Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFC9_LEIMA

TriTrypDb:

LmjF.15.0560 , LMJLV39_150011400 , LMJSD75_150011400

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.650
CLV_NRD_NRD_1	139	141	PF00675	0.595
CLV_NRD_NRD_1	2	4	PF00675	0.586
CLV_NRD_NRD_1	242	244	PF00675	0.648
CLV_NRD_NRD_1	245	247	PF00675	0.564
CLV_NRD_NRD_1	341	343	PF00675	0.486
CLV_NRD_NRD_1	382	384	PF00675	0.570
CLV_PCSK_FUR_1	243	247	PF00082	0.620
CLV_PCSK_KEX2_1	139	141	PF00082	0.579
CLV_PCSK_KEX2_1	242	244	PF00082	0.643
CLV_PCSK_KEX2_1	245	247	PF00082	0.580
CLV_PCSK_KEX2_1	341	343	PF00082	0.552
CLV_PCSK_SKI1_1	139	143	PF00082	0.550
CLV_PCSK_SKI1_1	217	221	PF00082	0.669
CLV_PCSK_SKI1_1	296	300	PF00082	0.504
CLV_PCSK_SKI1_1	458	462	PF00082	0.425
CLV_PCSK_SKI1_1	48	52	PF00082	0.689
CLV_PCSK_SKI1_1	6	10	PF00082	0.494
DEG_APCC_DBOX_1	252	260	PF00400	0.524
DEG_APCC_KENBOX_2	492	496	PF00400	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DEG_SPOP_SBC_1	195	199	PF00917	0.628
DEG_SPOP_SBC_1	233	237	PF00917	0.664
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.671
DOC_MAPK_gen_1	169	178	PF00069	0.453
DOC_MAPK_gen_1	3	12	PF00069	0.475
DOC_MAPK_gen_1	32	42	PF00069	0.621
DOC_MAPK_MEF2A_6	3	12	PF00069	0.475
DOC_PP1_RVXF_1	515	521	PF00149	0.499
DOC_PP2B_LxvP_1	210	213	PF13499	0.675
DOC_PP2B_LxvP_1	407	410	PF13499	0.611
DOC_USP7_MATH_1	116	120	PF00917	0.490
DOC_USP7_MATH_1	143	147	PF00917	0.657
DOC_USP7_MATH_1	194	198	PF00917	0.620
DOC_USP7_MATH_1	414	418	PF00917	0.544
DOC_USP7_MATH_1	529	533	PF00917	0.639
DOC_USP7_MATH_1	86	90	PF00917	0.539
DOC_USP7_UBL2_3	179	183	PF12436	0.445
DOC_USP7_UBL2_3	51	55	PF12436	0.636
DOC_USP7_UBL2_3	99	103	PF12436	0.475
DOC_WW_Pin1_4	527	532	PF00397	0.548
LIG_14-3-3_CanoR_1	231	241	PF00244	0.692
LIG_14-3-3_CanoR_1	294	299	PF00244	0.505
LIG_Clathr_ClatBox_1	464	468	PF01394	0.458
LIG_EVH1_1	407	411	PF00568	0.517
LIG_FHA_1	129	135	PF00498	0.575
LIG_FHA_1	205	211	PF00498	0.534
LIG_FHA_1	236	242	PF00498	0.683
LIG_FHA_1	31	37	PF00498	0.504
LIG_FHA_1	7	13	PF00498	0.502
LIG_FHA_2	309	315	PF00498	0.467
LIG_FHA_2	316	322	PF00498	0.447
LIG_LIR_Gen_1	421	429	PF02991	0.543
LIG_LIR_Nem_3	421	426	PF02991	0.542
LIG_PCNA_yPIPBox_3	112	121	PF02747	0.458
LIG_SH2_CRK	97	101	PF00017	0.500
LIG_SH2_STAT5	308	311	PF00017	0.490
LIG_SH3_3	238	244	PF00018	0.654
LIG_SH3_3	405	411	PF00018	0.762
LIG_SUMO_SIM_anti_2	173	180	PF11976	0.503
LIG_SUMO_SIM_par_1	173	180	PF11976	0.480
LIG_SUMO_SIM_par_1	463	468	PF11976	0.565
LIG_TRAF2_1	28	31	PF00917	0.517
LIG_TRAF2_1	333	336	PF00917	0.494
LIG_WRC_WIRS_1	415	420	PF05994	0.525
MOD_CK1_1	232	238	PF00069	0.615
MOD_CK1_1	481	487	PF00069	0.586
MOD_CK1_1	532	538	PF00069	0.652
MOD_CK1_1	79	85	PF00069	0.496
MOD_CK2_1	194	200	PF00069	0.624
MOD_CK2_1	308	314	PF00069	0.486
MOD_CK2_1	315	321	PF00069	0.484
MOD_CK2_1	418	424	PF00069	0.556
MOD_CK2_1	77	83	PF00069	0.653
MOD_GlcNHglycan	149	152	PF01048	0.597
MOD_GlcNHglycan	158	161	PF01048	0.586
MOD_GlcNHglycan	222	225	PF01048	0.622
MOD_GlcNHglycan	256	259	PF01048	0.608
MOD_GlcNHglycan	288	291	PF01048	0.510
MOD_GlcNHglycan	356	359	PF01048	0.603
MOD_GlcNHglycan	362	365	PF01048	0.565
MOD_GlcNHglycan	448	451	PF01048	0.560
MOD_GlcNHglycan	483	486	PF01048	0.684
MOD_GlcNHglycan	55	58	PF01048	0.592
MOD_GlcNHglycan	70	73	PF01048	0.549
MOD_GlcNHglycan	74	77	PF01048	0.629
MOD_GlcNHglycan	79	82	PF01048	0.503
MOD_GlcNHglycan	89	92	PF01048	0.380
MOD_GSK3_1	139	146	PF00069	0.538
MOD_GSK3_1	196	203	PF00069	0.540
MOD_GSK3_1	204	211	PF00069	0.791
MOD_GSK3_1	229	236	PF00069	0.628
MOD_GSK3_1	297	304	PF00069	0.496
MOD_GSK3_1	354	361	PF00069	0.607
MOD_GSK3_1	414	421	PF00069	0.679
MOD_GSK3_1	479	486	PF00069	0.699
MOD_GSK3_1	66	73	PF00069	0.672
MOD_N-GLC_1	200	205	PF02516	0.547
MOD_NEK2_1	12	17	PF00069	0.475
MOD_NEK2_1	177	182	PF00069	0.529
MOD_NEK2_1	286	291	PF00069	0.580
MOD_NEK2_1	313	318	PF00069	0.511
MOD_NEK2_1	360	365	PF00069	0.590
MOD_NEK2_1	418	423	PF00069	0.534
MOD_NEK2_1	519	524	PF00069	0.441
MOD_PIKK_1	12	18	PF00454	0.479
MOD_PIKK_1	30	36	PF00454	0.536
MOD_PKA_1	139	145	PF00069	0.565
MOD_PKA_2	139	145	PF00069	0.565
MOD_PKA_2	254	260	PF00069	0.486
MOD_PKA_2	286	292	PF00069	0.507
MOD_PKB_1	501	509	PF00069	0.482
MOD_Plk_1	6	12	PF00069	0.534
MOD_Plk_4	308	314	PF00069	0.489
MOD_Plk_4	486	492	PF00069	0.556
MOD_ProDKin_1	527	533	PF00069	0.550
MOD_SUMO_for_1	298	301	PF00179	0.498
MOD_SUMO_rev_2	124	134	PF00179	0.542
TRG_DiLeu_BaEn_1	133	138	PF01217	0.572
TRG_DiLeu_BaEn_1	173	178	PF01217	0.504
TRG_DiLeu_BaEn_4	173	179	PF01217	0.522
TRG_DiLeu_LyEn_5	133	138	PF01217	0.540
TRG_ENDOCYTIC_2	423	426	PF00928	0.549
TRG_ENDOCYTIC_2	97	100	PF00928	0.503
TRG_ER_diArg_1	138	140	PF00400	0.592
TRG_ER_diArg_1	168	171	PF00400	0.533
TRG_ER_diArg_1	241	243	PF00400	0.655
TRG_ER_diArg_1	244	246	PF00400	0.599
TRG_ER_diArg_1	340	342	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I948	Leptomonas seymouri	45%	87%
A0A0S4JZN8	Bodo saltans	24%	86%
A0A3Q8IA19	Leishmania donovani	92%	100%
A4H828	Leishmania braziliensis	70%	89%
A4HWF4	Leishmania infantum	92%	100%
E9AQ53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%