CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QFC4_LEIMA

TriTrypDb:

LmjF.15.0610 , LMJLV39_150011900 , LMJSD75_150012000

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.425
CLV_C14_Caspase3-7	393	397	PF00656	0.788
CLV_NRD_NRD_1	115	117	PF00675	0.590
CLV_NRD_NRD_1	256	258	PF00675	0.390
CLV_NRD_NRD_1	35	37	PF00675	0.469
CLV_NRD_NRD_1	511	513	PF00675	0.557
CLV_PCSK_KEX2_1	115	117	PF00082	0.590
CLV_PCSK_KEX2_1	197	199	PF00082	0.504
CLV_PCSK_KEX2_1	217	219	PF00082	0.400
CLV_PCSK_KEX2_1	256	258	PF00082	0.390
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.504
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.376
CLV_PCSK_SKI1_1	169	173	PF00082	0.465
CLV_PCSK_SKI1_1	181	185	PF00082	0.537
CLV_PCSK_SKI1_1	315	319	PF00082	0.408
CLV_PCSK_SKI1_1	36	40	PF00082	0.484
CLV_PCSK_SKI1_1	366	370	PF00082	0.408
CLV_PCSK_SKI1_1	416	420	PF00082	0.618
CLV_PCSK_SKI1_1	508	512	PF00082	0.541
CLV_PCSK_SKI1_1	88	92	PF00082	0.485
DEG_APCC_DBOX_1	245	253	PF00400	0.408
DEG_APCC_DBOX_1	374	382	PF00400	0.385
DEG_SCF_FBW7_1	236	241	PF00400	0.408
DOC_CYCLIN_RxL_1	316	330	PF00134	0.509
DOC_MAPK_gen_1	115	121	PF00069	0.585
DOC_MAPK_gen_1	197	203	PF00069	0.496
DOC_MAPK_gen_1	315	326	PF00069	0.509
DOC_MAPK_gen_1	36	42	PF00069	0.455
DOC_MAPK_gen_1	88	96	PF00069	0.513
DOC_PP2B_LxvP_1	94	97	PF13499	0.577
DOC_SPAK_OSR1_1	110	114	PF12202	0.446
DOC_USP7_MATH_1	501	505	PF00917	0.451
DOC_USP7_UBL2_3	315	319	PF12436	0.408
DOC_WW_Pin1_4	169	174	PF00397	0.593
DOC_WW_Pin1_4	234	239	PF00397	0.401
DOC_WW_Pin1_4	402	407	PF00397	0.604
DOC_WW_Pin1_4	442	447	PF00397	0.518
DOC_WW_Pin1_4	449	454	PF00397	0.591
LIG_14-3-3_CanoR_1	322	327	PF00244	0.509
LIG_14-3-3_CanoR_1	375	379	PF00244	0.385
LIG_Actin_RPEL_3	108	127	PF02755	0.459
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BRCT_BRCA1_1	444	448	PF00533	0.536
LIG_CtBP_PxDLS_1	333	337	PF00389	0.406
LIG_CtBP_PxDLS_1	79	83	PF00389	0.600
LIG_deltaCOP1_diTrp_1	497	502	PF00928	0.509
LIG_FHA_1	121	127	PF00498	0.555
LIG_FHA_1	178	184	PF00498	0.659
LIG_FHA_1	294	300	PF00498	0.408
LIG_FHA_1	403	409	PF00498	0.584
LIG_FHA_2	281	287	PF00498	0.406
LIG_FHA_2	375	381	PF00498	0.385
LIG_FHA_2	408	414	PF00498	0.570
LIG_FHA_2	81	87	PF00498	0.664
LIG_LIR_Gen_1	232	240	PF02991	0.428
LIG_LIR_Gen_1	497	505	PF02991	0.489
LIG_LIR_Nem_3	106	112	PF02991	0.375
LIG_LIR_Nem_3	128	132	PF02991	0.331
LIG_LIR_Nem_3	148	154	PF02991	0.554
LIG_LIR_Nem_3	216	222	PF02991	0.408
LIG_LIR_Nem_3	232	236	PF02991	0.408
LIG_LIR_Nem_3	237	243	PF02991	0.405
LIG_LIR_Nem_3	497	502	PF02991	0.509
LIG_MYND_1	357	361	PF01753	0.408
LIG_MYND_1	476	480	PF01753	0.463
LIG_Pex14_1	188	192	PF04695	0.365
LIG_Pex14_2	348	352	PF04695	0.408
LIG_Pex14_2	431	435	PF04695	0.440
LIG_PTB_Apo_2	227	234	PF02174	0.384
LIG_PTB_Apo_2	340	347	PF02174	0.408
LIG_PTB_Apo_2	457	464	PF02174	0.558
LIG_SH2_CRK	109	113	PF00017	0.435
LIG_SH2_CRK	204	208	PF00017	0.408
LIG_SH2_CRK	240	244	PF00017	0.520
LIG_SH2_GRB2like	240	243	PF00017	0.408
LIG_SH2_SRC	221	224	PF00017	0.408
LIG_SH2_STAP1	11	15	PF00017	0.595
LIG_SH2_STAP1	240	244	PF00017	0.408
LIG_SH2_STAT3	264	267	PF00017	0.384
LIG_SH2_STAT5	129	132	PF00017	0.414
LIG_SH2_STAT5	192	195	PF00017	0.365
LIG_SH2_STAT5	221	224	PF00017	0.408
LIG_SH2_STAT5	248	251	PF00017	0.408
LIG_SH2_STAT5	268	271	PF00017	0.180
LIG_SH2_STAT5	426	429	PF00017	0.478
LIG_SH3_3	233	239	PF00018	0.496
LIG_SH3_3	440	446	PF00018	0.607
LIG_SH3_3	53	59	PF00018	0.574
LIG_SH3_3	73	79	PF00018	0.497
LIG_SUMO_SIM_par_1	296	303	PF11976	0.408
LIG_SUMO_SIM_par_1	322	327	PF11976	0.426
LIG_SUMO_SIM_par_1	366	371	PF11976	0.408
LIG_TYR_ITIM	107	112	PF00017	0.532
LIG_UBA3_1	126	135	PF00899	0.464
LIG_UBA3_1	93	101	PF00899	0.567
MOD_CDC14_SPxK_1	452	455	PF00782	0.564
MOD_CDK_SPxK_1	449	455	PF00069	0.555
MOD_CDK_SPxxK_3	169	176	PF00069	0.631
MOD_CK1_1	137	143	PF00069	0.429
MOD_CK1_1	284	290	PF00069	0.440
MOD_CK1_1	307	313	PF00069	0.468
MOD_CK1_1	382	388	PF00069	0.427
MOD_CK1_1	391	397	PF00069	0.697
MOD_CK2_1	374	380	PF00069	0.385
MOD_CK2_1	407	413	PF00069	0.671
MOD_CK2_1	453	459	PF00069	0.550
MOD_CK2_1	501	507	PF00069	0.601
MOD_CMANNOS	188	191	PF00535	0.384
MOD_Cter_Amidation	254	257	PF01082	0.408
MOD_GlcNHglycan	370	373	PF01048	0.397
MOD_GlcNHglycan	72	75	PF01048	0.786
MOD_GSK3_1	234	241	PF00069	0.374
MOD_GSK3_1	276	283	PF00069	0.472
MOD_GSK3_1	300	307	PF00069	0.359
MOD_GSK3_1	370	377	PF00069	0.412
MOD_GSK3_1	382	389	PF00069	0.386
MOD_GSK3_1	449	456	PF00069	0.526
MOD_GSK3_1	513	520	PF00069	0.608
MOD_N-GLC_1	16	21	PF02516	0.549
MOD_N-GLC_1	334	339	PF02516	0.406
MOD_N-GLC_1	394	399	PF02516	0.721
MOD_N-GLC_1	80	85	PF02516	0.579
MOD_NEK2_1	309	314	PF00069	0.387
MOD_NEK2_1	324	329	PF00069	0.442
MOD_NEK2_1	370	375	PF00069	0.377
MOD_PIKK_1	360	366	PF00454	0.408
MOD_PIKK_1	386	392	PF00454	0.704
MOD_PIKK_1	514	520	PF00454	0.569
MOD_PKA_1	256	262	PF00069	0.408
MOD_PKA_2	256	262	PF00069	0.351
MOD_PKA_2	374	380	PF00069	0.385
MOD_PKA_2	51	57	PF00069	0.474
MOD_Plk_1	334	340	PF00069	0.406
MOD_Plk_1	506	512	PF00069	0.499
MOD_Plk_1	80	86	PF00069	0.571
MOD_Plk_2-3	134	140	PF00069	0.435
MOD_Plk_2-3	80	86	PF00069	0.696
MOD_Plk_4	125	131	PF00069	0.411
MOD_Plk_4	137	143	PF00069	0.509
MOD_Plk_4	284	290	PF00069	0.426
MOD_Plk_4	327	333	PF00069	0.425
MOD_Plk_4	431	437	PF00069	0.443
MOD_ProDKin_1	169	175	PF00069	0.597
MOD_ProDKin_1	234	240	PF00069	0.401
MOD_ProDKin_1	402	408	PF00069	0.600
MOD_ProDKin_1	442	448	PF00069	0.523
MOD_ProDKin_1	449	455	PF00069	0.594
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.547
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.408
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.440
TRG_ENDOCYTIC_2	109	112	PF00928	0.375
TRG_ENDOCYTIC_2	129	132	PF00928	0.223
TRG_ENDOCYTIC_2	192	195	PF00928	0.365
TRG_ENDOCYTIC_2	240	243	PF00928	0.404
TRG_ER_diArg_1	115	117	PF00400	0.590
TRG_ER_diArg_1	256	258	PF00400	0.408
TRG_ER_diArg_1	470	473	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ3	Leptomonas seymouri	66%	100%
A0A3Q8IC92	Leishmania donovani	96%	100%
A4H834	Leishmania braziliensis	78%	100%
E9AQ59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%