TMEM132 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFF9_LEIMA

TriTrypDb:

LmjF.15.0223 , LMJLV39_150007800 , LMJSD75_150007700

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.616
CLV_NRD_NRD_1	179	181	PF00675	0.698
CLV_NRD_NRD_1	9	11	PF00675	0.722
CLV_PCSK_KEX2_1	181	183	PF00082	0.701
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.701
CLV_PCSK_SKI1_1	122	126	PF00082	0.403
CLV_PCSK_SKI1_1	41	45	PF00082	0.572
DEG_APCC_DBOX_1	9	17	PF00400	0.609
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DEG_SCF_FBW7_1	153	159	PF00400	0.682
DOC_CDC14_PxL_1	23	31	PF14671	0.494
DOC_CKS1_1	153	158	PF01111	0.681
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.565
DOC_MAPK_DCC_7	91	101	PF00069	0.640
DOC_MAPK_MEF2A_6	91	99	PF00069	0.646
DOC_PP1_RVXF_1	120	127	PF00149	0.460
DOC_PP2B_LxvP_1	49	52	PF13499	0.540
DOC_PP4_FxxP_1	107	110	PF00568	0.656
DOC_USP7_MATH_1	132	136	PF00917	0.515
DOC_USP7_MATH_1	167	171	PF00917	0.700
DOC_USP7_MATH_1	174	178	PF00917	0.660
DOC_USP7_MATH_1	43	47	PF00917	0.497
DOC_USP7_MATH_1	72	76	PF00917	0.545
DOC_WD40_RPTOR_TOS_1	30	35	PF00400	0.499
DOC_WW_Pin1_4	152	157	PF00397	0.675
DOC_WW_Pin1_4	161	166	PF00397	0.775
LIG_14-3-3_CanoR_1	10	14	PF00244	0.682
LIG_14-3-3_CanoR_1	182	187	PF00244	0.731
LIG_Actin_WH2_2	25	43	PF00022	0.646
LIG_Actin_WH2_2	64	79	PF00022	0.554
LIG_BRCT_BRCA1_1	63	67	PF00533	0.491
LIG_Clathr_ClatBox_1	29	33	PF01394	0.426
LIG_FHA_1	55	61	PF00498	0.411
LIG_LIR_Apic_2	104	110	PF02991	0.660
LIG_LIR_Apic_2	148	153	PF02991	0.660
LIG_LIR_Gen_1	12	20	PF02991	0.600
LIG_LIR_Nem_3	12	17	PF02991	0.589
LIG_LIR_Nem_3	166	171	PF02991	0.792
LIG_LIR_Nem_3	202	208	PF02991	0.676
LIG_SH2_CRK	205	209	PF00017	0.679
LIG_SH2_NCK_1	205	209	PF00017	0.668
LIG_SH2_SRC	205	208	PF00017	0.667
LIG_SH2_STAT5	150	153	PF00017	0.645
LIG_SH3_1	150	156	PF00018	0.662
LIG_SH3_3	150	156	PF00018	0.683
LIG_SH3_3	168	174	PF00018	0.491
LIG_SH3_3	201	207	PF00018	0.652
LIG_SH3_3	49	55	PF00018	0.666
LIG_SH3_3	89	95	PF00018	0.542
LIG_SUMO_SIM_par_1	97	104	PF11976	0.530
LIG_TYR_ITIM	203	208	PF00017	0.676
MOD_CK1_1	117	123	PF00069	0.357
MOD_CK1_1	12	18	PF00069	0.611
MOD_CK1_1	159	165	PF00069	0.728
MOD_CK2_1	12	18	PF00069	0.611
MOD_CK2_1	167	173	PF00069	0.730
MOD_GlcNHglycan	116	119	PF01048	0.425
MOD_GlcNHglycan	134	137	PF01048	0.449
MOD_GlcNHglycan	139	142	PF01048	0.463
MOD_GlcNHglycan	145	148	PF01048	0.535
MOD_GlcNHglycan	176	179	PF01048	0.724
MOD_GlcNHglycan	208	211	PF01048	0.676
MOD_GSK3_1	101	108	PF00069	0.649
MOD_GSK3_1	152	159	PF00069	0.750
MOD_GSK3_1	35	42	PF00069	0.525
MOD_GSK3_1	56	63	PF00069	0.476
MOD_GSK3_1	67	74	PF00069	0.308
MOD_N-GLC_1	191	196	PF02516	0.730
MOD_NEK2_1	67	72	PF00069	0.515
MOD_NEK2_1	9	14	PF00069	0.585
MOD_NEK2_2	167	172	PF00069	0.730
MOD_NEK2_2	72	77	PF00069	0.537
MOD_PIKK_1	182	188	PF00454	0.733
MOD_PKA_2	127	133	PF00069	0.543
MOD_PKA_2	9	15	PF00069	0.621
MOD_PKB_1	180	188	PF00069	0.734
MOD_Plk_1	191	197	PF00069	0.729
MOD_Plk_1	60	66	PF00069	0.450
MOD_Plk_4	156	162	PF00069	0.668
MOD_Plk_4	191	197	PF00069	0.672
MOD_Plk_4	199	205	PF00069	0.585
MOD_Plk_4	61	67	PF00069	0.474
MOD_Plk_4	9	15	PF00069	0.599
MOD_ProDKin_1	152	158	PF00069	0.677
MOD_ProDKin_1	161	167	PF00069	0.775
MOD_SUMO_rev_2	87	93	PF00179	0.637
TRG_DiLeu_BaEn_1	199	204	PF01217	0.674
TRG_DiLeu_BaEn_4	18	24	PF01217	0.665
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.455
TRG_ENDOCYTIC_2	14	17	PF00928	0.651
TRG_ENDOCYTIC_2	205	208	PF00928	0.678
TRG_NLS_MonoExtC_3	179	184	PF00514	0.684
TRG_NLS_MonoExtN_4	180	185	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF0	Leptomonas seymouri	49%	100%
A0A3Q8IA55	Leishmania donovani	93%	100%
A4H7Z4	Leishmania braziliensis	71%	80%
A4HWC2	Leishmania infantum	93%	100%
E9AQ22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%