ER membrane protein complex subunit 6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFD8_LEIMA

TriTrypDb:

LmjF.15.0420 , LMJLV39_150010100 , LMJSD75_150010000

Length:

146


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Q4QFD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFD8


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.389
CLV_NRD_NRD_1	15	17	PF00675	0.521
CLV_NRD_NRD_1	85	87	PF00675	0.678
CLV_PCSK_KEX2_1	130	132	PF00082	0.407
CLV_PCSK_KEX2_1	15	17	PF00082	0.521
CLV_PCSK_KEX2_1	85	87	PF00082	0.656
CLV_PCSK_PC7_1	126	132	PF00082	0.413
CLV_PCSK_SKI1_1	131	135	PF00082	0.419
CLV_PCSK_SKI1_1	86	90	PF00082	0.598
DEG_Nend_UBRbox_3	1	3	PF02207	0.797
DOC_MAPK_DCC_7	60	70	PF00069	0.536
DOC_MAPK_RevD_3	72	86	PF00069	0.410
DOC_PP2B_PxIxI_1	65	71	PF00149	0.402
DOC_WW_Pin1_4	36	41	PF00397	0.732
DOC_WW_Pin1_4	90	95	PF00397	0.327
LIG_14-3-3_CanoR_1	130	139	PF00244	0.669
LIG_14-3-3_CanoR_1	85	95	PF00244	0.478
LIG_FHA_1	100	106	PF00498	0.353
LIG_FHA_1	132	138	PF00498	0.610
LIG_FHA_1	87	93	PF00498	0.477
LIG_LIR_Gen_1	75	83	PF02991	0.355
LIG_PCNA_PIPBox_1	48	57	PF02747	0.654
LIG_SH2_STAT5	54	57	PF00017	0.599
LIG_SH3_2	5	10	PF14604	0.647
LIG_SH3_3	17	23	PF00018	0.617
LIG_SH3_3	2	8	PF00018	0.658
LIG_SH3_3	31	37	PF00018	0.696
LIG_SxIP_EBH_1	60	71	PF03271	0.479
LIG_TRAF2_1	24	27	PF00917	0.677
MOD_CK1_1	132	138	PF00069	0.670
MOD_CK2_1	21	27	PF00069	0.671
MOD_GlcNHglycan	2	5	PF01048	0.436
MOD_GSK3_1	86	93	PF00069	0.435
MOD_NEK2_1	46	51	PF00069	0.531
MOD_NEK2_1	72	77	PF00069	0.393
MOD_NEK2_1	88	93	PF00069	0.395
MOD_PIKK_1	111	117	PF00454	0.493
MOD_PIKK_1	22	28	PF00454	0.674
MOD_PIKK_1	46	52	PF00454	0.715
MOD_PIKK_1	60	66	PF00454	0.466
MOD_PKA_2	129	135	PF00069	0.648
MOD_Plk_1	46	52	PF00069	0.687
MOD_Plk_4	54	60	PF00069	0.627
MOD_Plk_4	72	78	PF00069	0.214
MOD_ProDKin_1	36	42	PF00069	0.731
MOD_ProDKin_1	90	96	PF00069	0.327
TRG_ENDOCYTIC_2	78	81	PF00928	0.377
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.396


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK1	Leptomonas seymouri	71%	100%
A0A0S4JX73	Bodo saltans	39%	100%
A0A1X0NVE4	Trypanosomatidae	45%	100%
A0A3R7RL81	Trypanosoma rangeli	45%	90%
A0A3S7WTD5	Leishmania donovani	90%	100%
A4H814	Leishmania braziliensis	78%	100%
A4HWE4	Leishmania infantum	91%	100%
C9ZNY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQ44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%