Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFF1_LEIMA

TriTrypDb:

LmjF.15.0290 , LMJLV39_150008800 , LMJSD75_150008700

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.776
CLV_C14_Caspase3-7	200	204	PF00656	0.607
CLV_C14_Caspase3-7	407	411	PF00656	0.417
CLV_C14_Caspase3-7	643	647	PF00656	0.722
CLV_MEL_PAP_1	292	298	PF00089	0.524
CLV_NRD_NRD_1	117	119	PF00675	0.592
CLV_NRD_NRD_1	306	308	PF00675	0.530
CLV_NRD_NRD_1	323	325	PF00675	0.437
CLV_NRD_NRD_1	333	335	PF00675	0.546
CLV_NRD_NRD_1	455	457	PF00675	0.539
CLV_NRD_NRD_1	611	613	PF00675	0.688
CLV_NRD_NRD_1	614	616	PF00675	0.698
CLV_NRD_NRD_1	694	696	PF00675	0.660
CLV_NRD_NRD_1	728	730	PF00675	0.701
CLV_NRD_NRD_1	731	733	PF00675	0.718
CLV_NRD_NRD_1	773	775	PF00675	0.711
CLV_NRD_NRD_1	79	81	PF00675	0.740
CLV_PCSK_FUR_1	331	335	PF00082	0.547
CLV_PCSK_FUR_1	611	615	PF00082	0.757
CLV_PCSK_FUR_1	729	733	PF00082	0.745
CLV_PCSK_FUR_1	771	775	PF00082	0.684
CLV_PCSK_KEX2_1	117	119	PF00082	0.592
CLV_PCSK_KEX2_1	306	308	PF00082	0.535
CLV_PCSK_KEX2_1	333	335	PF00082	0.546
CLV_PCSK_KEX2_1	455	457	PF00082	0.541
CLV_PCSK_KEX2_1	610	612	PF00082	0.690
CLV_PCSK_KEX2_1	613	615	PF00082	0.710
CLV_PCSK_KEX2_1	694	696	PF00082	0.660
CLV_PCSK_KEX2_1	727	729	PF00082	0.698
CLV_PCSK_KEX2_1	731	733	PF00082	0.716
CLV_PCSK_KEX2_1	771	773	PF00082	0.692
CLV_PCSK_KEX2_1	79	81	PF00082	0.774
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.704
CLV_PCSK_PC7_1	610	616	PF00082	0.770
CLV_PCSK_PC7_1	727	733	PF00082	0.662
CLV_PCSK_PC7_1	768	774	PF00082	0.698
CLV_PCSK_SKI1_1	155	159	PF00082	0.546
CLV_PCSK_SKI1_1	26	30	PF00082	0.659
CLV_PCSK_SKI1_1	284	288	PF00082	0.580
CLV_PCSK_SKI1_1	325	329	PF00082	0.544
CLV_PCSK_SKI1_1	37	41	PF00082	0.671
CLV_PCSK_SKI1_1	4	8	PF00082	0.793
CLV_PCSK_SKI1_1	418	422	PF00082	0.448
CLV_PCSK_SKI1_1	555	559	PF00082	0.524
CLV_PCSK_SKI1_1	732	736	PF00082	0.724
DEG_APCC_DBOX_1	712	720	PF00400	0.778
DEG_COP1_1	435	443	PF00400	0.513
DEG_SPOP_SBC_1	197	201	PF00917	0.640
DEG_SPOP_SBC_1	652	656	PF00917	0.815
DEG_SPOP_SBC_1	745	749	PF00917	0.700
DEG_SPOP_SBC_1	791	795	PF00917	0.571
DOC_CYCLIN_RxL_1	152	161	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	593	599	PF00134	0.712
DOC_MAPK_DCC_7	155	164	PF00069	0.570
DOC_MAPK_DCC_7	284	294	PF00069	0.515
DOC_MAPK_DCC_7	471	479	PF00069	0.468
DOC_MAPK_gen_1	117	128	PF00069	0.522
DOC_MAPK_gen_1	306	312	PF00069	0.478
DOC_MAPK_gen_1	357	365	PF00069	0.426
DOC_MAPK_MEF2A_6	155	164	PF00069	0.570
DOC_MAPK_MEF2A_6	471	479	PF00069	0.468
DOC_PP1_RVXF_1	293	299	PF00149	0.547
DOC_PP1_RVXF_1	553	560	PF00149	0.631
DOC_PP2B_LxvP_1	113	116	PF13499	0.730
DOC_PP2B_LxvP_1	157	160	PF13499	0.449
DOC_PP2B_LxvP_1	365	368	PF13499	0.447
DOC_PP2B_LxvP_1	593	596	PF13499	0.635
DOC_PP2B_LxvP_1	719	722	PF13499	0.766
DOC_PP4_FxxP_1	401	404	PF00568	0.463
DOC_USP7_MATH_1	197	201	PF00917	0.632
DOC_USP7_MATH_1	244	248	PF00917	0.420
DOC_USP7_MATH_1	337	341	PF00917	0.501
DOC_USP7_MATH_1	478	482	PF00917	0.576
DOC_USP7_MATH_1	599	603	PF00917	0.772
DOC_USP7_MATH_1	605	609	PF00917	0.665
DOC_USP7_MATH_1	651	655	PF00917	0.769
DOC_USP7_MATH_1	657	661	PF00917	0.763
DOC_USP7_MATH_1	734	738	PF00917	0.757
DOC_USP7_MATH_1	744	748	PF00917	0.690
DOC_USP7_MATH_1	752	756	PF00917	0.628
DOC_WW_Pin1_4	12	17	PF00397	0.785
DOC_WW_Pin1_4	172	177	PF00397	0.672
DOC_WW_Pin1_4	43	48	PF00397	0.775
DOC_WW_Pin1_4	469	474	PF00397	0.450
DOC_WW_Pin1_4	521	526	PF00397	0.433
DOC_WW_Pin1_4	601	606	PF00397	0.748
DOC_WW_Pin1_4	653	658	PF00397	0.686
DOC_WW_Pin1_4	736	741	PF00397	0.661
DOC_WW_Pin1_4	777	782	PF00397	0.764
LIG_14-3-3_CanoR_1	139	144	PF00244	0.533
LIG_14-3-3_CanoR_1	169	176	PF00244	0.727
LIG_14-3-3_CanoR_1	192	202	PF00244	0.623
LIG_14-3-3_CanoR_1	295	299	PF00244	0.540
LIG_14-3-3_CanoR_1	37	42	PF00244	0.730
LIG_Actin_WH2_2	279	297	PF00022	0.508
LIG_BIR_III_4	106	110	PF00653	0.724
LIG_CNOT1_NIM_1	205	214	PF04054	0.532
LIG_CtBP_PxDLS_1	671	675	PF00389	0.774
LIG_Dynein_DLC8_1	498	504	PF01221	0.672
LIG_eIF4E_1	226	232	PF01652	0.586
LIG_FHA_1	144	150	PF00498	0.599
LIG_FHA_1	20	26	PF00498	0.551
LIG_FHA_1	214	220	PF00498	0.517
LIG_FHA_1	271	277	PF00498	0.416
LIG_FHA_1	291	297	PF00498	0.279
LIG_FHA_1	330	336	PF00498	0.626
LIG_FHA_1	38	44	PF00498	0.511
LIG_FHA_1	5	11	PF00498	0.761
LIG_FHA_2	213	219	PF00498	0.518
LIG_FHA_2	405	411	PF00498	0.404
LIG_FHA_2	685	691	PF00498	0.690
LIG_FHA_2	791	797	PF00498	0.793
LIG_LIR_Gen_1	203	211	PF02991	0.557
LIG_LIR_Nem_3	151	157	PF02991	0.473
LIG_LIR_Nem_3	203	208	PF02991	0.578
LIG_LIR_Nem_3	210	214	PF02991	0.517
LIG_LIR_Nem_3	461	466	PF02991	0.475
LIG_MYND_1	156	160	PF01753	0.454
LIG_PCNA_yPIPBox_3	222	232	PF02747	0.566
LIG_Rb_LxCxE_1	577	587	PF01857	0.378
LIG_SH2_CRK	211	215	PF00017	0.503
LIG_SH2_NCK_1	733	737	PF00017	0.749
LIG_SH2_PTP2	476	479	PF00017	0.458
LIG_SH2_SRC	571	574	PF00017	0.537
LIG_SH2_STAP1	205	209	PF00017	0.581
LIG_SH2_STAP1	345	349	PF00017	0.501
LIG_SH2_STAP1	361	365	PF00017	0.412
LIG_SH2_STAT3	345	348	PF00017	0.569
LIG_SH2_STAT3	397	400	PF00017	0.558
LIG_SH2_STAT5	143	146	PF00017	0.445
LIG_SH2_STAT5	239	242	PF00017	0.457
LIG_SH2_STAT5	259	262	PF00017	0.223
LIG_SH2_STAT5	397	400	PF00017	0.402
LIG_SH2_STAT5	476	479	PF00017	0.458
LIG_SH2_STAT5	546	549	PF00017	0.512
LIG_SH2_STAT5	571	574	PF00017	0.438
LIG_SH3_3	472	478	PF00018	0.470
LIG_SH3_3	519	525	PF00018	0.509
LIG_SH3_3	589	595	PF00018	0.549
LIG_SH3_3	778	784	PF00018	0.786
LIG_SH3_3	88	94	PF00018	0.754
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.518
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.384
LIG_SUMO_SIM_anti_2	380	388	PF11976	0.421
LIG_SUMO_SIM_par_1	155	161	PF11976	0.503
LIG_SUMO_SIM_par_1	215	221	PF11976	0.413
LIG_SUMO_SIM_par_1	278	285	PF11976	0.493
LIG_SUMO_SIM_par_1	308	314	PF11976	0.383
LIG_SUMO_SIM_par_1	530	536	PF11976	0.420
LIG_TRAF2_1	675	678	PF00917	0.769
LIG_TRAF2_1	681	684	PF00917	0.755
LIG_TYR_ITIM	209	214	PF00017	0.518
LIG_WRC_WIRS_1	240	245	PF05994	0.569
LIG_WW_1	473	476	PF00397	0.483
LIG_WW_3	1	5	PF00397	0.723
MOD_CDK_SPK_2	12	17	PF00069	0.785
MOD_CDK_SPK_2	172	177	PF00069	0.707
MOD_CDK_SPxK_1	601	607	PF00069	0.732
MOD_CDK_SPxxK_3	521	528	PF00069	0.462
MOD_CK1_1	172	178	PF00069	0.704
MOD_CK1_1	196	202	PF00069	0.637
MOD_CK1_1	258	264	PF00069	0.399
MOD_CK1_1	467	473	PF00069	0.424
MOD_CK1_1	501	507	PF00069	0.755
MOD_CK1_1	521	527	PF00069	0.488
MOD_CK1_1	625	631	PF00069	0.769
MOD_CK1_1	634	640	PF00069	0.683
MOD_CK1_1	655	661	PF00069	0.806
MOD_CK1_1	738	744	PF00069	0.706
MOD_CK1_1	747	753	PF00069	0.743
MOD_CK2_1	212	218	PF00069	0.518
MOD_CK2_1	310	316	PF00069	0.390
MOD_CK2_1	530	536	PF00069	0.512
MOD_CK2_1	684	690	PF00069	0.775
MOD_Cter_Amidation	608	611	PF01082	0.629
MOD_GlcNHglycan	195	198	PF01048	0.666
MOD_GlcNHglycan	351	354	PF01048	0.558
MOD_GlcNHglycan	432	437	PF01048	0.671
MOD_GlcNHglycan	552	555	PF01048	0.532
MOD_GlcNHglycan	568	571	PF01048	0.367
MOD_GlcNHglycan	576	579	PF01048	0.418
MOD_GlcNHglycan	601	604	PF01048	0.750
MOD_GlcNHglycan	607	610	PF01048	0.715
MOD_GlcNHglycan	624	627	PF01048	0.680
MOD_GlcNHglycan	638	641	PF01048	0.602
MOD_GlcNHglycan	659	662	PF01048	0.767
MOD_GlcNHglycan	741	744	PF01048	0.747
MOD_GlcNHglycan	749	752	PF01048	0.733
MOD_GlcNHglycan	94	97	PF01048	0.806
MOD_GSK3_1	105	112	PF00069	0.719
MOD_GSK3_1	127	134	PF00069	0.491
MOD_GSK3_1	139	146	PF00069	0.429
MOD_GSK3_1	183	190	PF00069	0.679
MOD_GSK3_1	192	199	PF00069	0.619
MOD_GSK3_1	290	297	PF00069	0.536
MOD_GSK3_1	337	344	PF00069	0.607
MOD_GSK3_1	428	435	PF00069	0.637
MOD_GSK3_1	494	501	PF00069	0.632
MOD_GSK3_1	601	608	PF00069	0.782
MOD_GSK3_1	621	628	PF00069	0.697
MOD_GSK3_1	651	658	PF00069	0.813
MOD_GSK3_1	734	741	PF00069	0.716
MOD_GSK3_1	790	797	PF00069	0.753
MOD_N-GLC_2	88	90	PF02516	0.689
MOD_NEK2_1	193	198	PF00069	0.691
MOD_NEK2_1	384	389	PF00069	0.558
MOD_NEK2_1	62	67	PF00069	0.749
MOD_NEK2_2	127	132	PF00069	0.510
MOD_NEK2_2	6	11	PF00069	0.784
MOD_PIKK_1	337	343	PF00454	0.512
MOD_PIKK_1	385	391	PF00454	0.469
MOD_PIKK_1	499	505	PF00454	0.724
MOD_PKA_2	191	197	PF00069	0.793
MOD_PKA_2	294	300	PF00069	0.575
MOD_PKA_2	499	505	PF00069	0.741
MOD_PKA_2	620	626	PF00069	0.719
MOD_Plk_1	255	261	PF00069	0.400
MOD_Plk_1	361	367	PF00069	0.406
MOD_Plk_1	634	640	PF00069	0.650
MOD_Plk_1	706	712	PF00069	0.711
MOD_Plk_4	139	145	PF00069	0.472
MOD_Plk_4	244	250	PF00069	0.382
MOD_Plk_4	255	261	PF00069	0.397
MOD_Plk_4	317	323	PF00069	0.484
MOD_Plk_4	361	367	PF00069	0.410
MOD_Plk_4	464	470	PF00069	0.475
MOD_Plk_4	530	536	PF00069	0.512
MOD_Plk_4	715	721	PF00069	0.703
MOD_ProDKin_1	12	18	PF00069	0.779
MOD_ProDKin_1	172	178	PF00069	0.675
MOD_ProDKin_1	43	49	PF00069	0.776
MOD_ProDKin_1	469	475	PF00069	0.454
MOD_ProDKin_1	521	527	PF00069	0.428
MOD_ProDKin_1	601	607	PF00069	0.747
MOD_ProDKin_1	653	659	PF00069	0.689
MOD_ProDKin_1	736	742	PF00069	0.664
MOD_ProDKin_1	777	783	PF00069	0.767
MOD_SUMO_rev_2	792	800	PF00179	0.734
TRG_DiLeu_BaEn_1	23	28	PF01217	0.686
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.465
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.522
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.658
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.623
TRG_ENDOCYTIC_2	205	208	PF00928	0.571
TRG_ENDOCYTIC_2	211	214	PF00928	0.494
TRG_ENDOCYTIC_2	476	479	PF00928	0.458
TRG_ER_diArg_1	10	13	PF00400	0.758
TRG_ER_diArg_1	116	118	PF00400	0.612
TRG_ER_diArg_1	305	307	PF00400	0.522
TRG_ER_diArg_1	331	334	PF00400	0.545
TRG_ER_diArg_1	357	360	PF00400	0.568
TRG_ER_diArg_1	454	456	PF00400	0.563
TRG_ER_diArg_1	610	612	PF00400	0.670
TRG_ER_diArg_1	614	616	PF00400	0.634
TRG_ER_diArg_1	727	729	PF00400	0.698
TRG_ER_diArg_1	730	732	PF00400	0.708
TRG_ER_diArg_1	765	768	PF00400	0.641
TRG_ER_diArg_1	770	773	PF00400	0.678
TRG_ER_diArg_1	79	81	PF00400	0.766
TRG_NLS_MonoCore_2	611	616	PF00514	0.770
TRG_NLS_MonoExtN_4	610	617	PF00514	0.731
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU74	Leptomonas seymouri	64%	100%
A0A1X0NU60	Trypanosomatidae	46%	100%
A0A3S7WTA7	Leishmania donovani	95%	100%
A0A422N3L6	Trypanosoma rangeli	51%	100%
A4H803	Leishmania braziliensis	80%	100%
A4HWD1	Leishmania infantum	95%	100%
C9ZNX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AQ31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BL46	Trypanosoma cruzi	49%	100%