Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFD9_LEIMA

TriTrypDb:

LmjF.15.0410 , LMJLV39_150010000 , LMJSD75_150009900

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.491
CLV_C14_Caspase3-7	544	548	PF00656	0.661
CLV_NRD_NRD_1	161	163	PF00675	0.333
CLV_NRD_NRD_1	212	214	PF00675	0.345
CLV_NRD_NRD_1	3	5	PF00675	0.426
CLV_NRD_NRD_1	300	302	PF00675	0.414
CLV_NRD_NRD_1	306	308	PF00675	0.278
CLV_NRD_NRD_1	38	40	PF00675	0.358
CLV_NRD_NRD_1	489	491	PF00675	0.393
CLV_PCSK_KEX2_1	160	162	PF00082	0.332
CLV_PCSK_KEX2_1	212	214	PF00082	0.401
CLV_PCSK_KEX2_1	260	262	PF00082	0.335
CLV_PCSK_KEX2_1	3	5	PF00082	0.426
CLV_PCSK_KEX2_1	300	302	PF00082	0.414
CLV_PCSK_KEX2_1	306	308	PF00082	0.278
CLV_PCSK_KEX2_1	38	40	PF00082	0.358
CLV_PCSK_KEX2_1	489	491	PF00082	0.353
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.376
CLV_PCSK_PC7_1	157	163	PF00082	0.344
CLV_PCSK_SKI1_1	353	357	PF00082	0.598
CLV_PCSK_SKI1_1	645	649	PF00082	0.311
CLV_PCSK_SKI1_1	88	92	PF00082	0.331
CLV_PCSK_SKI1_1	93	97	PF00082	0.323
DEG_APCC_DBOX_1	160	168	PF00400	0.516
DEG_APCC_DBOX_1	195	203	PF00400	0.525
DEG_APCC_DBOX_1	306	314	PF00400	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SPOP_SBC_1	445	449	PF00917	0.475
DEG_SPOP_SBC_1	580	584	PF00917	0.775
DOC_CKS1_1	52	57	PF01111	0.539
DOC_CYCLIN_RxL_1	688	700	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.552
DOC_MAPK_gen_1	108	117	PF00069	0.404
DOC_MAPK_gen_1	157	167	PF00069	0.528
DOC_MAPK_gen_1	212	220	PF00069	0.619
DOC_MAPK_gen_1	306	312	PF00069	0.476
DOC_MAPK_gen_1	44	50	PF00069	0.549
DOC_MAPK_gen_1	53	61	PF00069	0.545
DOC_MAPK_gen_1	686	695	PF00069	0.560
DOC_MAPK_gen_1	88	97	PF00069	0.529
DOC_MAPK_MEF2A_6	91	99	PF00069	0.530
DOC_PP1_RVXF_1	692	698	PF00149	0.531
DOC_PP2B_LxvP_1	250	253	PF13499	0.542
DOC_USP7_MATH_1	445	449	PF00917	0.413
DOC_USP7_MATH_1	579	583	PF00917	0.721
DOC_WW_Pin1_4	204	209	PF00397	0.525
DOC_WW_Pin1_4	391	396	PF00397	0.352
DOC_WW_Pin1_4	51	56	PF00397	0.540
DOC_WW_Pin1_4	565	570	PF00397	0.773
LIG_14-3-3_CanoR_1	261	271	PF00244	0.638
LIG_14-3-3_CanoR_1	3	11	PF00244	0.701
LIG_14-3-3_CanoR_1	300	310	PF00244	0.564
LIG_14-3-3_CanoR_1	581	587	PF00244	0.625
LIG_14-3-3_CanoR_1	60	64	PF00244	0.580
LIG_14-3-3_CanoR_1	75	81	PF00244	0.462
LIG_Actin_WH2_2	485	501	PF00022	0.662
LIG_AP2alpha_2	391	393	PF02296	0.384
LIG_APCC_ABBA_1	121	126	PF00400	0.506
LIG_BRCT_BRCA1_1	402	406	PF00533	0.447
LIG_CSL_BTD_1	392	395	PF09270	0.346
LIG_deltaCOP1_diTrp_1	57	61	PF00928	0.567
LIG_EH1_1	181	189	PF00400	0.576
LIG_FHA_1	322	328	PF00498	0.247
LIG_FHA_1	493	499	PF00498	0.558
LIG_FHA_2	142	148	PF00498	0.549
LIG_FHA_2	272	278	PF00498	0.567
LIG_FHA_2	52	58	PF00498	0.540
LIG_FHA_2	77	83	PF00498	0.576
LIG_Integrin_isoDGR_2	690	692	PF01839	0.431
LIG_LIR_Gen_1	118	129	PF02991	0.512
LIG_LIR_Gen_1	166	176	PF02991	0.517
LIG_LIR_Gen_1	57	66	PF02991	0.559
LIG_LIR_Gen_1	599	608	PF02991	0.512
LIG_LIR_Gen_1	635	644	PF02991	0.493
LIG_LIR_Gen_1	649	658	PF02991	0.537
LIG_LIR_LC3C_4	638	643	PF02991	0.555
LIG_LIR_Nem_3	118	124	PF02991	0.507
LIG_LIR_Nem_3	166	171	PF02991	0.519
LIG_LIR_Nem_3	209	214	PF02991	0.509
LIG_LIR_Nem_3	364	370	PF02991	0.362
LIG_LIR_Nem_3	391	396	PF02991	0.363
LIG_LIR_Nem_3	403	409	PF02991	0.342
LIG_LIR_Nem_3	57	61	PF02991	0.553
LIG_LIR_Nem_3	599	604	PF02991	0.517
LIG_LIR_Nem_3	62	66	PF02991	0.538
LIG_LIR_Nem_3	649	653	PF02991	0.550
LIG_NRBOX	101	107	PF00104	0.555
LIG_Pex14_1	27	31	PF04695	0.558
LIG_PTB_Apo_2	62	69	PF02174	0.548
LIG_PTB_Phospho_1	62	68	PF10480	0.547
LIG_Rb_pABgroove_1	118	126	PF01858	0.509
LIG_SH2_CRK	168	172	PF00017	0.511
LIG_SH2_CRK	63	67	PF00017	0.560
LIG_SH2_NCK_1	112	116	PF00017	0.555
LIG_SH2_SRC	112	115	PF00017	0.629
LIG_SH2_STAP1	31	35	PF00017	0.573
LIG_SH2_STAP1	323	327	PF00017	0.344
LIG_SH2_STAP1	400	404	PF00017	0.428
LIG_SH2_STAT5	170	173	PF00017	0.557
LIG_SH2_STAT5	214	217	PF00017	0.507
LIG_SH2_STAT5	235	238	PF00017	0.618
LIG_SH2_STAT5	309	312	PF00017	0.407
LIG_SH2_STAT5	323	326	PF00017	0.255
LIG_SH2_STAT5	386	389	PF00017	0.311
LIG_SH3_3	14	20	PF00018	0.557
LIG_SH3_3	371	377	PF00018	0.406
LIG_SH3_3	389	395	PF00018	0.273
LIG_SH3_3	49	55	PF00018	0.541
LIG_SH3_3	494	500	PF00018	0.604
LIG_SH3_3	5	11	PF00018	0.652
LIG_SUMO_SIM_par_1	490	495	PF11976	0.653
LIG_TRAF2_1	172	175	PF00917	0.512
LIG_TRAF2_1	514	517	PF00917	0.674
LIG_UBA3_1	327	336	PF00899	0.395
LIG_UBA3_1	491	499	PF00899	0.600
MOD_CDK_SPK_2	51	56	PF00069	0.551
MOD_CK1_1	138	144	PF00069	0.591
MOD_CK1_1	30	36	PF00069	0.573
MOD_CK1_1	418	424	PF00069	0.515
MOD_CK1_1	425	431	PF00069	0.529
MOD_CK1_1	447	453	PF00069	0.461
MOD_CK1_1	506	512	PF00069	0.688
MOD_CK2_1	141	147	PF00069	0.576
MOD_CK2_1	271	277	PF00069	0.549
MOD_CK2_1	76	82	PF00069	0.534
MOD_GlcNHglycan	188	191	PF01048	0.427
MOD_GlcNHglycan	318	321	PF01048	0.328
MOD_GlcNHglycan	359	362	PF01048	0.538
MOD_GlcNHglycan	464	467	PF01048	0.597
MOD_GlcNHglycan	505	508	PF01048	0.537
MOD_GlcNHglycan	510	513	PF01048	0.477
MOD_GlcNHglycan	583	586	PF01048	0.488
MOD_GlcNHglycan	673	676	PF01048	0.394
MOD_GSK3_1	202	209	PF00069	0.530
MOD_GSK3_1	27	34	PF00069	0.467
MOD_GSK3_1	276	283	PF00069	0.547
MOD_GSK3_1	311	318	PF00069	0.384
MOD_GSK3_1	415	422	PF00069	0.477
MOD_GSK3_1	423	430	PF00069	0.521
MOD_GSK3_1	502	509	PF00069	0.710
MOD_GSK3_1	9	16	PF00069	0.630
MOD_N-GLC_1	202	207	PF02516	0.398
MOD_NEK2_1	202	207	PF00069	0.528
MOD_NEK2_1	220	225	PF00069	0.585
MOD_NEK2_1	254	259	PF00069	0.534
MOD_NEK2_1	315	320	PF00069	0.340
MOD_NEK2_1	356	361	PF00069	0.353
MOD_NEK2_1	59	64	PF00069	0.550
MOD_NEK2_1	652	657	PF00069	0.616
MOD_NEK2_1	671	676	PF00069	0.567
MOD_PIKK_1	413	419	PF00454	0.555
MOD_PIKK_1	512	518	PF00454	0.724
MOD_PIKK_1	652	658	PF00454	0.579
MOD_PK_1	44	50	PF00069	0.573
MOD_PKA_1	44	50	PF00069	0.560
MOD_PKA_2	156	162	PF00069	0.620
MOD_PKA_2	2	8	PF00069	0.709
MOD_PKA_2	356	362	PF00069	0.361
MOD_PKA_2	580	586	PF00069	0.761
MOD_PKA_2	59	65	PF00069	0.618
MOD_Plk_1	125	131	PF00069	0.543
MOD_Plk_1	202	208	PF00069	0.596
MOD_Plk_1	400	406	PF00069	0.434
MOD_Plk_2-3	135	141	PF00069	0.604
MOD_Plk_4	141	147	PF00069	0.529
MOD_Plk_4	206	212	PF00069	0.518
MOD_Plk_4	220	226	PF00069	0.524
MOD_Plk_4	254	260	PF00069	0.540
MOD_Plk_4	280	286	PF00069	0.525
MOD_Plk_4	311	317	PF00069	0.337
MOD_ProDKin_1	204	210	PF00069	0.521
MOD_ProDKin_1	391	397	PF00069	0.352
MOD_ProDKin_1	51	57	PF00069	0.539
MOD_ProDKin_1	565	571	PF00069	0.772
TRG_DiLeu_BaEn_2	226	232	PF01217	0.560
TRG_DiLeu_BaEn_4	174	180	PF01217	0.522
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.354
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.506
TRG_ENDOCYTIC_2	112	115	PF00928	0.555
TRG_ENDOCYTIC_2	168	171	PF00928	0.506
TRG_ENDOCYTIC_2	309	312	PF00928	0.381
TRG_ENDOCYTIC_2	367	370	PF00928	0.369
TRG_ENDOCYTIC_2	542	545	PF00928	0.675
TRG_ENDOCYTIC_2	63	66	PF00928	0.568
TRG_ENDOCYTIC_2	87	90	PF00928	0.510
TRG_ER_diArg_1	160	162	PF00400	0.533
TRG_ER_diArg_1	2	4	PF00400	0.629
TRG_ER_diArg_1	211	213	PF00400	0.544
TRG_ER_diArg_1	300	302	PF00400	0.604
TRG_ER_diArg_1	306	308	PF00400	0.466
TRG_ER_diArg_1	488	490	PF00400	0.573
TRG_ER_diArg_1	686	689	PF00400	0.537
TRG_ER_diArg_1	692	695	PF00400	0.537
TRG_NES_CRM1_1	163	177	PF08389	0.519
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	694	699	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B6	Leptomonas seymouri	75%	100%
A0A0S4JZM2	Bodo saltans	44%	100%
A0A1X0NV52	Trypanosomatidae	55%	98%
A0A3S7WTC9	Leishmania donovani	94%	100%
A0A422NLJ2	Trypanosoma rangeli	56%	100%
A4H813	Leishmania braziliensis	85%	100%
A4HWE3	Leishmania infantum	94%	100%
C9ZNY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AQ43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BGN8	Trypanosoma cruzi	55%	100%