Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFG5_LEIMA

TriTrypDb:

LmjF.15.0185 , LMJLV39_150007100 , LMJSD75_150007100

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.579
CLV_MEL_PAP_1	406	412	PF00089	0.692
CLV_NRD_NRD_1	276	278	PF00675	0.839
CLV_NRD_NRD_1	321	323	PF00675	0.782
CLV_NRD_NRD_1	368	370	PF00675	0.766
CLV_NRD_NRD_1	394	396	PF00675	0.716
CLV_NRD_NRD_1	477	479	PF00675	0.756
CLV_NRD_NRD_1	581	583	PF00675	0.746
CLV_PCSK_KEX2_1	276	278	PF00082	0.839
CLV_PCSK_KEX2_1	321	323	PF00082	0.780
CLV_PCSK_KEX2_1	368	370	PF00082	0.766
CLV_PCSK_KEX2_1	394	396	PF00082	0.650
CLV_PCSK_KEX2_1	477	479	PF00082	0.756
CLV_PCSK_KEX2_1	581	583	PF00082	0.808
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.614
CLV_PCSK_SKI1_1	396	400	PF00082	0.590
CLV_PCSK_SKI1_1	405	409	PF00082	0.647
CLV_PCSK_SKI1_1	500	504	PF00082	0.701
DEG_SCF_FBW7_1	197	204	PF00400	0.707
DEG_SPOP_SBC_1	22	26	PF00917	0.592
DEG_SPOP_SBC_1	467	471	PF00917	0.663
DEG_SPOP_SBC_1	94	98	PF00917	0.712
DOC_CKS1_1	198	203	PF01111	0.581
DOC_CKS1_1	2	7	PF01111	0.709
DOC_CYCLIN_RxL_1	399	412	PF00134	0.656
DOC_MAPK_gen_1	394	406	PF00069	0.596
DOC_MAPK_MEF2A_6	103	112	PF00069	0.724
DOC_MAPK_MEF2A_6	399	408	PF00069	0.644
DOC_MAPK_NFAT4_5	403	411	PF00069	0.690
DOC_PP2B_LxvP_1	520	523	PF13499	0.796
DOC_USP7_MATH_1	102	106	PF00917	0.602
DOC_USP7_MATH_1	133	137	PF00917	0.748
DOC_USP7_MATH_1	143	147	PF00917	0.595
DOC_USP7_MATH_1	17	21	PF00917	0.749
DOC_USP7_MATH_1	176	180	PF00917	0.757
DOC_USP7_MATH_1	22	26	PF00917	0.772
DOC_USP7_MATH_1	287	291	PF00917	0.681
DOC_USP7_MATH_1	326	330	PF00917	0.697
DOC_USP7_MATH_1	346	350	PF00917	0.816
DOC_USP7_MATH_1	356	360	PF00917	0.675
DOC_USP7_MATH_1	457	461	PF00917	0.707
DOC_USP7_MATH_1	467	471	PF00917	0.601
DOC_USP7_MATH_1	485	489	PF00917	0.506
DOC_USP7_MATH_1	530	534	PF00917	0.748
DOC_USP7_MATH_1	81	85	PF00917	0.787
DOC_USP7_MATH_1	88	92	PF00917	0.704
DOC_WW_Pin1_4	1	6	PF00397	0.649
DOC_WW_Pin1_4	165	170	PF00397	0.748
DOC_WW_Pin1_4	197	202	PF00397	0.799
DOC_WW_Pin1_4	225	230	PF00397	0.812
DOC_WW_Pin1_4	237	242	PF00397	0.594
DOC_WW_Pin1_4	255	260	PF00397	0.561
DOC_WW_Pin1_4	289	294	PF00397	0.781
DOC_WW_Pin1_4	342	347	PF00397	0.578
DOC_WW_Pin1_4	509	514	PF00397	0.717
DOC_WW_Pin1_4	515	520	PF00397	0.724
DOC_WW_Pin1_4	523	528	PF00397	0.668
DOC_WW_Pin1_4	59	64	PF00397	0.796
DOC_WW_Pin1_4	84	89	PF00397	0.788
LIG_14-3-3_CanoR_1	135	144	PF00244	0.691
LIG_14-3-3_CanoR_1	161	166	PF00244	0.714
LIG_14-3-3_CanoR_1	172	176	PF00244	0.711
LIG_14-3-3_CanoR_1	276	285	PF00244	0.659
LIG_14-3-3_CanoR_1	334	338	PF00244	0.656
LIG_14-3-3_CanoR_1	456	466	PF00244	0.683
LIG_14-3-3_CanoR_1	494	499	PF00244	0.515
LIG_14-3-3_CanoR_1	531	536	PF00244	0.775
LIG_14-3-3_CanoR_1	563	568	PF00244	0.735
LIG_Actin_WH2_2	394	411	PF00022	0.695
LIG_BRCT_BRCA1_1	55	59	PF00533	0.687
LIG_BRCT_BRCA1_1	554	558	PF00533	0.596
LIG_FHA_1	155	161	PF00498	0.808
LIG_FHA_1	202	208	PF00498	0.654
LIG_FHA_1	24	30	PF00498	0.805
LIG_FHA_1	281	287	PF00498	0.847
LIG_FHA_1	303	309	PF00498	0.744
LIG_FHA_1	326	332	PF00498	0.701
LIG_FHA_1	384	390	PF00498	0.710
LIG_FHA_1	96	102	PF00498	0.749
LIG_FHA_2	279	285	PF00498	0.825
LIG_FHA_2	290	296	PF00498	0.681
LIG_GBD_Chelix_1	458	466	PF00786	0.547
LIG_GBD_Chelix_1	495	503	PF00786	0.636
LIG_HP1_1	243	247	PF01393	0.691
LIG_Integrin_RGD_1	451	453	PF01839	0.639
LIG_LIR_Gen_1	139	147	PF02991	0.541
LIG_LIR_Nem_3	139	144	PF02991	0.543
LIG_LIR_Nem_3	238	242	PF02991	0.755
LIG_LIR_Nem_3	555	561	PF02991	0.593
LIG_NRBOX	403	409	PF00104	0.689
LIG_NRBOX	494	500	PF00104	0.648
LIG_SH2_NCK_1	16	20	PF00017	0.597
LIG_SH2_SRC	16	19	PF00017	0.702
LIG_SH2_STAT3	42	45	PF00017	0.731
LIG_SH2_STAT5	501	504	PF00017	0.699
LIG_SH3_1	554	560	PF00018	0.822
LIG_SH3_3	148	154	PF00018	0.747
LIG_SH3_3	195	201	PF00018	0.707
LIG_SH3_3	226	232	PF00018	0.771
LIG_SH3_3	25	31	PF00018	0.634
LIG_SH3_3	522	528	PF00018	0.790
LIG_SH3_3	554	560	PF00018	0.806
LIG_SH3_3	58	64	PF00018	0.745
LIG_SH3_3	66	72	PF00018	0.670
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.684
LIG_SUMO_SIM_par_1	242	248	PF11976	0.794
MOD_CDC14_SPxK_1	526	529	PF00782	0.753
MOD_CDK_SPxK_1	523	529	PF00069	0.754
MOD_CDK_SPxxK_3	165	172	PF00069	0.747
MOD_CDK_SPxxK_3	289	296	PF00069	0.739
MOD_CK1_1	136	142	PF00069	0.540
MOD_CK1_1	164	170	PF00069	0.614
MOD_CK1_1	205	211	PF00069	0.813
MOD_CK1_1	230	236	PF00069	0.767
MOD_CK1_1	251	257	PF00069	0.811
MOD_CK1_1	270	276	PF00069	0.809
MOD_CK1_1	278	284	PF00069	0.715
MOD_CK1_1	302	308	PF00069	0.604
MOD_CK1_1	364	370	PF00069	0.731
MOD_CK1_1	470	476	PF00069	0.797
MOD_CK1_1	481	487	PF00069	0.630
MOD_CK1_1	62	68	PF00069	0.796
MOD_CK1_1	84	90	PF00069	0.846
MOD_CK1_1	93	99	PF00069	0.693
MOD_CK2_1	136	142	PF00069	0.540
MOD_CK2_1	176	182	PF00069	0.786
MOD_CK2_1	208	214	PF00069	0.814
MOD_CK2_1	346	352	PF00069	0.820
MOD_CK2_1	457	463	PF00069	0.708
MOD_GlcNHglycan	135	138	PF01048	0.756
MOD_GlcNHglycan	173	176	PF01048	0.745
MOD_GlcNHglycan	184	187	PF01048	0.590
MOD_GlcNHglycan	36	39	PF01048	0.700
MOD_GlcNHglycan	363	366	PF01048	0.748
MOD_GlcNHglycan	373	376	PF01048	0.623
MOD_GlcNHglycan	429	433	PF01048	0.736
MOD_GlcNHglycan	470	473	PF01048	0.694
MOD_GlcNHglycan	513	516	PF01048	0.749
MOD_GlcNHglycan	569	572	PF01048	0.785
MOD_GlcNHglycan	83	86	PF01048	0.726
MOD_GlcNHglycan	92	95	PF01048	0.719
MOD_GSK3_1	133	140	PF00069	0.724
MOD_GSK3_1	161	168	PF00069	0.610
MOD_GSK3_1	17	24	PF00069	0.652
MOD_GSK3_1	193	200	PF00069	0.789
MOD_GSK3_1	201	208	PF00069	0.658
MOD_GSK3_1	223	230	PF00069	0.842
MOD_GSK3_1	231	238	PF00069	0.694
MOD_GSK3_1	247	254	PF00069	0.678
MOD_GSK3_1	267	274	PF00069	0.856
MOD_GSK3_1	276	283	PF00069	0.695
MOD_GSK3_1	285	292	PF00069	0.550
MOD_GSK3_1	298	305	PF00069	0.603
MOD_GSK3_1	30	37	PF00069	0.661
MOD_GSK3_1	322	329	PF00069	0.765
MOD_GSK3_1	342	349	PF00069	0.633
MOD_GSK3_1	457	464	PF00069	0.695
MOD_GSK3_1	466	473	PF00069	0.634
MOD_GSK3_1	481	488	PF00069	0.552
MOD_GSK3_1	511	518	PF00069	0.635
MOD_GSK3_1	530	537	PF00069	0.650
MOD_GSK3_1	559	566	PF00069	0.814
MOD_GSK3_1	77	84	PF00069	0.749
MOD_GSK3_1	88	95	PF00069	0.715
MOD_N-GLC_1	346	351	PF02516	0.592
MOD_N-GLC_1	567	572	PF02516	0.569
MOD_NEK2_1	126	131	PF00069	0.692
MOD_NEK2_1	247	252	PF00069	0.791
MOD_NEK2_1	427	432	PF00069	0.761
MOD_NEK2_1	466	471	PF00069	0.758
MOD_NEK2_1	92	97	PF00069	0.781
MOD_NEK2_2	356	361	PF00069	0.615
MOD_OFUCOSY	454	461	PF10250	0.708
MOD_PIKK_1	278	284	PF00454	0.843
MOD_PIKK_1	446	452	PF00454	0.649
MOD_PK_1	161	167	PF00069	0.586
MOD_PK_1	369	375	PF00069	0.748
MOD_PKA_1	276	282	PF00069	0.842
MOD_PKA_1	414	420	PF00069	0.728
MOD_PKA_2	102	108	PF00069	0.794
MOD_PKA_2	171	177	PF00069	0.746
MOD_PKA_2	275	281	PF00069	0.841
MOD_PKA_2	333	339	PF00069	0.680
MOD_PKA_2	408	414	PF00069	0.701
MOD_PKA_2	427	433	PF00069	0.445
MOD_PKA_2	530	536	PF00069	0.756
MOD_PKB_1	159	167	PF00069	0.587
MOD_Plk_1	17	23	PF00069	0.694
MOD_Plk_1	247	253	PF00069	0.791
MOD_Plk_1	326	332	PF00069	0.660
MOD_Plk_1	462	468	PF00069	0.728
MOD_Plk_4	193	199	PF00069	0.581
MOD_Plk_4	248	254	PF00069	0.733
MOD_Plk_4	326	332	PF00069	0.701
MOD_Plk_4	333	339	PF00069	0.587
MOD_Plk_4	494	500	PF00069	0.704
MOD_ProDKin_1	1	7	PF00069	0.647
MOD_ProDKin_1	165	171	PF00069	0.747
MOD_ProDKin_1	197	203	PF00069	0.799
MOD_ProDKin_1	225	231	PF00069	0.810
MOD_ProDKin_1	237	243	PF00069	0.590
MOD_ProDKin_1	255	261	PF00069	0.563
MOD_ProDKin_1	289	295	PF00069	0.780
MOD_ProDKin_1	342	348	PF00069	0.579
MOD_ProDKin_1	509	515	PF00069	0.721
MOD_ProDKin_1	523	529	PF00069	0.670
MOD_ProDKin_1	59	65	PF00069	0.798
MOD_ProDKin_1	84	90	PF00069	0.784
MOD_SUMO_rev_2	392	401	PF00179	0.480
TRG_DiLeu_BaLyEn_6	402	407	PF01217	0.687
TRG_ENDOCYTIC_2	141	144	PF00928	0.542
TRG_ER_diArg_1	321	323	PF00400	0.780
TRG_ER_diArg_1	368	370	PF00400	0.708
TRG_ER_diArg_1	403	406	PF00400	0.679
TRG_ER_diArg_1	435	438	PF00400	0.673
TRG_NES_CRM1_1	493	508	PF08389	0.647
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC62	Leishmania donovani	90%	100%
A4H7Y8	Leishmania braziliensis	62%	88%
A4HWB6	Leishmania infantum	90%	100%
E9AQ16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%