Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFD1_LEIMA

TriTrypDb:

LmjF.15.0540 , LMJLV39_150011200 , LMJSD75_150011200

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0035253	ciliary rootlet	2	2
GO:0036064	ciliary basal body	3	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QFD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFD1

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.396
CLV_C14_Caspase3-7	394	398	PF00656	0.721
CLV_C14_Caspase3-7	610	614	PF00656	0.507
CLV_NRD_NRD_1	152	154	PF00675	0.409
CLV_NRD_NRD_1	222	224	PF00675	0.406
CLV_NRD_NRD_1	229	231	PF00675	0.432
CLV_NRD_NRD_1	275	277	PF00675	0.659
CLV_NRD_NRD_1	35	37	PF00675	0.453
CLV_NRD_NRD_1	424	426	PF00675	0.442
CLV_NRD_NRD_1	428	430	PF00675	0.386
CLV_NRD_NRD_1	45	47	PF00675	0.456
CLV_NRD_NRD_1	664	666	PF00675	0.486
CLV_NRD_NRD_1	672	674	PF00675	0.531
CLV_PCSK_KEX2_1	152	154	PF00082	0.409
CLV_PCSK_KEX2_1	229	231	PF00082	0.463
CLV_PCSK_KEX2_1	236	238	PF00082	0.490
CLV_PCSK_KEX2_1	274	276	PF00082	0.654
CLV_PCSK_KEX2_1	35	37	PF00082	0.436
CLV_PCSK_KEX2_1	424	426	PF00082	0.465
CLV_PCSK_KEX2_1	428	430	PF00082	0.404
CLV_PCSK_KEX2_1	45	47	PF00082	0.430
CLV_PCSK_KEX2_1	666	668	PF00082	0.610
CLV_PCSK_KEX2_1	672	674	PF00082	0.531
CLV_PCSK_KEX2_1	86	88	PF00082	0.432
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.427
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.610
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.411
CLV_PCSK_PC7_1	424	430	PF00082	0.421
CLV_PCSK_SKI1_1	111	115	PF00082	0.372
CLV_PCSK_SKI1_1	229	233	PF00082	0.420
CLV_PCSK_SKI1_1	307	311	PF00082	0.398
CLV_PCSK_SKI1_1	350	354	PF00082	0.508
CLV_PCSK_SKI1_1	429	433	PF00082	0.406
CLV_PCSK_SKI1_1	52	56	PF00082	0.536
DEG_APCC_DBOX_1	23	31	PF00400	0.477
DEG_APCC_DBOX_1	645	653	PF00400	0.477
DOC_CYCLIN_RxL_1	424	434	PF00134	0.494
DOC_MAPK_gen_1	13	21	PF00069	0.470
DOC_MAPK_gen_1	242	249	PF00069	0.546
DOC_MAPK_gen_1	298	306	PF00069	0.529
DOC_MAPK_gen_1	323	332	PF00069	0.561
DOC_MAPK_gen_1	424	432	PF00069	0.649
DOC_MAPK_gen_1	45	55	PF00069	0.557
DOC_MAPK_MEF2A_6	242	251	PF00069	0.558
DOC_MAPK_MEF2A_6	46	55	PF00069	0.434
DOC_USP7_MATH_1	352	356	PF00917	0.575
DOC_USP7_MATH_1	367	371	PF00917	0.512
DOC_USP7_MATH_1	504	508	PF00917	0.589
DOC_USP7_MATH_1	586	590	PF00917	0.572
DOC_USP7_MATH_1	619	623	PF00917	0.736
DOC_USP7_UBL2_3	140	144	PF12436	0.372
DOC_USP7_UBL2_3	195	199	PF12436	0.476
DOC_WW_Pin1_4	286	291	PF00397	0.569
DOC_WW_Pin1_4	525	530	PF00397	0.495
DOC_WW_Pin1_4	576	581	PF00397	0.771
LIG_14-3-3_CanoR_1	105	113	PF00244	0.577
LIG_14-3-3_CanoR_1	15	19	PF00244	0.596
LIG_14-3-3_CanoR_1	152	156	PF00244	0.373
LIG_14-3-3_CanoR_1	257	263	PF00244	0.704
LIG_14-3-3_CanoR_1	279	288	PF00244	0.578
LIG_14-3-3_CanoR_1	372	380	PF00244	0.430
LIG_14-3-3_CanoR_1	63	68	PF00244	0.552
LIG_Actin_WH2_2	37	54	PF00022	0.492
LIG_Actin_WH2_2	85	103	PF00022	0.551
LIG_CaM_IQ_9	27	42	PF13499	0.478
LIG_FHA_1	299	305	PF00498	0.549
LIG_FHA_1	507	513	PF00498	0.542
LIG_FHA_1	586	592	PF00498	0.577
LIG_FHA_1	6	12	PF00498	0.451
LIG_FHA_2	155	161	PF00498	0.401
LIG_FHA_2	333	339	PF00498	0.440
LIG_FHA_2	374	380	PF00498	0.458
LIG_FHA_2	4	10	PF00498	0.524
LIG_FHA_2	608	614	PF00498	0.628
LIG_IRF3_LxIS_1	470	477	PF10401	0.465
LIG_LIR_Gen_1	154	162	PF02991	0.368
LIG_LIR_Gen_1	301	311	PF02991	0.421
LIG_LIR_Gen_1	355	364	PF02991	0.522
LIG_LIR_Nem_3	154	158	PF02991	0.370
LIG_LIR_Nem_3	301	306	PF02991	0.407
LIG_LIR_Nem_3	355	360	PF02991	0.459
LIG_LIR_Nem_3	417	421	PF02991	0.681
LIG_NRBOX	455	461	PF00104	0.476
LIG_PDZ_Class_3	674	679	PF00595	0.592
LIG_SH2_CRK	155	159	PF00017	0.314
LIG_SH2_CRK	418	422	PF00017	0.532
LIG_SH2_STAT5	303	306	PF00017	0.549
LIG_SH2_STAT5	469	472	PF00017	0.530
LIG_SH3_3	548	554	PF00018	0.668
LIG_SUMO_SIM_anti_2	509	514	PF11976	0.472
LIG_SUMO_SIM_par_1	485	491	PF11976	0.450
LIG_TRAF2_1	106	109	PF00917	0.401
LIG_TRAF2_1	252	255	PF00917	0.508
LIG_TRAF2_1	674	677	PF00917	0.558
LIG_TRAF2_1	72	75	PF00917	0.536
LIG_TYR_ITIM	416	421	PF00017	0.510
LIG_UBA3_1	41	49	PF00899	0.463
LIG_UBA3_1	523	530	PF00899	0.371
MOD_CDK_SPK_2	525	530	PF00069	0.374
MOD_CK1_1	280	286	PF00069	0.674
MOD_CK1_1	491	497	PF00069	0.609
MOD_CK1_1	571	577	PF00069	0.753
MOD_CK1_1	589	595	PF00069	0.773
MOD_CK1_1	609	615	PF00069	0.684
MOD_CK1_1	653	659	PF00069	0.445
MOD_CK2_1	154	160	PF00069	0.401
MOD_CK2_1	171	177	PF00069	0.537
MOD_CK2_1	3	9	PF00069	0.533
MOD_CK2_1	332	338	PF00069	0.439
MOD_CK2_1	352	358	PF00069	0.296
MOD_CK2_1	379	385	PF00069	0.453
MOD_CK2_1	525	531	PF00069	0.528
MOD_CK2_1	671	677	PF00069	0.600
MOD_GlcNHglycan	122	127	PF01048	0.436
MOD_GlcNHglycan	195	198	PF01048	0.529
MOD_GlcNHglycan	266	269	PF01048	0.729
MOD_GlcNHglycan	271	274	PF01048	0.736
MOD_GlcNHglycan	283	286	PF01048	0.750
MOD_GlcNHglycan	369	372	PF01048	0.594
MOD_GlcNHglycan	381	384	PF01048	0.678
MOD_GlcNHglycan	387	390	PF01048	0.770
MOD_GlcNHglycan	476	479	PF01048	0.543
MOD_GlcNHglycan	484	487	PF01048	0.575
MOD_GlcNHglycan	489	493	PF01048	0.591
MOD_GlcNHglycan	501	504	PF01048	0.595
MOD_GlcNHglycan	571	574	PF01048	0.735
MOD_GlcNHglycan	595	598	PF01048	0.694
MOD_GlcNHglycan	613	617	PF01048	0.636
MOD_GlcNHglycan	621	624	PF01048	0.624
MOD_GSK3_1	147	154	PF00069	0.494
MOD_GSK3_1	168	175	PF00069	0.430
MOD_GSK3_1	277	284	PF00069	0.687
MOD_GSK3_1	499	506	PF00069	0.523
MOD_GSK3_1	576	583	PF00069	0.730
MOD_GSK3_1	585	592	PF00069	0.634
MOD_LATS_1	497	503	PF00433	0.506
MOD_N-GLC_1	3	8	PF02516	0.660
MOD_N-GLC_1	63	68	PF02516	0.603
MOD_NEK2_1	232	237	PF00069	0.413
MOD_NEK2_1	3	8	PF00069	0.538
MOD_NEK2_1	332	337	PF00069	0.450
MOD_NEK2_1	474	479	PF00069	0.526
MOD_NEK2_1	488	493	PF00069	0.602
MOD_NEK2_1	55	60	PF00069	0.523
MOD_NEK2_1	593	598	PF00069	0.684
MOD_NEK2_1	85	90	PF00069	0.380
MOD_PIKK_1	168	174	PF00454	0.411
MOD_PIKK_1	454	460	PF00454	0.463
MOD_PIKK_1	491	497	PF00454	0.524
MOD_PK_1	63	69	PF00069	0.554
MOD_PKA_2	104	110	PF00069	0.609
MOD_PKA_2	14	20	PF00069	0.568
MOD_PKA_2	151	157	PF00069	0.409
MOD_PKA_2	280	286	PF00069	0.680
MOD_PKA_2	671	677	PF00069	0.512
MOD_PKB_1	279	287	PF00069	0.570
MOD_PKB_1	305	313	PF00069	0.544
MOD_Plk_1	122	128	PF00069	0.531
MOD_Plk_1	307	313	PF00069	0.441
MOD_Plk_1	339	345	PF00069	0.535
MOD_Plk_1	488	494	PF00069	0.630
MOD_Plk_1	63	69	PF00069	0.598
MOD_Plk_2-3	104	110	PF00069	0.427
MOD_Plk_4	14	20	PF00069	0.472
MOD_Plk_4	154	160	PF00069	0.397
MOD_Plk_4	586	592	PF00069	0.518
MOD_ProDKin_1	286	292	PF00069	0.563
MOD_ProDKin_1	525	531	PF00069	0.496
MOD_ProDKin_1	576	582	PF00069	0.770
MOD_SUMO_for_1	113	116	PF00179	0.504
MOD_SUMO_for_1	204	207	PF00179	0.399
MOD_SUMO_for_1	72	75	PF00179	0.547
MOD_SUMO_rev_2	43	51	PF00179	0.404
MOD_SUMO_rev_2	642	652	PF00179	0.509
TRG_DiLeu_BaEn_1	186	191	PF01217	0.511
TRG_DiLeu_BaEn_2	107	113	PF01217	0.499
TRG_DiLeu_BaEn_3	227	233	PF01217	0.467
TRG_ENDOCYTIC_2	155	158	PF00928	0.370
TRG_ENDOCYTIC_2	303	306	PF00928	0.405
TRG_ENDOCYTIC_2	418	421	PF00928	0.536
TRG_ER_diArg_1	151	153	PF00400	0.371
TRG_ER_diArg_1	229	231	PF00400	0.565
TRG_ER_diArg_1	274	276	PF00400	0.660
TRG_ER_diArg_1	304	307	PF00400	0.479
TRG_ER_diArg_1	34	36	PF00400	0.458
TRG_ER_diArg_1	428	430	PF00400	0.407
TRG_ER_diArg_1	44	46	PF00400	0.457
TRG_NLS_MonoExtN_4	663	669	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF92	Leptomonas seymouri	66%	100%
A0A0S4JUS3	Bodo saltans	29%	100%
A0A1X0NV64	Trypanosomatidae	39%	97%
A0A3Q8IA72	Leishmania donovani	93%	100%
A0A422NLI6	Trypanosoma rangeli	40%	100%
A4H826	Leishmania braziliensis	81%	100%
C9ZNZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9AQ51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BBE7	Trypanosoma cruzi	41%	100%