Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QFF8_LEIMA

TriTrypDb:

LmjF.15.0225 , LMJLV39_150007900 , LMJSD75_150007800

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

Q4QFF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFF8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.334
CLV_NRD_NRD_1	293	295	PF00675	0.398
CLV_NRD_NRD_1	89	91	PF00675	0.264
CLV_PCSK_KEX2_1	293	295	PF00082	0.398
CLV_PCSK_SKI1_1	247	251	PF00082	0.259
DEG_Nend_UBRbox_1	1	4	PF02207	0.348
DOC_MAPK_gen_1	333	339	PF00069	0.369
DOC_PP1_RVXF_1	115	121	PF00149	0.374
DOC_PP1_RVXF_1	89	96	PF00149	0.230
DOC_SPAK_OSR1_1	31	35	PF12202	0.325
DOC_USP7_MATH_1	255	259	PF00917	0.423
DOC_USP7_MATH_1	37	41	PF00917	0.476
DOC_USP7_MATH_1	85	89	PF00917	0.378
DOC_WW_Pin1_4	308	313	PF00397	0.427
DOC_WW_Pin1_4	72	77	PF00397	0.334
LIG_14-3-3_CanoR_1	14	20	PF00244	0.284
LIG_14-3-3_CanoR_1	2	9	PF00244	0.315
LIG_14-3-3_CanoR_1	236	246	PF00244	0.503
LIG_BRCT_BRCA1_1	156	160	PF00533	0.258
LIG_BRCT_BRCA1_1	201	205	PF00533	0.447
LIG_BRCT_BRCA1_1	257	261	PF00533	0.425
LIG_FHA_1	137	143	PF00498	0.393
LIG_FHA_1	206	212	PF00498	0.329
LIG_FHA_1	275	281	PF00498	0.424
LIG_FHA_1	52	58	PF00498	0.407
LIG_FHA_2	207	213	PF00498	0.390
LIG_LIR_Gen_1	212	221	PF02991	0.505
LIG_LIR_Gen_1	226	237	PF02991	0.346
LIG_LIR_Gen_1	258	269	PF02991	0.423
LIG_LIR_Nem_3	128	132	PF02991	0.393
LIG_LIR_Nem_3	212	216	PF02991	0.501
LIG_LIR_Nem_3	226	232	PF02991	0.334
LIG_LIR_Nem_3	258	264	PF02991	0.464
LIG_PCNA_yPIPBox_3	127	141	PF02747	0.319
LIG_SH2_CRK	115	119	PF00017	0.356
LIG_SH2_PTP2	229	232	PF00017	0.423
LIG_SH2_SRC	229	232	PF00017	0.433
LIG_SH2_STAP1	115	119	PF00017	0.356
LIG_SH2_STAP1	207	211	PF00017	0.441
LIG_SH2_STAT5	154	157	PF00017	0.387
LIG_SH2_STAT5	207	210	PF00017	0.463
LIG_SH2_STAT5	229	232	PF00017	0.433
LIG_SH3_3	165	171	PF00018	0.438
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.258
LIG_SUMO_SIM_par_1	184	190	PF11976	0.460
LIG_SUMO_SIM_par_1	81	88	PF11976	0.340
LIG_UBA3_1	245	250	PF00899	0.308
LIG_WRC_WIRS_1	261	266	PF05994	0.455
MOD_CK1_1	15	21	PF00069	0.343
MOD_CK1_1	177	183	PF00069	0.516
MOD_CK1_1	195	201	PF00069	0.455
MOD_CK1_1	223	229	PF00069	0.385
MOD_CK1_1	23	29	PF00069	0.384
MOD_CK1_1	260	266	PF00069	0.447
MOD_CK1_1	271	277	PF00069	0.395
MOD_CK1_1	308	314	PF00069	0.376
MOD_CK1_1	79	85	PF00069	0.372
MOD_GlcNHglycan	156	159	PF01048	0.531
MOD_GlcNHglycan	2	5	PF01048	0.435
MOD_GlcNHglycan	222	225	PF01048	0.303
MOD_GlcNHglycan	307	310	PF01048	0.320
MOD_GlcNHglycan	39	42	PF01048	0.383
MOD_GlcNHglycan	78	81	PF01048	0.532
MOD_GSK3_1	136	143	PF00069	0.395
MOD_GSK3_1	148	155	PF00069	0.536
MOD_GSK3_1	187	194	PF00069	0.419
MOD_GSK3_1	195	202	PF00069	0.379
MOD_GSK3_1	270	277	PF00069	0.450
MOD_GSK3_1	33	40	PF00069	0.489
MOD_GSK3_1	72	79	PF00069	0.390
MOD_N-GLC_1	113	118	PF02516	0.318
MOD_N-GLC_1	152	157	PF02516	0.341
MOD_N-GLC_1	237	242	PF02516	0.475
MOD_N-GLC_2	172	174	PF02516	0.279
MOD_NEK2_1	141	146	PF00069	0.489
MOD_NEK2_1	196	201	PF00069	0.442
MOD_NEK2_1	205	210	PF00069	0.367
MOD_NEK2_1	268	273	PF00069	0.405
MOD_NEK2_1	305	310	PF00069	0.305
MOD_NEK2_1	325	330	PF00069	0.157
MOD_NEK2_1	33	38	PF00069	0.398
MOD_NEK2_1	84	89	PF00069	0.305
MOD_NEK2_2	85	90	PF00069	0.221
MOD_PIKK_1	23	29	PF00454	0.502
MOD_PK_1	333	339	PF00069	0.474
MOD_PKA_1	191	197	PF00069	0.384
MOD_PKA_1	333	339	PF00069	0.474
MOD_Plk_1	113	119	PF00069	0.404
MOD_Plk_1	274	280	PF00069	0.419
MOD_Plk_2-3	53	59	PF00069	0.461
MOD_Plk_4	136	142	PF00069	0.299
MOD_Plk_4	15	21	PF00069	0.314
MOD_Plk_4	298	304	PF00069	0.297
MOD_Plk_4	333	339	PF00069	0.474
MOD_Plk_4	58	64	PF00069	0.366
MOD_Plk_4	79	85	PF00069	0.327
MOD_ProDKin_1	308	314	PF00069	0.424
MOD_ProDKin_1	72	78	PF00069	0.351
MOD_SUMO_rev_2	282	292	PF00179	0.494
MOD_SUMO_rev_2	327	336	PF00179	0.317
MOD_SUMO_rev_2	40	45	PF00179	0.467
MOD_SUMO_rev_2	49	57	PF00179	0.396
MOD_SUMO_rev_2	98	108	PF00179	0.467
TRG_DiLeu_BaEn_2	27	33	PF01217	0.379
TRG_ENDOCYTIC_2	115	118	PF00928	0.358
TRG_ENDOCYTIC_2	229	232	PF00928	0.431
TRG_ER_diArg_1	292	294	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZX3	Leptomonas seymouri	73%	100%
A0A0S4JKW8	Bodo saltans	29%	87%
A0A1X0NTY1	Trypanosomatidae	47%	100%
A0A3Q8IA26	Leishmania donovani	95%	100%
A0A422NSA5	Trypanosoma rangeli	48%	100%
A4H7Z5	Leishmania braziliensis	86%	100%
A4HWC3	Leishmania infantum	94%	100%
C9ZNW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQ23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q3KPT3	Xenopus laevis	24%	90%
Q4R571	Macaca fascicularis	25%	90%
Q53HC9	Homo sapiens	25%	90%
Q5M8I4	Xenopus tropicalis	23%	90%
Q5PPK9	Rattus norvegicus	24%	90%
Q5RE10	Pongo abelii	25%	84%
Q5XJP1	Danio rerio	24%	90%
Q6DUZ9	Gekko japonicus	25%	90%
Q6NPN9	Arabidopsis thaliana	24%	99%
Q8K0G5	Mus musculus	24%	90%
Q9U1Q0	Caenorhabditis elegans	23%	96%
V5BGM5	Trypanosoma cruzi	45%	100%