SPARK domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFC8_LEIMA

TriTrypDb:

LmjF.15.0570 , LMJLV39_150011500 , LMJSD75_150011500

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.583
CLV_C14_Caspase3-7	274	278	PF00656	0.521
CLV_NRD_NRD_1	73	75	PF00675	0.707
CLV_PCSK_SKI1_1	296	300	PF00082	0.715
DEG_Kelch_Keap1_1	151	156	PF01344	0.491
DEG_ODPH_VHL_1	15	26	PF01847	0.564
DEG_SPOP_SBC_1	111	115	PF00917	0.543
DEG_SPOP_SBC_1	271	275	PF00917	0.454
DOC_CDC14_PxL_1	13	21	PF14671	0.593
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.609
DOC_PP2B_LxvP_1	241	244	PF13499	0.454
DOC_PP2B_LxvP_1	9	12	PF13499	0.613
DOC_USP7_MATH_1	109	113	PF00917	0.566
DOC_USP7_MATH_1	220	224	PF00917	0.517
DOC_USP7_MATH_1	226	230	PF00917	0.487
DOC_USP7_MATH_1	311	315	PF00917	0.439
DOC_USP7_MATH_1	47	51	PF00917	0.507
DOC_USP7_UBL2_3	75	79	PF12436	0.478
DOC_WW_Pin1_4	107	112	PF00397	0.464
DOC_WW_Pin1_4	115	120	PF00397	0.553
DOC_WW_Pin1_4	181	186	PF00397	0.469
DOC_WW_Pin1_4	307	312	PF00397	0.594
LIG_14-3-3_CanoR_1	31	39	PF00244	0.651
LIG_14-3-3_CanoR_1	40	47	PF00244	0.477
LIG_APCC_ABBA_1	196	201	PF00400	0.574
LIG_BRCT_BRCA1_1	117	121	PF00533	0.548
LIG_CSL_BTD_1	119	122	PF09270	0.539
LIG_FHA_1	170	176	PF00498	0.579
LIG_FHA_1	20	26	PF00498	0.648
LIG_FHA_1	216	222	PF00498	0.500
LIG_FHA_1	229	235	PF00498	0.491
LIG_FHA_1	256	262	PF00498	0.472
LIG_FHA_1	97	103	PF00498	0.579
LIG_FHA_2	166	172	PF00498	0.488
LIG_FHA_2	59	65	PF00498	0.510
LIG_Integrin_isoDGR_2	264	266	PF01839	0.720
LIG_MYND_1	181	185	PF01753	0.537
LIG_NRBOX	19	25	PF00104	0.562
LIG_PCNA_yPIPBox_3	188	199	PF02747	0.517
LIG_SH2_CRK	205	209	PF00017	0.515
LIG_SH2_GRB2like	205	208	PF00017	0.492
LIG_SH2_NCK_1	199	203	PF00017	0.573
LIG_SH2_NCK_1	205	209	PF00017	0.500
LIG_SH2_SRC	205	208	PF00017	0.495
LIG_SH2_STAP1	199	203	PF00017	0.488
LIG_SH2_STAP1	52	56	PF00017	0.546
LIG_SH2_STAT3	52	55	PF00017	0.421
LIG_SH2_STAT5	199	202	PF00017	0.488
LIG_SH2_STAT5	203	206	PF00017	0.479
LIG_SH2_STAT5	292	295	PF00017	0.489
LIG_SH3_3	116	122	PF00018	0.544
LIG_SH3_3	141	147	PF00018	0.533
LIG_SH3_3	305	311	PF00018	0.551
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.603
LIG_SUMO_SIM_par_1	16	22	PF11976	0.587
MOD_CDK_SPxxK_3	181	188	PF00069	0.435
MOD_CK1_1	110	116	PF00069	0.462
MOD_CK1_1	158	164	PF00069	0.543
MOD_CK1_1	307	313	PF00069	0.522
MOD_CK1_1	96	102	PF00069	0.547
MOD_CK2_1	150	156	PF00069	0.533
MOD_CK2_1	221	227	PF00069	0.571
MOD_GlcNHglycan	153	156	PF01048	0.781
MOD_GlcNHglycan	160	163	PF01048	0.804
MOD_GlcNHglycan	224	227	PF01048	0.843
MOD_GlcNHglycan	279	282	PF01048	0.715
MOD_GlcNHglycan	283	286	PF01048	0.681
MOD_GlcNHglycan	48	52	PF01048	0.728
MOD_GlcNHglycan	5	8	PF01048	0.716
MOD_GSK3_1	107	114	PF00069	0.615
MOD_GSK3_1	151	158	PF00069	0.591
MOD_GSK3_1	165	172	PF00069	0.504
MOD_GSK3_1	222	229	PF00069	0.542
MOD_GSK3_1	277	284	PF00069	0.532
MOD_GSK3_1	288	295	PF00069	0.527
MOD_GSK3_1	300	307	PF00069	0.454
MOD_GSK3_1	66	73	PF00069	0.437
MOD_N-GLC_1	104	109	PF02516	0.707
MOD_N-GLC_1	221	226	PF02516	0.784
MOD_N-GLC_1	271	276	PF02516	0.735
MOD_NEK2_1	19	24	PF00069	0.494
MOD_NEK2_1	221	226	PF00069	0.551
MOD_NEK2_1	255	260	PF00069	0.465
MOD_NEK2_1	288	293	PF00069	0.539
MOD_NEK2_1	3	8	PF00069	0.703
MOD_NEK2_1	70	75	PF00069	0.432
MOD_NEK2_1	90	95	PF00069	0.550
MOD_PIKK_1	121	127	PF00454	0.582
MOD_PKA_2	255	261	PF00069	0.479
MOD_PKA_2	39	45	PF00069	0.456
MOD_Plk_1	170	176	PF00069	0.524
MOD_Plk_1	47	53	PF00069	0.456
MOD_Plk_1	90	96	PF00069	0.459
MOD_Plk_4	19	25	PF00069	0.571
MOD_Plk_4	322	328	PF00069	0.368
MOD_ProDKin_1	107	113	PF00069	0.466
MOD_ProDKin_1	115	121	PF00069	0.552
MOD_ProDKin_1	181	187	PF00069	0.463
MOD_ProDKin_1	307	313	PF00069	0.592
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.657
TRG_ENDOCYTIC_2	205	208	PF00928	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P748	Leptomonas seymouri	40%	100%
A0A3S7WTK4	Leishmania donovani	89%	100%
A4H829	Leishmania braziliensis	62%	100%
A4HWF5	Leishmania infantum	89%	100%
E9AQ54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%