DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFC3_LEIMA

TriTrypDb:

LmjF.15.0620 , LMJLV39_150012000 , LMJSD75_150012100

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	348	350	PF00675	0.558
CLV_NRD_NRD_1	395	397	PF00675	0.585
CLV_NRD_NRD_1	428	430	PF00675	0.510
CLV_NRD_NRD_1	77	79	PF00675	0.747
CLV_PCSK_KEX2_1	260	262	PF00082	0.465
CLV_PCSK_KEX2_1	330	332	PF00082	0.664
CLV_PCSK_KEX2_1	348	350	PF00082	0.570
CLV_PCSK_KEX2_1	395	397	PF00082	0.678
CLV_PCSK_KEX2_1	428	430	PF00082	0.541
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.574
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.664
CLV_PCSK_SKI1_1	117	121	PF00082	0.444
CLV_PCSK_SKI1_1	159	163	PF00082	0.449
CLV_PCSK_SKI1_1	221	225	PF00082	0.445
CLV_PCSK_SKI1_1	239	243	PF00082	0.437
CLV_PCSK_SKI1_1	444	448	PF00082	0.536
DEG_APCC_DBOX_1	116	124	PF00400	0.499
DEG_APCC_DBOX_1	398	406	PF00400	0.464
DOC_ANK_TNKS_1	162	169	PF00023	0.594
DOC_CKS1_1	152	157	PF01111	0.403
DOC_CKS1_1	351	356	PF01111	0.503
DOC_CYCLIN_RxL_1	236	245	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.787
DOC_MAPK_gen_1	219	228	PF00069	0.457
DOC_MAPK_gen_1	329	337	PF00069	0.659
DOC_PP2B_LxvP_1	11	14	PF13499	0.546
DOC_PP4_FxxP_1	150	153	PF00568	0.372
DOC_PP4_FxxP_1	419	422	PF00568	0.490
DOC_PP4_FxxP_1	58	61	PF00568	0.291
DOC_USP7_MATH_1	102	106	PF00917	0.649
DOC_USP7_MATH_1	42	46	PF00917	0.674
DOC_USP7_MATH_1	442	446	PF00917	0.586
DOC_USP7_MATH_1	91	95	PF00917	0.793
DOC_USP7_UBL2_3	79	83	PF12436	0.687
DOC_WW_Pin1_4	151	156	PF00397	0.379
DOC_WW_Pin1_4	267	272	PF00397	0.564
DOC_WW_Pin1_4	28	33	PF00397	0.725
DOC_WW_Pin1_4	350	355	PF00397	0.475
DOC_WW_Pin1_4	82	87	PF00397	0.695
LIG_14-3-3_CanoR_1	221	226	PF00244	0.462
LIG_14-3-3_CterR_2	444	448	PF00244	0.564
LIG_Actin_WH2_2	219	234	PF00022	0.402
LIG_APCC_ABBA_1	210	215	PF00400	0.618
LIG_BIR_II_1	1	5	PF00653	0.772
LIG_BIR_III_2	109	113	PF00653	0.489
LIG_BRCT_BRCA1_1	244	248	PF00533	0.541
LIG_BRCT_BRCA1_1	357	361	PF00533	0.466
LIG_FHA_1	17	23	PF00498	0.746
LIG_FHA_1	402	408	PF00498	0.457
LIG_FHA_2	280	286	PF00498	0.636
LIG_FHA_2	323	329	PF00498	0.484
LIG_FHA_2	98	104	PF00498	0.703
LIG_LIR_Apic_2	148	153	PF02991	0.391
LIG_LIR_Gen_1	198	205	PF02991	0.630
LIG_LIR_Gen_1	224	233	PF02991	0.425
LIG_LIR_Gen_1	51	61	PF02991	0.473
LIG_LIR_Nem_3	141	147	PF02991	0.495
LIG_LIR_Nem_3	167	173	PF02991	0.632
LIG_LIR_Nem_3	197	203	PF02991	0.627
LIG_LIR_Nem_3	224	228	PF02991	0.457
LIG_LIR_Nem_3	51	56	PF02991	0.468
LIG_MYND_1	9	13	PF01753	0.556
LIG_Pex14_2	126	130	PF04695	0.391
LIG_Pex14_2	146	150	PF04695	0.211
LIG_SH2_CRK	170	174	PF00017	0.668
LIG_SH2_CRK	352	356	PF00017	0.574
LIG_SH2_NCK_1	352	356	PF00017	0.574
LIG_SH2_NCK_1	63	67	PF00017	0.488
LIG_SH2_STAT5	145	148	PF00017	0.453
LIG_SH2_STAT5	200	203	PF00017	0.511
LIG_SH2_STAT5	225	228	PF00017	0.420
LIG_SH2_STAT5	352	355	PF00017	0.613
LIG_SH2_STAT5	401	404	PF00017	0.446
LIG_SH3_1	348	354	PF00018	0.578
LIG_SH3_3	152	158	PF00018	0.412
LIG_SH3_3	170	176	PF00018	0.613
LIG_SH3_3	348	354	PF00018	0.478
LIG_SH3_3	35	41	PF00018	0.689
LIG_SH3_3	402	408	PF00018	0.418
LIG_SH3_3	6	12	PF00018	0.728
LIG_SUMO_SIM_par_1	439	445	PF11976	0.519
LIG_TRAF2_1	13	16	PF00917	0.778
LIG_TRAF2_1	325	328	PF00917	0.657
LIG_TRAF2_1	362	365	PF00917	0.481
LIG_TRFH_1	201	205	PF08558	0.661
LIG_UBA3_1	360	366	PF00899	0.517
LIG_UBA3_1	440	447	PF00899	0.578
LIG_WRC_WIRS_1	147	152	PF05994	0.391
MOD_CDK_SPK_2	151	156	PF00069	0.398
MOD_CDK_SPxxK_3	350	357	PF00069	0.499
MOD_CK1_1	251	257	PF00069	0.573
MOD_CK1_1	31	37	PF00069	0.788
MOD_CK1_1	322	328	PF00069	0.484
MOD_CK1_1	51	57	PF00069	0.337
MOD_CK1_1	77	83	PF00069	0.775
MOD_CK1_1	85	91	PF00069	0.812
MOD_CK1_1	94	100	PF00069	0.501
MOD_CK2_1	161	167	PF00069	0.572
MOD_CK2_1	279	285	PF00069	0.684
MOD_CK2_1	322	328	PF00069	0.683
MOD_CK2_1	359	365	PF00069	0.448
MOD_GlcNHglycan	276	279	PF01048	0.637
MOD_GlcNHglycan	313	316	PF01048	0.723
MOD_GlcNHglycan	432	435	PF01048	0.521
MOD_GlcNHglycan	44	47	PF01048	0.642
MOD_GlcNHglycan	53	56	PF01048	0.393
MOD_GlcNHglycan	79	82	PF01048	0.768
MOD_GlcNHglycan	87	90	PF01048	0.757
MOD_GlcNHglycan	97	100	PF01048	0.635
MOD_GSK3_1	16	23	PF00069	0.739
MOD_GSK3_1	190	197	PF00069	0.677
MOD_GSK3_1	281	288	PF00069	0.585
MOD_GSK3_1	319	326	PF00069	0.632
MOD_GSK3_1	355	362	PF00069	0.440
MOD_GSK3_1	70	77	PF00069	0.638
MOD_GSK3_1	81	88	PF00069	0.635
MOD_GSK3_1	91	98	PF00069	0.666
MOD_N-GLC_1	195	200	PF02516	0.659
MOD_N-GLC_1	248	253	PF02516	0.635
MOD_N-GLC_1	265	270	PF02516	0.430
MOD_N-GLC_1	291	296	PF02516	0.704
MOD_NEK2_1	1	6	PF00069	0.743
MOD_NEK2_1	146	151	PF00069	0.413
MOD_NEK2_1	189	194	PF00069	0.701
MOD_NEK2_1	242	247	PF00069	0.558
MOD_NEK2_1	274	279	PF00069	0.616
MOD_NEK2_2	442	447	PF00069	0.584
MOD_PKA_2	285	291	PF00069	0.552
MOD_PKA_2	387	393	PF00069	0.637
MOD_PKA_2	77	83	PF00069	0.719
MOD_Plk_1	102	108	PF00069	0.660
MOD_Plk_1	195	201	PF00069	0.643
MOD_Plk_1	436	442	PF00069	0.547
MOD_Plk_4	333	339	PF00069	0.438
MOD_Plk_4	436	442	PF00069	0.547
MOD_ProDKin_1	151	157	PF00069	0.381
MOD_ProDKin_1	267	273	PF00069	0.561
MOD_ProDKin_1	28	34	PF00069	0.726
MOD_ProDKin_1	350	356	PF00069	0.477
MOD_ProDKin_1	82	88	PF00069	0.695
MOD_SUMO_rev_2	240	248	PF00179	0.442
MOD_SUMO_rev_2	322	332	PF00179	0.603
MOD_SUMO_rev_2	358	367	PF00179	0.509
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.535
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.455
TRG_ENDOCYTIC_2	144	147	PF00928	0.469
TRG_ENDOCYTIC_2	170	173	PF00928	0.669
TRG_ENDOCYTIC_2	200	203	PF00928	0.611
TRG_ENDOCYTIC_2	225	228	PF00928	0.414
TRG_ENDOCYTIC_2	352	355	PF00928	0.571
TRG_ER_diArg_1	348	350	PF00400	0.570
TRG_NES_CRM1_1	218	229	PF08389	0.441
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I615	Leptomonas seymouri	71%	100%
A0A1X0NTS1	Trypanosomatidae	37%	100%
A0A3S5H6U7	Leishmania donovani	93%	100%
A0A422NLQ5	Trypanosoma rangeli	37%	100%
A4H835	Leishmania braziliensis	78%	99%
A4HWG0	Leishmania infantum	93%	100%
C9ZP02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQ60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%