Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFD7_LEIMA

TriTrypDb:

LmjF.15.0430 , LMJLV39_150010200 , LMJSD75_150010100

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.677
CLV_NRD_NRD_1	76	78	PF00675	0.744
CLV_PCSK_KEX2_1	76	78	PF00082	0.744
CLV_PCSK_SKI1_1	33	37	PF00082	0.596
DEG_Nend_UBRbox_3	1	3	PF02207	0.637
DEG_SPOP_SBC_1	105	109	PF00917	0.671
DOC_PP4_FxxP_1	246	249	PF00568	0.575
DOC_USP7_MATH_1	105	109	PF00917	0.775
DOC_USP7_MATH_1	111	115	PF00917	0.679
DOC_USP7_MATH_1	258	262	PF00917	0.692
DOC_USP7_UBL2_3	49	53	PF12436	0.711
DOC_WW_Pin1_4	114	119	PF00397	0.712
DOC_WW_Pin1_4	206	211	PF00397	0.699
DOC_WW_Pin1_4	279	284	PF00397	0.668
LIG_14-3-3_CanoR_1	136	144	PF00244	0.749
LIG_14-3-3_CanoR_1	177	181	PF00244	0.618
LIG_eIF4E_1	4	10	PF01652	0.664
LIG_FHA_1	105	111	PF00498	0.715
LIG_FHA_1	130	136	PF00498	0.723
LIG_FHA_1	15	21	PF00498	0.615
LIG_FHA_1	188	194	PF00498	0.610
LIG_FHA_1	212	218	PF00498	0.740
LIG_FHA_1	219	225	PF00498	0.640
LIG_FHA_1	284	290	PF00498	0.722
LIG_FHA_1	338	344	PF00498	0.615
LIG_FHA_1	55	61	PF00498	0.715
LIG_FHA_2	297	303	PF00498	0.624
LIG_FHA_2	313	319	PF00498	0.432
LIG_LIR_Apic_2	243	249	PF02991	0.572
LIG_LIR_Nem_3	117	122	PF02991	0.676
LIG_LIR_Nem_3	30	35	PF02991	0.601
LIG_SH2_STAT5	4	7	PF00017	0.671
LIG_SH3_1	183	189	PF00018	0.688
LIG_SH3_3	183	189	PF00018	0.688
LIG_SH3_3	95	101	PF00018	0.741
MOD_CDC14_SPxK_1	282	285	PF00782	0.643
MOD_CDK_SPxK_1	279	285	PF00069	0.646
MOD_CK1_1	114	120	PF00069	0.693
MOD_CK1_1	179	185	PF00069	0.619
MOD_CK1_1	206	212	PF00069	0.636
MOD_CK1_1	296	302	PF00069	0.630
MOD_CK2_1	296	302	PF00069	0.630
MOD_CK2_1	312	318	PF00069	0.427
MOD_CK2_1	96	102	PF00069	0.690
MOD_GlcNHglycan	139	142	PF01048	0.778
MOD_GlcNHglycan	166	169	PF01048	0.713
MOD_GlcNHglycan	205	208	PF01048	0.729
MOD_GlcNHglycan	252	255	PF01048	0.819
MOD_GlcNHglycan	295	298	PF01048	0.577
MOD_GlcNHglycan	64	67	PF01048	0.791
MOD_GlcNHglycan	85	88	PF01048	0.698
MOD_GSK3_1	101	108	PF00069	0.667
MOD_GSK3_1	14	21	PF00069	0.789
MOD_GSK3_1	154	161	PF00069	0.728
MOD_GSK3_1	209	216	PF00069	0.685
MOD_GSK3_1	244	251	PF00069	0.762
MOD_GSK3_1	279	286	PF00069	0.690
MOD_GSK3_1	337	344	PF00069	0.607
MOD_GSK3_1	54	61	PF00069	0.706
MOD_GSK3_1	92	99	PF00069	0.649
MOD_N-GLC_1	164	169	PF02516	0.755
MOD_N-GLC_1	217	222	PF02516	0.723
MOD_N-GLC_1	244	249	PF02516	0.694
MOD_N-GLC_1	91	96	PF02516	0.660
MOD_N-GLC_2	169	171	PF02516	0.718
MOD_NEK2_1	122	127	PF00069	0.681
MOD_NEK2_1	176	181	PF00069	0.590
MOD_NEK2_1	213	218	PF00069	0.721
MOD_NEK2_1	235	240	PF00069	0.626
MOD_NEK2_1	312	317	PF00069	0.596
MOD_NEK2_1	336	341	PF00069	0.598
MOD_NEK2_1	9	14	PF00069	0.636
MOD_PIKK_1	258	264	PF00454	0.657
MOD_PKA_2	176	182	PF00069	0.619
MOD_Plk_1	244	250	PF00069	0.654
MOD_Plk_1	317	323	PF00069	0.645
MOD_Plk_1	91	97	PF00069	0.675
MOD_Plk_4	220	226	PF00069	0.639
MOD_Plk_4	92	98	PF00069	0.642
MOD_ProDKin_1	114	120	PF00069	0.712
MOD_ProDKin_1	206	212	PF00069	0.735
MOD_ProDKin_1	279	285	PF00069	0.669
MOD_SUMO_for_1	52	55	PF00179	0.666
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.616
TRG_ENDOCYTIC_2	119	122	PF00928	0.670
TRG_ENDOCYTIC_2	32	35	PF00928	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6U3	Leishmania donovani	92%	100%
A4H815	Leishmania braziliensis	67%	100%
A4HWE5	Leishmania infantum	92%	100%
E9AQ45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%