Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFD6_LEIMA

TriTrypDb:

LmjF.15.0490 , LMJLV39_150010700 , LMJSD75_150010700

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.627
CLV_C14_Caspase3-7	63	67	PF00656	0.656
CLV_C14_Caspase3-7	78	82	PF00656	0.774
CLV_NRD_NRD_1	237	239	PF00675	0.658
CLV_NRD_NRD_1	28	30	PF00675	0.601
CLV_NRD_NRD_1	335	337	PF00675	0.682
CLV_NRD_NRD_1	392	394	PF00675	0.656
CLV_NRD_NRD_1	44	46	PF00675	0.679
CLV_NRD_NRD_1	518	520	PF00675	0.535
CLV_NRD_NRD_1	553	555	PF00675	0.579
CLV_NRD_NRD_1	629	631	PF00675	0.652
CLV_NRD_NRD_1	659	661	PF00675	0.546
CLV_PCSK_FUR_1	335	339	PF00082	0.676
CLV_PCSK_KEX2_1	237	239	PF00082	0.658
CLV_PCSK_KEX2_1	28	30	PF00082	0.601
CLV_PCSK_KEX2_1	334	336	PF00082	0.695
CLV_PCSK_KEX2_1	337	339	PF00082	0.652
CLV_PCSK_KEX2_1	392	394	PF00082	0.656
CLV_PCSK_KEX2_1	518	520	PF00082	0.535
CLV_PCSK_KEX2_1	553	555	PF00082	0.573
CLV_PCSK_KEX2_1	629	631	PF00082	0.523
CLV_PCSK_KEX2_1	659	661	PF00082	0.676
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.670
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.630
CLV_PCSK_SKI1_1	381	385	PF00082	0.588
CLV_PCSK_SKI1_1	439	443	PF00082	0.597
CLV_PCSK_SKI1_1	50	54	PF00082	0.764
DEG_Nend_Nbox_1	1	3	PF02207	0.715
DEG_SIAH_1	240	248	PF03145	0.601
DOC_CYCLIN_RxL_1	436	443	PF00134	0.594
DOC_CYCLIN_RxL_1	45	54	PF00134	0.695
DOC_CYCLIN_RxL_1	493	505	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.627
DOC_MAPK_gen_1	137	144	PF00069	0.637
DOC_MAPK_gen_1	334	345	PF00069	0.687
DOC_MAPK_gen_1	494	503	PF00069	0.662
DOC_MAPK_gen_1	553	559	PF00069	0.562
DOC_MAPK_gen_1	656	665	PF00069	0.533
DOC_PP4_FxxP_1	274	277	PF00568	0.684
DOC_USP7_MATH_1	149	153	PF00917	0.691
DOC_USP7_MATH_1	203	207	PF00917	0.660
DOC_USP7_MATH_1	222	226	PF00917	0.771
DOC_USP7_MATH_1	250	254	PF00917	0.682
DOC_USP7_MATH_1	285	289	PF00917	0.603
DOC_USP7_MATH_1	39	43	PF00917	0.763
DOC_USP7_MATH_1	445	449	PF00917	0.595
DOC_USP7_MATH_1	48	52	PF00917	0.703
DOC_USP7_MATH_1	520	524	PF00917	0.586
DOC_USP7_MATH_1	598	602	PF00917	0.616
DOC_WW_Pin1_4	152	157	PF00397	0.794
DOC_WW_Pin1_4	190	195	PF00397	0.654
DOC_WW_Pin1_4	232	237	PF00397	0.742
DOC_WW_Pin1_4	275	280	PF00397	0.812
DOC_WW_Pin1_4	281	286	PF00397	0.749
DOC_WW_Pin1_4	290	295	PF00397	0.754
DOC_WW_Pin1_4	413	418	PF00397	0.639
LIG_14-3-3_CanoR_1	12	17	PF00244	0.705
LIG_14-3-3_CanoR_1	150	157	PF00244	0.593
LIG_14-3-3_CanoR_1	223	232	PF00244	0.673
LIG_14-3-3_CanoR_1	28	33	PF00244	0.531
LIG_14-3-3_CanoR_1	392	396	PF00244	0.637
LIG_14-3-3_CanoR_1	519	528	PF00244	0.548
LIG_14-3-3_CanoR_1	553	559	PF00244	0.608
LIG_Actin_WH2_2	576	594	PF00022	0.540
LIG_BIR_III_2	153	157	PF00653	0.673
LIG_BIR_III_4	408	412	PF00653	0.518
LIG_BRCT_BRCA1_1	270	274	PF00533	0.659
LIG_CaM_IQ_9	371	386	PF13499	0.527
LIG_CaM_NSCaTE_8	615	622	PF13499	0.488
LIG_deltaCOP1_diTrp_1	166	174	PF00928	0.656
LIG_deltaCOP1_diTrp_1	667	673	PF00928	0.569
LIG_DLG_GKlike_1	12	19	PF00625	0.600
LIG_EH1_1	396	404	PF00400	0.586
LIG_FHA_1	284	290	PF00498	0.668
LIG_FHA_1	367	373	PF00498	0.535
LIG_FHA_1	430	436	PF00498	0.597
LIG_FHA_1	496	502	PF00498	0.610
LIG_FHA_1	595	601	PF00498	0.680
LIG_FHA_2	414	420	PF00498	0.608
LIG_FHA_2	477	483	PF00498	0.566
LIG_FHA_2	606	612	PF00498	0.773
LIG_GBD_Chelix_1	583	591	PF00786	0.580
LIG_LIR_Apic_2	271	277	PF02991	0.681
LIG_LIR_Gen_1	504	514	PF02991	0.529
LIG_LIR_Nem_3	504	509	PF02991	0.521
LIG_LIR_Nem_3	671	676	PF02991	0.524
LIG_MYND_1	690	694	PF01753	0.588
LIG_Pex14_1	670	674	PF04695	0.582
LIG_PTAP_UEV_1	194	199	PF05743	0.679
LIG_SH2_CRK	466	470	PF00017	0.576
LIG_SH2_NCK_1	292	296	PF00017	0.648
LIG_SH2_STAT5	234	237	PF00017	0.720
LIG_SH2_STAT5	292	295	PF00017	0.648
LIG_SH2_STAT5	674	677	PF00017	0.610
LIG_SH3_3	143	149	PF00018	0.654
LIG_SH3_3	189	195	PF00018	0.755
LIG_SH3_3	216	222	PF00018	0.661
LIG_SH3_3	421	427	PF00018	0.600
LIG_SH3_3	508	514	PF00018	0.580
LIG_SH3_3	691	697	PF00018	0.653
LIG_SUMO_SIM_par_1	369	376	PF11976	0.502
LIG_SUMO_SIM_par_1	416	421	PF11976	0.523
LIG_SUMO_SIM_par_1	637	644	PF11976	0.544
LIG_TRAF2_1	228	231	PF00917	0.619
LIG_TRAF2_1	373	376	PF00917	0.571
LIG_TRAF2_1	398	401	PF00917	0.617
LIG_WW_3	9	13	PF00397	0.656
MOD_CDC14_SPxK_1	278	281	PF00782	0.660
MOD_CDK_SPK_2	232	237	PF00069	0.667
MOD_CDK_SPxK_1	232	238	PF00069	0.645
MOD_CDK_SPxK_1	275	281	PF00069	0.663
MOD_CK1_1	152	158	PF00069	0.697
MOD_CK1_1	190	196	PF00069	0.695
MOD_CK1_1	267	273	PF00069	0.731
MOD_CK1_1	284	290	PF00069	0.703
MOD_CK1_1	348	354	PF00069	0.574
MOD_CK1_1	448	454	PF00069	0.782
MOD_CK1_1	51	57	PF00069	0.789
MOD_CK1_1	567	573	PF00069	0.582
MOD_CK1_1	594	600	PF00069	0.708
MOD_CK1_1	601	607	PF00069	0.653
MOD_CK1_1	95	101	PF00069	0.690
MOD_CK2_1	413	419	PF00069	0.613
MOD_CK2_1	476	482	PF00069	0.553
MOD_CK2_1	605	611	PF00069	0.671
MOD_CMANNOS	670	673	PF00535	0.552
MOD_GlcNHglycan	12	15	PF01048	0.763
MOD_GlcNHglycan	176	179	PF01048	0.674
MOD_GlcNHglycan	195	198	PF01048	0.672
MOD_GlcNHglycan	252	255	PF01048	0.640
MOD_GlcNHglycan	267	270	PF01048	0.663
MOD_GlcNHglycan	300	303	PF01048	0.747
MOD_GlcNHglycan	307	310	PF01048	0.737
MOD_GlcNHglycan	313	316	PF01048	0.718
MOD_GlcNHglycan	328	331	PF01048	0.603
MOD_GlcNHglycan	34	37	PF01048	0.670
MOD_GlcNHglycan	355	358	PF01048	0.638
MOD_GlcNHglycan	41	44	PF01048	0.660
MOD_GlcNHglycan	522	525	PF01048	0.595
MOD_GlcNHglycan	53	56	PF01048	0.800
MOD_GlcNHglycan	58	61	PF01048	0.672
MOD_GlcNHglycan	593	596	PF01048	0.616
MOD_GlcNHglycan	600	603	PF01048	0.569
MOD_GlcNHglycan	66	69	PF01048	0.550
MOD_GlcNHglycan	698	701	PF01048	0.611
MOD_GSK3_1	193	200	PF00069	0.792
MOD_GSK3_1	24	31	PF00069	0.719
MOD_GSK3_1	248	255	PF00069	0.681
MOD_GSK3_1	261	268	PF00069	0.695
MOD_GSK3_1	281	288	PF00069	0.669
MOD_GSK3_1	326	333	PF00069	0.678
MOD_GSK3_1	345	352	PF00069	0.624
MOD_GSK3_1	444	451	PF00069	0.685
MOD_GSK3_1	56	63	PF00069	0.720
MOD_GSK3_1	590	597	PF00069	0.728
MOD_GSK3_1	598	605	PF00069	0.679
MOD_GSK3_1	706	713	PF00069	0.656
MOD_LATS_1	74	80	PF00433	0.721
MOD_N-GLC_1	76	81	PF02516	0.668
MOD_NEK2_1	350	355	PF00069	0.554
MOD_NEK2_1	564	569	PF00069	0.733
MOD_NEK2_1	591	596	PF00069	0.616
MOD_NEK2_1	92	97	PF00069	0.682
MOD_NEK2_2	48	53	PF00069	0.669
MOD_NEK2_2	558	563	PF00069	0.496
MOD_PIKK_1	104	110	PF00454	0.605
MOD_PIKK_1	131	137	PF00454	0.814
MOD_PIKK_1	222	228	PF00454	0.673
MOD_PIKK_1	261	267	PF00454	0.648
MOD_PIKK_1	28	34	PF00454	0.623
MOD_PIKK_1	474	480	PF00454	0.616
MOD_PKA_1	28	34	PF00069	0.597
MOD_PKA_2	149	155	PF00069	0.642
MOD_PKA_2	222	228	PF00069	0.673
MOD_PKA_2	28	34	PF00069	0.700
MOD_PKA_2	311	317	PF00069	0.670
MOD_PKA_2	391	397	PF00069	0.639
MOD_PKA_2	445	451	PF00069	0.559
MOD_PKA_2	552	558	PF00069	0.564
MOD_Plk_1	187	193	PF00069	0.601
MOD_Plk_1	230	236	PF00069	0.666
MOD_Plk_4	367	373	PF00069	0.509
MOD_Plk_4	465	471	PF00069	0.603
MOD_Plk_4	558	564	PF00069	0.581
MOD_Plk_4	95	101	PF00069	0.612
MOD_ProDKin_1	152	158	PF00069	0.794
MOD_ProDKin_1	190	196	PF00069	0.654
MOD_ProDKin_1	232	238	PF00069	0.746
MOD_ProDKin_1	275	281	PF00069	0.813
MOD_ProDKin_1	290	296	PF00069	0.753
MOD_ProDKin_1	413	419	PF00069	0.644
MOD_SUMO_rev_2	529	534	PF00179	0.561
TRG_ENDOCYTIC_2	466	469	PF00928	0.572
TRG_ER_diArg_1	136	139	PF00400	0.705
TRG_ER_diArg_1	236	238	PF00400	0.646
TRG_ER_diArg_1	335	338	PF00400	0.633
TRG_ER_diArg_1	379	382	PF00400	0.614
TRG_ER_diArg_1	492	495	PF00400	0.625
TRG_ER_diArg_1	517	519	PF00400	0.540
TRG_ER_diArg_1	628	630	PF00400	0.537
TRG_ER_diArg_1	658	660	PF00400	0.552
TRG_NLS_MonoCore_2	333	338	PF00514	0.664
TRG_NLS_MonoExtC_3	333	338	PF00514	0.664
TRG_NLS_MonoExtN_4	334	340	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC82	Leishmania donovani	89%	100%
A4H819	Leishmania braziliensis	55%	99%
A4HWE7	Leishmania infantum	88%	83%
E9AQ47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%