Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CMGC/DYRK protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QFG6_LEIMA

TriTrypDb:

LmjF.15.0180 , LMJLV39_150006900 , LMJSD75_150007000

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFG6

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	11
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0016310	phosphorylation	5	11
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018107	peptidyl-threonine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0018210	peptidyl-threonine modification	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	11
GO:0080090	regulation of primary metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003712	transcription coregulator activity	2	2
GO:0003713	transcription coactivator activity	3	2
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	7
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0140110	transcription regulator activity	1	2
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.440
CLV_C14_Caspase3-7	70	74	PF00656	0.598
CLV_NRD_NRD_1	104	106	PF00675	0.338
CLV_NRD_NRD_1	168	170	PF00675	0.356
CLV_NRD_NRD_1	238	240	PF00675	0.255
CLV_NRD_NRD_1	389	391	PF00675	0.279
CLV_NRD_NRD_1	406	408	PF00675	0.140
CLV_PCSK_FUR_1	404	408	PF00082	0.353
CLV_PCSK_KEX2_1	104	106	PF00082	0.349
CLV_PCSK_KEX2_1	157	159	PF00082	0.219
CLV_PCSK_KEX2_1	168	170	PF00082	0.219
CLV_PCSK_KEX2_1	293	295	PF00082	0.353
CLV_PCSK_KEX2_1	389	391	PF00082	0.253
CLV_PCSK_KEX2_1	406	408	PF00082	0.146
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.219
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.353
CLV_PCSK_SKI1_1	199	203	PF00082	0.232
CLV_PCSK_SKI1_1	440	444	PF00082	0.328
DEG_APCC_DBOX_1	320	328	PF00400	0.206
DEG_APCC_DBOX_1	388	396	PF00400	0.295
DEG_SPOP_SBC_1	49	53	PF00917	0.522
DEG_SPOP_SBC_1	500	504	PF00917	0.651
DOC_CKS1_1	315	320	PF01111	0.238
DOC_CKS1_1	408	413	PF01111	0.353
DOC_MAPK_gen_1	226	235	PF00069	0.219
DOC_MAPK_gen_1	302	312	PF00069	0.206
DOC_MAPK_HePTP_8	299	311	PF00069	0.206
DOC_MAPK_MEF2A_6	174	183	PF00069	0.308
DOC_MAPK_MEF2A_6	229	237	PF00069	0.219
DOC_MAPK_MEF2A_6	28	37	PF00069	0.545
DOC_MAPK_MEF2A_6	302	311	PF00069	0.206
DOC_MAPK_MEF2A_6	80	89	PF00069	0.401
DOC_PP1_RVXF_1	279	286	PF00149	0.206
DOC_PP2B_LxvP_1	125	128	PF13499	0.418
DOC_PP4_FxxP_1	447	450	PF00568	0.317
DOC_USP7_MATH_1	13	17	PF00917	0.734
DOC_USP7_MATH_1	40	44	PF00917	0.675
DOC_USP7_MATH_1	50	54	PF00917	0.541
DOC_USP7_MATH_1	67	71	PF00917	0.599
DOC_WW_Pin1_4	105	110	PF00397	0.503
DOC_WW_Pin1_4	26	31	PF00397	0.477
DOC_WW_Pin1_4	303	308	PF00397	0.206
DOC_WW_Pin1_4	314	319	PF00397	0.206
DOC_WW_Pin1_4	362	367	PF00397	0.206
DOC_WW_Pin1_4	407	412	PF00397	0.243
LIG_14-3-3_CanoR_1	168	174	PF00244	0.249
LIG_14-3-3_CanoR_1	321	325	PF00244	0.239
LIG_14-3-3_CanoR_1	389	393	PF00244	0.345
LIG_14-3-3_CanoR_1	513	520	PF00244	0.543
LIG_14-3-3_CanoR_1	80	86	PF00244	0.442
LIG_APCC_ABBA_1	309	314	PF00400	0.219
LIG_Clathr_ClatBox_1	249	253	PF01394	0.353
LIG_EH1_1	194	202	PF00400	0.295
LIG_FHA_1	244	250	PF00498	0.286
LIG_FHA_1	451	457	PF00498	0.496
LIG_FHA_1	50	56	PF00498	0.569
LIG_FHA_1	501	507	PF00498	0.566
LIG_FHA_2	315	321	PF00498	0.206
LIG_FHA_2	505	511	PF00498	0.745
LIG_Integrin_isoDGR_2	9	11	PF01839	0.542
LIG_LIR_Apic_2	301	307	PF02991	0.206
LIG_LIR_Apic_2	314	318	PF02991	0.206
LIG_LIR_Apic_2	76	81	PF02991	0.560
LIG_LIR_Gen_1	121	132	PF02991	0.261
LIG_LIR_Gen_1	420	429	PF02991	0.353
LIG_LIR_Nem_3	121	127	PF02991	0.280
LIG_LIR_Nem_3	130	136	PF02991	0.260
LIG_LIR_Nem_3	146	150	PF02991	0.141
LIG_LIR_Nem_3	218	222	PF02991	0.206
LIG_LIR_Nem_3	228	233	PF02991	0.206
LIG_LIR_Nem_3	415	421	PF02991	0.219
LIG_LIR_Nem_3	426	431	PF02991	0.219
LIG_LIR_Nem_3	91	96	PF02991	0.321
LIG_MYND_1	446	450	PF01753	0.236
LIG_NRBOX	180	186	PF00104	0.219
LIG_PCNA_yPIPBox_3	186	197	PF02747	0.236
LIG_Pex14_2	424	428	PF04695	0.349
LIG_PTB_Apo_2	94	101	PF02174	0.341
LIG_PTB_Phospho_1	94	100	PF10480	0.346
LIG_RPA_C_Fungi	94	106	PF08784	0.332
LIG_SH2_CRK	222	226	PF00017	0.206
LIG_SH2_CRK	315	319	PF00017	0.454
LIG_SH2_CRK	78	82	PF00017	0.533
LIG_SH2_CRK	93	97	PF00017	0.247
LIG_SH2_NCK_1	78	82	PF00017	0.437
LIG_SH2_STAP1	452	456	PF00017	0.496
LIG_SH2_STAT3	100	103	PF00017	0.333
LIG_SH2_STAT3	136	139	PF00017	0.253
LIG_SH2_STAT5	100	103	PF00017	0.351
LIG_SH2_STAT5	124	127	PF00017	0.260
LIG_SH2_STAT5	136	139	PF00017	0.241
LIG_SH2_STAT5	290	293	PF00017	0.232
LIG_SH2_STAT5	298	301	PF00017	0.231
LIG_SH2_STAT5	452	455	PF00017	0.495
LIG_SH3_2	471	476	PF14604	0.557
LIG_SH3_3	27	33	PF00018	0.677
LIG_SH3_3	468	474	PF00018	0.677
LIG_SH3_3	489	495	PF00018	0.645
LIG_SH3_4	487	494	PF00018	0.701
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.235
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.236
LIG_SUMO_SIM_par_1	209	215	PF11976	0.231
LIG_UBA3_1	249	256	PF00899	0.353
LIG_UBA3_1	89	94	PF00899	0.407
LIG_WRC_WIRS_1	216	221	PF05994	0.219
MOD_CDK_SPK_2	362	367	PF00069	0.206
MOD_CDK_SPxxK_3	105	112	PF00069	0.508
MOD_CDK_SPxxK_3	314	321	PF00069	0.238
MOD_CK1_1	146	152	PF00069	0.206
MOD_CK1_1	172	178	PF00069	0.219
MOD_CK1_1	18	24	PF00069	0.561
MOD_CK1_1	38	44	PF00069	0.588
MOD_CK1_1	483	489	PF00069	0.712
MOD_CK1_1	512	518	PF00069	0.715
MOD_CK1_1	53	59	PF00069	0.669
MOD_CK2_1	504	510	PF00069	0.744
MOD_Cter_Amidation	404	407	PF01082	0.353
MOD_GlcNHglycan	114	117	PF01048	0.427
MOD_GlcNHglycan	277	280	PF01048	0.211
MOD_GlcNHglycan	286	289	PF01048	0.198
MOD_GlcNHglycan	377	380	PF01048	0.314
MOD_GlcNHglycan	43	46	PF01048	0.613
MOD_GlcNHglycan	468	471	PF01048	0.537
MOD_GlcNHglycan	514	517	PF01048	0.729
MOD_GSK3_1	15	22	PF00069	0.587
MOD_GSK3_1	164	171	PF00069	0.353
MOD_GSK3_1	24	31	PF00069	0.529
MOD_GSK3_1	284	291	PF00069	0.236
MOD_GSK3_1	49	56	PF00069	0.503
MOD_GSK3_1	494	501	PF00069	0.708
MOD_GSK3_1	502	509	PF00069	0.651
MOD_N-GLC_1	275	280	PF02516	0.219
MOD_N-GLC_1	374	379	PF02516	0.238
MOD_NEK2_1	164	169	PF00069	0.206
MOD_NEK2_1	245	250	PF00069	0.248
MOD_PIKK_1	172	178	PF00454	0.216
MOD_PIKK_1	477	483	PF00454	0.700
MOD_PKA_1	168	174	PF00069	0.353
MOD_PKA_2	168	174	PF00069	0.381
MOD_PKA_2	320	326	PF00069	0.209
MOD_PKA_2	388	394	PF00069	0.275
MOD_PKA_2	512	518	PF00069	0.557
MOD_Plk_1	350	356	PF00069	0.299
MOD_Plk_1	413	419	PF00069	0.176
MOD_Plk_2-3	388	394	PF00069	0.353
MOD_Plk_4	146	152	PF00069	0.206
MOD_Plk_4	245	251	PF00069	0.322
MOD_Plk_4	391	397	PF00069	0.295
MOD_ProDKin_1	105	111	PF00069	0.507
MOD_ProDKin_1	26	32	PF00069	0.476
MOD_ProDKin_1	303	309	PF00069	0.206
MOD_ProDKin_1	314	320	PF00069	0.206
MOD_ProDKin_1	362	368	PF00069	0.206
MOD_ProDKin_1	407	413	PF00069	0.243
MOD_SUMO_for_1	177	180	PF00179	0.219
MOD_SUMO_for_1	265	268	PF00179	0.206
MOD_SUMO_for_1	348	351	PF00179	0.347
TRG_DiLeu_BaEn_1	180	185	PF01217	0.219
TRG_DiLeu_BaEn_2	307	313	PF01217	0.353
TRG_DiLeu_BaEn_2	419	425	PF01217	0.353
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.353
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.219
TRG_ENDOCYTIC_2	124	127	PF00928	0.260
TRG_ENDOCYTIC_2	222	225	PF00928	0.206
TRG_ENDOCYTIC_2	418	421	PF00928	0.208
TRG_ENDOCYTIC_2	93	96	PF00928	0.318
TRG_ER_diArg_1	104	106	PF00400	0.342
TRG_ER_diArg_1	403	406	PF00400	0.295
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	427	432	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z9	Leptomonas seymouri	28%	100%
A0A0N0P4D6	Leptomonas seymouri	36%	72%
A0A0N1I0B6	Leptomonas seymouri	26%	97%
A0A0N1I9B7	Leptomonas seymouri	25%	100%
A0A0N1IIU9	Leptomonas seymouri	27%	100%
A0A0N1PBM1	Leptomonas seymouri	79%	71%
A0A0N1PC31	Leptomonas seymouri	24%	100%
A0A0S4IIU2	Bodo saltans	37%	100%
A0A0S4IL53	Bodo saltans	24%	77%
A0A0S4ILC2	Bodo saltans	27%	100%
A0A0S4IUF2	Bodo saltans	33%	95%
A0A0S4J2K6	Bodo saltans	60%	100%
A0A0S4JCK3	Bodo saltans	23%	100%
A0A1X0NHA6	Trypanosomatidae	28%	99%
A0A1X0NMR5	Trypanosomatidae	26%	100%
A0A1X0NMS0	Trypanosomatidae	24%	100%
A0A1X0NNI0	Trypanosomatidae	29%	67%
A0A1X0NV34	Trypanosomatidae	73%	68%
A0A1X0NVV9	Trypanosomatidae	25%	100%
A0A1X0P018	Trypanosomatidae	26%	94%
A0A1X0P020	Trypanosomatidae	28%	100%
A0A1X0P1G1	Trypanosomatidae	33%	93%
A0A1X0P2I7	Trypanosomatidae	26%	100%
A0A1X0P3K5	Trypanosomatidae	37%	100%
A0A3Q8IB74	Leishmania donovani	30%	100%
A0A3Q8IH39	Leishmania donovani	29%	100%
A0A3Q8II44	Leishmania donovani	30%	100%
A0A3Q8ITZ9	Leishmania donovani	25%	100%
A0A3Q8IVR8	Leishmania donovani	25%	100%
A0A3R7KDC2	Trypanosoma rangeli	28%	100%
A0A3R7KRL6	Trypanosoma rangeli	37%	100%
A0A3R7KRM5	Trypanosoma rangeli	64%	78%
A0A3R7L9Q6	Trypanosoma rangeli	28%	100%
A0A3R7LCG7	Trypanosoma rangeli	26%	90%
A0A3R7M0A0	Trypanosoma rangeli	30%	100%
A0A3S5H6C8	Leishmania donovani	28%	100%
A0A3S5H725	Leishmania donovani	27%	100%
A0A3S5H7N7	Leishmania donovani	27%	100%
A0A3S7WQK7	Leishmania donovani	28%	100%
A0A3S7WTA3	Leishmania donovani	94%	70%
A0A3S7X2Z6	Leishmania donovani	27%	100%
A0A3S7X9D1	Leishmania donovani	35%	91%
A0A3S7XA45	Leishmania donovani	27%	100%
A0A422N7C9	Trypanosoma rangeli	27%	83%
A0A422NYI3	Trypanosoma rangeli	28%	81%
A2X6X1	Oryza sativa subsp. indica	28%	75%
A2XUW1	Oryza sativa subsp. indica	27%	73%
A4H5L7	Leishmania braziliensis	27%	100%
A4H601	Leishmania braziliensis	29%	100%
A4H9D1	Leishmania braziliensis	28%	100%
A4H9X5	Leishmania braziliensis	30%	100%
A4HA94	Leishmania braziliensis	24%	100%
A4HC27	Leishmania braziliensis	33%	100%
A4HIM5	Leishmania braziliensis	25%	100%
A4HMK7	Leishmania braziliensis	35%	90%
A4HNG3	Leishmania braziliensis	27%	100%
A4HQG8	Leishmania braziliensis	31%	100%
A4HTV4	Leishmania infantum	28%	100%
A4HTV5	Leishmania infantum	28%	100%
A4HUC8	Leishmania infantum	29%	100%
A4HWB5	Leishmania infantum	94%	70%
A4HXQ3	Leishmania infantum	27%	100%
A4HYH4	Leishmania infantum	24%	100%
A4I564	Leishmania infantum	27%	100%
A4I5X0	Leishmania infantum	27%	100%
A4I910	Leishmania infantum	25%	100%
A4IB86	Leishmania infantum	35%	91%
A4IC54	Leishmania infantum	27%	100%
A4ICA4	Leishmania infantum	30%	100%
A4ICR2	Leishmania infantum	25%	100%
C9ZNW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	76%
C9ZQJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZSX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	67%
D0A3L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A6D0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A7P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E8NHS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AEZ4	Leishmania major	25%	100%
E9AF07	Leishmania major	36%	91%
E9AFX4	Leishmania major	28%	100%
E9AGS0	Leishmania infantum	30%	100%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AN28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AQ15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	70%
E9ARG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AS98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ASJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B0G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B164	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	91%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O35491	Mus musculus	31%	100%
O35492	Mus musculus	33%	82%
O35493	Mus musculus	32%	100%
O43781	Homo sapiens	39%	89%
O44408	Caenorhabditis elegans	28%	100%
P20793	Rattus norvegicus	28%	84%
P22518	Mus musculus	31%	100%
P27361	Homo sapiens	25%	100%
P27638	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P46551	Caenorhabditis elegans	25%	71%
P49759	Homo sapiens	31%	100%
P49760	Homo sapiens	31%	100%
P49761	Homo sapiens	33%	82%
P50750	Homo sapiens	26%	100%
P50873	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P51136	Dictyostelium discoideum	29%	100%
P51566	Arabidopsis thaliana	33%	100%
P51567	Arabidopsis thaliana	32%	100%
P51568	Arabidopsis thaliana	31%	100%
P53779	Homo sapiens	29%	100%
P92208	Drosophila melanogaster	28%	100%
Q00532	Homo sapiens	29%	100%
Q04859	Mus musculus	27%	84%
Q0IJ08	Xenopus tropicalis	41%	69%
Q10156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	76%
Q13627	Homo sapiens	41%	68%
Q2TAE3	Xenopus laevis	41%	69%
Q39021	Arabidopsis thaliana	29%	100%
Q39022	Arabidopsis thaliana	29%	100%
Q3SX21	Bos taurus	33%	100%
Q45FA5	Physarum polycephalum	30%	100%
Q4Q0B0	Leishmania major	30%	100%
Q4Q204	Leishmania major	26%	100%
Q4Q449	Leishmania major	25%	100%
Q4Q701	Leishmania major	27%	100%
Q4QC19	Leishmania major	31%	100%
Q4QD66	Leishmania major	24%	100%
Q4QDK3	Leishmania major	30%	100%
Q4QE15	Leishmania major	29%	100%
Q4QHJ8	Leishmania major	29%	100%
Q4QHY3	Leishmania major	28%	100%
Q4QHY4	Leishmania major	28%	100%
Q4R6S5	Macaca fascicularis	39%	92%
Q4R7T5	Macaca fascicularis	27%	91%
Q4V8A3	Rattus norvegicus	38%	89%
Q501Q9	Xenopus laevis	27%	89%
Q53N72	Oryza sativa subsp. japonica	30%	100%
Q5EAB2	Bos taurus	27%	100%
Q5U4C9	Mus musculus	42%	87%
Q5VP69	Oryza sativa subsp. japonica	29%	100%
Q5Z7J0	Oryza sativa subsp. japonica	28%	100%
Q5Z859	Oryza sativa subsp. japonica	28%	100%
Q5ZIU3	Gallus gallus	42%	99%
Q60EZ2	Oryza sativa subsp. japonica	29%	100%
Q61214	Mus musculus	41%	68%
Q63117	Rattus norvegicus	33%	100%
Q63470	Rattus norvegicus	41%	68%
Q641Z4	Rattus norvegicus	26%	100%
Q6K5F8	Oryza sativa subsp. japonica	28%	75%
Q6L5F7	Oryza sativa subsp. japonica	29%	90%
Q6Z437	Oryza sativa subsp. japonica	27%	100%
Q75KK8	Oryza sativa subsp. japonica	29%	96%
Q7SXE8	Danio rerio	24%	100%
Q7XUF4	Oryza sativa subsp. japonica	27%	73%
Q80Y86	Mus musculus	28%	95%
Q84M93	Arabidopsis thaliana	28%	100%
Q8QHK8	Xenopus laevis	28%	100%
Q8TD08	Homo sapiens	27%	96%
Q91757	Xenopus laevis	28%	100%
Q922Y0	Mus musculus	39%	89%
Q92630	Homo sapiens	43%	87%
Q99J95	Mus musculus	26%	100%
Q9FVS6	Arabidopsis thaliana	29%	100%
Q9HAZ1	Homo sapiens	32%	100%
Q9NR20	Homo sapiens	39%	100%
Q9P6P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	98%
Q9TTK0	Oryctolagus cuniculus	27%	92%
Q9U6D2	Ancylostoma caninum	29%	100%
Q9U6V4	Leishmania donovani	24%	100%
Q9UPZ9	Homo sapiens	29%	82%
Q9V3D5	Drosophila melanogaster	42%	72%
Q9WVS4	Mus musculus	28%	100%
Q9Y463	Homo sapiens	44%	83%
Q9Z188	Mus musculus	44%	83%
Q9Z2A6	Rattus norvegicus	28%	95%
V5AWK7	Trypanosoma cruzi	65%	77%
V5AX03	Trypanosoma cruzi	29%	100%
V5AZ01	Trypanosoma cruzi	30%	67%
V5B8S3	Trypanosoma cruzi	38%	100%
V5BN23	Trypanosoma cruzi	26%	100%
V5BPE2	Trypanosoma cruzi	28%	100%
V5DCD4	Trypanosoma cruzi	27%	89%
V5DDT1	Trypanosoma cruzi	27%	100%
V5DIC3	Trypanosoma cruzi	31%	86%