LeishMANIAdb
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Abhydrolase_3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Abhydrolase_3 domain-containing protein
Gene product:
alpha/beta hydrolase fold, putative
Species:
Leishmania major
UniProt:
Q4QFE7_LEIMA
TriTrypDb:
LmjF.15.0330 , LMJLV39_150009200 * , LMJSD75_150009100
Length:
1022

Annotations

LeishMANIAdb annotations

A hydrolase similar to plant isoprenylcysteine alpha-carbonyl methylesterase (ICME). These might have a very special topology, with 2TMs on the N-terminus.. The family has 2 paralogs in Leishmaniids.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

Q4QFE7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFE7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016787 hydrolase activity 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 578 582 PF00656 0.351
CLV_C14_Caspase3-7 966 970 PF00656 0.518
CLV_MEL_PAP_1 60 66 PF00089 0.417
CLV_NRD_NRD_1 124 126 PF00675 0.543
CLV_NRD_NRD_1 218 220 PF00675 0.632
CLV_NRD_NRD_1 302 304 PF00675 0.552
CLV_NRD_NRD_1 338 340 PF00675 0.559
CLV_NRD_NRD_1 428 430 PF00675 0.626
CLV_NRD_NRD_1 437 439 PF00675 0.578
CLV_NRD_NRD_1 440 442 PF00675 0.559
CLV_NRD_NRD_1 450 452 PF00675 0.558
CLV_NRD_NRD_1 522 524 PF00675 0.351
CLV_NRD_NRD_1 62 64 PF00675 0.427
CLV_NRD_NRD_1 707 709 PF00675 0.658
CLV_NRD_NRD_1 761 763 PF00675 0.668
CLV_NRD_NRD_1 770 772 PF00675 0.610
CLV_NRD_NRD_1 777 779 PF00675 0.583
CLV_NRD_NRD_1 92 94 PF00675 0.464
CLV_PCSK_FUR_1 122 126 PF00082 0.551
CLV_PCSK_FUR_1 214 218 PF00082 0.527
CLV_PCSK_FUR_1 438 442 PF00082 0.610
CLV_PCSK_FUR_1 520 524 PF00082 0.493
CLV_PCSK_FUR_1 775 779 PF00082 0.692
CLV_PCSK_KEX2_1 122 124 PF00082 0.552
CLV_PCSK_KEX2_1 214 216 PF00082 0.657
CLV_PCSK_KEX2_1 217 219 PF00082 0.630
CLV_PCSK_KEX2_1 302 304 PF00082 0.552
CLV_PCSK_KEX2_1 338 340 PF00082 0.573
CLV_PCSK_KEX2_1 428 430 PF00082 0.674
CLV_PCSK_KEX2_1 437 439 PF00082 0.586
CLV_PCSK_KEX2_1 440 442 PF00082 0.549
CLV_PCSK_KEX2_1 450 452 PF00082 0.512
CLV_PCSK_KEX2_1 519 521 PF00082 0.502
CLV_PCSK_KEX2_1 522 524 PF00082 0.331
CLV_PCSK_KEX2_1 62 64 PF00082 0.427
CLV_PCSK_KEX2_1 707 709 PF00082 0.658
CLV_PCSK_KEX2_1 761 763 PF00082 0.668
CLV_PCSK_KEX2_1 770 772 PF00082 0.610
CLV_PCSK_KEX2_1 777 779 PF00082 0.583
CLV_PCSK_PC1ET2_1 519 521 PF00082 0.500
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.318
CLV_PCSK_PC7_1 214 220 PF00082 0.470
CLV_PCSK_PC7_1 520 526 PF00082 0.351
CLV_PCSK_PC7_1 757 763 PF00082 0.651
CLV_PCSK_SKI1_1 398 402 PF00082 0.547
CLV_PCSK_SKI1_1 727 731 PF00082 0.583
CLV_PCSK_SKI1_1 75 79 PF00082 0.483
CLV_PCSK_SKI1_1 777 781 PF00082 0.713
CLV_PCSK_SKI1_1 89 93 PF00082 0.385
CLV_Separin_Metazoa 90 94 PF03568 0.621
DEG_APCC_DBOX_1 74 82 PF00400 0.675
DEG_SPOP_SBC_1 208 212 PF00917 0.778
DEG_SPOP_SBC_1 791 795 PF00917 0.547
DOC_CKS1_1 184 189 PF01111 0.700
DOC_CKS1_1 680 685 PF01111 0.375
DOC_CYCLIN_RxL_1 771 783 PF00134 0.382
DOC_CYCLIN_yCln2_LP_2 501 507 PF00134 0.590
DOC_CYCLIN_yCln2_LP_2 680 686 PF00134 0.375
DOC_MAPK_gen_1 122 129 PF00069 0.680
DOC_MAPK_gen_1 519 530 PF00069 0.550
DOC_MAPK_gen_1 71 80 PF00069 0.678
DOC_MAPK_gen_1 896 906 PF00069 0.490
DOC_MAPK_MEF2A_6 494 501 PF00069 0.608
DOC_MAPK_MEF2A_6 523 532 PF00069 0.551
DOC_MAPK_MEF2A_6 899 908 PF00069 0.455
DOC_PP1_RVXF_1 5 12 PF00149 0.551
DOC_PP2B_LxvP_1 1002 1005 PF13499 0.434
DOC_PP2B_LxvP_1 501 504 PF13499 0.615
DOC_PP2B_LxvP_1 909 912 PF13499 0.379
DOC_PP4_FxxP_1 803 806 PF00568 0.496
DOC_USP7_MATH_1 130 134 PF00917 0.653
DOC_USP7_MATH_1 177 181 PF00917 0.776
DOC_USP7_MATH_1 220 224 PF00917 0.751
DOC_USP7_MATH_1 237 241 PF00917 0.731
DOC_USP7_MATH_1 262 266 PF00917 0.767
DOC_USP7_MATH_1 320 324 PF00917 0.796
DOC_USP7_MATH_1 353 357 PF00917 0.824
DOC_USP7_MATH_1 389 393 PF00917 0.740
DOC_USP7_MATH_1 407 411 PF00917 0.752
DOC_USP7_MATH_1 652 656 PF00917 0.401
DOC_USP7_MATH_1 735 739 PF00917 0.429
DOC_USP7_MATH_1 773 777 PF00917 0.478
DOC_USP7_MATH_1 927 931 PF00917 0.411
DOC_USP7_MATH_1 962 966 PF00917 0.478
DOC_USP7_MATH_2 1005 1011 PF00917 0.427
DOC_USP7_UBL2_3 384 388 PF12436 0.759
DOC_WW_Pin1_4 109 114 PF00397 0.741
DOC_WW_Pin1_4 164 169 PF00397 0.825
DOC_WW_Pin1_4 183 188 PF00397 0.616
DOC_WW_Pin1_4 366 371 PF00397 0.755
DOC_WW_Pin1_4 444 449 PF00397 0.713
DOC_WW_Pin1_4 54 59 PF00397 0.484
DOC_WW_Pin1_4 679 684 PF00397 0.384
DOC_WW_Pin1_4 802 807 PF00397 0.499
DOC_WW_Pin1_4 881 886 PF00397 0.542
LIG_14-3-3_CanoR_1 158 166 PF00244 0.780
LIG_14-3-3_CanoR_1 218 228 PF00244 0.742
LIG_14-3-3_CanoR_1 275 280 PF00244 0.717
LIG_14-3-3_CanoR_1 467 472 PF00244 0.791
LIG_14-3-3_CanoR_1 494 498 PF00244 0.618
LIG_14-3-3_CanoR_1 62 67 PF00244 0.631
LIG_14-3-3_CanoR_1 757 761 PF00244 0.443
LIG_14-3-3_CanoR_1 915 921 PF00244 0.373
LIG_Actin_WH2_2 73 91 PF00022 0.674
LIG_APCC_ABBA_1 729 734 PF00400 0.395
LIG_BIR_III_4 340 344 PF00653 0.727
LIG_BRCT_BRCA1_1 916 920 PF00533 0.408
LIG_CtBP_PxDLS_1 903 907 PF00389 0.388
LIG_EH1_1 3 11 PF00400 0.619
LIG_EH1_1 665 673 PF00400 0.397
LIG_eIF4E_1 666 672 PF01652 0.393
LIG_FHA_1 12 18 PF00498 0.412
LIG_FHA_1 142 148 PF00498 0.666
LIG_FHA_1 23 29 PF00498 0.295
LIG_FHA_1 254 260 PF00498 0.770
LIG_FHA_1 411 417 PF00498 0.804
LIG_FHA_1 494 500 PF00498 0.671
LIG_FHA_1 574 580 PF00498 0.351
LIG_FHA_1 679 685 PF00498 0.380
LIG_FHA_1 710 716 PF00498 0.444
LIG_FHA_1 743 749 PF00498 0.313
LIG_FHA_1 940 946 PF00498 0.388
LIG_FHA_2 244 250 PF00498 0.761
LIG_FHA_2 468 474 PF00498 0.744
LIG_FHA_2 568 574 PF00498 0.351
LIG_FHA_2 828 834 PF00498 0.513
LIG_GBD_Chelix_1 244 252 PF00786 0.453
LIG_GBD_Chelix_1 535 543 PF00786 0.362
LIG_GBD_Chelix_1 9 17 PF00786 0.412
LIG_LIR_Apic_2 642 648 PF02991 0.447
LIG_LIR_Gen_1 167 177 PF02991 0.780
LIG_LIR_Gen_1 474 484 PF02991 0.738
LIG_LIR_Gen_1 541 552 PF02991 0.412
LIG_LIR_Gen_1 718 729 PF02991 0.391
LIG_LIR_Gen_1 819 828 PF02991 0.493
LIG_LIR_Gen_1 905 912 PF02991 0.379
LIG_LIR_Nem_3 167 172 PF02991 0.774
LIG_LIR_Nem_3 474 480 PF02991 0.746
LIG_LIR_Nem_3 563 567 PF02991 0.351
LIG_LIR_Nem_3 718 724 PF02991 0.392
LIG_LIR_Nem_3 819 823 PF02991 0.489
LIG_LIR_Nem_3 905 911 PF02991 0.411
LIG_PCNA_yPIPBox_3 67 81 PF02747 0.565
LIG_Pex14_2 47 51 PF04695 0.362
LIG_RPA_C_Fungi 120 132 PF08784 0.544
LIG_SH2_CRK 383 387 PF00017 0.714
LIG_SH2_CRK 645 649 PF00017 0.559
LIG_SH2_NCK_1 202 206 PF00017 0.645
LIG_SH2_PTP2 659 662 PF00017 0.455
LIG_SH2_SRC 202 205 PF00017 0.646
LIG_SH2_SRC 686 689 PF00017 0.490
LIG_SH2_STAP1 698 702 PF00017 0.471
LIG_SH2_STAP1 939 943 PF00017 0.564
LIG_SH2_STAT3 514 517 PF00017 0.587
LIG_SH2_STAT5 514 517 PF00017 0.537
LIG_SH2_STAT5 54 57 PF00017 0.480
LIG_SH2_STAT5 557 560 PF00017 0.412
LIG_SH2_STAT5 659 662 PF00017 0.455
LIG_SH2_STAT5 703 706 PF00017 0.496
LIG_SH2_STAT5 758 761 PF00017 0.545
LIG_SH3_2 334 339 PF14604 0.685
LIG_SH3_3 107 113 PF00018 0.666
LIG_SH3_3 331 337 PF00018 0.698
LIG_SH3_3 419 425 PF00018 0.680
LIG_SH3_3 556 562 PF00018 0.412
LIG_SH3_3 634 640 PF00018 0.591
LIG_SH3_3 887 893 PF00018 0.701
LIG_SH3_3 897 903 PF00018 0.527
LIG_SH3_4 457 464 PF00018 0.612
LIG_SUMO_SIM_anti_2 496 501 PF11976 0.476
LIG_SUMO_SIM_par_1 526 531 PF11976 0.412
LIG_SUMO_SIM_par_1 575 581 PF11976 0.412
LIG_TRAF2_1 356 359 PF00917 0.730
LIG_TRAF2_1 753 756 PF00917 0.505
LIG_TYR_ITIM 381 386 PF00017 0.751
MOD_CDC14_SPxK_1 369 372 PF00782 0.693
MOD_CDC14_SPxK_1 447 450 PF00782 0.602
MOD_CDK_SPxK_1 366 372 PF00069 0.697
MOD_CDK_SPxK_1 444 450 PF00069 0.601
MOD_CDK_SPxxK_3 444 451 PF00069 0.604
MOD_CK1_1 167 173 PF00069 0.716
MOD_CK1_1 206 212 PF00069 0.681
MOD_CK1_1 222 228 PF00069 0.541
MOD_CK1_1 323 329 PF00069 0.783
MOD_CK1_1 410 416 PF00069 0.703
MOD_CK1_1 615 621 PF00069 0.412
MOD_CK1_1 65 71 PF00069 0.558
MOD_CK1_1 795 801 PF00069 0.680
MOD_CK1_1 805 811 PF00069 0.578
MOD_CK1_1 872 878 PF00069 0.671
MOD_CK1_1 963 969 PF00069 0.688
MOD_CK2_1 198 204 PF00069 0.663
MOD_CK2_1 243 249 PF00069 0.807
MOD_CK2_1 353 359 PF00069 0.699
MOD_CK2_1 467 473 PF00069 0.701
MOD_CK2_1 567 573 PF00069 0.412
MOD_CK2_1 827 833 PF00069 0.685
MOD_CK2_1 972 978 PF00069 0.610
MOD_GlcNHglycan 132 135 PF01048 0.618
MOD_GlcNHglycan 14 17 PF01048 0.412
MOD_GlcNHglycan 176 180 PF01048 0.702
MOD_GlcNHglycan 239 242 PF01048 0.762
MOD_GlcNHglycan 263 267 PF01048 0.759
MOD_GlcNHglycan 326 329 PF01048 0.801
MOD_GlcNHglycan 431 434 PF01048 0.779
MOD_GlcNHglycan 531 535 PF01048 0.412
MOD_GlcNHglycan 605 608 PF01048 0.412
MOD_GlcNHglycan 622 625 PF01048 0.299
MOD_GlcNHglycan 662 665 PF01048 0.455
MOD_GlcNHglycan 736 740 PF01048 0.519
MOD_GlcNHglycan 762 765 PF01048 0.438
MOD_GlcNHglycan 794 797 PF01048 0.640
MOD_GlcNHglycan 824 827 PF01048 0.637
MOD_GlcNHglycan 874 877 PF01048 0.546
MOD_GlcNHglycan 962 965 PF01048 0.698
MOD_GSK3_1 143 150 PF00069 0.713
MOD_GSK3_1 164 171 PF00069 0.688
MOD_GSK3_1 203 210 PF00069 0.719
MOD_GSK3_1 218 225 PF00069 0.680
MOD_GSK3_1 232 239 PF00069 0.589
MOD_GSK3_1 262 269 PF00069 0.759
MOD_GSK3_1 308 315 PF00069 0.713
MOD_GSK3_1 320 327 PF00069 0.671
MOD_GSK3_1 410 417 PF00069 0.797
MOD_GSK3_1 508 515 PF00069 0.622
MOD_GSK3_1 538 545 PF00069 0.412
MOD_GSK3_1 573 580 PF00069 0.412
MOD_GSK3_1 62 69 PF00069 0.534
MOD_GSK3_1 735 742 PF00069 0.476
MOD_GSK3_1 756 763 PF00069 0.551
MOD_GSK3_1 791 798 PF00069 0.677
MOD_GSK3_1 805 812 PF00069 0.548
MOD_GSK3_1 963 970 PF00069 0.642
MOD_N-GLC_1 598 603 PF02516 0.412
MOD_N-GLC_2 362 364 PF02516 0.733
MOD_NEK2_1 12 17 PF00069 0.412
MOD_NEK2_1 207 212 PF00069 0.683
MOD_NEK2_1 512 517 PF00069 0.525
MOD_NEK2_1 543 548 PF00069 0.412
MOD_NEK2_1 760 765 PF00069 0.526
MOD_NEK2_1 856 861 PF00069 0.651
MOD_NEK2_1 967 972 PF00069 0.688
MOD_NEK2_2 168 173 PF00069 0.644
MOD_NEK2_2 652 657 PF00069 0.485
MOD_NEK2_2 696 701 PF00069 0.394
MOD_OFUCOSY 924 931 PF10250 0.491
MOD_PIKK_1 158 164 PF00454 0.679
MOD_PIKK_1 209 215 PF00454 0.681
MOD_PIKK_1 275 281 PF00454 0.699
MOD_PIKK_1 329 335 PF00454 0.723
MOD_PIKK_1 414 420 PF00454 0.755
MOD_PIKK_1 512 518 PF00454 0.522
MOD_PIKK_1 615 621 PF00454 0.412
MOD_PIKK_1 95 101 PF00454 0.593
MOD_PK_1 93 99 PF00069 0.566
MOD_PKA_1 218 224 PF00069 0.662
MOD_PKA_1 62 68 PF00069 0.532
MOD_PKA_1 93 99 PF00069 0.566
MOD_PKA_2 196 202 PF00069 0.713
MOD_PKA_2 218 224 PF00069 0.675
MOD_PKA_2 452 458 PF00069 0.723
MOD_PKA_2 493 499 PF00069 0.553
MOD_PKA_2 62 68 PF00069 0.532
MOD_PKA_2 652 658 PF00069 0.483
MOD_PKA_2 696 702 PF00069 0.470
MOD_PKA_2 756 762 PF00069 0.547
MOD_PKA_2 914 920 PF00069 0.438
MOD_PKB_1 216 224 PF00069 0.574
MOD_PKB_1 273 281 PF00069 0.653
MOD_Plk_1 1007 1013 PF00069 0.385
MOD_Plk_1 156 162 PF00069 0.679
MOD_Plk_1 203 209 PF00069 0.675
MOD_Plk_1 410 416 PF00069 0.686
MOD_Plk_1 598 604 PF00069 0.412
MOD_Plk_1 742 748 PF00069 0.411
MOD_Plk_1 939 945 PF00069 0.540
MOD_Plk_1 990 996 PF00069 0.589
MOD_Plk_2-3 198 204 PF00069 0.663
MOD_Plk_2-3 573 579 PF00069 0.412
MOD_Plk_4 203 209 PF00069 0.672
MOD_Plk_4 223 229 PF00069 0.509
MOD_Plk_4 543 549 PF00069 0.412
MOD_Plk_4 598 604 PF00069 0.412
MOD_Plk_4 609 615 PF00069 0.295
MOD_Plk_4 743 749 PF00069 0.509
MOD_Plk_4 883 889 PF00069 0.612
MOD_Plk_4 967 973 PF00069 0.688
MOD_Plk_4 990 996 PF00069 0.628
MOD_ProDKin_1 109 115 PF00069 0.676
MOD_ProDKin_1 164 170 PF00069 0.795
MOD_ProDKin_1 183 189 PF00069 0.507
MOD_ProDKin_1 366 372 PF00069 0.697
MOD_ProDKin_1 444 450 PF00069 0.641
MOD_ProDKin_1 54 60 PF00069 0.478
MOD_ProDKin_1 679 685 PF00069 0.451
MOD_ProDKin_1 802 808 PF00069 0.618
MOD_ProDKin_1 881 887 PF00069 0.681
TRG_DiLeu_BaEn_1 743 748 PF01217 0.504
TRG_DiLeu_BaEn_1 905 910 PF01217 0.499
TRG_DiLeu_BaEn_2 845 851 PF01217 0.532
TRG_DiLeu_BaLyEn_6 279 284 PF01217 0.578
TRG_DiLeu_BaLyEn_6 775 780 PF01217 0.615
TRG_ENDOCYTIC_2 383 386 PF00928 0.764
TRG_ENDOCYTIC_2 557 560 PF00928 0.412
TRG_ENDOCYTIC_2 564 567 PF00928 0.337
TRG_ENDOCYTIC_2 659 662 PF00928 0.420
TRG_ER_diArg_1 122 125 PF00400 0.693
TRG_ER_diArg_1 214 217 PF00400 0.728
TRG_ER_diArg_1 218 220 PF00400 0.683
TRG_ER_diArg_1 337 339 PF00400 0.720
TRG_ER_diArg_1 437 440 PF00400 0.806
TRG_ER_diArg_1 450 453 PF00400 0.657
TRG_ER_diArg_1 466 469 PF00400 0.728
TRG_ER_diArg_1 520 523 PF00400 0.614
TRG_ER_diArg_1 61 63 PF00400 0.510
TRG_ER_diArg_1 760 762 PF00400 0.531
TRG_ER_diArg_1 775 778 PF00400 0.481
TRG_NLS_MonoExtC_3 518 523 PF00514 0.602
TRG_NLS_MonoExtN_4 520 527 PF00514 0.412
TRG_Pf-PMV_PEXEL_1 158 162 PF00026 0.681
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.661
TRG_Pf-PMV_PEXEL_1 550 554 PF00026 0.412
TRG_Pf-PMV_PEXEL_1 79 84 PF00026 0.573

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H6U1 Leishmania donovani 92% 100%
A4H807 Leishmania braziliensis 69% 96%
A4HWD5 Leishmania infantum 93% 100%
E9AQ35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS