Putative ecotin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ecotin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFE9_LEIMA

TriTrypDb:

LmjF.15.0310 , LMJLV39_150009000 , LMJSD75_150008900

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.642
CLV_C14_Caspase3-7	359	363	PF00656	0.560
CLV_NRD_NRD_1	192	194	PF00675	0.704
CLV_NRD_NRD_1	286	288	PF00675	0.749
CLV_PCSK_FUR_1	189	193	PF00082	0.793
CLV_PCSK_KEX2_1	191	193	PF00082	0.705
CLV_PCSK_KEX2_1	286	288	PF00082	0.749
CLV_PCSK_KEX2_1	465	467	PF00082	0.759
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.739
CLV_PCSK_SKI1_1	218	222	PF00082	0.699
CLV_PCSK_SKI1_1	286	290	PF00082	0.756
CLV_PCSK_SKI1_1	43	47	PF00082	0.649
CLV_PCSK_SKI1_1	634	638	PF00082	0.567
DEG_APCC_DBOX_1	633	641	PF00400	0.647
DEG_ODPH_VHL_1	578	589	PF01847	0.747
DEG_SPOP_SBC_1	143	147	PF00917	0.571
DEG_SPOP_SBC_1	345	349	PF00917	0.717
DOC_MAPK_gen_1	191	200	PF00069	0.755
DOC_MAPK_gen_1	372	381	PF00069	0.667
DOC_MAPK_MEF2A_6	346	355	PF00069	0.608
DOC_MAPK_MEF2A_6	374	383	PF00069	0.665
DOC_PP1_RVXF_1	637	643	PF00149	0.640
DOC_PP2B_LxvP_1	51	54	PF13499	0.658
DOC_PP2B_LxvP_1	572	575	PF13499	0.761
DOC_USP7_MATH_1	118	122	PF00917	0.635
DOC_USP7_MATH_1	132	136	PF00917	0.643
DOC_USP7_MATH_1	143	147	PF00917	0.716
DOC_USP7_MATH_1	199	203	PF00917	0.748
DOC_USP7_MATH_1	303	307	PF00917	0.774
DOC_USP7_MATH_1	315	319	PF00917	0.670
DOC_USP7_MATH_1	345	349	PF00917	0.733
DOC_USP7_MATH_1	563	567	PF00917	0.743
DOC_WW_Pin1_4	116	121	PF00397	0.654
DOC_WW_Pin1_4	275	280	PF00397	0.688
DOC_WW_Pin1_4	347	352	PF00397	0.744
DOC_WW_Pin1_4	435	440	PF00397	0.824
DOC_WW_Pin1_4	468	473	PF00397	0.733
DOC_WW_Pin1_4	486	491	PF00397	0.732
LIG_14-3-3_CanoR_1	232	240	PF00244	0.728
LIG_14-3-3_CanoR_1	266	274	PF00244	0.664
LIG_14-3-3_CanoR_1	346	351	PF00244	0.838
LIG_14-3-3_CanoR_1	372	381	PF00244	0.745
LIG_14-3-3_CanoR_1	408	415	PF00244	0.688
LIG_Actin_WH2_2	159	175	PF00022	0.637
LIG_Actin_WH2_2	619	636	PF00022	0.716
LIG_AP_GAE_1	523	529	PF02883	0.635
LIG_BIR_II_1	1	5	PF00653	0.751
LIG_BIR_III_2	137	141	PF00653	0.577
LIG_BIR_III_4	213	217	PF00653	0.671
LIG_BRCT_BRCA1_1	510	514	PF00533	0.693
LIG_FHA_1	348	354	PF00498	0.768
LIG_FHA_1	374	380	PF00498	0.600
LIG_FHA_1	507	513	PF00498	0.822
LIG_FHA_2	409	415	PF00498	0.685
LIG_FHA_2	592	598	PF00498	0.599
LIG_GBD_Chelix_1	629	637	PF00786	0.571
LIG_LIR_Gen_1	523	533	PF02991	0.656
LIG_LIR_Nem_3	523	529	PF02991	0.664
LIG_Pex14_2	642	646	PF04695	0.719
LIG_PTAP_UEV_1	193	198	PF05743	0.727
LIG_RPA_C_Fungi	527	539	PF08784	0.657
LIG_SH2_CRK	240	244	PF00017	0.649
LIG_SH2_NCK_1	240	244	PF00017	0.707
LIG_SH2_SRC	168	171	PF00017	0.581
LIG_SH2_STAP1	164	168	PF00017	0.753
LIG_SH2_STAP1	322	326	PF00017	0.730
LIG_SH2_STAP1	336	340	PF00017	0.555
LIG_SH2_STAP1	643	647	PF00017	0.642
LIG_SH2_STAT5	240	243	PF00017	0.782
LIG_SH2_STAT5	641	644	PF00017	0.568
LIG_SH3_1	191	197	PF00018	0.725
LIG_SH3_2	571	576	PF14604	0.579
LIG_SH3_3	11	17	PF00018	0.724
LIG_SH3_3	137	143	PF00018	0.790
LIG_SH3_3	191	197	PF00018	0.667
LIG_SH3_3	241	247	PF00018	0.793
LIG_SH3_3	395	401	PF00018	0.718
LIG_SH3_3	448	454	PF00018	0.730
LIG_SH3_3	478	484	PF00018	0.775
LIG_SH3_3	568	574	PF00018	0.720
LIG_SH3_3	604	610	PF00018	0.725
LIG_SH3_3	63	69	PF00018	0.816
LIG_TRAF2_1	167	170	PF00917	0.637
LIG_WW_3	343	347	PF00397	0.828
LIG_WW_3	52	56	PF00397	0.639
MOD_CDK_SPxK_1	468	474	PF00069	0.734
MOD_CDK_SPxxK_3	347	354	PF00069	0.611
MOD_CK1_1	208	214	PF00069	0.709
MOD_CK1_1	245	251	PF00069	0.712
MOD_CK1_1	269	275	PF00069	0.732
MOD_CK1_1	280	286	PF00069	0.711
MOD_CK1_1	306	312	PF00069	0.755
MOD_CK1_1	318	324	PF00069	0.671
MOD_CK1_1	347	353	PF00069	0.763
MOD_CK1_1	455	461	PF00069	0.813
MOD_CK1_1	489	495	PF00069	0.782
MOD_CK1_1	565	571	PF00069	0.832
MOD_CK1_1	591	597	PF00069	0.703
MOD_CK1_1	599	605	PF00069	0.685
MOD_CK1_1	70	76	PF00069	0.742
MOD_CK2_1	164	170	PF00069	0.705
MOD_CK2_1	408	414	PF00069	0.740
MOD_CK2_1	550	556	PF00069	0.759
MOD_GlcNHglycan	106	109	PF01048	0.721
MOD_GlcNHglycan	120	123	PF01048	0.595
MOD_GlcNHglycan	134	137	PF01048	0.502
MOD_GlcNHglycan	146	149	PF01048	0.594
MOD_GlcNHglycan	194	197	PF01048	0.787
MOD_GlcNHglycan	207	210	PF01048	0.716
MOD_GlcNHglycan	247	250	PF01048	0.711
MOD_GlcNHglycan	262	265	PF01048	0.587
MOD_GlcNHglycan	274	277	PF01048	0.796
MOD_GlcNHglycan	317	320	PF01048	0.588
MOD_GlcNHglycan	362	365	PF01048	0.730
MOD_GlcNHglycan	454	457	PF01048	0.821
MOD_GlcNHglycan	477	480	PF01048	0.779
MOD_GlcNHglycan	491	494	PF01048	0.710
MOD_GlcNHglycan	516	519	PF01048	0.714
MOD_GlcNHglycan	565	568	PF01048	0.776
MOD_GlcNHglycan	597	601	PF01048	0.690
MOD_GlcNHglycan	611	614	PF01048	0.747
MOD_GlcNHglycan	647	650	PF01048	0.604
MOD_GlcNHglycan	74	77	PF01048	0.688
MOD_GlcNHglycan	83	86	PF01048	0.693
MOD_GlcNHglycan	88	91	PF01048	0.692
MOD_GlcNHglycan	95	98	PF01048	0.718
MOD_GSK3_1	128	135	PF00069	0.734
MOD_GSK3_1	179	186	PF00069	0.666
MOD_GSK3_1	238	245	PF00069	0.712
MOD_GSK3_1	262	269	PF00069	0.685
MOD_GSK3_1	277	284	PF00069	0.676
MOD_GSK3_1	305	312	PF00069	0.651
MOD_GSK3_1	314	321	PF00069	0.623
MOD_GSK3_1	32	39	PF00069	0.588
MOD_GSK3_1	373	380	PF00069	0.663
MOD_GSK3_1	485	492	PF00069	0.791
MOD_GSK3_1	587	594	PF00069	0.667
MOD_N-GLC_1	416	421	PF02516	0.537
MOD_NEK2_1	184	189	PF00069	0.655
MOD_NEK2_1	262	267	PF00069	0.719
MOD_NEK2_1	514	519	PF00069	0.705
MOD_NEK2_1	550	555	PF00069	0.679
MOD_NEK2_1	629	634	PF00069	0.642
MOD_NEK2_1	645	650	PF00069	0.551
MOD_NEK2_2	216	221	PF00069	0.558
MOD_PIKK_1	233	239	PF00454	0.635
MOD_PIKK_1	266	272	PF00454	0.720
MOD_PIKK_1	36	42	PF00454	0.541
MOD_PKA_1	192	198	PF00069	0.670
MOD_PKA_2	192	198	PF00069	0.670
MOD_PKA_2	245	251	PF00069	0.710
MOD_PKA_2	345	351	PF00069	0.759
MOD_PKA_2	373	379	PF00069	0.663
MOD_PKA_2	4	10	PF00069	0.752
MOD_PKA_2	533	539	PF00069	0.652
MOD_Plk_1	164	170	PF00069	0.627
MOD_Plk_1	216	222	PF00069	0.647
MOD_Plk_1	522	528	PF00069	0.648
MOD_Plk_1	618	624	PF00069	0.756
MOD_Plk_4	269	275	PF00069	0.766
MOD_ProDKin_1	116	122	PF00069	0.656
MOD_ProDKin_1	275	281	PF00069	0.688
MOD_ProDKin_1	347	353	PF00069	0.744
MOD_ProDKin_1	435	441	PF00069	0.824
MOD_ProDKin_1	468	474	PF00069	0.734
MOD_ProDKin_1	486	492	PF00069	0.734
MOD_SUMO_for_1	47	50	PF00179	0.726
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.586
TRG_ENDOCYTIC_2	152	155	PF00928	0.602
TRG_ER_diArg_1	188	191	PF00400	0.682
TRG_ER_diArg_1	192	194	PF00400	0.691
TRG_ER_diArg_1	286	288	PF00400	0.749
TRG_ER_diArg_1	326	329	PF00400	0.582
TRG_ER_diArg_1	371	374	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC10	Leptomonas seymouri	33%	100%
A0A3S7WTB9	Leishmania donovani	84%	100%
A4H805	Leishmania braziliensis	58%	100%
A4HWD3	Leishmania infantum	85%	100%
E9AQ33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%