Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFG3_LEIMA

TriTrypDb:

LmjF.15.0195 , LMJLV39_150007300 , LMJSD75_150007300

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QFG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.530
CLV_NRD_NRD_1	161	163	PF00675	0.591
CLV_NRD_NRD_1	177	179	PF00675	0.331
CLV_NRD_NRD_1	185	187	PF00675	0.461
CLV_NRD_NRD_1	362	364	PF00675	0.746
CLV_PCSK_KEX2_1	161	163	PF00082	0.591
CLV_PCSK_KEX2_1	177	179	PF00082	0.331
CLV_PCSK_KEX2_1	185	187	PF00082	0.461
CLV_PCSK_SKI1_1	186	190	PF00082	0.531
CLV_PCSK_SKI1_1	348	352	PF00082	0.755
DEG_APCC_DBOX_1	286	294	PF00400	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_ODPH_VHL_1	43	55	PF01847	0.293
DEG_SCF_FBW7_1	237	242	PF00400	0.764
DOC_CDC14_PxL_1	41	49	PF14671	0.307
DOC_CKS1_1	133	138	PF01111	0.762
DOC_CKS1_1	247	252	PF01111	0.783
DOC_CYCLIN_yClb1_LxF_4	96	101	PF00134	0.603
DOC_MAPK_gen_1	17	27	PF00069	0.414
DOC_MAPK_gen_1	185	193	PF00069	0.638
DOC_MAPK_gen_1	285	293	PF00069	0.567
DOC_MAPK_JIP1_4	117	123	PF00069	0.730
DOC_MAPK_MEF2A_6	287	295	PF00069	0.635
DOC_PP1_RVXF_1	96	102	PF00149	0.605
DOC_USP7_MATH_1	140	144	PF00917	0.832
DOC_USP7_MATH_1	210	214	PF00917	0.592
DOC_USP7_MATH_1	7	11	PF00917	0.567
DOC_WW_Pin1_4	132	137	PF00397	0.714
DOC_WW_Pin1_4	153	158	PF00397	0.729
DOC_WW_Pin1_4	235	240	PF00397	0.813
DOC_WW_Pin1_4	246	251	PF00397	0.705
DOC_WW_Pin1_4	33	38	PF00397	0.405
DOC_WW_Pin1_4	92	97	PF00397	0.602
LIG_14-3-3_CanoR_1	161	167	PF00244	0.751
LIG_14-3-3_CanoR_1	20	26	PF00244	0.220
LIG_14-3-3_CanoR_1	98	102	PF00244	0.635
LIG_BIR_III_4	187	191	PF00653	0.669
LIG_CORNRBOX	47	55	PF00104	0.287
LIG_EH1_1	309	317	PF00400	0.446
LIG_FHA_1	307	313	PF00498	0.446
LIG_FHA_1	381	387	PF00498	0.549
LIG_FHA_1	44	50	PF00498	0.293
LIG_FHA_2	133	139	PF00498	0.768
LIG_FHA_2	148	154	PF00498	0.671
LIG_FHA_2	230	236	PF00498	0.812
LIG_LIR_Gen_1	165	174	PF02991	0.677
LIG_LIR_Nem_3	165	169	PF02991	0.681
LIG_LIR_Nem_3	224	230	PF02991	0.646
LIG_LIR_Nem_3	379	384	PF02991	0.557
LIG_NRBOX	289	295	PF00104	0.524
LIG_Pex14_2	327	331	PF04695	0.491
LIG_SH2_PTP2	301	304	PF00017	0.529
LIG_SH2_PTP2	318	321	PF00017	0.318
LIG_SH2_PTP2	56	59	PF00017	0.220
LIG_SH2_PTP2	64	67	PF00017	0.212
LIG_SH2_PTP2	68	71	PF00017	0.208
LIG_SH2_PTP2	72	75	PF00017	0.203
LIG_SH2_SRC	56	59	PF00017	0.220
LIG_SH2_SRC	64	67	PF00017	0.212
LIG_SH2_SRC	68	71	PF00017	0.208
LIG_SH2_STAT5	173	176	PF00017	0.620
LIG_SH2_STAT5	181	184	PF00017	0.594
LIG_SH2_STAT5	2	5	PF00017	0.568
LIG_SH2_STAT5	301	304	PF00017	0.529
LIG_SH2_STAT5	318	321	PF00017	0.318
LIG_SH2_STAT5	367	370	PF00017	0.393
LIG_SH2_STAT5	56	59	PF00017	0.231
LIG_SH2_STAT5	64	67	PF00017	0.211
LIG_SH2_STAT5	68	71	PF00017	0.212
LIG_SH2_STAT5	72	75	PF00017	0.216
LIG_SH3_3	119	125	PF00018	0.775
LIG_SH3_3	130	136	PF00018	0.660
LIG_SH3_3	244	250	PF00018	0.847
LIG_SH3_3	254	260	PF00018	0.638
LIG_SH3_3	39	45	PF00018	0.352
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.290
LIG_TRAF2_1	165	168	PF00917	0.719
LIG_TYR_ITIM	299	304	PF00017	0.529
LIG_TYR_ITIM	316	321	PF00017	0.368
LIG_TYR_ITIM	54	59	PF00017	0.220
LIG_UBA3_1	314	322	PF00899	0.567
LIG_UBA3_1	345	351	PF00899	0.494
LIG_Vh1_VBS_1	265	283	PF01044	0.565
LIG_WRC_WIRS_1	163	168	PF05994	0.584
MOD_CDC14_SPxK_1	95	98	PF00782	0.612
MOD_CDK_SPxK_1	92	98	PF00069	0.614
MOD_CK1_1	104	110	PF00069	0.662
MOD_CK1_1	156	162	PF00069	0.817
MOD_CK1_1	334	340	PF00069	0.527
MOD_CK1_1	97	103	PF00069	0.693
MOD_CK2_1	162	168	PF00069	0.631
MOD_GlcNHglycan	108	111	PF01048	0.501
MOD_GlcNHglycan	27	30	PF01048	0.236
MOD_GlcNHglycan	37	40	PF01048	0.542
MOD_GSK3_1	140	147	PF00069	0.727
MOD_GSK3_1	21	28	PF00069	0.236
MOD_GSK3_1	235	242	PF00069	0.734
MOD_GSK3_1	337	344	PF00069	0.528
MOD_GSK3_1	376	383	PF00069	0.547
MOD_GSK3_1	97	104	PF00069	0.629
MOD_N-GLC_2	19	21	PF02516	0.214
MOD_NEK2_1	101	106	PF00069	0.666
MOD_NEK2_1	25	30	PF00069	0.232
MOD_NEK2_1	306	311	PF00069	0.353
MOD_NEK2_1	317	322	PF00069	0.399
MOD_NEK2_1	376	381	PF00069	0.537
MOD_PIKK_1	237	243	PF00454	0.749
MOD_PKA_2	97	103	PF00069	0.608
MOD_Plk_4	341	347	PF00069	0.570
MOD_Plk_4	376	382	PF00069	0.543
MOD_Plk_4	43	49	PF00069	0.316
MOD_Plk_4	97	103	PF00069	0.770
MOD_ProDKin_1	132	138	PF00069	0.717
MOD_ProDKin_1	153	159	PF00069	0.725
MOD_ProDKin_1	235	241	PF00069	0.815
MOD_ProDKin_1	246	252	PF00069	0.704
MOD_ProDKin_1	33	39	PF00069	0.404
MOD_ProDKin_1	92	98	PF00069	0.602
MOD_SUMO_for_1	350	353	PF00179	0.561
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.662
TRG_ENDOCYTIC_2	301	304	PF00928	0.529
TRG_ENDOCYTIC_2	318	321	PF00928	0.318
TRG_ENDOCYTIC_2	56	59	PF00928	0.226
TRG_ENDOCYTIC_2	64	67	PF00928	0.212
TRG_ENDOCYTIC_2	68	71	PF00928	0.211
TRG_ENDOCYTIC_2	72	75	PF00928	0.207
TRG_ER_diArg_1	161	163	PF00400	0.643
TRG_ER_diArg_1	177	179	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6T8	Leishmania donovani	86%	100%
A4H7Z0	Leishmania braziliensis	66%	100%
A4HWB8	Leishmania infantum	89%	100%
E9AQ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%