C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein, putative

Species:

Leishmania major

UniProt:

Q4QFH0_LEIMA

TriTrypDb:

LmjF.15.0140 , LMJLV39_150006500 , LMJSD75_150006600

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFH0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.567
CLV_PCSK_FUR_1	107	111	PF00082	0.651
CLV_PCSK_KEX2_1	109	111	PF00082	0.571
CLV_PCSK_SKI1_1	34	38	PF00082	0.413
DOC_CKS1_1	98	103	PF01111	0.747
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.528
DOC_MAPK_gen_1	107	117	PF00069	0.536
DOC_MAPK_MEF2A_6	109	117	PF00069	0.552
DOC_PP2B_LxvP_1	172	175	PF13499	0.585
DOC_USP7_MATH_1	168	172	PF00917	0.609
DOC_USP7_MATH_1	190	194	PF00917	0.526
DOC_WW_Pin1_4	126	131	PF00397	0.611
DOC_WW_Pin1_4	75	80	PF00397	0.689
DOC_WW_Pin1_4	97	102	PF00397	0.684
LIG_14-3-3_CanoR_1	109	114	PF00244	0.645
LIG_14-3-3_CanoR_1	187	197	PF00244	0.549
LIG_FHA_1	110	116	PF00498	0.643
LIG_FHA_1	206	212	PF00498	0.600
LIG_FHA_2	120	126	PF00498	0.645
LIG_FHA_2	132	138	PF00498	0.633
LIG_IBAR_NPY_1	203	205	PF08397	0.531
LIG_LIR_Apic_2	124	130	PF02991	0.648
LIG_LIR_Apic_2	147	151	PF02991	0.620
LIG_LIR_Nem_3	137	143	PF02991	0.590
LIG_REV1ctd_RIR_1	20	29	PF16727	0.431
LIG_SH2_CRK	127	131	PF00017	0.649
LIG_SH2_CRK	148	152	PF00017	0.614
LIG_SH2_CRK	160	164	PF00017	0.558
LIG_SH2_SRC	136	139	PF00017	0.442
LIG_SH2_SRC	173	176	PF00017	0.494
LIG_SH2_STAT3	150	153	PF00017	0.636
LIG_SH2_STAT5	183	186	PF00017	0.568
LIG_SH3_3	112	118	PF00018	0.565
LIG_SH3_3	132	138	PF00018	0.387
LIG_SH3_3	95	101	PF00018	0.700
LIG_SUMO_SIM_par_1	111	116	PF11976	0.550
MOD_CDK_SPxxK_3	100	107	PF00069	0.670
MOD_CK1_1	129	135	PF00069	0.616
MOD_CK1_1	80	86	PF00069	0.660
MOD_CK1_1	87	93	PF00069	0.691
MOD_CK2_1	119	125	PF00069	0.646
MOD_CK2_1	131	137	PF00069	0.636
MOD_GlcNHglycan	131	134	PF01048	0.615
MOD_GlcNHglycan	188	191	PF01048	0.600
MOD_GlcNHglycan	86	89	PF01048	0.746
MOD_GSK3_1	10	17	PF00069	0.435
MOD_GSK3_1	109	116	PF00069	0.744
MOD_GSK3_1	186	193	PF00069	0.557
MOD_GSK3_1	73	80	PF00069	0.595
MOD_GSK3_1	82	89	PF00069	0.593
MOD_GSK3_1	93	100	PF00069	0.579
MOD_NEK2_1	188	193	PF00069	0.531
MOD_NEK2_1	54	59	PF00069	0.438
MOD_NEK2_2	168	173	PF00069	0.483
MOD_OFUCOSY	186	192	PF10250	0.566
MOD_PIKK_1	149	155	PF00454	0.641
MOD_PIKK_1	190	196	PF00454	0.607
MOD_PKA_1	109	115	PF00069	0.675
MOD_PKA_2	109	115	PF00069	0.673
MOD_PKA_2	186	192	PF00069	0.573
MOD_PKB_1	107	115	PF00069	0.646
MOD_Plk_4	168	174	PF00069	0.583
MOD_ProDKin_1	126	132	PF00069	0.610
MOD_ProDKin_1	75	81	PF00069	0.686
MOD_ProDKin_1	97	103	PF00069	0.692
MOD_SUMO_rev_2	41	51	PF00179	0.569
TRG_ER_diArg_1	106	109	PF00400	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Y1	Leptomonas seymouri	69%	100%
A0A1X0NV29	Trypanosomatidae	41%	100%
A0A3S7WT90	Leishmania donovani	94%	100%
A0A422NSB0	Trypanosoma rangeli	38%	100%
A4H7Y4	Leishmania braziliensis	81%	100%
A4HWB1	Leishmania infantum	94%	100%
C9ZNU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AQ11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%