Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFC6_LEIMA

TriTrypDb:

LmjF.15.0590 , LMJLV39_150011700 , LMJSD75_150011700

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.673
CLV_NRD_NRD_1	209	211	PF00675	0.727
CLV_NRD_NRD_1	215	217	PF00675	0.607
CLV_PCSK_KEX2_1	208	210	PF00082	0.731
CLV_PCSK_PC7_1	205	211	PF00082	0.700
CLV_PCSK_SKI1_1	151	155	PF00082	0.520
CLV_PCSK_SKI1_1	4	8	PF00082	0.644
DOC_USP7_MATH_1	141	145	PF00917	0.677
DOC_USP7_MATH_1	192	196	PF00917	0.761
DOC_WW_Pin1_4	117	122	PF00397	0.736
DOC_WW_Pin1_4	199	204	PF00397	0.730
LIG_14-3-3_CanoR_1	148	154	PF00244	0.560
LIG_14-3-3_CanoR_1	163	168	PF00244	0.512
LIG_14-3-3_CanoR_1	191	197	PF00244	0.714
LIG_14-3-3_CanoR_1	20	30	PF00244	0.530
LIG_FHA_2	123	129	PF00498	0.775
LIG_LIR_Apic_2	84	89	PF02991	0.665
LIG_LIR_Gen_1	94	104	PF02991	0.552
LIG_LIR_Nem_3	94	99	PF02991	0.641
LIG_Pex14_1	54	58	PF04695	0.549
LIG_SH2_CRK	96	100	PF00017	0.632
LIG_SH2_GRB2like	86	89	PF00017	0.603
LIG_SH2_PTP2	86	89	PF00017	0.657
LIG_SH2_SRC	86	89	PF00017	0.657
LIG_SH2_STAP1	96	100	PF00017	0.539
LIG_SH2_STAT3	58	61	PF00017	0.552
LIG_SH2_STAT5	157	160	PF00017	0.530
LIG_SH2_STAT5	86	89	PF00017	0.603
LIG_SH3_3	169	175	PF00018	0.621
MOD_CDC14_SPxK_1	202	205	PF00782	0.697
MOD_CDK_SPxK_1	199	205	PF00069	0.702
MOD_CK1_1	106	112	PF00069	0.585
MOD_CK1_1	149	155	PF00069	0.666
MOD_CK1_1	193	199	PF00069	0.729
MOD_CK1_1	33	39	PF00069	0.551
MOD_CK2_1	122	128	PF00069	0.758
MOD_CK2_1	192	198	PF00069	0.778
MOD_GlcNHglycan	143	146	PF01048	0.653
MOD_GlcNHglycan	148	151	PF01048	0.612
MOD_GlcNHglycan	172	175	PF01048	0.696
MOD_GlcNHglycan	192	195	PF01048	0.697
MOD_GSK3_1	131	138	PF00069	0.753
MOD_GSK3_1	170	177	PF00069	0.649
MOD_GSK3_1	186	193	PF00069	0.698
MOD_GSK3_1	29	36	PF00069	0.574
MOD_NEK2_1	146	151	PF00069	0.649
MOD_NEK2_1	197	202	PF00069	0.719
MOD_NEK2_1	30	35	PF00069	0.555
MOD_NEK2_1	95	100	PF00069	0.462
MOD_PIKK_1	151	157	PF00454	0.594
MOD_PIKK_1	30	36	PF00454	0.625
MOD_PKA_2	190	196	PF00069	0.759
MOD_PKB_1	161	169	PF00069	0.682
MOD_Plk_4	95	101	PF00069	0.529
MOD_ProDKin_1	117	123	PF00069	0.740
MOD_ProDKin_1	199	205	PF00069	0.729
TRG_ENDOCYTIC_2	229	232	PF00928	0.518
TRG_ENDOCYTIC_2	96	99	PF00928	0.631
TRG_ER_diArg_1	208	210	PF00400	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F5	Leptomonas seymouri	49%	100%
A0A3Q8IDE0	Leishmania donovani	92%	100%
A0A3R7KEI8	Trypanosoma rangeli	31%	100%
A4H831	Leishmania braziliensis	73%	100%
A4HWF7	Leishmania infantum	92%	100%
C9ZNZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQ56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%