Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFF4_LEIMA

TriTrypDb:

LmjF.15.0260 , LMJLV39_150008300 , LMJSD75_150008200

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QFF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.443
CLV_C14_Caspase3-7	401	405	PF00656	0.494
CLV_C14_Caspase3-7	438	442	PF00656	0.618
CLV_C14_Caspase3-7	84	88	PF00656	0.452
CLV_NRD_NRD_1	115	117	PF00675	0.581
CLV_NRD_NRD_1	153	155	PF00675	0.466
CLV_NRD_NRD_1	203	205	PF00675	0.677
CLV_NRD_NRD_1	270	272	PF00675	0.567
CLV_PCSK_FUR_1	113	117	PF00082	0.452
CLV_PCSK_KEX2_1	115	117	PF00082	0.420
CLV_PCSK_KEX2_1	151	153	PF00082	0.475
CLV_PCSK_KEX2_1	270	272	PF00082	0.567
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.515
CLV_PCSK_PC7_1	147	153	PF00082	0.578
CLV_PCSK_SKI1_1	123	127	PF00082	0.382
CLV_PCSK_SKI1_1	207	211	PF00082	0.440
CLV_PCSK_SKI1_1	224	228	PF00082	0.385
CLV_PCSK_SKI1_1	270	274	PF00082	0.522
CLV_PCSK_SKI1_1	290	294	PF00082	0.450
CLV_PCSK_SKI1_1	31	35	PF00082	0.477
CLV_PCSK_SKI1_1	311	315	PF00082	0.551
CLV_PCSK_SKI1_1	334	338	PF00082	0.469
CLV_PCSK_SKI1_1	342	346	PF00082	0.336
CLV_PCSK_SKI1_1	373	377	PF00082	0.435
CLV_PCSK_SKI1_1	92	96	PF00082	0.453
DEG_Nend_UBRbox_2	1	3	PF02207	0.530
DOC_MAPK_gen_1	89	97	PF00069	0.366
DOC_USP7_MATH_1	199	203	PF00917	0.469
DOC_USP7_MATH_1	354	358	PF00917	0.503
DOC_USP7_MATH_1	436	440	PF00917	0.653
DOC_WW_Pin1_4	282	287	PF00397	0.623
DOC_WW_Pin1_4	352	357	PF00397	0.498
DOC_WW_Pin1_4	406	411	PF00397	0.725
DOC_WW_Pin1_4	61	66	PF00397	0.546
LIG_14-3-3_CanoR_1	103	111	PF00244	0.502
LIG_14-3-3_CanoR_1	116	122	PF00244	0.331
LIG_14-3-3_CanoR_1	123	129	PF00244	0.290
LIG_14-3-3_CanoR_1	270	280	PF00244	0.510
LIG_14-3-3_CanoR_1	364	368	PF00244	0.434
LIG_BIR_III_2	431	435	PF00653	0.633
LIG_BRCT_BRCA1_1	63	67	PF00533	0.619
LIG_FHA_1	465	471	PF00498	0.453
LIG_FHA_2	1	7	PF00498	0.516
LIG_FHA_2	209	215	PF00498	0.404
LIG_FHA_2	271	277	PF00498	0.580
LIG_LIR_Gen_1	234	242	PF02991	0.387
LIG_LIR_LC3C_4	422	426	PF02991	0.637
LIG_LIR_Nem_3	2	7	PF02991	0.521
LIG_LIR_Nem_3	234	238	PF02991	0.388
LIG_LIR_Nem_3	28	33	PF02991	0.477
LIG_Pex14_1	117	121	PF04695	0.382
LIG_Pex14_2	238	242	PF04695	0.504
LIG_SH2_CRK	30	34	PF00017	0.479
LIG_SH2_CRK	474	478	PF00017	0.444
LIG_SH2_NCK_1	437	441	PF00017	0.516
LIG_SH2_STAP1	21	25	PF00017	0.524
LIG_SH2_STAP1	235	239	PF00017	0.375
LIG_SH2_STAT5	21	24	PF00017	0.525
LIG_SH2_STAT5	472	475	PF00017	0.464
LIG_SH3_3	280	286	PF00018	0.538
LIG_SH3_3	412	418	PF00018	0.738
LIG_SH3_3	6	12	PF00018	0.635
LIG_SH3_3	63	69	PF00018	0.544
LIG_TRAF2_1	211	214	PF00917	0.550
LIG_UBA3_1	456	464	PF00899	0.556
LIG_ULM_U2AF65_1	204	209	PF00076	0.489
LIG_WRC_WIRS_1	118	123	PF05994	0.384
MOD_CK1_1	19	25	PF00069	0.540
MOD_CK1_1	282	288	PF00069	0.582
MOD_CK1_1	327	333	PF00069	0.547
MOD_CK1_1	392	398	PF00069	0.538
MOD_CK1_1	70	76	PF00069	0.514
MOD_CK1_1	82	88	PF00069	0.462
MOD_CK2_1	124	130	PF00069	0.429
MOD_CK2_1	208	214	PF00069	0.417
MOD_CK2_1	237	243	PF00069	0.413
MOD_CK2_1	282	288	PF00069	0.561
MOD_GlcNHglycan	173	176	PF01048	0.521
MOD_GlcNHglycan	18	21	PF01048	0.726
MOD_GlcNHglycan	329	332	PF01048	0.473
MOD_GlcNHglycan	394	397	PF01048	0.677
MOD_GlcNHglycan	400	403	PF01048	0.664
MOD_GlcNHglycan	43	46	PF01048	0.595
MOD_GlcNHglycan	438	441	PF01048	0.624
MOD_GlcNHglycan	446	449	PF01048	0.625
MOD_GSK3_1	105	112	PF00069	0.658
MOD_GSK3_1	124	131	PF00069	0.319
MOD_GSK3_1	16	23	PF00069	0.649
MOD_GSK3_1	167	174	PF00069	0.568
MOD_GSK3_1	188	195	PF00069	0.536
MOD_GSK3_1	37	44	PF00069	0.646
MOD_GSK3_1	460	467	PF00069	0.477
MOD_N-GLC_1	171	176	PF02516	0.633
MOD_N-GLC_1	192	197	PF02516	0.454
MOD_N-GLC_1	262	267	PF02516	0.449
MOD_N-GLC_1	60	65	PF02516	0.659
MOD_N-GLC_1	70	75	PF02516	0.462
MOD_NEK2_1	192	197	PF00069	0.717
MOD_PIKK_1	105	111	PF00454	0.580
MOD_PIKK_1	14	20	PF00454	0.581
MOD_PIKK_1	464	470	PF00454	0.485
MOD_PKA_1	270	276	PF00069	0.473
MOD_PKA_2	102	108	PF00069	0.526
MOD_PKA_2	270	276	PF00069	0.573
MOD_PKA_2	363	369	PF00069	0.499
MOD_PKA_2	37	43	PF00069	0.616
MOD_Plk_1	161	167	PF00069	0.385
MOD_Plk_1	262	268	PF00069	0.573
MOD_Plk_1	383	389	PF00069	0.552
MOD_Plk_4	279	285	PF00069	0.635
MOD_Plk_4	383	389	PF00069	0.576
MOD_ProDKin_1	282	288	PF00069	0.624
MOD_ProDKin_1	352	358	PF00069	0.496
MOD_ProDKin_1	406	412	PF00069	0.723
MOD_ProDKin_1	61	67	PF00069	0.549
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.434
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.582
TRG_ENDOCYTIC_2	235	238	PF00928	0.374
TRG_ENDOCYTIC_2	30	33	PF00928	0.486
TRG_ENDOCYTIC_2	4	7	PF00928	0.522
TRG_ER_diArg_1	113	116	PF00400	0.514
TRG_ER_diArg_1	152	154	PF00400	0.523
TRG_ER_diArg_1	269	271	PF00400	0.561
TRG_ER_diArg_1	332	335	PF00400	0.507
TRG_NLS_MonoCore_2	203	208	PF00514	0.491
TRG_NLS_MonoExtN_4	201	208	PF00514	0.472
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P362	Leptomonas seymouri	66%	100%
A0A0S4JPG7	Bodo saltans	37%	98%
A0A1X0NUB6	Trypanosomatidae	41%	100%
A0A3R7NLS4	Trypanosoma rangeli	41%	100%
A0A3S7WTC2	Leishmania donovani	94%	100%
A4H7Z9	Leishmania braziliensis	80%	100%
A4HWC7	Leishmania infantum	94%	100%
C9ZNW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQ27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%