Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFE0_LEIMA

TriTrypDb:

LmjF.15.0400 , LMJLV39_150009900 , LMJSD75_150009800

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.633
CLV_C14_Caspase3-7	163	167	PF00656	0.535
CLV_C14_Caspase3-7	33	37	PF00656	0.688
CLV_C14_Caspase3-7	338	342	PF00656	0.502
CLV_C14_Caspase3-7	593	597	PF00656	0.700
CLV_MEL_PAP_1	280	286	PF00089	0.502
CLV_NRD_NRD_1	111	113	PF00675	0.600
CLV_NRD_NRD_1	150	152	PF00675	0.677
CLV_NRD_NRD_1	219	221	PF00675	0.776
CLV_NRD_NRD_1	282	284	PF00675	0.650
CLV_NRD_NRD_1	348	350	PF00675	0.545
CLV_NRD_NRD_1	440	442	PF00675	0.742
CLV_NRD_NRD_1	588	590	PF00675	0.480
CLV_PCSK_FUR_1	586	590	PF00082	0.471
CLV_PCSK_KEX2_1	111	113	PF00082	0.600
CLV_PCSK_KEX2_1	150	152	PF00082	0.677
CLV_PCSK_KEX2_1	219	221	PF00082	0.739
CLV_PCSK_KEX2_1	282	284	PF00082	0.650
CLV_PCSK_KEX2_1	348	350	PF00082	0.480
CLV_PCSK_KEX2_1	440	442	PF00082	0.742
CLV_PCSK_KEX2_1	588	590	PF00082	0.633
CLV_PCSK_PC7_1	146	152	PF00082	0.601
CLV_PCSK_SKI1_1	657	661	PF00082	0.646
DEG_SCF_FBW7_2	123	129	PF00400	0.595
DEG_SPOP_SBC_1	28	32	PF00917	0.682
DEG_SPOP_SBC_1	290	294	PF00917	0.753
DEG_SPOP_SBC_1	410	414	PF00917	0.592
DOC_CKS1_1	123	128	PF01111	0.627
DOC_CYCLIN_RxL_1	86	100	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.705
DOC_MAPK_gen_1	111	117	PF00069	0.634
DOC_MAPK_gen_1	227	237	PF00069	0.701
DOC_MAPK_gen_1	325	335	PF00069	0.606
DOC_MAPK_MEF2A_6	102	110	PF00069	0.541
DOC_PP1_RVXF_1	90	97	PF00149	0.638
DOC_PP2B_LxvP_1	274	277	PF13499	0.548
DOC_PP2B_LxvP_1	8	11	PF13499	0.550
DOC_USP7_MATH_1	167	171	PF00917	0.736
DOC_USP7_MATH_1	290	294	PF00917	0.716
DOC_USP7_MATH_1	410	414	PF00917	0.588
DOC_USP7_MATH_1	46	50	PF00917	0.701
DOC_USP7_MATH_1	469	473	PF00917	0.478
DOC_USP7_MATH_1	499	503	PF00917	0.530
DOC_USP7_MATH_1	90	94	PF00917	0.651
DOC_USP7_MATH_1	97	101	PF00917	0.582
DOC_USP7_MATH_2	66	72	PF00917	0.544
DOC_USP7_UBL2_3	429	433	PF12436	0.605
DOC_WW_Pin1_4	122	127	PF00397	0.611
DOC_WW_Pin1_4	209	214	PF00397	0.745
DOC_WW_Pin1_4	286	291	PF00397	0.758
DOC_WW_Pin1_4	313	318	PF00397	0.715
DOC_WW_Pin1_4	352	357	PF00397	0.570
DOC_WW_Pin1_4	424	429	PF00397	0.654
DOC_WW_Pin1_4	59	64	PF00397	0.688
LIG_14-3-3_CanoR_1	247	251	PF00244	0.565
LIG_14-3-3_CanoR_1	282	290	PF00244	0.570
LIG_14-3-3_CanoR_1	328	336	PF00244	0.552
LIG_14-3-3_CanoR_1	361	366	PF00244	0.612
LIG_14-3-3_CanoR_1	539	545	PF00244	0.480
LIG_Actin_WH2_2	572	590	PF00022	0.392
LIG_AP2alpha_1	20	24	PF02296	0.619
LIG_APCC_ABBA_1	248	253	PF00400	0.446
LIG_APCC_ABBAyCdc20_2	247	253	PF00400	0.468
LIG_BRCT_BRCA1_1	204	208	PF00533	0.622
LIG_BRCT_BRCA1_1	92	96	PF00533	0.563
LIG_Clathr_ClatBox_1	506	510	PF01394	0.467
LIG_FHA_1	137	143	PF00498	0.602
LIG_FHA_1	328	334	PF00498	0.570
LIG_FHA_1	415	421	PF00498	0.515
LIG_FHA_1	502	508	PF00498	0.493
LIG_FHA_1	520	526	PF00498	0.486
LIG_FHA_1	530	536	PF00498	0.538
LIG_FHA_1	568	574	PF00498	0.421
LIG_FHA_2	560	566	PF00498	0.544
LIG_FHA_2	591	597	PF00498	0.648
LIG_Integrin_RGD_1	112	114	PF01839	0.573
LIG_LIR_Apic_2	384	389	PF02991	0.482
LIG_LIR_Gen_1	2	13	PF02991	0.528
LIG_LIR_Nem_3	2	8	PF02991	0.567
LIG_LIR_Nem_3	22	27	PF02991	0.367
LIG_NRBOX	378	384	PF00104	0.681
LIG_Pex14_2	20	24	PF04695	0.543
LIG_Pex14_2	5	9	PF04695	0.682
LIG_SH2_GRB2like	152	155	PF00017	0.581
LIG_SH2_NCK_1	152	156	PF00017	0.586
LIG_SH2_NCK_1	663	667	PF00017	0.689
LIG_SH2_STAP1	256	260	PF00017	0.571
LIG_SH2_STAP1	645	649	PF00017	0.601
LIG_SH2_STAT5	198	201	PF00017	0.608
LIG_SH2_STAT5	236	239	PF00017	0.479
LIG_SH2_STAT5	256	259	PF00017	0.282
LIG_SH2_STAT5	592	595	PF00017	0.557
LIG_SH3_3	270	276	PF00018	0.551
LIG_SH3_3	314	320	PF00018	0.752
LIG_SH3_3	356	362	PF00018	0.605
LIG_SH3_3	370	376	PF00018	0.370
LIG_SH3_3	570	576	PF00018	0.467
LIG_SH3_3	60	66	PF00018	0.689
LIG_SH3_4	429	436	PF00018	0.612
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.568
LIG_SUMO_SIM_anti_2	341	347	PF11976	0.514
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.578
LIG_SUMO_SIM_anti_2	471	477	PF11976	0.464
LIG_SUMO_SIM_anti_2	481	487	PF11976	0.476
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.467
LIG_SUMO_SIM_par_1	504	511	PF11976	0.467
LIG_TRAF2_1	13	16	PF00917	0.597
LIG_TRAF2_1	443	446	PF00917	0.722
LIG_UBA3_1	482	487	PF00899	0.468
MOD_CDK_SPK_2	424	429	PF00069	0.555
MOD_CK1_1	160	166	PF00069	0.734
MOD_CK1_1	207	213	PF00069	0.672
MOD_CK1_1	249	255	PF00069	0.554
MOD_CK1_1	289	295	PF00069	0.657
MOD_CK1_1	30	36	PF00069	0.612
MOD_CK1_1	316	322	PF00069	0.693
MOD_CK1_1	363	369	PF00069	0.617
MOD_CK1_1	377	383	PF00069	0.558
MOD_CK1_1	434	440	PF00069	0.622
MOD_CK1_1	481	487	PF00069	0.475
MOD_CK1_1	62	68	PF00069	0.723
MOD_CK2_1	223	229	PF00069	0.699
MOD_CK2_1	387	393	PF00069	0.730
MOD_CK2_1	440	446	PF00069	0.732
MOD_CK2_1	62	68	PF00069	0.677
MOD_CK2_1	640	646	PF00069	0.635
MOD_GlcNHglycan	159	162	PF01048	0.713
MOD_GlcNHglycan	169	172	PF01048	0.698
MOD_GlcNHglycan	204	207	PF01048	0.605
MOD_GlcNHglycan	209	212	PF01048	0.589
MOD_GlcNHglycan	310	313	PF01048	0.694
MOD_GlcNHglycan	337	340	PF01048	0.475
MOD_GlcNHglycan	376	379	PF01048	0.578
MOD_GlcNHglycan	436	439	PF01048	0.637
MOD_GlcNHglycan	452	455	PF01048	0.605
MOD_GlcNHglycan	460	463	PF01048	0.583
MOD_GlcNHglycan	48	51	PF01048	0.713
MOD_GlcNHglycan	491	494	PF01048	0.542
MOD_GlcNHglycan	519	522	PF01048	0.422
MOD_GlcNHglycan	56	59	PF01048	0.715
MOD_GlcNHglycan	593	596	PF01048	0.592
MOD_GlcNHglycan	621	624	PF01048	0.641
MOD_GlcNHglycan	626	629	PF01048	0.603
MOD_GlcNHglycan	99	102	PF01048	0.616
MOD_GSK3_1	202	209	PF00069	0.632
MOD_GSK3_1	23	30	PF00069	0.591
MOD_GSK3_1	252	259	PF00069	0.601
MOD_GSK3_1	282	289	PF00069	0.682
MOD_GSK3_1	291	298	PF00069	0.726
MOD_GSK3_1	308	315	PF00069	0.453
MOD_GSK3_1	360	367	PF00069	0.518
MOD_GSK3_1	377	384	PF00069	0.610
MOD_GSK3_1	398	405	PF00069	0.639
MOD_GSK3_1	40	47	PF00069	0.424
MOD_GSK3_1	410	417	PF00069	0.505
MOD_GSK3_1	424	431	PF00069	0.552
MOD_GSK3_1	456	463	PF00069	0.500
MOD_GSK3_1	54	61	PF00069	0.701
MOD_GSK3_1	555	562	PF00069	0.427
MOD_GSK3_1	635	642	PF00069	0.707
MOD_N-GLC_1	286	291	PF02516	0.719
MOD_NEK2_1	204	209	PF00069	0.644
MOD_NEK2_1	251	256	PF00069	0.585
MOD_NEK2_1	27	32	PF00069	0.652
MOD_NEK2_1	297	302	PF00069	0.785
MOD_NEK2_1	335	340	PF00069	0.447
MOD_NEK2_1	350	355	PF00069	0.417
MOD_NEK2_1	382	387	PF00069	0.642
MOD_NEK2_1	478	483	PF00069	0.495
MOD_NEK2_1	508	513	PF00069	0.441
MOD_NEK2_1	559	564	PF00069	0.494
MOD_NEK2_1	602	607	PF00069	0.606
MOD_NEK2_2	246	251	PF00069	0.567
MOD_NEK2_2	640	645	PF00069	0.601
MOD_PIKK_1	136	142	PF00454	0.689
MOD_PIKK_1	327	333	PF00454	0.636
MOD_PIKK_1	387	393	PF00454	0.665
MOD_PIKK_1	501	507	PF00454	0.500
MOD_PK_1	440	446	PF00069	0.731
MOD_PKA_1	150	156	PF00069	0.695
MOD_PKA_1	282	288	PF00069	0.658
MOD_PKA_1	440	446	PF00069	0.731
MOD_PKA_2	150	156	PF00069	0.659
MOD_PKA_2	246	252	PF00069	0.564
MOD_PKA_2	282	288	PF00069	0.670
MOD_PKA_2	327	333	PF00069	0.581
MOD_PKA_2	360	366	PF00069	0.575
MOD_PKA_2	440	446	PF00069	0.684
MOD_Plk_1	252	258	PF00069	0.596
MOD_Plk_1	40	46	PF00069	0.650
MOD_Plk_2-3	68	74	PF00069	0.712
MOD_Plk_4	23	29	PF00069	0.565
MOD_Plk_4	246	252	PF00069	0.524
MOD_Plk_4	4	10	PF00069	0.522
MOD_Plk_4	471	477	PF00069	0.491
MOD_Plk_4	478	484	PF00069	0.431
MOD_Plk_4	555	561	PF00069	0.469
MOD_Plk_4	640	646	PF00069	0.637
MOD_ProDKin_1	122	128	PF00069	0.604
MOD_ProDKin_1	209	215	PF00069	0.747
MOD_ProDKin_1	286	292	PF00069	0.759
MOD_ProDKin_1	313	319	PF00069	0.710
MOD_ProDKin_1	352	358	PF00069	0.573
MOD_ProDKin_1	424	430	PF00069	0.661
MOD_ProDKin_1	59	65	PF00069	0.689
TRG_DiLeu_BaEn_3	667	673	PF01217	0.689
TRG_DiLeu_BaLyEn_6	654	659	PF01217	0.636
TRG_ER_diArg_1	110	112	PF00400	0.587
TRG_ER_diArg_1	132	135	PF00400	0.543
TRG_ER_diArg_1	150	152	PF00400	0.385
TRG_ER_diArg_1	218	220	PF00400	0.720
TRG_ER_diArg_1	282	284	PF00400	0.654
TRG_ER_diArg_1	347	349	PF00400	0.531
TRG_ER_diArg_1	418	421	PF00400	0.472
TRG_ER_diArg_1	536	539	PF00400	0.578
TRG_ER_diArg_1	585	588	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD21	Leptomonas seymouri	51%	100%
A0A0S4JR70	Bodo saltans	25%	100%
A0A1X0NU73	Trypanosomatidae	27%	100%
A0A3R7NGV0	Trypanosoma rangeli	28%	100%
A0A3S7WTC1	Leishmania donovani	92%	100%
A4H812	Leishmania braziliensis	70%	100%
A4HWE2	Leishmania infantum	91%	100%
C9ZNY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AQ42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5DCS7	Trypanosoma cruzi	27%	100%