PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania major

UniProt:

Q4QFE4_LEIMA

TriTrypDb:

LmjF.15.0360 , LMJLV39_150009500 , LMJSD75_150009400

Length:

1067

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFE4

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	2
GO:0001522	pseudouridine synthesis	6	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	2
GO:0031118	rRNA pseudouridine synthesis	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0009982	pseudouridine synthase activity	4	6
GO:0016853	isomerase activity	2	6
GO:0016866	intramolecular transferase activity	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.668
CLV_C14_Caspase3-7	620	624	PF00656	0.689
CLV_C14_Caspase3-7	693	697	PF00656	0.680
CLV_C14_Caspase3-7	994	998	PF00656	0.585
CLV_NRD_NRD_1	211	213	PF00675	0.652
CLV_NRD_NRD_1	241	243	PF00675	0.625
CLV_NRD_NRD_1	255	257	PF00675	0.659
CLV_NRD_NRD_1	388	390	PF00675	0.538
CLV_NRD_NRD_1	448	450	PF00675	0.606
CLV_NRD_NRD_1	470	472	PF00675	0.730
CLV_NRD_NRD_1	511	513	PF00675	0.708
CLV_NRD_NRD_1	660	662	PF00675	0.703
CLV_NRD_NRD_1	889	891	PF00675	0.380
CLV_PCSK_FUR_1	253	257	PF00082	0.608
CLV_PCSK_KEX2_1	211	213	PF00082	0.652
CLV_PCSK_KEX2_1	241	243	PF00082	0.625
CLV_PCSK_KEX2_1	255	257	PF00082	0.659
CLV_PCSK_KEX2_1	388	390	PF00082	0.538
CLV_PCSK_KEX2_1	470	472	PF00082	0.730
CLV_PCSK_KEX2_1	511	513	PF00082	0.738
CLV_PCSK_KEX2_1	590	592	PF00082	0.747
CLV_PCSK_KEX2_1	660	662	PF00082	0.647
CLV_PCSK_KEX2_1	889	891	PF00082	0.380
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.749
CLV_PCSK_PC7_1	237	243	PF00082	0.601
CLV_PCSK_PC7_1	507	513	PF00082	0.699
CLV_PCSK_SKI1_1	131	135	PF00082	0.595
CLV_PCSK_SKI1_1	211	215	PF00082	0.639
CLV_PCSK_SKI1_1	244	248	PF00082	0.585
CLV_PCSK_SKI1_1	316	320	PF00082	0.680
CLV_PCSK_SKI1_1	336	340	PF00082	0.663
CLV_PCSK_SKI1_1	548	552	PF00082	0.622
CLV_PCSK_SKI1_1	555	559	PF00082	0.747
CLV_PCSK_SKI1_1	57	61	PF00082	0.668
CLV_PCSK_SKI1_1	587	591	PF00082	0.836
CLV_PCSK_SKI1_1	593	597	PF00082	0.752
CLV_PCSK_SKI1_1	847	851	PF00082	0.692
DEG_APCC_DBOX_1	315	323	PF00400	0.565
DEG_APCC_DBOX_1	877	885	PF00400	0.569
DEG_APCC_DBOX_1	931	939	PF00400	0.542
DEG_SCF_FBW7_1	978	985	PF00400	0.753
DEG_SPOP_SBC_1	708	712	PF00917	0.637
DOC_CKS1_1	979	984	PF01111	0.761
DOC_CYCLIN_RxL_1	125	135	PF00134	0.595
DOC_CYCLIN_RxL_1	333	343	PF00134	0.662
DOC_CYCLIN_RxL_1	545	554	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	528	534	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	938	944	PF00134	0.563
DOC_MAPK_DCC_7	174	182	PF00069	0.632
DOC_MAPK_DCC_7	367	376	PF00069	0.638
DOC_MAPK_HePTP_8	496	510	PF00069	0.582
DOC_MAPK_MEF2A_6	131	138	PF00069	0.589
DOC_MAPK_MEF2A_6	174	182	PF00069	0.681
DOC_MAPK_MEF2A_6	367	376	PF00069	0.638
DOC_MAPK_MEF2A_6	927	935	PF00069	0.542
DOC_MAPK_NFAT4_5	131	139	PF00069	0.588
DOC_PP1_RVXF_1	104	111	PF00149	0.649
DOC_PP1_RVXF_1	314	321	PF00149	0.603
DOC_PP2B_LxvP_1	528	531	PF13499	0.601
DOC_PP2B_LxvP_1	705	708	PF13499	0.815
DOC_PP2B_LxvP_1	752	755	PF13499	0.745
DOC_PP4_FxxP_1	120	123	PF00568	0.627
DOC_PP4_FxxP_1	213	216	PF00568	0.619
DOC_USP7_MATH_1	1061	1065	PF00917	0.646
DOC_USP7_MATH_1	154	158	PF00917	0.635
DOC_USP7_MATH_1	162	166	PF00917	0.544
DOC_USP7_MATH_1	172	176	PF00917	0.519
DOC_USP7_MATH_1	254	258	PF00917	0.664
DOC_USP7_MATH_1	298	302	PF00917	0.736
DOC_USP7_MATH_1	306	310	PF00917	0.624
DOC_USP7_MATH_1	361	365	PF00917	0.675
DOC_USP7_MATH_1	43	47	PF00917	0.720
DOC_USP7_MATH_1	483	487	PF00917	0.650
DOC_USP7_MATH_1	492	496	PF00917	0.607
DOC_USP7_MATH_1	524	528	PF00917	0.703
DOC_USP7_MATH_1	562	566	PF00917	0.755
DOC_USP7_MATH_1	644	648	PF00917	0.616
DOC_USP7_MATH_1	667	671	PF00917	0.769
DOC_USP7_MATH_1	708	712	PF00917	0.640
DOC_USP7_MATH_1	758	762	PF00917	0.734
DOC_USP7_MATH_1	763	767	PF00917	0.818
DOC_USP7_MATH_1	97	101	PF00917	0.657
DOC_USP7_MATH_1	982	986	PF00917	0.772
DOC_USP7_MATH_1	998	1002	PF00917	0.654
DOC_WW_Pin1_4	257	262	PF00397	0.627
DOC_WW_Pin1_4	340	345	PF00397	0.622
DOC_WW_Pin1_4	418	423	PF00397	0.673
DOC_WW_Pin1_4	46	51	PF00397	0.581
DOC_WW_Pin1_4	510	515	PF00397	0.644
DOC_WW_Pin1_4	563	568	PF00397	0.705
DOC_WW_Pin1_4	6	11	PF00397	0.590
DOC_WW_Pin1_4	699	704	PF00397	0.760
DOC_WW_Pin1_4	739	744	PF00397	0.691
DOC_WW_Pin1_4	791	796	PF00397	0.770
DOC_WW_Pin1_4	832	837	PF00397	0.685
DOC_WW_Pin1_4	978	983	PF00397	0.724
DOC_WW_Pin1_4	992	997	PF00397	0.637
LIG_14-3-3_CanoR_1	114	119	PF00244	0.710
LIG_14-3-3_CanoR_1	185	190	PF00244	0.615
LIG_14-3-3_CanoR_1	19	29	PF00244	0.552
LIG_14-3-3_CanoR_1	193	198	PF00244	0.758
LIG_14-3-3_CanoR_1	211	216	PF00244	0.602
LIG_14-3-3_CanoR_1	253	261	PF00244	0.604
LIG_14-3-3_CanoR_1	449	454	PF00244	0.560
LIG_14-3-3_CanoR_1	491	497	PF00244	0.587
LIG_14-3-3_CanoR_1	660	666	PF00244	0.708
LIG_14-3-3_CanoR_1	706	716	PF00244	0.635
LIG_14-3-3_CanoR_1	747	755	PF00244	0.754
LIG_14-3-3_CanoR_1	821	826	PF00244	0.725
LIG_14-3-3_CanoR_1	899	908	PF00244	0.538
LIG_BIR_III_4	756	760	PF00653	0.698
LIG_BRCT_BRCA1_1	1020	1024	PF00533	0.644
LIG_BRCT_BRCA1_1	116	120	PF00533	0.638
LIG_BRCT_BRCA1_1	169	173	PF00533	0.610
LIG_BRCT_BRCA1_1	22	26	PF00533	0.586
LIG_Clathr_ClatBox_1	1055	1059	PF01394	0.732
LIG_deltaCOP1_diTrp_1	310	314	PF00928	0.636
LIG_deltaCOP1_diTrp_1	542	551	PF00928	0.705
LIG_eIF4E_1	1050	1056	PF01652	0.731
LIG_FHA_1	11	17	PF00498	0.576
LIG_FHA_1	192	198	PF00498	0.618
LIG_FHA_1	35	41	PF00498	0.631
LIG_FHA_1	452	458	PF00498	0.484
LIG_FHA_1	47	53	PF00498	0.700
LIG_FHA_1	611	617	PF00498	0.727
LIG_FHA_1	644	650	PF00498	0.683
LIG_FHA_1	926	932	PF00498	0.542
LIG_FHA_2	538	544	PF00498	0.638
LIG_FHA_2	88	94	PF00498	0.773
LIG_GBD_Chelix_1	76	84	PF00786	0.562
LIG_HP1_1	335	339	PF01393	0.544
LIG_Integrin_RGD_1	271	273	PF01839	0.673
LIG_Integrin_RGD_1	621	623	PF01839	0.626
LIG_LIR_Apic_2	117	123	PF02991	0.632
LIG_LIR_Apic_2	210	216	PF02991	0.635
LIG_LIR_Apic_2	476	482	PF02991	0.591
LIG_LIR_Apic_2	790	795	PF02991	0.673
LIG_LIR_Gen_1	107	118	PF02991	0.695
LIG_LIR_Gen_1	140	146	PF02991	0.624
LIG_LIR_Gen_1	35	45	PF02991	0.599
LIG_LIR_Gen_1	542	552	PF02991	0.704
LIG_LIR_Gen_1	945	955	PF02991	0.604
LIG_LIR_Nem_3	107	113	PF02991	0.624
LIG_LIR_Nem_3	140	146	PF02991	0.624
LIG_LIR_Nem_3	23	29	PF02991	0.557
LIG_LIR_Nem_3	35	41	PF02991	0.524
LIG_LIR_Nem_3	542	547	PF02991	0.595
LIG_LIR_Nem_3	945	951	PF02991	0.693
LIG_LIR_Nem_3	95	101	PF02991	0.631
LIG_MAD2	336	344	PF02301	0.560
LIG_PCNA_TLS_4	131	138	PF02747	0.589
LIG_Pex14_2	137	141	PF04695	0.589
LIG_RPA_C_Fungi	616	628	PF08784	0.618
LIG_SH2_CRK	116	120	PF00017	0.638
LIG_SH2_CRK	493	497	PF00017	0.550
LIG_SH2_NCK_1	1046	1050	PF00017	0.608
LIG_SH2_NCK_1	910	914	PF00017	0.407
LIG_SH2_NCK_1	993	997	PF00017	0.563
LIG_SH2_PTP2	479	482	PF00017	0.546
LIG_SH2_PTP2	948	951	PF00017	0.693
LIG_SH2_SRC	1050	1053	PF00017	0.630
LIG_SH2_STAP1	1046	1050	PF00017	0.621
LIG_SH2_STAP1	116	120	PF00017	0.638
LIG_SH2_STAP1	493	497	PF00017	0.570
LIG_SH2_STAP1	632	636	PF00017	0.719
LIG_SH2_STAT5	1046	1049	PF00017	0.622
LIG_SH2_STAT5	118	121	PF00017	0.638
LIG_SH2_STAT5	218	221	PF00017	0.569
LIG_SH2_STAT5	479	482	PF00017	0.569
LIG_SH2_STAT5	58	61	PF00017	0.665
LIG_SH2_STAT5	632	635	PF00017	0.735
LIG_SH2_STAT5	657	660	PF00017	0.463
LIG_SH2_STAT5	716	719	PF00017	0.581
LIG_SH2_STAT5	894	897	PF00017	0.506
LIG_SH2_STAT5	948	951	PF00017	0.595
LIG_SH3_1	561	567	PF00018	0.692
LIG_SH3_3	1055	1061	PF00018	0.636
LIG_SH3_3	26	32	PF00018	0.536
LIG_SH3_3	319	325	PF00018	0.523
LIG_SH3_3	363	369	PF00018	0.726
LIG_SH3_3	431	437	PF00018	0.560
LIG_SH3_3	438	444	PF00018	0.595
LIG_SH3_3	486	492	PF00018	0.649
LIG_SH3_3	561	567	PF00018	0.749
LIG_SH3_3	586	592	PF00018	0.834
LIG_SH3_3	775	781	PF00018	0.672
LIG_SH3_3	976	982	PF00018	0.719
LIG_SUMO_SIM_par_1	1054	1059	PF11976	0.734
LIG_SUMO_SIM_par_1	320	327	PF11976	0.501
LIG_SUMO_SIM_par_1	430	435	PF11976	0.590
LIG_TRAF2_1	276	279	PF00917	0.623
LIG_TRAF2_1	566	569	PF00917	0.753
LIG_WRC_WIRS_1	11	16	PF05994	0.577
LIG_WW_1	629	632	PF00397	0.694
MOD_CDK_SPxxK_3	510	517	PF00069	0.654
MOD_CDK_SPxxK_3	699	706	PF00069	0.628
MOD_CK1_1	165	171	PF00069	0.661
MOD_CK1_1	257	263	PF00069	0.701
MOD_CK1_1	302	308	PF00069	0.679
MOD_CK1_1	346	352	PF00069	0.719
MOD_CK1_1	452	458	PF00069	0.524
MOD_CK1_1	46	52	PF00069	0.677
MOD_CK1_1	684	690	PF00069	0.770
MOD_CK1_1	885	891	PF00069	0.488
MOD_CK1_1	900	906	PF00069	0.291
MOD_CK1_1	985	991	PF00069	0.744
MOD_CK2_1	323	329	PF00069	0.611
MOD_CK2_1	452	458	PF00069	0.539
MOD_CK2_1	530	536	PF00069	0.732
MOD_CK2_1	563	569	PF00069	0.745
MOD_CMANNOS	311	314	PF00535	0.613
MOD_Cter_Amidation	239	242	PF01082	0.600
MOD_GlcNHglycan	1006	1009	PF01048	0.755
MOD_GlcNHglycan	170	173	PF01048	0.715
MOD_GlcNHglycan	174	177	PF01048	0.747
MOD_GlcNHglycan	273	276	PF01048	0.751
MOD_GlcNHglycan	303	307	PF01048	0.680
MOD_GlcNHglycan	345	348	PF01048	0.711
MOD_GlcNHglycan	361	364	PF01048	0.584
MOD_GlcNHglycan	423	426	PF01048	0.703
MOD_GlcNHglycan	444	447	PF01048	0.567
MOD_GlcNHglycan	46	49	PF01048	0.626
MOD_GlcNHglycan	532	535	PF01048	0.784
MOD_GlcNHglycan	646	649	PF01048	0.573
MOD_GlcNHglycan	676	679	PF01048	0.747
MOD_GlcNHglycan	72	75	PF01048	0.658
MOD_GlcNHglycan	760	763	PF01048	0.771
MOD_GlcNHglycan	765	768	PF01048	0.787
MOD_GlcNHglycan	825	828	PF01048	0.761
MOD_GlcNHglycan	868	871	PF01048	0.685
MOD_GlcNHglycan	899	902	PF01048	0.407
MOD_GSK3_1	146	153	PF00069	0.632
MOD_GSK3_1	162	169	PF00069	0.670
MOD_GSK3_1	185	192	PF00069	0.684
MOD_GSK3_1	193	200	PF00069	0.660
MOD_GSK3_1	257	264	PF00069	0.750
MOD_GSK3_1	298	305	PF00069	0.763
MOD_GSK3_1	339	346	PF00069	0.703
MOD_GSK3_1	357	364	PF00069	0.618
MOD_GSK3_1	421	428	PF00069	0.639
MOD_GSK3_1	526	533	PF00069	0.736
MOD_GSK3_1	6	13	PF00069	0.556
MOD_GSK3_1	655	662	PF00069	0.582
MOD_GSK3_1	787	794	PF00069	0.774
MOD_GSK3_1	978	985	PF00069	0.718
MOD_N-GLC_1	667	672	PF02516	0.649
MOD_N-GLC_1	821	826	PF02516	0.748
MOD_N-GLC_2	15	17	PF02516	0.526
MOD_NEK2_1	146	151	PF00069	0.659
MOD_NEK2_1	20	25	PF00069	0.561
MOD_NEK2_1	339	344	PF00069	0.687
MOD_NEK2_1	617	622	PF00069	0.690
MOD_NEK2_1	884	889	PF00069	0.715
MOD_NEK2_2	372	377	PF00069	0.658
MOD_NEK2_2	630	635	PF00069	0.626
MOD_NEK2_2	709	714	PF00069	0.555
MOD_NEK2_2	894	899	PF00069	0.407
MOD_PIKK_1	278	284	PF00454	0.626
MOD_PIKK_1	556	562	PF00454	0.772
MOD_PK_1	449	455	PF00069	0.558
MOD_PK_1	517	523	PF00069	0.582
MOD_PKA_1	211	217	PF00069	0.626
MOD_PKA_1	449	455	PF00069	0.558
MOD_PKA_2	211	217	PF00069	0.617
MOD_PKA_2	254	260	PF00069	0.627
MOD_PKA_2	617	623	PF00069	0.686
MOD_PKA_2	659	665	PF00069	0.647
MOD_PKA_2	681	687	PF00069	0.739
MOD_PKA_2	70	76	PF00069	0.657
MOD_PKA_2	746	752	PF00069	0.801
MOD_PKA_2	877	883	PF00069	0.698
MOD_PKB_1	269	277	PF00069	0.738
MOD_PKB_1	553	561	PF00069	0.801
MOD_PKB_1	821	829	PF00069	0.611
MOD_PKB_1	845	853	PF00069	0.683
MOD_Plk_1	278	284	PF00069	0.701
MOD_Plk_1	517	523	PF00069	0.657
MOD_Plk_1	600	606	PF00069	0.705
MOD_Plk_1	667	673	PF00069	0.654
MOD_Plk_1	821	827	PF00069	0.609
MOD_Plk_1	914	920	PF00069	0.407
MOD_Plk_1	985	991	PF00069	0.697
MOD_Plk_2-3	1054	1060	PF00069	0.734
MOD_Plk_2-3	323	329	PF00069	0.721
MOD_Plk_4	114	120	PF00069	0.643
MOD_Plk_4	185	191	PF00069	0.682
MOD_Plk_4	193	199	PF00069	0.596
MOD_Plk_4	452	458	PF00069	0.482
MOD_Plk_4	492	498	PF00069	0.587
MOD_Plk_4	546	552	PF00069	0.563
MOD_Plk_4	787	793	PF00069	0.679
MOD_Plk_4	914	920	PF00069	0.481
MOD_ProDKin_1	257	263	PF00069	0.631
MOD_ProDKin_1	340	346	PF00069	0.625
MOD_ProDKin_1	418	424	PF00069	0.670
MOD_ProDKin_1	46	52	PF00069	0.583
MOD_ProDKin_1	510	516	PF00069	0.650
MOD_ProDKin_1	563	569	PF00069	0.702
MOD_ProDKin_1	6	12	PF00069	0.584
MOD_ProDKin_1	699	705	PF00069	0.759
MOD_ProDKin_1	739	745	PF00069	0.692
MOD_ProDKin_1	791	797	PF00069	0.768
MOD_ProDKin_1	832	838	PF00069	0.684
MOD_ProDKin_1	978	984	PF00069	0.721
MOD_ProDKin_1	992	998	PF00069	0.636
MOD_SUMO_for_1	841	844	PF00179	0.674
TRG_DiLeu_BaEn_1	329	334	PF01217	0.718
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.747
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.803
TRG_ENDOCYTIC_2	116	119	PF00928	0.638
TRG_ENDOCYTIC_2	493	496	PF00928	0.571
TRG_ENDOCYTIC_2	948	951	PF00928	0.595
TRG_ER_diArg_1	211	213	PF00400	0.652
TRG_ER_diArg_1	241	243	PF00400	0.625
TRG_ER_diArg_1	253	256	PF00400	0.646
TRG_ER_diArg_1	376	379	PF00400	0.651
TRG_ER_diArg_1	387	389	PF00400	0.572
TRG_ER_diArg_1	469	471	PF00400	0.707
TRG_ER_diArg_1	510	512	PF00400	0.715
TRG_ER_diArg_1	820	823	PF00400	0.607
TRG_ER_diArg_1	889	891	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	956	961	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P442	Leptomonas seymouri	43%	100%
A0A3S7WTI6	Leishmania donovani	87%	100%
A4H810	Leishmania braziliensis	65%	100%
E9AQ38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%