%
A0A422NS84	Trypanosoma rangeli	37%	100%
A4H7Y1	Leishmania braziliensis	72%	100%
A4HWA8	Leishmania infantum	93%	100%
C9ZNU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AQ08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AWK1	Trypanosoma cruzi	35%	96%