DUF667 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFG1_LEIMA

TriTrypDb:

LmjF.15.0210 , LMJLV39_150007600 , LMJSD75_150007500

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.526
CLV_C14_Caspase3-7	316	320	PF00656	0.746
CLV_NRD_NRD_1	378	380	PF00675	0.643
CLV_NRD_NRD_1	381	383	PF00675	0.697
CLV_NRD_NRD_1	405	407	PF00675	0.595
CLV_NRD_NRD_1	430	432	PF00675	0.553
CLV_NRD_NRD_1	437	439	PF00675	0.535
CLV_PCSK_FUR_1	434	438	PF00082	0.579
CLV_PCSK_KEX2_1	378	380	PF00082	0.689
CLV_PCSK_KEX2_1	430	432	PF00082	0.556
CLV_PCSK_KEX2_1	436	438	PF00082	0.539
CLV_PCSK_KEX2_1	94	96	PF00082	0.299
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.302
CLV_PCSK_SKI1_1	256	260	PF00082	0.662
CLV_PCSK_SKI1_1	37	41	PF00082	0.325
DEG_SCF_FBW7_1	42	49	PF00400	0.526
DEG_SPOP_SBC_1	167	171	PF00917	0.526
DEG_SPOP_SBC_1	342	346	PF00917	0.536
DOC_CYCLIN_yCln2_LP_2	263	269	PF00134	0.529
DOC_MAPK_gen_1	127	135	PF00069	0.483
DOC_MAPK_gen_1	430	441	PF00069	0.536
DOC_MAPK_gen_1	55	65	PF00069	0.509
DOC_MAPK_gen_1	94	100	PF00069	0.499
DOC_MAPK_MEF2A_6	127	135	PF00069	0.487
DOC_MAPK_MEF2A_6	33	42	PF00069	0.573
DOC_PP2B_LxvP_1	123	126	PF13499	0.483
DOC_PP2B_LxvP_1	263	266	PF13499	0.524
DOC_PP4_FxxP_1	145	148	PF00568	0.528
DOC_PP4_FxxP_1	187	190	PF00568	0.400
DOC_USP7_MATH_1	268	272	PF00917	0.721
DOC_USP7_MATH_1	341	345	PF00917	0.613
DOC_USP7_MATH_1	391	395	PF00917	0.703
DOC_USP7_MATH_1	59	63	PF00917	0.577
DOC_USP7_UBL2_3	33	37	PF12436	0.573
DOC_WW_Pin1_4	177	182	PF00397	0.468
DOC_WW_Pin1_4	200	205	PF00397	0.678
DOC_WW_Pin1_4	234	239	PF00397	0.622
DOC_WW_Pin1_4	240	245	PF00397	0.646
DOC_WW_Pin1_4	261	266	PF00397	0.556
DOC_WW_Pin1_4	408	413	PF00397	0.644
DOC_WW_Pin1_4	42	47	PF00397	0.526
LIG_14-3-3_CanoR_1	58	64	PF00244	0.509
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	164	168	PF00533	0.573
LIG_Clathr_ClatBox_1	210	214	PF01394	0.658
LIG_EH1_1	134	142	PF00400	0.466
LIG_EH1_1	81	89	PF00400	0.430
LIG_FHA_1	116	122	PF00498	0.531
LIG_FHA_1	220	226	PF00498	0.689
LIG_FHA_1	245	251	PF00498	0.655
LIG_FHA_1	344	350	PF00498	0.605
LIG_FHA_1	360	366	PF00498	0.618
LIG_FHA_1	94	100	PF00498	0.535
LIG_FHA_2	110	116	PF00498	0.538
LIG_FHA_2	149	155	PF00498	0.599
LIG_FHA_2	167	173	PF00498	0.428
LIG_LIR_Apic_2	143	148	PF02991	0.528
LIG_LIR_Gen_1	294	299	PF02991	0.601
LIG_LIR_Gen_1	350	360	PF02991	0.668
LIG_LIR_LC3C_4	362	365	PF02991	0.664
LIG_LIR_Nem_3	117	123	PF02991	0.573
LIG_LIR_Nem_3	264	270	PF02991	0.649
LIG_LIR_Nem_3	294	298	PF02991	0.617
LIG_LIR_Nem_3	350	355	PF02991	0.685
LIG_LYPXL_yS_3	267	270	PF13949	0.673
LIG_MYND_1	253	257	PF01753	0.560
LIG_NRBOX	206	212	PF00104	0.656
LIG_SH2_CRK	295	299	PF00017	0.650
LIG_SH2_PTP2	192	195	PF00017	0.573
LIG_SH2_SRC	192	195	PF00017	0.490
LIG_SH2_STAP1	109	113	PF00017	0.499
LIG_SH2_STAT5	120	123	PF00017	0.538
LIG_SH2_STAT5	192	195	PF00017	0.585
LIG_SH2_STAT5	488	491	PF00017	0.489
LIG_SH2_STAT5	91	94	PF00017	0.564
LIG_SH3_1	378	384	PF00018	0.725
LIG_SH3_1	385	391	PF00018	0.647
LIG_SH3_3	18	24	PF00018	0.472
LIG_SH3_3	247	253	PF00018	0.667
LIG_SH3_3	262	268	PF00018	0.661
LIG_SH3_3	378	384	PF00018	0.645
LIG_SH3_3	385	391	PF00018	0.647
LIG_SH3_3	48	54	PF00018	0.529
LIG_SH3_3	488	494	PF00018	0.627
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.631
LIG_SUMO_SIM_par_1	361	368	PF11976	0.732
LIG_TRAF2_1	325	328	PF00917	0.792
LIG_UBA3_1	251	259	PF00899	0.662
LIG_WW_3	379	383	PF00397	0.692
MOD_CDK_SPK_2	177	182	PF00069	0.351
MOD_CDK_SPK_2	408	413	PF00069	0.578
MOD_CK1_1	226	232	PF00069	0.637
MOD_CK1_1	237	243	PF00069	0.718
MOD_CK1_1	246	252	PF00069	0.570
MOD_CK1_1	272	278	PF00069	0.740
MOD_CK1_1	288	294	PF00069	0.658
MOD_CK1_1	311	317	PF00069	0.616
MOD_CK1_1	334	340	PF00069	0.756
MOD_CK1_1	416	422	PF00069	0.714
MOD_CK1_1	426	432	PF00069	0.592
MOD_CK1_1	89	95	PF00069	0.437
MOD_CK2_1	109	115	PF00069	0.364
MOD_CK2_1	167	173	PF00069	0.454
MOD_CK2_1	270	276	PF00069	0.748
MOD_CK2_1	347	353	PF00069	0.681
MOD_CK2_1	391	397	PF00069	0.768
MOD_CK2_1	513	519	PF00069	0.612
MOD_GlcNHglycan	272	275	PF01048	0.713
MOD_GlcNHglycan	287	290	PF01048	0.711
MOD_GlcNHglycan	349	352	PF01048	0.667
MOD_GlcNHglycan	367	370	PF01048	0.473
MOD_GlcNHglycan	418	421	PF01048	0.642
MOD_GSK3_1	154	161	PF00069	0.385
MOD_GSK3_1	162	169	PF00069	0.370
MOD_GSK3_1	196	203	PF00069	0.567
MOD_GSK3_1	219	226	PF00069	0.680
MOD_GSK3_1	236	243	PF00069	0.621
MOD_GSK3_1	268	275	PF00069	0.667
MOD_GSK3_1	284	291	PF00069	0.563
MOD_GSK3_1	309	316	PF00069	0.656
MOD_GSK3_1	343	350	PF00069	0.590
MOD_GSK3_1	42	49	PF00069	0.437
MOD_GSK3_1	89	96	PF00069	0.381
MOD_N-GLC_1	342	347	PF02516	0.705
MOD_N-GLC_1	426	431	PF02516	0.687
MOD_N-GLC_1	449	454	PF02516	0.555
MOD_N-GLC_1	76	81	PF02516	0.364
MOD_NEK2_1	158	163	PF00069	0.375
MOD_NEK2_1	258	263	PF00069	0.784
MOD_NEK2_1	65	70	PF00069	0.387
MOD_NEK2_2	59	64	PF00069	0.451
MOD_PIKK_1	288	294	PF00454	0.658
MOD_PIKK_1	44	50	PF00454	0.454
MOD_PIKK_1	463	469	PF00454	0.652
MOD_PIKK_1	86	92	PF00454	0.362
MOD_PK_1	25	31	PF00069	0.388
MOD_PKA_2	162	168	PF00069	0.297
MOD_Plk_1	172	178	PF00069	0.548
MOD_Plk_1	223	229	PF00069	0.633
MOD_Plk_1	308	314	PF00069	0.692
MOD_Plk_4	140	146	PF00069	0.387
MOD_Plk_4	206	212	PF00069	0.656
MOD_Plk_4	246	252	PF00069	0.719
MOD_Plk_4	359	365	PF00069	0.770
MOD_Plk_4	510	516	PF00069	0.724
MOD_Plk_4	65	71	PF00069	0.387
MOD_ProDKin_1	177	183	PF00069	0.474
MOD_ProDKin_1	200	206	PF00069	0.680
MOD_ProDKin_1	234	240	PF00069	0.622
MOD_ProDKin_1	261	267	PF00069	0.558
MOD_ProDKin_1	408	414	PF00069	0.647
MOD_ProDKin_1	42	48	PF00069	0.388
MOD_SUMO_for_1	306	309	PF00179	0.695
MOD_SUMO_rev_2	208	217	PF00179	0.519
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.327
TRG_ENDOCYTIC_2	120	123	PF00928	0.461
TRG_ENDOCYTIC_2	267	270	PF00928	0.673
TRG_ENDOCYTIC_2	295	298	PF00928	0.630
TRG_ENDOCYTIC_2	488	491	PF00928	0.489
TRG_ER_diArg_1	378	380	PF00400	0.586
TRG_ER_diArg_1	434	437	PF00400	0.671
TRG_ER_diArg_1	438	441	PF00400	0.553
TRG_NLS_MonoCore_2	381	386	PF00514	0.704
TRG_NLS_MonoExtN_4	379	386	PF00514	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P363	Leptomonas seymouri	50%	91%
A0A3Q8IIK6	Leishmania donovani	92%	100%
A0A3R7KIM5	Trypanosoma rangeli	29%	83%
A4H7Z2	Leishmania braziliensis	74%	99%
A4HWC0	Leishmania infantum	93%	100%
E9AQ20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%