Putative ecotin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ecotin

Gene product:

Isoprenylcysteine alpha-carbonyl methylesterase, putative

Species:

Leishmania major

UniProt:

Q4QFE8_LEIMA

TriTrypDb:

LmjF.15.0320 , LMJLV39_150009100 , LMJSD75_150009000

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QFE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFE8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.743
CLV_C14_Caspase3-7	410	414	PF00656	0.284
CLV_C14_Caspase3-7	620	624	PF00656	0.409
CLV_C14_Caspase3-7	733	737	PF00656	0.481
CLV_MEL_PAP_1	99	105	PF00089	0.359
CLV_NRD_NRD_1	101	103	PF00675	0.342
CLV_NRD_NRD_1	312	314	PF00675	0.428
CLV_NRD_NRD_1	349	351	PF00675	0.502
CLV_NRD_NRD_1	354	356	PF00675	0.263
CLV_NRD_NRD_1	509	511	PF00675	0.534
CLV_NRD_NRD_1	539	541	PF00675	0.619
CLV_NRD_NRD_1	650	652	PF00675	0.642
CLV_PCSK_KEX2_1	101	103	PF00082	0.342
CLV_PCSK_KEX2_1	125	127	PF00082	0.456
CLV_PCSK_KEX2_1	348	350	PF00082	0.580
CLV_PCSK_KEX2_1	356	358	PF00082	0.317
CLV_PCSK_KEX2_1	509	511	PF00082	0.534
CLV_PCSK_KEX2_1	539	541	PF00082	0.618
CLV_PCSK_KEX2_1	650	652	PF00082	0.642
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.456
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.613
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.312
CLV_PCSK_PC7_1	344	350	PF00082	0.500
CLV_PCSK_SKI1_1	122	126	PF00082	0.458
CLV_PCSK_SKI1_1	514	518	PF00082	0.538
CLV_PCSK_SKI1_1	559	563	PF00082	0.529
CLV_PCSK_SKI1_1	607	611	PF00082	0.602
CLV_PCSK_SKI1_1	67	71	PF00082	0.571
CLV_PCSK_SKI1_1	74	78	PF00082	0.461
DEG_APCC_DBOX_1	513	521	PF00400	0.361
DEG_APCC_DBOX_1	747	755	PF00400	0.412
DEG_SCF_FBW7_1	18	25	PF00400	0.337
DOC_CKS1_1	19	24	PF01111	0.337
DOC_CYCLIN_yClb5_NLxxxL_5	112	120	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	605	611	PF00134	0.411
DOC_MAPK_DCC_7	603	611	PF00069	0.422
DOC_MAPK_gen_1	352	362	PF00069	0.483
DOC_MAPK_HePTP_8	288	300	PF00069	0.534
DOC_MAPK_MEF2A_6	291	300	PF00069	0.530
DOC_MAPK_MEF2A_6	355	364	PF00069	0.484
DOC_PP1_RVXF_1	72	79	PF00149	0.296
DOC_PP2B_LxvP_1	298	301	PF13499	0.538
DOC_USP7_MATH_1	142	146	PF00917	0.632
DOC_USP7_MATH_1	269	273	PF00917	0.758
DOC_USP7_MATH_1	301	305	PF00917	0.656
DOC_USP7_MATH_1	484	488	PF00917	0.349
DOC_USP7_MATH_1	567	571	PF00917	0.377
DOC_USP7_MATH_1	675	679	PF00917	0.560
DOC_USP7_MATH_1	684	688	PF00917	0.450
DOC_USP7_MATH_1	693	697	PF00917	0.373
DOC_USP7_MATH_1	9	13	PF00917	0.367
DOC_USP7_UBL2_3	348	352	PF12436	0.789
DOC_USP7_UBL2_3	603	607	PF12436	0.444
DOC_WW_Pin1_4	138	143	PF00397	0.634
DOC_WW_Pin1_4	161	166	PF00397	0.825
DOC_WW_Pin1_4	18	23	PF00397	0.228
DOC_WW_Pin1_4	262	267	PF00397	0.754
DOC_WW_Pin1_4	327	332	PF00397	0.717
DOC_WW_Pin1_4	4	9	PF00397	0.432
DOC_WW_Pin1_4	710	715	PF00397	0.519
DOC_WW_Pin1_4	717	722	PF00397	0.530
DOC_WW_Pin1_4	738	743	PF00397	0.391
DOC_WW_Pin1_4	93	98	PF00397	0.411
LIG_14-3-3_CanoR_1	101	106	PF00244	0.584
LIG_14-3-3_CanoR_1	134	142	PF00244	0.625
LIG_14-3-3_CanoR_1	183	190	PF00244	0.693
LIG_14-3-3_CanoR_1	214	221	PF00244	0.698
LIG_14-3-3_CanoR_1	237	246	PF00244	0.676
LIG_14-3-3_CanoR_1	291	295	PF00244	0.539
LIG_14-3-3_CanoR_1	529	533	PF00244	0.379
LIG_14-3-3_CanoR_1	658	662	PF00244	0.450
LIG_14-3-3_CanoR_1	679	684	PF00244	0.541
LIG_14-3-3_CanoR_1	724	728	PF00244	0.503
LIG_14-3-3_CanoR_1	74	79	PF00244	0.331
LIG_14-3-3_CanoR_1	753	758	PF00244	0.421
LIG_APCC_ABBA_1	561	566	PF00400	0.345
LIG_APCC_ABBAyCdc20_2	509	515	PF00400	0.380
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_BRCT_BRCA1_1	494	498	PF00533	0.326
LIG_CaM_IQ_9	229	245	PF13499	0.709
LIG_Clathr_ClatBox_1	702	706	PF01394	0.470
LIG_CSL_BTD_1	139	142	PF09270	0.634
LIG_EH1_1	497	505	PF00400	0.320
LIG_eIF4E_1	374	380	PF01652	0.406
LIG_FHA_1	108	114	PF00498	0.645
LIG_FHA_1	214	220	PF00498	0.700
LIG_FHA_1	263	269	PF00498	0.693
LIG_FHA_1	291	297	PF00498	0.531
LIG_FHA_1	406	412	PF00498	0.347
LIG_FHA_1	53	59	PF00498	0.395
LIG_FHA_1	542	548	PF00498	0.380
LIG_FHA_1	620	626	PF00498	0.329
LIG_FHA_1	671	677	PF00498	0.539
LIG_FHA_1	678	684	PF00498	0.527
LIG_FHA_1	724	730	PF00498	0.504
LIG_FHA_2	272	278	PF00498	0.742
LIG_FHA_2	400	406	PF00498	0.284
LIG_FHA_2	618	624	PF00498	0.391
LIG_FHA_2	731	737	PF00498	0.487
LIG_LIR_Apic_2	474	480	PF02991	0.429
LIG_LIR_Apic_2	722	728	PF02991	0.526
LIG_LIR_Apic_2	756	760	PF02991	0.383
LIG_LIR_Apic_2	82	88	PF02991	0.314
LIG_LIR_Gen_1	21	31	PF02991	0.501
LIG_LIR_Gen_1	32	41	PF02991	0.541
LIG_LIR_Gen_1	42	52	PF02991	0.518
LIG_LIR_Gen_1	550	561	PF02991	0.358
LIG_LIR_Gen_1	610	619	PF02991	0.331
LIG_LIR_Gen_1	77	86	PF02991	0.406
LIG_LIR_Nem_3	21	27	PF02991	0.501
LIG_LIR_Nem_3	295	300	PF02991	0.508
LIG_LIR_Nem_3	39	44	PF02991	0.573
LIG_LIR_Nem_3	395	399	PF02991	0.284
LIG_LIR_Nem_3	550	556	PF02991	0.365
LIG_LIR_Nem_3	610	616	PF02991	0.341
LIG_LIR_Nem_3	638	642	PF02991	0.353
LIG_LIR_Nem_3	726	730	PF02991	0.524
LIG_LRP6_Inhibitor_1	95	101	PF00058	0.348
LIG_LYPXL_yS_3	727	730	PF13949	0.413
LIG_NRBOX	115	121	PF00104	0.646
LIG_PCNA_TLS_4	291	298	PF02747	0.515
LIG_PCNA_yPIPBox_3	377	387	PF02747	0.336
LIG_Pex14_1	369	373	PF04695	0.372
LIG_Pex14_2	221	225	PF04695	0.694
LIG_Pex14_2	41	45	PF04695	0.622
LIG_PTB_Apo_2	267	274	PF02174	0.734
LIG_SH2_CRK	477	481	PF00017	0.416
LIG_SH2_CRK	725	729	PF00017	0.532
LIG_SH2_PTP2	491	494	PF00017	0.302
LIG_SH2_PTP2	613	616	PF00017	0.350
LIG_SH2_PTP2	757	760	PF00017	0.385
LIG_SH2_SRC	297	300	PF00017	0.511
LIG_SH2_SRC	518	521	PF00017	0.351
LIG_SH2_STAP1	147	151	PF00017	0.685
LIG_SH2_STAP1	530	534	PF00017	0.390
LIG_SH2_STAT3	43	46	PF00017	0.551
LIG_SH2_STAT5	297	300	PF00017	0.511
LIG_SH2_STAT5	374	377	PF00017	0.379
LIG_SH2_STAT5	389	392	PF00017	0.245
LIG_SH2_STAT5	43	46	PF00017	0.551
LIG_SH2_STAT5	491	494	PF00017	0.302
LIG_SH2_STAT5	530	533	PF00017	0.334
LIG_SH2_STAT5	535	538	PF00017	0.353
LIG_SH2_STAT5	581	584	PF00017	0.376
LIG_SH2_STAT5	613	616	PF00017	0.350
LIG_SH2_STAT5	725	728	PF00017	0.504
LIG_SH2_STAT5	757	760	PF00017	0.418
LIG_SH2_STAT5	85	88	PF00017	0.326
LIG_SH2_STAT5	93	96	PF00017	0.415
LIG_SH3_1	725	731	PF00018	0.526
LIG_SH3_3	136	142	PF00018	0.674
LIG_SH3_3	16	22	PF00018	0.186
LIG_SH3_3	164	170	PF00018	0.773
LIG_SH3_3	2	8	PF00018	0.376
LIG_SH3_3	244	250	PF00018	0.635
LIG_SH3_3	263	269	PF00018	0.716
LIG_SH3_3	388	394	PF00018	0.284
LIG_SH3_3	466	472	PF00018	0.500
LIG_SH3_3	725	731	PF00018	0.526
LIG_SH3_3	739	745	PF00018	0.259
LIG_SUMO_SIM_par_1	260	265	PF11976	0.695
LIG_SUMO_SIM_par_1	358	363	PF11976	0.333
LIG_SUMO_SIM_par_1	407	413	PF11976	0.284
LIG_SUMO_SIM_par_1	607	612	PF11976	0.355
LIG_TRFH_1	613	617	PF08558	0.330
LIG_TRFH_1	93	97	PF08558	0.487
LIG_TYR_ITIM	611	616	PF00017	0.384
LIG_TYR_ITIM	640	645	PF00017	0.420
LIG_UBA3_1	305	314	PF00899	0.588
LIG_UBA3_1	58	67	PF00899	0.314
LIG_WRC_WIRS_1	23	28	PF05994	0.462
MOD_CDK_SPK_2	327	332	PF00069	0.661
MOD_CDK_SPxxK_3	717	724	PF00069	0.470
MOD_CK1_1	104	110	PF00069	0.572
MOD_CK1_1	128	134	PF00069	0.668
MOD_CK1_1	213	219	PF00069	0.750
MOD_CK1_1	248	254	PF00069	0.727
MOD_CK1_1	29	35	PF00069	0.337
MOD_CK1_1	315	321	PF00069	0.653
MOD_CK1_1	4	10	PF00069	0.432
MOD_CK1_1	447	453	PF00069	0.305
MOD_CK1_1	678	684	PF00069	0.541
MOD_CK1_1	746	752	PF00069	0.443
MOD_CK2_1	142	148	PF00069	0.634
MOD_CK2_1	248	254	PF00069	0.778
MOD_CK2_1	273	279	PF00069	0.745
MOD_CK2_1	36	42	PF00069	0.515
MOD_CK2_1	399	405	PF00069	0.284
MOD_CK2_1	621	627	PF00069	0.414
MOD_GlcNHglycan	135	138	PF01048	0.497
MOD_GlcNHglycan	151	154	PF01048	0.537
MOD_GlcNHglycan	196	199	PF01048	0.414
MOD_GlcNHglycan	334	337	PF01048	0.542
MOD_GlcNHglycan	437	440	PF01048	0.498
MOD_GlcNHglycan	454	457	PF01048	0.527
MOD_GlcNHglycan	494	497	PF01048	0.502
MOD_GlcNHglycan	568	572	PF01048	0.556
MOD_GlcNHglycan	575	578	PF01048	0.534
MOD_GlcNHglycan	686	689	PF01048	0.773
MOD_GlcNHglycan	694	698	PF01048	0.720
MOD_GSK3_1	101	108	PF00069	0.553
MOD_GSK3_1	128	135	PF00069	0.706
MOD_GSK3_1	138	145	PF00069	0.570
MOD_GSK3_1	147	154	PF00069	0.687
MOD_GSK3_1	18	25	PF00069	0.337
MOD_GSK3_1	206	213	PF00069	0.724
MOD_GSK3_1	217	224	PF00069	0.754
MOD_GSK3_1	269	276	PF00069	0.707
MOD_GSK3_1	405	412	PF00069	0.347
MOD_GSK3_1	567	574	PF00069	0.365
MOD_GSK3_1	617	624	PF00069	0.413
MOD_GSK3_1	675	682	PF00069	0.574
MOD_GSK3_1	706	713	PF00069	0.516
MOD_LATS_1	677	683	PF00433	0.538
MOD_N-GLC_1	221	226	PF02516	0.537
MOD_N-GLC_1	269	274	PF02516	0.579
MOD_N-GLC_1	430	435	PF02516	0.547
MOD_NEK2_1	1	6	PF00069	0.452
MOD_NEK2_1	151	156	PF00069	0.690
MOD_NEK2_1	255	260	PF00069	0.648
MOD_NEK2_1	26	31	PF00069	0.337
MOD_NEK2_1	36	41	PF00069	0.663
MOD_NEK2_1	51	56	PF00069	0.407
MOD_NEK2_1	683	688	PF00069	0.540
MOD_NEK2_1	69	74	PF00069	0.426
MOD_NEK2_2	301	306	PF00069	0.638
MOD_NEK2_2	484	489	PF00069	0.359
MOD_PIKK_1	237	243	PF00454	0.731
MOD_PIKK_1	253	259	PF00454	0.767
MOD_PIKK_1	447	453	PF00454	0.284
MOD_PIKK_1	706	712	PF00454	0.458
MOD_PKA_1	101	107	PF00069	0.573
MOD_PKA_1	125	131	PF00069	0.649
MOD_PKA_2	101	107	PF00069	0.552
MOD_PKA_2	108	114	PF00069	0.586
MOD_PKA_2	125	131	PF00069	0.682
MOD_PKA_2	133	139	PF00069	0.558
MOD_PKA_2	177	183	PF00069	0.714
MOD_PKA_2	213	219	PF00069	0.669
MOD_PKA_2	290	296	PF00069	0.548
MOD_PKA_2	312	318	PF00069	0.674
MOD_PKA_2	343	349	PF00069	0.650
MOD_PKA_2	484	490	PF00069	0.332
MOD_PKA_2	528	534	PF00069	0.353
MOD_PKA_2	657	663	PF00069	0.449
MOD_PKA_2	678	684	PF00069	0.540
MOD_PKA_2	723	729	PF00069	0.501
MOD_Plk_1	147	153	PF00069	0.717
MOD_Plk_1	221	227	PF00069	0.729
MOD_Plk_1	269	275	PF00069	0.778
MOD_Plk_1	430	436	PF00069	0.284
MOD_Plk_2-3	177	183	PF00069	0.729
MOD_Plk_2-3	271	277	PF00069	0.743
MOD_Plk_2-3	312	318	PF00069	0.647
MOD_Plk_2-3	405	411	PF00069	0.347
MOD_Plk_4	191	197	PF00069	0.679
MOD_Plk_4	301	307	PF00069	0.689
MOD_Plk_4	430	436	PF00069	0.297
MOD_Plk_4	441	447	PF00069	0.263
MOD_Plk_4	621	627	PF00069	0.430
MOD_Plk_4	753	759	PF00069	0.387
MOD_Plk_4	9	15	PF00069	0.428
MOD_ProDKin_1	138	144	PF00069	0.634
MOD_ProDKin_1	161	167	PF00069	0.827
MOD_ProDKin_1	18	24	PF00069	0.228
MOD_ProDKin_1	262	268	PF00069	0.754
MOD_ProDKin_1	327	333	PF00069	0.718
MOD_ProDKin_1	4	10	PF00069	0.432
MOD_ProDKin_1	710	716	PF00069	0.520
MOD_ProDKin_1	717	723	PF00069	0.529
MOD_ProDKin_1	738	744	PF00069	0.392
MOD_ProDKin_1	93	99	PF00069	0.405
MOD_SUMO_for_1	124	127	PF00179	0.623
TRG_ENDOCYTIC_2	297	300	PF00928	0.511
TRG_ENDOCYTIC_2	389	392	PF00928	0.284
TRG_ENDOCYTIC_2	396	399	PF00928	0.284
TRG_ENDOCYTIC_2	491	494	PF00928	0.309
TRG_ENDOCYTIC_2	513	516	PF00928	0.353
TRG_ENDOCYTIC_2	613	616	PF00928	0.350
TRG_ENDOCYTIC_2	642	645	PF00928	0.436
TRG_ENDOCYTIC_2	727	730	PF00928	0.589
TRG_ER_diArg_1	100	102	PF00400	0.541
TRG_ER_diArg_1	236	239	PF00400	0.732
TRG_ER_diArg_1	355	358	PF00400	0.521
TRG_NLS_MonoExtC_3	347	352	PF00514	0.744
TRG_NLS_MonoExtC_3	354	359	PF00514	0.485
TRG_NLS_MonoExtN_4	345	352	PF00514	0.740
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ74	Leptomonas seymouri	64%	100%
A0A1X0NTZ0	Trypanosomatidae	43%	100%
A0A3Q8IC72	Leishmania donovani	93%	100%
A0A3R7K197	Trypanosoma rangeli	48%	100%
A4H806	Leishmania braziliensis	78%	100%
A4HWD4	Leishmania infantum	93%	100%
E9AQ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%