Signal peptidase complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal peptidase subunit, putative

Species:

Leishmania major

UniProt:

Q4QFC7_LEIMA

TriTrypDb:

LmjF.15.0580 , LMJLV39_150011600 , LMJSD75_150011600

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005787	signal peptidase complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1905368	peptidase complex	3	7

Expansion

Sequence features

Q4QFC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFC7

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	7
GO:0006508	proteolysis	4	7
GO:0006518	peptide metabolic process	4	7
GO:0006605	protein targeting	5	2
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016485	protein processing	5	7
GO:0019538	protein metabolic process	3	7
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0043170	macromolecule metabolic process	3	7
GO:0043603	amide metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0045047	protein targeting to ER	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051604	protein maturation	4	7
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070972	protein localization to endoplasmic reticulum	6	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	7
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	2
GO:1901564	organonitrogen compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.481
CLV_C14_Caspase3-7	78	82	PF00656	0.426
CLV_NRD_NRD_1	111	113	PF00675	0.594
CLV_NRD_NRD_1	196	198	PF00675	0.575
CLV_NRD_NRD_1	200	202	PF00675	0.583
CLV_PCSK_KEX2_1	196	198	PF00082	0.572
CLV_PCSK_KEX2_1	200	202	PF00082	0.599
CLV_PCSK_KEX2_1	257	259	PF00082	0.565
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.565
CLV_PCSK_PC7_1	196	202	PF00082	0.587
CLV_PCSK_SKI1_1	133	137	PF00082	0.475
CLV_PCSK_SKI1_1	191	195	PF00082	0.656
CLV_PCSK_SKI1_1	201	205	PF00082	0.631
CLV_PCSK_SKI1_1	258	262	PF00082	0.522
DOC_MAPK_gen_1	119	128	PF00069	0.469
DOC_MAPK_HePTP_8	126	138	PF00069	0.329
DOC_MAPK_MEF2A_6	129	138	PF00069	0.275
DOC_USP7_MATH_1	103	107	PF00917	0.443
DOC_USP7_MATH_1	164	168	PF00917	0.344
DOC_USP7_MATH_1	41	45	PF00917	0.416
DOC_WW_Pin1_4	142	147	PF00397	0.329
DOC_WW_Pin1_4	216	221	PF00397	0.522
DOC_WW_Pin1_4	56	61	PF00397	0.350
LIG_14-3-3_CanoR_1	181	186	PF00244	0.428
LIG_14-3-3_CanoR_1	47	52	PF00244	0.343
LIG_14-3-3_CanoR_1	5	12	PF00244	0.590
LIG_AP2alpha_1	268	272	PF02296	0.349
LIG_BRCT_BRCA1_1	140	144	PF00533	0.329
LIG_DLG_GKlike_1	47	54	PF00625	0.281
LIG_FHA_1	150	156	PF00498	0.275
LIG_FHA_1	20	26	PF00498	0.371
LIG_FHA_1	279	285	PF00498	0.386
LIG_FHA_2	76	82	PF00498	0.470
LIG_LIR_Gen_1	49	57	PF02991	0.276
LIG_LIR_Nem_3	264	268	PF02991	0.372
LIG_LIR_Nem_3	294	299	PF02991	0.362
LIG_LIR_Nem_3	49	54	PF02991	0.350
LIG_Pex14_2	144	148	PF04695	0.275
LIG_Pex14_2	159	163	PF04695	0.275
LIG_Pex14_2	268	272	PF04695	0.349
LIG_PTB_Apo_2	259	266	PF02174	0.319
LIG_SH2_SRC	251	254	PF00017	0.348
LIG_SH2_STAT5	137	140	PF00017	0.303
LIG_SH2_STAT5	156	159	PF00017	0.303
LIG_SH2_STAT5	251	254	PF00017	0.361
LIG_SH2_STAT5	267	270	PF00017	0.347
LIG_SH3_3	176	182	PF00018	0.285
LIG_SH3_3	307	313	PF00018	0.389
LIG_SH3_3	33	39	PF00018	0.421
LIG_SH3_3	54	60	PF00018	0.382
LIG_SH3_3	62	68	PF00018	0.503
LIG_SH3_3	97	103	PF00018	0.462
LIG_SUMO_SIM_anti_2	172	177	PF11976	0.329
LIG_SUMO_SIM_anti_2	281	286	PF11976	0.371
LIG_SUMO_SIM_anti_2	92	99	PF11976	0.361
LIG_SUMO_SIM_par_1	172	177	PF11976	0.329
LIG_TRAF2_1	226	229	PF00917	0.422
LIG_WRC_WIRS_1	156	161	PF05994	0.275
LIG_WRC_WIRS_1	48	53	PF05994	0.352
MOD_CK1_1	14	20	PF00069	0.312
MOD_CK1_1	49	55	PF00069	0.332
MOD_CK1_1	77	83	PF00069	0.449
MOD_CK2_1	204	210	PF00069	0.504
MOD_CK2_1	89	95	PF00069	0.355
MOD_GlcNHglycan	138	141	PF01048	0.475
MOD_GlcNHglycan	16	19	PF01048	0.388
MOD_GlcNHglycan	166	169	PF01048	0.495
MOD_GlcNHglycan	293	296	PF01048	0.570
MOD_GlcNHglycan	43	46	PF01048	0.493
MOD_GlcNHglycan	51	54	PF01048	0.486
MOD_GSK3_1	138	145	PF00069	0.329
MOD_GSK3_1	19	26	PF00069	0.371
MOD_GSK3_1	216	223	PF00069	0.494
MOD_LATS_1	56	62	PF00433	0.400
MOD_N-GLC_1	261	266	PF02516	0.521
MOD_NEK2_1	12	17	PF00069	0.380
MOD_NEK2_1	136	141	PF00069	0.283
MOD_NEK2_1	19	24	PF00069	0.325
MOD_NEK2_1	236	241	PF00069	0.392
MOD_NEK2_1	25	30	PF00069	0.263
MOD_NEK2_1	261	266	PF00069	0.321
MOD_NEK2_1	272	277	PF00069	0.357
MOD_NEK2_1	291	296	PF00069	0.294
MOD_PKA_2	210	216	PF00069	0.533
MOD_PKA_2	46	52	PF00069	0.346
MOD_PKA_2	74	80	PF00069	0.403
MOD_Plk_1	236	242	PF00069	0.363
MOD_Plk_1	261	267	PF00069	0.324
MOD_Plk_1	272	278	PF00069	0.354
MOD_Plk_4	155	161	PF00069	0.416
MOD_Plk_4	220	226	PF00069	0.397
MOD_Plk_4	246	252	PF00069	0.384
MOD_Plk_4	27	33	PF00069	0.402
MOD_Plk_4	58	64	PF00069	0.399
MOD_ProDKin_1	142	148	PF00069	0.329
MOD_ProDKin_1	216	222	PF00069	0.518
MOD_ProDKin_1	56	62	PF00069	0.351
TRG_DiLeu_BaEn_4	228	234	PF01217	0.394
TRG_ENDOCYTIC_2	156	159	PF00928	0.374
TRG_ENDOCYTIC_2	288	291	PF00928	0.310
TRG_ER_diArg_1	117	120	PF00400	0.355
TRG_ER_diArg_1	195	197	PF00400	0.365
TRG_ER_diArg_1	37	40	PF00400	0.385
TRG_ER_diArg_1	4	7	PF00400	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I7	Leptomonas seymouri	57%	100%
A0A3S5H6U6	Leishmania donovani	95%	100%
A4H830	Leishmania braziliensis	77%	99%
A4HWF6	Leishmania infantum	95%	100%
E9AQ55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%