C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein, putative

Species:

Leishmania major

UniProt:

Q4QFG8_LEIMA

TriTrypDb:

LmjF.15.0160 , LMJLV39_150006700 , LMJSD75_150006800

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFG8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.608
CLV_NRD_NRD_1	117	119	PF00675	0.675
CLV_NRD_NRD_1	166	168	PF00675	0.654
CLV_NRD_NRD_1	289	291	PF00675	0.772
CLV_NRD_NRD_1	5	7	PF00675	0.530
CLV_NRD_NRD_1	686	688	PF00675	0.591
CLV_NRD_NRD_1	708	710	PF00675	0.632
CLV_NRD_NRD_1	759	761	PF00675	0.806
CLV_NRD_NRD_1	816	818	PF00675	0.597
CLV_PCSK_FUR_1	817	821	PF00082	0.690
CLV_PCSK_KEX2_1	116	118	PF00082	0.781
CLV_PCSK_KEX2_1	166	168	PF00082	0.653
CLV_PCSK_KEX2_1	289	291	PF00082	0.750
CLV_PCSK_KEX2_1	5	7	PF00082	0.530
CLV_PCSK_KEX2_1	685	687	PF00082	0.597
CLV_PCSK_KEX2_1	708	710	PF00082	0.642
CLV_PCSK_KEX2_1	758	760	PF00082	0.823
CLV_PCSK_KEX2_1	819	821	PF00082	0.688
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.781
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.576
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.693
CLV_PCSK_SKI1_1	34	38	PF00082	0.421
CLV_PCSK_SKI1_1	820	824	PF00082	0.785
CLV_PCSK_SKI1_1	84	88	PF00082	0.609
DEG_SCF_FBW7_1	441	448	PF00400	0.629
DEG_SCF_TRCP1_1	435	440	PF00400	0.731
DEG_SPOP_SBC_1	277	281	PF00917	0.782
DEG_SPOP_SBC_1	510	514	PF00917	0.641
DEG_SPOP_SBC_1	521	525	PF00917	0.557
DEG_SPOP_SBC_1	764	768	PF00917	0.629
DOC_CKS1_1	197	202	PF01111	0.635
DOC_CKS1_1	267	272	PF01111	0.537
DOC_CKS1_1	341	346	PF01111	0.665
DOC_CKS1_1	442	447	PF01111	0.579
DOC_CKS1_1	798	803	PF01111	0.741
DOC_PP2B_LxvP_1	170	173	PF13499	0.617
DOC_PP2B_LxvP_1	188	191	PF13499	0.689
DOC_PP2B_LxvP_1	674	677	PF13499	0.633
DOC_PP4_FxxP_1	458	461	PF00568	0.599
DOC_USP7_MATH_1	104	108	PF00917	0.606
DOC_USP7_MATH_1	142	146	PF00917	0.684
DOC_USP7_MATH_1	213	217	PF00917	0.608
DOC_USP7_MATH_1	276	280	PF00917	0.784
DOC_USP7_MATH_1	299	303	PF00917	0.648
DOC_USP7_MATH_1	365	369	PF00917	0.625
DOC_USP7_MATH_1	370	374	PF00917	0.615
DOC_USP7_MATH_1	386	390	PF00917	0.566
DOC_USP7_MATH_1	418	422	PF00917	0.632
DOC_USP7_MATH_1	423	427	PF00917	0.602
DOC_USP7_MATH_1	431	435	PF00917	0.597
DOC_USP7_MATH_1	449	453	PF00917	0.527
DOC_USP7_MATH_1	477	481	PF00917	0.633
DOC_USP7_MATH_1	510	514	PF00917	0.625
DOC_USP7_MATH_1	516	520	PF00917	0.659
DOC_USP7_MATH_1	521	525	PF00917	0.724
DOC_USP7_MATH_1	632	636	PF00917	0.574
DOC_USP7_MATH_1	653	657	PF00917	0.619
DOC_USP7_MATH_1	664	668	PF00917	0.535
DOC_USP7_MATH_1	670	674	PF00917	0.496
DOC_USP7_MATH_1	677	681	PF00917	0.562
DOC_USP7_UBL2_3	116	120	PF12436	0.618
DOC_WW_Pin1_4	196	201	PF00397	0.701
DOC_WW_Pin1_4	266	271	PF00397	0.632
DOC_WW_Pin1_4	340	345	PF00397	0.587
DOC_WW_Pin1_4	358	363	PF00397	0.615
DOC_WW_Pin1_4	419	424	PF00397	0.657
DOC_WW_Pin1_4	437	442	PF00397	0.529
DOC_WW_Pin1_4	464	469	PF00397	0.564
DOC_WW_Pin1_4	499	504	PF00397	0.546
DOC_WW_Pin1_4	603	608	PF00397	0.611
DOC_WW_Pin1_4	621	626	PF00397	0.601
DOC_WW_Pin1_4	72	77	PF00397	0.620
DOC_WW_Pin1_4	752	757	PF00397	0.643
DOC_WW_Pin1_4	797	802	PF00397	0.646
LIG_14-3-3_CanoR_1	314	322	PF00244	0.621
LIG_14-3-3_CanoR_1	424	431	PF00244	0.661
LIG_14-3-3_CanoR_1	709	717	PF00244	0.529
LIG_14-3-3_CanoR_1	817	823	PF00244	0.631
LIG_BIR_III_2	298	302	PF00653	0.645
LIG_BRCT_BRCA1_1	205	209	PF00533	0.654
LIG_BRCT_BRCA1_1	77	81	PF00533	0.646
LIG_CSL_BTD_1	500	503	PF09270	0.522
LIG_deltaCOP1_diTrp_1	575	585	PF00928	0.446
LIG_EVH1_1	170	174	PF00568	0.692
LIG_EVH1_1	267	271	PF00568	0.654
LIG_EVH1_2	182	186	PF00568	0.537
LIG_EVH1_2	459	463	PF00568	0.629
LIG_FHA_1	262	268	PF00498	0.608
LIG_FHA_1	311	317	PF00498	0.631
LIG_FHA_1	49	55	PF00498	0.683
LIG_FHA_1	490	496	PF00498	0.528
LIG_FHA_1	510	516	PF00498	0.634
LIG_FHA_1	577	583	PF00498	0.434
LIG_FHA_1	639	645	PF00498	0.648
LIG_FHA_1	766	772	PF00498	0.634
LIG_FHA_2	334	340	PF00498	0.644
LIG_FHA_2	635	641	PF00498	0.625
LIG_FHA_2	764	770	PF00498	0.539
LIG_FHA_2	825	831	PF00498	0.603
LIG_Integrin_RGD_1	152	154	PF01839	0.732
LIG_LIR_Gen_1	410	419	PF02991	0.638
LIG_LIR_Gen_1	535	543	PF02991	0.480
LIG_LIR_Gen_1	548	558	PF02991	0.416
LIG_LIR_Gen_1	583	589	PF02991	0.365
LIG_LIR_Gen_1	767	774	PF02991	0.523
LIG_LIR_Nem_3	206	212	PF02991	0.665
LIG_LIR_Nem_3	255	261	PF02991	0.686
LIG_LIR_Nem_3	410	414	PF02991	0.728
LIG_LIR_Nem_3	535	539	PF02991	0.480
LIG_LIR_Nem_3	548	553	PF02991	0.418
LIG_LIR_Nem_3	767	773	PF02991	0.530
LIG_LYPXL_yS_3	258	261	PF13949	0.644
LIG_PDZ_Class_2	830	835	PF00595	0.580
LIG_Rb_LxCxE_1	727	748	PF01857	0.425
LIG_REV1ctd_RIR_1	20	28	PF16727	0.500
LIG_SH2_CRK	536	540	PF00017	0.472
LIG_SH2_CRK	550	554	PF00017	0.409
LIG_SH2_NCK_1	550	554	PF00017	0.409
LIG_SH2_SRC	227	230	PF00017	0.658
LIG_SH2_SRC	742	745	PF00017	0.447
LIG_SH2_STAT3	642	645	PF00017	0.602
LIG_SH2_STAT5	227	230	PF00017	0.577
LIG_SH2_STAT5	346	349	PF00017	0.600
LIG_SH2_STAT5	550	553	PF00017	0.406
LIG_SH2_STAT5	733	736	PF00017	0.425
LIG_SH2_STAT5	742	745	PF00017	0.417
LIG_SH3_3	168	174	PF00018	0.658
LIG_SH3_3	187	193	PF00018	0.630
LIG_SH3_3	195	201	PF00018	0.628
LIG_SH3_3	216	222	PF00018	0.538
LIG_SH3_3	265	271	PF00018	0.639
LIG_SH3_3	338	344	PF00018	0.587
LIG_SH3_3	371	377	PF00018	0.670
LIG_SH3_3	382	388	PF00018	0.557
LIG_SH3_3	471	477	PF00018	0.550
LIG_SH3_3	738	744	PF00018	0.419
LIG_SH3_3	768	774	PF00018	0.594
LIG_SH3_3	93	99	PF00018	0.570
LIG_SUMO_SIM_par_1	656	662	PF11976	0.599
LIG_TRAF2_1	525	528	PF00917	0.650
LIG_TRAF2_1	826	829	PF00917	0.623
LIG_WRC_WIRS_1	19	24	PF05994	0.413
LIG_WW_2	173	176	PF00397	0.588
LIG_WW_2	193	196	PF00397	0.619
MOD_CDK_SPK_2	419	424	PF00069	0.613
MOD_CDK_SPxK_1	752	758	PF00069	0.706
MOD_CDK_SPxxK_3	752	759	PF00069	0.706
MOD_CK1_1	123	129	PF00069	0.639
MOD_CK1_1	145	151	PF00069	0.584
MOD_CK1_1	18	24	PF00069	0.427
MOD_CK1_1	257	263	PF00069	0.732
MOD_CK1_1	279	285	PF00069	0.626
MOD_CK1_1	318	324	PF00069	0.658
MOD_CK1_1	426	432	PF00069	0.643
MOD_CK1_1	433	439	PF00069	0.657
MOD_CK1_1	490	496	PF00069	0.631
MOD_CK1_1	499	505	PF00069	0.734
MOD_CK1_1	514	520	PF00069	0.637
MOD_CK1_1	548	554	PF00069	0.466
MOD_CK1_1	646	652	PF00069	0.727
MOD_CK1_1	679	685	PF00069	0.662
MOD_CK1_1	745	751	PF00069	0.636
MOD_CK1_1	75	81	PF00069	0.652
MOD_CK1_1	781	787	PF00069	0.543
MOD_CK1_1	794	800	PF00069	0.669
MOD_CK1_1	803	809	PF00069	0.569
MOD_CK2_1	357	363	PF00069	0.768
MOD_CK2_1	499	505	PF00069	0.524
MOD_CK2_1	521	527	PF00069	0.682
MOD_CK2_1	634	640	PF00069	0.695
MOD_CK2_1	677	683	PF00069	0.637
MOD_CK2_1	818	824	PF00069	0.685
MOD_Cter_Amidation	756	759	PF01082	0.712
MOD_Cter_Amidation	815	818	PF01082	0.595
MOD_GlcNHglycan	103	107	PF01048	0.639
MOD_GlcNHglycan	127	130	PF01048	0.658
MOD_GlcNHglycan	144	147	PF01048	0.734
MOD_GlcNHglycan	148	151	PF01048	0.610
MOD_GlcNHglycan	205	208	PF01048	0.679
MOD_GlcNHglycan	236	239	PF01048	0.654
MOD_GlcNHglycan	281	284	PF01048	0.763
MOD_GlcNHglycan	333	336	PF01048	0.651
MOD_GlcNHglycan	388	391	PF01048	0.566
MOD_GlcNHglycan	435	438	PF01048	0.766
MOD_GlcNHglycan	451	454	PF01048	0.532
MOD_GlcNHglycan	485	488	PF01048	0.615
MOD_GlcNHglycan	518	521	PF01048	0.626
MOD_GlcNHglycan	531	534	PF01048	0.681
MOD_GlcNHglycan	540	543	PF01048	0.495
MOD_GlcNHglycan	562	565	PF01048	0.513
MOD_GlcNHglycan	645	648	PF01048	0.593
MOD_GlcNHglycan	679	682	PF01048	0.614
MOD_GlcNHglycan	726	729	PF01048	0.447
MOD_GlcNHglycan	744	747	PF01048	0.521
MOD_GlcNHglycan	780	783	PF01048	0.516
MOD_GSK3_1	10	17	PF00069	0.460
MOD_GSK3_1	116	123	PF00069	0.707
MOD_GSK3_1	124	131	PF00069	0.661
MOD_GSK3_1	142	149	PF00069	0.708
MOD_GSK3_1	18	25	PF00069	0.422
MOD_GSK3_1	199	206	PF00069	0.675
MOD_GSK3_1	253	260	PF00069	0.702
MOD_GSK3_1	279	286	PF00069	0.708
MOD_GSK3_1	318	325	PF00069	0.657
MOD_GSK3_1	395	402	PF00069	0.641
MOD_GSK3_1	403	410	PF00069	0.554
MOD_GSK3_1	419	426	PF00069	0.636
MOD_GSK3_1	433	440	PF00069	0.608
MOD_GSK3_1	441	448	PF00069	0.775
MOD_GSK3_1	479	486	PF00069	0.619
MOD_GSK3_1	510	517	PF00069	0.651
MOD_GSK3_1	613	620	PF00069	0.611
MOD_GSK3_1	621	628	PF00069	0.590
MOD_GSK3_1	634	641	PF00069	0.731
MOD_GSK3_1	66	73	PF00069	0.639
MOD_N-GLC_1	331	336	PF02516	0.669
MOD_N-GLC_1	358	363	PF02516	0.672
MOD_N-GLC_1	478	483	PF02516	0.549
MOD_N-GLC_1	670	675	PF02516	0.633
MOD_NEK2_1	124	129	PF00069	0.669
MOD_NEK2_1	252	257	PF00069	0.686
MOD_NEK2_1	261	266	PF00069	0.626
MOD_NEK2_1	322	327	PF00069	0.626
MOD_NEK2_1	357	362	PF00069	0.638
MOD_NEK2_1	478	483	PF00069	0.633
MOD_NEK2_1	496	501	PF00069	0.501
MOD_NEK2_1	511	516	PF00069	0.523
MOD_NEK2_1	576	581	PF00069	0.441
MOD_NEK2_1	717	722	PF00069	0.539
MOD_PIKK_1	365	371	PF00454	0.647
MOD_PIKK_1	701	707	PF00454	0.698
MOD_PIKK_1	791	797	PF00454	0.633
MOD_PK_1	818	824	PF00069	0.604
MOD_PKA_1	116	122	PF00069	0.650
MOD_PKA_1	778	784	PF00069	0.512
MOD_PKA_1	818	824	PF00069	0.604
MOD_PKA_2	116	122	PF00069	0.753
MOD_PKA_2	423	429	PF00069	0.671
MOD_PKB_1	308	316	PF00069	0.631
MOD_Plk_1	670	676	PF00069	0.635
MOD_Plk_2-3	824	830	PF00069	0.608
MOD_Plk_4	18	24	PF00069	0.413
MOD_Plk_4	181	187	PF00069	0.540
MOD_Plk_4	469	475	PF00069	0.523
MOD_Plk_4	496	502	PF00069	0.643
MOD_Plk_4	66	72	PF00069	0.637
MOD_Plk_4	736	742	PF00069	0.395
MOD_ProDKin_1	196	202	PF00069	0.705
MOD_ProDKin_1	266	272	PF00069	0.628
MOD_ProDKin_1	340	346	PF00069	0.588
MOD_ProDKin_1	358	364	PF00069	0.619
MOD_ProDKin_1	419	425	PF00069	0.662
MOD_ProDKin_1	437	443	PF00069	0.525
MOD_ProDKin_1	464	470	PF00069	0.559
MOD_ProDKin_1	499	505	PF00069	0.549
MOD_ProDKin_1	603	609	PF00069	0.612
MOD_ProDKin_1	621	627	PF00069	0.602
MOD_ProDKin_1	72	78	PF00069	0.621
MOD_ProDKin_1	752	758	PF00069	0.644
MOD_ProDKin_1	797	803	PF00069	0.646
MOD_SUMO_rev_2	41	51	PF00179	0.602
MOD_SUMO_rev_2	776	781	PF00179	0.607
MOD_SUMO_rev_2	78	86	PF00179	0.550
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.624
TRG_ENDOCYTIC_2	214	217	PF00928	0.623
TRG_ENDOCYTIC_2	258	261	PF00928	0.695
TRG_ENDOCYTIC_2	348	351	PF00928	0.589
TRG_ENDOCYTIC_2	536	539	PF00928	0.480
TRG_ENDOCYTIC_2	550	553	PF00928	0.406
TRG_ER_diArg_1	686	688	PF00400	0.669
TRG_ER_diArg_1	758	760	PF00400	0.661
TRG_NLS_MonoCore_2	816	821	PF00514	0.635
TRG_NLS_MonoExtC_3	115	120	PF00514	0.631
TRG_NLS_MonoExtN_4	815	822	PF00514	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y8	Leptomonas seymouri	42%	100%
A0A3Q8I906	Leishmania donovani	91%	100%
A4H7Y5	Leishmania braziliensis	61%	100%
A4HWB3	Leishmania infantum	90%	99%
E9AQ13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%