Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFC0_LEIMA

TriTrypDb:

LmjF.15.0650 , LMJLV39_150012300 , LMJSD75_150012400

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.679
CLV_C14_Caspase3-7	213	217	PF00656	0.620
CLV_C14_Caspase3-7	623	627	PF00656	0.714
CLV_NRD_NRD_1	511	513	PF00675	0.658
CLV_PCSK_FUR_1	509	513	PF00082	0.653
CLV_PCSK_KEX2_1	208	210	PF00082	0.670
CLV_PCSK_KEX2_1	269	271	PF00082	0.605
CLV_PCSK_KEX2_1	511	513	PF00082	0.658
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.670
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.605
CLV_PCSK_SKI1_1	410	414	PF00082	0.680
CLV_PCSK_SKI1_1	58	62	PF00082	0.613
DEG_SCF_FBW7_1	21	28	PF00400	0.787
DEG_SPOP_SBC_1	301	305	PF00917	0.644
DEG_SPOP_SBC_1	353	357	PF00917	0.702
DEG_SPOP_SBC_1	559	563	PF00917	0.691
DOC_ANK_TNKS_1	269	276	PF00023	0.692
DOC_CKS1_1	22	27	PF01111	0.835
DOC_CKS1_1	343	348	PF01111	0.796
DOC_CKS1_1	54	59	PF01111	0.557
DOC_CYCLIN_RxL_1	55	64	PF00134	0.633
DOC_CYCLIN_yCln2_LP_2	398	401	PF00134	0.589
DOC_PP1_RVXF_1	56	62	PF00149	0.633
DOC_PP2B_LxvP_1	246	249	PF13499	0.629
DOC_PP2B_LxvP_1	398	401	PF13499	0.589
DOC_PP2B_LxvP_1	412	415	PF13499	0.589
DOC_PP4_MxPP_1	247	250	PF00568	0.734
DOC_PP4_MxPP_1	298	301	PF00568	0.771
DOC_USP7_MATH_1	118	122	PF00917	0.728
DOC_USP7_MATH_1	195	199	PF00917	0.812
DOC_USP7_MATH_1	229	233	PF00917	0.688
DOC_USP7_MATH_1	264	268	PF00917	0.658
DOC_USP7_MATH_1	301	305	PF00917	0.644
DOC_USP7_MATH_1	319	323	PF00917	0.678
DOC_USP7_MATH_1	333	337	PF00917	0.641
DOC_USP7_MATH_1	352	356	PF00917	0.490
DOC_USP7_MATH_1	386	390	PF00917	0.679
DOC_USP7_MATH_1	620	624	PF00917	0.821
DOC_WW_Pin1_4	139	144	PF00397	0.778
DOC_WW_Pin1_4	163	168	PF00397	0.704
DOC_WW_Pin1_4	17	22	PF00397	0.774
DOC_WW_Pin1_4	183	188	PF00397	0.727
DOC_WW_Pin1_4	198	203	PF00397	0.654
DOC_WW_Pin1_4	224	229	PF00397	0.640
DOC_WW_Pin1_4	25	30	PF00397	0.643
DOC_WW_Pin1_4	250	255	PF00397	0.620
DOC_WW_Pin1_4	257	262	PF00397	0.665
DOC_WW_Pin1_4	288	293	PF00397	0.626
DOC_WW_Pin1_4	296	301	PF00397	0.672
DOC_WW_Pin1_4	326	331	PF00397	0.764
DOC_WW_Pin1_4	342	347	PF00397	0.634
DOC_WW_Pin1_4	354	359	PF00397	0.646
DOC_WW_Pin1_4	45	50	PF00397	0.785
DOC_WW_Pin1_4	53	58	PF00397	0.705
DOC_WW_Pin1_4	69	74	PF00397	0.694
LIG_14-3-3_CanoR_1	16	20	PF00244	0.794
LIG_14-3-3_CanoR_1	302	311	PF00244	0.642
LIG_14-3-3_CanoR_1	410	415	PF00244	0.710
LIG_14-3-3_CanoR_1	424	429	PF00244	0.518
LIG_14-3-3_CanoR_1	58	64	PF00244	0.636
LIG_14-3-3_CanoR_1	67	73	PF00244	0.641
LIG_APCC_ABBA_1	651	656	PF00400	0.718
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	434	438	PF00533	0.562
LIG_BRCT_BRCA1_1	647	651	PF00533	0.653
LIG_BRCT_BRCA1_1	656	660	PF00533	0.573
LIG_Clathr_ClatBox_1	279	283	PF01394	0.616
LIG_CtBP_PxDLS_1	249	253	PF00389	0.632
LIG_deltaCOP1_diTrp_1	656	660	PF00928	0.744
LIG_EVH1_1	399	403	PF00568	0.565
LIG_FHA_1	106	112	PF00498	0.786
LIG_FHA_1	171	177	PF00498	0.728
LIG_FHA_1	343	349	PF00498	0.747
LIG_FHA_1	45	51	PF00498	0.825
LIG_FHA_1	484	490	PF00498	0.595
LIG_FHA_1	54	60	PF00498	0.563
LIG_FHA_1	74	80	PF00498	0.510
LIG_FHA_2	114	120	PF00498	0.725
LIG_FHA_2	461	467	PF00498	0.709
LIG_FHA_2	471	477	PF00498	0.584
LIG_IBAR_NPY_1	341	343	PF08397	0.611
LIG_IBAR_NPY_1	652	654	PF08397	0.589
LIG_IRF3_LxIS_1	148	153	PF10401	0.760
LIG_LIR_Gen_1	435	446	PF02991	0.711
LIG_LIR_Gen_1	476	484	PF02991	0.549
LIG_LIR_Nem_3	310	314	PF02991	0.700
LIG_LIR_Nem_3	435	441	PF02991	0.569
LIG_LIR_Nem_3	476	481	PF02991	0.534
LIG_LIR_Nem_3	62	66	PF02991	0.634
LIG_LIR_Nem_3	648	654	PF02991	0.593
LIG_PAM2_1	649	661	PF00658	0.602
LIG_PROFILIN_1	400	406	PF00235	0.692
LIG_PTAP_UEV_1	201	206	PF05743	0.583
LIG_PTAP_UEV_1	260	265	PF05743	0.631
LIG_SH2_CRK	343	347	PF00017	0.746
LIG_SH2_CRK	66	70	PF00017	0.641
LIG_SH2_SRC	654	657	PF00017	0.731
LIG_SH2_STAP1	471	475	PF00017	0.670
LIG_SH2_STAP1	616	620	PF00017	0.759
LIG_SH2_STAP1	654	658	PF00017	0.601
LIG_SH2_STAT3	527	530	PF00017	0.771
LIG_SH2_STAT5	220	223	PF00017	0.636
LIG_SH2_STAT5	311	314	PF00017	0.559
LIG_SH2_STAT5	428	431	PF00017	0.642
LIG_SH3_1	397	403	PF00018	0.571
LIG_SH3_3	199	205	PF00018	0.655
LIG_SH3_3	255	261	PF00018	0.657
LIG_SH3_3	327	333	PF00018	0.761
LIG_SH3_3	397	403	PF00018	0.571
LIG_SH3_3	442	448	PF00018	0.628
LIG_SH3_3	51	57	PF00018	0.664
LIG_SUMO_SIM_anti_2	380	385	PF11976	0.517
LIG_SUMO_SIM_par_1	148	153	PF11976	0.633
LIG_SUMO_SIM_par_1	172	177	PF11976	0.661
LIG_SUMO_SIM_par_1	278	283	PF11976	0.683
LIG_TRAF2_1	463	466	PF00917	0.589
LIG_TRAF2_1	87	90	PF00917	0.730
LIG_WW_2	403	406	PF00397	0.685
LIG_WW_3	299	303	PF00397	0.644
MOD_CDC14_SPxK_1	299	302	PF00782	0.643
MOD_CDK_SPK_2	183	188	PF00069	0.586
MOD_CDK_SPK_2	53	58	PF00069	0.608
MOD_CDK_SPxK_1	296	302	PF00069	0.648
MOD_CK1_1	106	112	PF00069	0.659
MOD_CK1_1	132	138	PF00069	0.640
MOD_CK1_1	139	145	PF00069	0.707
MOD_CK1_1	170	176	PF00069	0.779
MOD_CK1_1	186	192	PF00069	0.672
MOD_CK1_1	197	203	PF00069	0.773
MOD_CK1_1	2	8	PF00069	0.650
MOD_CK1_1	227	233	PF00069	0.627
MOD_CK1_1	237	243	PF00069	0.656
MOD_CK1_1	285	291	PF00069	0.618
MOD_CK1_1	303	309	PF00069	0.711
MOD_CK1_1	310	316	PF00069	0.663
MOD_CK1_1	324	330	PF00069	0.660
MOD_CK1_1	389	395	PF00069	0.686
MOD_CK1_1	450	456	PF00069	0.677
MOD_CK1_1	459	465	PF00069	0.723
MOD_CK1_1	507	513	PF00069	0.738
MOD_CK1_1	515	521	PF00069	0.684
MOD_CK1_1	614	620	PF00069	0.695
MOD_CK1_1	661	667	PF00069	0.641
MOD_CK2_1	113	119	PF00069	0.790
MOD_CK2_1	459	465	PF00069	0.596
MOD_GlcNHglycan	119	123	PF01048	0.748
MOD_GlcNHglycan	125	128	PF01048	0.744
MOD_GlcNHglycan	138	141	PF01048	0.578
MOD_GlcNHglycan	152	155	PF01048	0.674
MOD_GlcNHglycan	169	172	PF01048	0.576
MOD_GlcNHglycan	202	205	PF01048	0.715
MOD_GlcNHglycan	212	215	PF01048	0.686
MOD_GlcNHglycan	231	234	PF01048	0.652
MOD_GlcNHglycan	261	264	PF01048	0.631
MOD_GlcNHglycan	326	329	PF01048	0.809
MOD_GlcNHglycan	390	394	PF01048	0.678
MOD_GlcNHglycan	506	509	PF01048	0.633
MOD_GlcNHglycan	518	521	PF01048	0.671
MOD_GlcNHglycan	535	538	PF01048	0.686
MOD_GlcNHglycan	604	607	PF01048	0.800
MOD_GlcNHglycan	613	616	PF01048	0.579
MOD_GlcNHglycan	622	625	PF01048	0.815
MOD_GlcNHglycan	660	663	PF01048	0.630
MOD_GlcNHglycan	76	79	PF01048	0.774
MOD_GSK3_1	103	110	PF00069	0.654
MOD_GSK3_1	113	120	PF00069	0.664
MOD_GSK3_1	128	135	PF00069	0.586
MOD_GSK3_1	163	170	PF00069	0.747
MOD_GSK3_1	17	24	PF00069	0.752
MOD_GSK3_1	194	201	PF00069	0.656
MOD_GSK3_1	223	230	PF00069	0.565
MOD_GSK3_1	25	32	PF00069	0.647
MOD_GSK3_1	250	257	PF00069	0.636
MOD_GSK3_1	284	291	PF00069	0.624
MOD_GSK3_1	296	303	PF00069	0.684
MOD_GSK3_1	448	455	PF00069	0.635
MOD_GSK3_1	456	463	PF00069	0.615
MOD_GSK3_1	512	519	PF00069	0.691
MOD_GSK3_1	584	591	PF00069	0.565
MOD_GSK3_1	614	621	PF00069	0.608
MOD_GSK3_1	654	661	PF00069	0.612
MOD_GSK3_1	69	76	PF00069	0.647
MOD_N-GLC_1	111	116	PF02516	0.666
MOD_N-GLC_1	132	137	PF02516	0.646
MOD_N-GLC_1	25	30	PF02516	0.722
MOD_N-GLC_1	250	255	PF02516	0.642
MOD_N-GLC_1	288	293	PF02516	0.726
MOD_N-GLC_1	459	464	PF02516	0.723
MOD_N-GLC_1	516	521	PF02516	0.677
MOD_N-GLC_1	67	72	PF02516	0.769
MOD_N-GLC_1	74	79	PF02516	0.693
MOD_NEK2_1	1	6	PF00069	0.782
MOD_NEK2_1	150	155	PF00069	0.639
MOD_NEK2_1	169	174	PF00069	0.668
MOD_NEK2_1	222	227	PF00069	0.609
MOD_NEK2_1	282	287	PF00069	0.570
MOD_NEK2_1	660	665	PF00069	0.794
MOD_PIKK_1	174	180	PF00454	0.758
MOD_PIKK_1	264	270	PF00454	0.790
MOD_PIKK_1	29	35	PF00454	0.724
MOD_PIKK_1	512	518	PF00454	0.790
MOD_PIKK_1	8	14	PF00454	0.775
MOD_PKA_1	208	214	PF00069	0.624
MOD_PKA_2	128	134	PF00069	0.782
MOD_PKA_2	15	21	PF00069	0.791
MOD_PKA_2	208	214	PF00069	0.624
MOD_PKA_2	301	307	PF00069	0.781
MOD_PKA_2	602	608	PF00069	0.772
MOD_Plk_1	618	624	PF00069	0.575
MOD_Plk_1	74	80	PF00069	0.693
MOD_Plk_4	307	313	PF00069	0.580
MOD_Plk_4	321	327	PF00069	0.632
MOD_Plk_4	424	430	PF00069	0.501
MOD_ProDKin_1	139	145	PF00069	0.776
MOD_ProDKin_1	163	169	PF00069	0.706
MOD_ProDKin_1	17	23	PF00069	0.774
MOD_ProDKin_1	183	189	PF00069	0.726
MOD_ProDKin_1	198	204	PF00069	0.654
MOD_ProDKin_1	224	230	PF00069	0.639
MOD_ProDKin_1	25	31	PF00069	0.644
MOD_ProDKin_1	250	256	PF00069	0.622
MOD_ProDKin_1	257	263	PF00069	0.666
MOD_ProDKin_1	288	294	PF00069	0.629
MOD_ProDKin_1	296	302	PF00069	0.674
MOD_ProDKin_1	326	332	PF00069	0.759
MOD_ProDKin_1	342	348	PF00069	0.634
MOD_ProDKin_1	354	360	PF00069	0.647
MOD_ProDKin_1	45	51	PF00069	0.784
MOD_ProDKin_1	53	59	PF00069	0.705
MOD_ProDKin_1	69	75	PF00069	0.698
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.575
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.631
TRG_ENDOCYTIC_2	66	69	PF00928	0.642
TRG_ENDOCYTIC_2	680	683	PF00928	0.774
TRG_ER_diArg_1	509	512	PF00400	0.651
TRG_ER_diArg_1	538	541	PF00400	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J0	Leptomonas seymouri	37%	95%
A0A3S5H6U8	Leishmania donovani	90%	98%
A4HWG3	Leishmania infantum	89%	98%
E9AI50	Leishmania braziliensis	75%	98%
E9AQ63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	96%