Rix1 complex component

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFB9_LEIMA

TriTrypDb:

LmjF.15.0660 , LMJLV39_150012400 , LMJSD75_150012500

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.793
CLV_C14_Caspase3-7	393	397	PF00656	0.744
CLV_NRD_NRD_1	122	124	PF00675	0.555
CLV_NRD_NRD_1	209	211	PF00675	0.599
CLV_NRD_NRD_1	259	261	PF00675	0.657
CLV_NRD_NRD_1	288	290	PF00675	0.646
CLV_NRD_NRD_1	292	294	PF00675	0.695
CLV_PCSK_FUR_1	207	211	PF00082	0.600
CLV_PCSK_KEX2_1	203	205	PF00082	0.567
CLV_PCSK_KEX2_1	209	211	PF00082	0.599
CLV_PCSK_KEX2_1	259	261	PF00082	0.657
CLV_PCSK_KEX2_1	288	290	PF00082	0.646
CLV_PCSK_KEX2_1	292	294	PF00082	0.695
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.582
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.646
CLV_PCSK_SKI1_1	385	389	PF00082	0.808
CLV_Separin_Metazoa	99	103	PF03568	0.581
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.514
DOC_MAPK_gen_1	292	302	PF00069	0.708
DOC_PP2B_LxvP_1	113	116	PF13499	0.522
DOC_PP2B_LxvP_1	88	91	PF13499	0.694
DOC_PP4_FxxP_1	87	90	PF00568	0.706
DOC_PP4_MxPP_1	112	115	PF00568	0.549
DOC_USP7_MATH_1	211	215	PF00917	0.499
DOC_USP7_MATH_1	258	262	PF00917	0.503
DOC_USP7_MATH_1	29	33	PF00917	0.755
DOC_USP7_MATH_1	379	383	PF00917	0.523
DOC_USP7_MATH_1	399	403	PF00917	0.682
DOC_WW_Pin1_4	240	245	PF00397	0.826
DOC_WW_Pin1_4	35	40	PF00397	0.678
DOC_WW_Pin1_4	432	437	PF00397	0.660
DOC_WW_Pin1_4	80	85	PF00397	0.721
LIG_14-3-3_CanoR_1	187	195	PF00244	0.430
LIG_14-3-3_CanoR_1	259	268	PF00244	0.568
LIG_14-3-3_CanoR_1	452	459	PF00244	0.685
LIG_Actin_WH2_2	436	454	PF00022	0.740
LIG_BIR_III_2	433	437	PF00653	0.697
LIG_BRCT_BRCA1_1	454	458	PF00533	0.810
LIG_FHA_1	116	122	PF00498	0.518
LIG_FHA_1	313	319	PF00498	0.803
LIG_FHA_1	446	452	PF00498	0.715
LIG_FHA_1	467	473	PF00498	0.597
LIG_FHA_2	452	458	PF00498	0.762
LIG_LIR_Apic_2	86	90	PF02991	0.716
LIG_LIR_Gen_1	386	395	PF02991	0.726
LIG_LIR_Gen_1	41	50	PF02991	0.789
LIG_LIR_Nem_3	179	184	PF02991	0.503
LIG_LIR_Nem_3	382	387	PF02991	0.711
LIG_LIR_Nem_3	41	45	PF02991	0.698
LIG_SH2_CRK	181	185	PF00017	0.487
LIG_SH2_CRK	42	46	PF00017	0.770
LIG_SH2_GRB2like	366	369	PF00017	0.726
LIG_SH2_NCK_1	360	364	PF00017	0.670
LIG_SH2_NCK_1	42	46	PF00017	0.794
LIG_SH2_SRC	366	369	PF00017	0.713
LIG_SH2_STAT5	360	363	PF00017	0.724
LIG_SH3_3	222	228	PF00018	0.713
LIG_SH3_3	244	250	PF00018	0.769
LIG_SH3_3	327	333	PF00018	0.724
LIG_SH3_3	342	348	PF00018	0.605
LIG_SH3_3	422	428	PF00018	0.795
LIG_SH3_3	440	446	PF00018	0.685
LIG_TRAF2_1	214	217	PF00917	0.527
LIG_TRAF2_1	475	478	PF00917	0.683
LIG_WRC_WIRS_1	384	389	PF05994	0.712
MOD_CK1_1	242	248	PF00069	0.625
MOD_CK1_1	309	315	PF00069	0.597
MOD_CK1_1	38	44	PF00069	0.700
MOD_CK1_1	383	389	PF00069	0.689
MOD_CK1_1	406	412	PF00069	0.699
MOD_CK1_1	83	89	PF00069	0.647
MOD_CK2_1	124	130	PF00069	0.595
MOD_CK2_1	211	217	PF00069	0.516
MOD_CK2_1	472	478	PF00069	0.676
MOD_CMANNOS	280	283	PF00535	0.502
MOD_GlcNHglycan	11	14	PF01048	0.728
MOD_GlcNHglycan	159	163	PF01048	0.712
MOD_GlcNHglycan	2	5	PF01048	0.776
MOD_GlcNHglycan	308	311	PF01048	0.668
MOD_GlcNHglycan	31	34	PF01048	0.686
MOD_GlcNHglycan	315	318	PF01048	0.643
MOD_GlcNHglycan	342	345	PF01048	0.787
MOD_GlcNHglycan	370	374	PF01048	0.743
MOD_GlcNHglycan	401	404	PF01048	0.759
MOD_GlcNHglycan	58	61	PF01048	0.801
MOD_GlcNHglycan	63	66	PF01048	0.609
MOD_GlcNHglycan	75	78	PF01048	0.806
MOD_GSK3_1	158	165	PF00069	0.796
MOD_GSK3_1	20	27	PF00069	0.725
MOD_GSK3_1	308	315	PF00069	0.670
MOD_GSK3_1	358	365	PF00069	0.698
MOD_GSK3_1	379	386	PF00069	0.633
MOD_GSK3_1	399	406	PF00069	0.668
MOD_GSK3_1	414	421	PF00069	0.670
MOD_GSK3_1	462	469	PF00069	0.574
MOD_LATS_1	122	128	PF00433	0.564
MOD_N-GLC_1	324	329	PF02516	0.621
MOD_NEK2_1	103	108	PF00069	0.584
MOD_NEK2_1	24	29	PF00069	0.801
MOD_NEK2_1	313	318	PF00069	0.558
MOD_NEK2_1	340	345	PF00069	0.696
MOD_NEK2_2	283	288	PF00069	0.548
MOD_PIKK_1	418	424	PF00454	0.792
MOD_PKA_1	259	265	PF00069	0.630
MOD_PKA_2	258	264	PF00069	0.730
MOD_PKA_2	423	429	PF00069	0.563
MOD_PKA_2	451	457	PF00069	0.743
MOD_Plk_4	20	26	PF00069	0.799
MOD_Plk_4	324	330	PF00069	0.618
MOD_Plk_4	40	46	PF00069	0.795
MOD_Plk_4	83	89	PF00069	0.820
MOD_ProDKin_1	240	246	PF00069	0.826
MOD_ProDKin_1	35	41	PF00069	0.678
MOD_ProDKin_1	432	438	PF00069	0.660
MOD_ProDKin_1	80	86	PF00069	0.724
MOD_SUMO_rev_2	190	199	PF00179	0.490
TRG_ENDOCYTIC_2	181	184	PF00928	0.495
TRG_ENDOCYTIC_2	189	192	PF00928	0.481
TRG_ENDOCYTIC_2	384	387	PF00928	0.694
TRG_ENDOCYTIC_2	42	45	PF00928	0.771
TRG_ER_diArg_1	206	209	PF00400	0.620
TRG_ER_diArg_1	291	293	PF00400	0.695
TRG_NLS_MonoCore_2	288	293	PF00514	0.670
TRG_NLS_MonoExtC_3	287	292	PF00514	0.647
TRG_NLS_MonoExtN_4	288	293	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEA5	Leptomonas seymouri	48%	76%
A0A3Q8IA81	Leishmania donovani	94%	100%
A4H822	Leishmania braziliensis	77%	100%
A4HWG4	Leishmania infantum	94%	100%
E9AQ64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%