Putative sterol carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sterol carrier protein, putative

Species:

Leishmania major

UniProt:

Q4QFF6_LEIMA

TriTrypDb:

LmjF.15.0240 , LMJLV39_150008100 , LMJSD75_150008000

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QFF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFF6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.436
CLV_NRD_NRD_1	185	187	PF00675	0.423
CLV_NRD_NRD_1	209	211	PF00675	0.380
CLV_NRD_NRD_1	237	239	PF00675	0.514
CLV_NRD_NRD_1	323	325	PF00675	0.492
CLV_NRD_NRD_1	381	383	PF00675	0.411
CLV_PCSK_KEX2_1	100	102	PF00082	0.479
CLV_PCSK_KEX2_1	126	128	PF00082	0.477
CLV_PCSK_KEX2_1	155	157	PF00082	0.365
CLV_PCSK_KEX2_1	160	162	PF00082	0.339
CLV_PCSK_KEX2_1	18	20	PF00082	0.470
CLV_PCSK_KEX2_1	184	186	PF00082	0.476
CLV_PCSK_KEX2_1	209	211	PF00082	0.365
CLV_PCSK_KEX2_1	237	239	PF00082	0.534
CLV_PCSK_KEX2_1	323	325	PF00082	0.492
CLV_PCSK_KEX2_1	381	383	PF00082	0.335
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.489
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.365
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.333
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.465
CLV_PCSK_PC7_1	156	162	PF00082	0.367
CLV_PCSK_SKI1_1	381	385	PF00082	0.385
DEG_APCC_DBOX_1	160	168	PF00400	0.299
DEG_APCC_DBOX_1	185	193	PF00400	0.468
DEG_APCC_DBOX_1	2	10	PF00400	0.414
DEG_Nend_UBRbox_3	1	3	PF02207	0.498
DEG_SCF_FBW7_1	46	53	PF00400	0.407
DOC_CDC14_PxL_1	164	172	PF14671	0.289
DOC_CKS1_1	47	52	PF01111	0.407
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.451
DOC_MAPK_gen_1	100	107	PF00069	0.436
DOC_MAPK_gen_1	18	24	PF00069	0.389
DOC_MAPK_gen_1	209	217	PF00069	0.285
DOC_MAPK_gen_1	237	244	PF00069	0.487
DOC_MAPK_JIP1_4	238	244	PF00069	0.445
DOC_MAPK_MEF2A_6	100	109	PF00069	0.389
DOC_MAPK_MEF2A_6	210	219	PF00069	0.278
DOC_PP2B_LxvP_1	251	254	PF13499	0.383
DOC_PP4_FxxP_1	348	351	PF00568	0.276
DOC_USP7_MATH_1	125	129	PF00917	0.384
DOC_USP7_MATH_1	48	52	PF00917	0.275
DOC_USP7_MATH_1	88	92	PF00917	0.334
DOC_WW_Pin1_4	131	136	PF00397	0.484
DOC_WW_Pin1_4	258	263	PF00397	0.369
DOC_WW_Pin1_4	376	381	PF00397	0.477
DOC_WW_Pin1_4	46	51	PF00397	0.316
DOC_WW_Pin1_4	84	89	PF00397	0.416
LIG_14-3-3_CanoR_1	184	190	PF00244	0.395
LIG_Actin_WH2_2	2	20	PF00022	0.373
LIG_BRCT_BRCA1_1	120	124	PF00533	0.393
LIG_BRCT_BRCA1_1	53	57	PF00533	0.350
LIG_BRCT_BRCA1_2	120	126	PF00533	0.507
LIG_FHA_1	229	235	PF00498	0.560
LIG_FHA_1	276	282	PF00498	0.474
LIG_FHA_1	47	53	PF00498	0.408
LIG_FHA_2	254	260	PF00498	0.447
LIG_LIR_Nem_3	285	291	PF02991	0.279
LIG_Pex14_2	148	152	PF04695	0.422
LIG_Pex14_2	295	299	PF04695	0.302
LIG_Pex14_2	348	352	PF04695	0.281
LIG_REV1ctd_RIR_1	96	102	PF16727	0.422
LIG_SH2_NCK_1	358	362	PF00017	0.418
LIG_SH2_STAP1	146	150	PF00017	0.279
LIG_SH2_STAT5	136	139	PF00017	0.456
LIG_SH2_STAT5	240	243	PF00017	0.423
LIG_SH2_STAT5	62	65	PF00017	0.350
LIG_SH3_3	129	135	PF00018	0.512
LIG_SH3_3	137	143	PF00018	0.229
LIG_SH3_3	173	179	PF00018	0.339
LIG_SH3_3	247	253	PF00018	0.400
LIG_SUMO_SIM_anti_2	395	403	PF11976	0.292
LIG_TRAF2_1	188	191	PF00917	0.467
LIG_TRAF2_1	220	223	PF00917	0.313
LIG_TRAF2_1	256	259	PF00917	0.457
MOD_CDK_SPK_2	376	381	PF00069	0.494
MOD_CDK_SPxK_1	376	382	PF00069	0.490
MOD_CK1_1	128	134	PF00069	0.369
MOD_CK1_1	172	178	PF00069	0.432
MOD_CK1_1	51	57	PF00069	0.369
MOD_CK1_1	87	93	PF00069	0.412
MOD_CK2_1	185	191	PF00069	0.388
MOD_CK2_1	253	259	PF00069	0.479
MOD_Cter_Amidation	235	238	PF01082	0.541
MOD_GlcNHglycan	171	174	PF01048	0.423
MOD_GlcNHglycan	246	250	PF01048	0.406
MOD_GlcNHglycan	392	395	PF01048	0.277
MOD_GlcNHglycan	53	56	PF01048	0.384
MOD_GSK3_1	115	122	PF00069	0.459
MOD_GSK3_1	275	282	PF00069	0.287
MOD_GSK3_1	46	53	PF00069	0.434
MOD_GSK3_1	80	87	PF00069	0.382
MOD_N-GLC_1	128	133	PF02516	0.397
MOD_NEK2_1	17	22	PF00069	0.286
MOD_NEK2_1	392	397	PF00069	0.278
MOD_NEK2_1	67	72	PF00069	0.465
MOD_PIKK_1	62	68	PF00454	0.246
MOD_PK_1	18	24	PF00069	0.331
MOD_PKA_1	18	24	PF00069	0.398
MOD_PKA_1	185	191	PF00069	0.476
MOD_PKA_2	18	24	PF00069	0.421
MOD_PKA_2	185	191	PF00069	0.476
MOD_Plk_1	128	134	PF00069	0.370
MOD_ProDKin_1	131	137	PF00069	0.478
MOD_ProDKin_1	258	264	PF00069	0.363
MOD_ProDKin_1	376	382	PF00069	0.473
MOD_ProDKin_1	46	52	PF00069	0.317
MOD_ProDKin_1	84	90	PF00069	0.416
MOD_SUMO_for_1	159	162	PF00179	0.335
TRG_ENDOCYTIC_2	292	295	PF00928	0.265
TRG_ER_diArg_1	184	186	PF00400	0.448
TRG_ER_diArg_1	237	239	PF00400	0.411
TRG_ER_diArg_1	3	6	PF00400	0.334
TRG_ER_diArg_1	322	324	PF00400	0.498
TRG_ER_diArg_1	380	382	PF00400	0.415
TRG_ER_diArg_1	99	101	PF00400	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB7	Leptomonas seymouri	80%	100%
A0A0S4JDZ8	Bodo saltans	62%	100%
A0A3S5H6U0	Leishmania donovani	95%	100%
A0A422NT95	Trypanosoma rangeli	58%	100%
A4H7Z7	Leishmania braziliensis	91%	100%
A4HWC5	Leishmania infantum	96%	100%
C9ZUV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
D1AB74	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)	25%	100%
E9AQ25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
I6Y3T7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
O26884	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
O62742	Oryctolagus cuniculus	31%	74%
P07857	Bos taurus	28%	75%
P22307	Homo sapiens	28%	74%
P32020	Mus musculus	27%	74%
Q07598	Gallus gallus	25%	74%
Q58944	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
V5BHW0	Trypanosoma cruzi	61%	87%