Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFE6_LEIMA

TriTrypDb:

LmjF.15.0340 , LMJLV39_150009300 , LMJSD75_150009200

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.518
CLV_C14_Caspase3-7	240	244	PF00656	0.526
CLV_C14_Caspase3-7	386	390	PF00656	0.657
CLV_NRD_NRD_1	13	15	PF00675	0.388
CLV_NRD_NRD_1	142	144	PF00675	0.704
CLV_NRD_NRD_1	207	209	PF00675	0.508
CLV_NRD_NRD_1	285	287	PF00675	0.539
CLV_NRD_NRD_1	323	325	PF00675	0.533
CLV_NRD_NRD_1	375	377	PF00675	0.637
CLV_NRD_NRD_1	403	405	PF00675	0.667
CLV_PCSK_FUR_1	282	286	PF00082	0.538
CLV_PCSK_FUR_1	401	405	PF00082	0.535
CLV_PCSK_KEX2_1	142	144	PF00082	0.704
CLV_PCSK_KEX2_1	207	209	PF00082	0.504
CLV_PCSK_KEX2_1	282	284	PF00082	0.537
CLV_PCSK_KEX2_1	285	287	PF00082	0.547
CLV_PCSK_KEX2_1	353	355	PF00082	0.594
CLV_PCSK_KEX2_1	375	377	PF00082	0.633
CLV_PCSK_KEX2_1	392	394	PF00082	0.712
CLV_PCSK_KEX2_1	400	402	PF00082	0.615
CLV_PCSK_KEX2_1	403	405	PF00082	0.588
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.594
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.708
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.566
CLV_PCSK_SKI1_1	212	216	PF00082	0.451
CLV_PCSK_SKI1_1	414	418	PF00082	0.517
DEG_SCF_FBW7_1	190	197	PF00400	0.465
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.602
DOC_MAPK_gen_1	324	330	PF00069	0.578
DOC_MAPK_gen_1	410	417	PF00069	0.496
DOC_PP1_RVXF_1	412	418	PF00149	0.494
DOC_USP7_MATH_1	125	129	PF00917	0.725
DOC_USP7_MATH_1	157	161	PF00917	0.627
DOC_USP7_MATH_1	237	241	PF00917	0.509
DOC_USP7_MATH_1	245	249	PF00917	0.627
DOC_USP7_MATH_1	269	273	PF00917	0.523
DOC_USP7_MATH_1	329	333	PF00917	0.713
DOC_USP7_MATH_1	435	439	PF00917	0.700
DOC_WW_Pin1_4	118	123	PF00397	0.731
DOC_WW_Pin1_4	145	150	PF00397	0.573
DOC_WW_Pin1_4	190	195	PF00397	0.564
DOC_WW_Pin1_4	25	30	PF00397	0.547
DOC_WW_Pin1_4	252	257	PF00397	0.576
DOC_WW_Pin1_4	32	37	PF00397	0.569
DOC_WW_Pin1_4	379	384	PF00397	0.768
DOC_WW_Pin1_4	47	52	PF00397	0.632
DOC_WW_Pin1_4	90	95	PF00397	0.770
LIG_14-3-3_CanoR_1	127	133	PF00244	0.572
LIG_14-3-3_CanoR_1	142	150	PF00244	0.693
LIG_14-3-3_CanoR_1	163	171	PF00244	0.618
LIG_14-3-3_CanoR_1	181	190	PF00244	0.587
LIG_14-3-3_CanoR_1	337	343	PF00244	0.548
LIG_14-3-3_CanoR_1	360	365	PF00244	0.693
LIG_14-3-3_CanoR_1	414	423	PF00244	0.625
LIG_14-3-3_CanoR_1	45	51	PF00244	0.641
LIG_Actin_WH2_2	167	185	PF00022	0.520
LIG_APCC_ABBA_1	16	21	PF00400	0.514
LIG_APCC_ABBAyCdc20_2	15	21	PF00400	0.512
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_CaM_IQ_9	340	356	PF13499	0.578
LIG_FHA_1	337	343	PF00498	0.521
LIG_FHA_1	417	423	PF00498	0.620
LIG_FHA_1	450	456	PF00498	0.488
LIG_FHA_2	384	390	PF00498	0.651
LIG_FHA_2	48	54	PF00498	0.552
LIG_LIR_Gen_1	126	137	PF02991	0.762
LIG_LIR_Nem_3	126	132	PF02991	0.766
LIG_PTAP_UEV_1	364	369	PF05743	0.532
LIG_SH2_CRK	129	133	PF00017	0.573
LIG_SH2_CRK	327	331	PF00017	0.618
LIG_SH2_NCK_1	129	133	PF00017	0.657
LIG_SH2_SRC	176	179	PF00017	0.491
LIG_SH2_STAP1	19	23	PF00017	0.607
LIG_SH2_STAT5	176	179	PF00017	0.632
LIG_SH2_STAT5	68	71	PF00017	0.655
LIG_SH3_1	27	33	PF00018	0.589
LIG_SH3_2	122	127	PF14604	0.633
LIG_SH3_2	29	34	PF14604	0.516
LIG_SH3_3	119	125	PF00018	0.773
LIG_SH3_3	26	32	PF00018	0.609
LIG_SH3_3	301	307	PF00018	0.510
LIG_SH3_3	323	329	PF00018	0.685
LIG_SH3_3	362	368	PF00018	0.632
LIG_SH3_CIN85_PxpxPR_1	29	34	PF14604	0.502
LIG_WW_3	31	35	PF00397	0.631
MOD_CDK_SPxxK_3	34	41	PF00069	0.603
MOD_CDK_SPxxK_3	90	97	PF00069	0.676
MOD_CK1_1	105	111	PF00069	0.647
MOD_CK1_1	128	134	PF00069	0.662
MOD_CK1_1	248	254	PF00069	0.706
MOD_CK1_1	302	308	PF00069	0.576
MOD_CK1_1	319	325	PF00069	0.432
MOD_CK1_1	363	369	PF00069	0.680
MOD_CK1_1	70	76	PF00069	0.622
MOD_CK2_1	164	170	PF00069	0.629
MOD_CK2_1	261	267	PF00069	0.628
MOD_CK2_1	428	434	PF00069	0.562
MOD_CK2_1	47	53	PF00069	0.547
MOD_DYRK1A_RPxSP_1	34	38	PF00069	0.620
MOD_GlcNHglycan	104	107	PF01048	0.543
MOD_GlcNHglycan	159	162	PF01048	0.675
MOD_GlcNHglycan	166	169	PF01048	0.685
MOD_GlcNHglycan	183	186	PF01048	0.603
MOD_GlcNHglycan	250	253	PF01048	0.613
MOD_GlcNHglycan	355	358	PF01048	0.660
MOD_GlcNHglycan	365	368	PF01048	0.671
MOD_GlcNHglycan	377	380	PF01048	0.610
MOD_GlcNHglycan	429	433	PF01048	0.529
MOD_GlcNHglycan	69	72	PF01048	0.667
MOD_GSK3_1	141	148	PF00069	0.730
MOD_GSK3_1	190	197	PF00069	0.566
MOD_GSK3_1	248	255	PF00069	0.635
MOD_GSK3_1	298	305	PF00069	0.567
MOD_GSK3_1	363	370	PF00069	0.737
MOD_GSK3_1	375	382	PF00069	0.645
MOD_GSK3_1	47	54	PF00069	0.644
MOD_GSK3_1	485	492	PF00069	0.481
MOD_GSK3_1	98	105	PF00069	0.619
MOD_N-GLC_1	248	253	PF02516	0.712
MOD_N-GLC_1	292	297	PF02516	0.565
MOD_NEK2_1	292	297	PF00069	0.553
MOD_NEK2_1	415	420	PF00069	0.599
MOD_PIKK_1	198	204	PF00454	0.451
MOD_PIKK_1	269	275	PF00454	0.507
MOD_PKA_1	142	148	PF00069	0.697
MOD_PKA_1	285	291	PF00069	0.498
MOD_PKA_1	353	359	PF00069	0.605
MOD_PKA_1	375	381	PF00069	0.572
MOD_PKA_2	141	147	PF00069	0.686
MOD_PKA_2	164	170	PF00069	0.640
MOD_PKA_2	285	291	PF00069	0.631
MOD_PKA_2	302	308	PF00069	0.618
MOD_PKA_2	336	342	PF00069	0.627
MOD_PKA_2	353	359	PF00069	0.682
MOD_PKA_2	375	381	PF00069	0.766
MOD_PKA_2	449	455	PF00069	0.509
MOD_PKB_1	187	195	PF00069	0.489
MOD_PKB_1	283	291	PF00069	0.495
MOD_Plk_1	194	200	PF00069	0.536
MOD_Plk_1	225	231	PF00069	0.558
MOD_Plk_1	261	267	PF00069	0.516
MOD_Plk_1	428	434	PF00069	0.584
MOD_Plk_4	338	344	PF00069	0.520
MOD_Plk_4	417	423	PF00069	0.562
MOD_ProDKin_1	118	124	PF00069	0.731
MOD_ProDKin_1	145	151	PF00069	0.572
MOD_ProDKin_1	190	196	PF00069	0.554
MOD_ProDKin_1	25	31	PF00069	0.548
MOD_ProDKin_1	252	258	PF00069	0.576
MOD_ProDKin_1	32	38	PF00069	0.568
MOD_ProDKin_1	379	385	PF00069	0.764
MOD_ProDKin_1	47	53	PF00069	0.635
MOD_ProDKin_1	90	96	PF00069	0.770
MOD_SUMO_rev_2	218	224	PF00179	0.483
TRG_DiLeu_BaEn_1	4	9	PF01217	0.529
TRG_ENDOCYTIC_2	129	132	PF00928	0.657
TRG_ENDOCYTIC_2	19	22	PF00928	0.550
TRG_ENDOCYTIC_2	327	330	PF00928	0.706
TRG_ER_diArg_1	206	208	PF00400	0.505
TRG_ER_diArg_1	282	285	PF00400	0.561
TRG_ER_diArg_1	401	404	PF00400	0.640
TRG_ER_diArg_1	409	412	PF00400	0.547
TRG_NLS_MonoCore_2	399	404	PF00514	0.622
TRG_NLS_MonoExtC_3	399	404	PF00514	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I2	Leptomonas seymouri	38%	94%
A0A3Q8IIM0	Leishmania donovani	84%	100%
A0A3R7M601	Trypanosoma rangeli	27%	100%
A4HWD6	Leishmania infantum	84%	100%
E9AQ36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5DCS2	Trypanosoma cruzi	28%	100%