Putative flavoprotein monooxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flavoprotein monooxygenase, putative

Species:

Leishmania major

UniProt:

Q4QFB3_LEIMA

TriTrypDb:

LmjF.15.0720 , LMJLV39_150013000 , LMJSD75_150013100

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFB3

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	2
GO:0006744	ubiquinone biosynthetic process	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0042180	cellular ketone metabolic process	3	2
GO:0042181	ketone biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901661	quinone metabolic process	4	2
GO:1901663	quinone biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004497	monooxygenase activity	3	10
GO:0016491	oxidoreductase activity	2	10
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	563	567	PF00656	0.524
CLV_NRD_NRD_1	141	143	PF00675	0.675
CLV_NRD_NRD_1	196	198	PF00675	0.412
CLV_NRD_NRD_1	256	258	PF00675	0.490
CLV_NRD_NRD_1	3	5	PF00675	0.612
CLV_NRD_NRD_1	333	335	PF00675	0.611
CLV_NRD_NRD_1	344	346	PF00675	0.502
CLV_NRD_NRD_1	410	412	PF00675	0.426
CLV_NRD_NRD_1	580	582	PF00675	0.466
CLV_PCSK_KEX2_1	141	143	PF00082	0.675
CLV_PCSK_KEX2_1	196	198	PF00082	0.412
CLV_PCSK_KEX2_1	256	258	PF00082	0.490
CLV_PCSK_KEX2_1	3	5	PF00082	0.574
CLV_PCSK_KEX2_1	333	335	PF00082	0.656
CLV_PCSK_KEX2_1	409	411	PF00082	0.463
CLV_PCSK_KEX2_1	580	582	PF00082	0.495
CLV_PCSK_PC7_1	137	143	PF00082	0.673
CLV_PCSK_PC7_1	405	411	PF00082	0.432
CLV_PCSK_SKI1_1	196	200	PF00082	0.523
CLV_PCSK_SKI1_1	256	260	PF00082	0.371
CLV_PCSK_SKI1_1	569	573	PF00082	0.426
CLV_Separin_Metazoa	462	466	PF03568	0.523
DEG_APCC_DBOX_1	195	203	PF00400	0.514
DEG_APCC_DBOX_1	464	472	PF00400	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DEG_SPOP_SBC_1	175	179	PF00917	0.672
DEG_SPOP_SBC_1	472	476	PF00917	0.629
DOC_CYCLIN_RxL_1	253	260	PF00134	0.412
DOC_MAPK_gen_1	208	217	PF00069	0.480
DOC_MAPK_gen_1	333	342	PF00069	0.517
DOC_MAPK_HePTP_8	207	219	PF00069	0.350
DOC_MAPK_MEF2A_6	182	189	PF00069	0.508
DOC_MAPK_MEF2A_6	210	219	PF00069	0.482
DOC_MAPK_MEF2A_6	581	590	PF00069	0.450
DOC_USP7_MATH_1	108	112	PF00917	0.782
DOC_USP7_MATH_1	175	179	PF00917	0.713
DOC_USP7_MATH_1	228	232	PF00917	0.470
DOC_USP7_MATH_1	294	298	PF00917	0.469
DOC_USP7_MATH_1	305	309	PF00917	0.628
DOC_USP7_MATH_1	336	340	PF00917	0.619
DOC_USP7_MATH_1	414	418	PF00917	0.622
DOC_USP7_MATH_1	472	476	PF00917	0.563
DOC_USP7_UBL2_3	346	350	PF12436	0.476
DOC_USP7_UBL2_3	639	643	PF12436	0.509
DOC_WW_Pin1_4	120	125	PF00397	0.769
DOC_WW_Pin1_4	176	181	PF00397	0.660
DOC_WW_Pin1_4	475	480	PF00397	0.665
DOC_WW_Pin1_4	55	60	PF00397	0.571
DOC_WW_Pin1_4	582	587	PF00397	0.529
DOC_WW_Pin1_4	90	95	PF00397	0.516
LIG_14-3-3_CanoR_1	334	342	PF00244	0.627
LIG_14-3-3_CanoR_1	409	416	PF00244	0.516
LIG_14-3-3_CanoR_1	604	610	PF00244	0.617
LIG_14-3-3_CanoR_1	629	635	PF00244	0.519
LIG_14-3-3_CterR_2	652	655	PF00244	0.581
LIG_APCC_ABBA_1	272	277	PF00400	0.535
LIG_BRCT_BRCA1_1	440	444	PF00533	0.457
LIG_BRCT_BRCA1_1	546	550	PF00533	0.431
LIG_BRCT_BRCA1_1	76	80	PF00533	0.514
LIG_Clathr_ClatBox_1	374	378	PF01394	0.414
LIG_EH_1	521	525	PF12763	0.374
LIG_FHA_1	113	119	PF00498	0.812
LIG_FHA_1	232	238	PF00498	0.486
LIG_FHA_1	320	326	PF00498	0.578
LIG_FHA_1	410	416	PF00498	0.496
LIG_FHA_1	503	509	PF00498	0.507
LIG_FHA_1	85	91	PF00498	0.425
LIG_FHA_2	606	612	PF00498	0.630
LIG_FHA_2	630	636	PF00498	0.542
LIG_FHA_2	86	92	PF00498	0.433
LIG_LIR_Apic_2	47	51	PF02991	0.741
LIG_LIR_Gen_1	184	194	PF02991	0.484
LIG_LIR_Gen_1	357	364	PF02991	0.400
LIG_LIR_Gen_1	441	451	PF02991	0.364
LIG_LIR_Gen_1	500	511	PF02991	0.422
LIG_LIR_Gen_1	585	594	PF02991	0.526
LIG_LIR_Nem_3	181	186	PF02991	0.537
LIG_LIR_Nem_3	188	194	PF02991	0.455
LIG_LIR_Nem_3	357	361	PF02991	0.410
LIG_LIR_Nem_3	432	438	PF02991	0.479
LIG_LIR_Nem_3	441	447	PF02991	0.419
LIG_LIR_Nem_3	47	52	PF02991	0.641
LIG_LIR_Nem_3	500	506	PF02991	0.438
LIG_LIR_Nem_3	585	590	PF02991	0.521
LIG_LIR_Nem_3	628	634	PF02991	0.598
LIG_LYPXL_yS_3	494	497	PF13949	0.449
LIG_NRBOX	254	260	PF00104	0.413
LIG_Pex14_1	347	351	PF04695	0.458
LIG_Pex14_1	606	610	PF04695	0.613
LIG_PTB_Apo_2	36	43	PF02174	0.577
LIG_PTB_Phospho_1	36	42	PF10480	0.579
LIG_SH2_CRK	136	140	PF00017	0.664
LIG_SH2_CRK	191	195	PF00017	0.460
LIG_SH2_CRK	358	362	PF00017	0.375
LIG_SH2_CRK	503	507	PF00017	0.522
LIG_SH2_CRK	551	555	PF00017	0.410
LIG_SH2_CRK	6	10	PF00017	0.696
LIG_SH2_GRB2like	557	560	PF00017	0.495
LIG_SH2_NCK_1	191	195	PF00017	0.479
LIG_SH2_NCK_1	503	507	PF00017	0.522
LIG_SH2_SRC	276	279	PF00017	0.499
LIG_SH2_SRC	634	637	PF00017	0.522
LIG_SH2_STAP1	276	280	PF00017	0.482
LIG_SH2_STAP1	351	355	PF00017	0.440
LIG_SH2_STAP1	358	362	PF00017	0.347
LIG_SH2_STAP1	546	550	PF00017	0.451
LIG_SH2_STAP1	618	622	PF00017	0.486
LIG_SH2_STAT3	42	45	PF00017	0.662
LIG_SH2_STAT3	421	424	PF00017	0.544
LIG_SH2_STAT3	449	452	PF00017	0.467
LIG_SH2_STAT3	498	501	PF00017	0.523
LIG_SH2_STAT5	15	18	PF00017	0.593
LIG_SH2_STAT5	33	36	PF00017	0.597
LIG_SH2_STAT5	467	470	PF00017	0.477
LIG_SH2_STAT5	498	501	PF00017	0.484
LIG_SH2_STAT5	631	634	PF00017	0.522
LIG_SH3_3	121	127	PF00018	0.782
LIG_SH3_3	288	294	PF00018	0.423
LIG_SH3_3	445	451	PF00018	0.396
LIG_SH3_3	503	509	PF00018	0.460
LIG_SH3_3	597	603	PF00018	0.518
LIG_SUMO_SIM_par_1	373	378	PF11976	0.416
LIG_TRAF2_1	316	319	PF00917	0.620
LIG_TYR_ITIM	189	194	PF00017	0.488
LIG_TYR_ITIM	274	279	PF00017	0.493
LIG_TYR_ITIM	356	361	PF00017	0.397
LIG_WRC_WIRS_1	168	173	PF05994	0.570
LIG_WRC_WIRS_1	484	489	PF05994	0.484
MOD_CDC14_SPxK_1	179	182	PF00782	0.647
MOD_CDC14_SPxK_1	58	61	PF00782	0.521
MOD_CDK_SPxK_1	176	182	PF00069	0.681
MOD_CDK_SPxK_1	55	61	PF00069	0.556
MOD_CDK_SPxxK_3	582	589	PF00069	0.535
MOD_CK1_1	111	117	PF00069	0.752
MOD_CK1_1	125	131	PF00069	0.732
MOD_CK1_1	149	155	PF00069	0.789
MOD_CK1_1	156	162	PF00069	0.684
MOD_CK1_1	174	180	PF00069	0.636
MOD_CK1_1	181	187	PF00069	0.549
MOD_CK1_1	231	237	PF00069	0.473
MOD_CK1_1	266	272	PF00069	0.559
MOD_CK1_1	308	314	PF00069	0.676
MOD_CK1_1	417	423	PF00069	0.617
MOD_CK1_1	473	479	PF00069	0.630
MOD_CK1_1	486	492	PF00069	0.421
MOD_CK2_1	312	318	PF00069	0.593
MOD_CK2_1	605	611	PF00069	0.588
MOD_CK2_1	85	91	PF00069	0.403
MOD_GlcNHglycan	17	21	PF01048	0.603
MOD_GlcNHglycan	171	174	PF01048	0.765
MOD_GlcNHglycan	268	271	PF01048	0.584
MOD_GlcNHglycan	296	300	PF01048	0.517
MOD_GlcNHglycan	342	345	PF01048	0.536
MOD_GlcNHglycan	362	365	PF01048	0.183
MOD_GlcNHglycan	416	419	PF01048	0.672
MOD_GlcNHglycan	424	427	PF01048	0.463
MOD_GlcNHglycan	509	512	PF01048	0.372
MOD_GlcNHglycan	563	566	PF01048	0.456
MOD_GlcNHglycan	66	69	PF01048	0.388
MOD_GlcNHglycan	76	79	PF01048	0.350
MOD_GSK3_1	108	115	PF00069	0.676
MOD_GSK3_1	118	125	PF00069	0.784
MOD_GSK3_1	146	153	PF00069	0.740
MOD_GSK3_1	167	174	PF00069	0.797
MOD_GSK3_1	231	238	PF00069	0.512
MOD_GSK3_1	304	311	PF00069	0.670
MOD_GSK3_1	336	343	PF00069	0.551
MOD_GSK3_1	392	399	PF00069	0.398
MOD_GSK3_1	410	417	PF00069	0.388
MOD_GSK3_1	438	445	PF00069	0.462
MOD_GSK3_1	470	477	PF00069	0.524
MOD_GSK3_1	625	632	PF00069	0.628
MOD_GSK3_1	9	16	PF00069	0.592
MOD_LATS_1	408	414	PF00433	0.575
MOD_N-GLC_1	312	317	PF02516	0.678
MOD_N-GLC_2	599	601	PF02516	0.591
MOD_NEK2_1	340	345	PF00069	0.491
MOD_NEK2_1	471	476	PF00069	0.587
MOD_NEK2_1	502	507	PF00069	0.447
MOD_NEK2_1	625	630	PF00069	0.573
MOD_NEK2_1	74	79	PF00069	0.493
MOD_NEK2_1	8	13	PF00069	0.593
MOD_NEK2_2	605	610	PF00069	0.618
MOD_PKA_1	409	415	PF00069	0.524
MOD_PKA_2	13	19	PF00069	0.608
MOD_PKA_2	409	415	PF00069	0.502
MOD_PKA_2	560	566	PF00069	0.520
MOD_Plk_1	295	301	PF00069	0.518
MOD_Plk_1	305	311	PF00069	0.501
MOD_Plk_4	228	234	PF00069	0.467
MOD_Plk_4	493	499	PF00069	0.409
MOD_Plk_4	605	611	PF00069	0.611
MOD_Plk_4	85	91	PF00069	0.406
MOD_ProDKin_1	120	126	PF00069	0.767
MOD_ProDKin_1	176	182	PF00069	0.643
MOD_ProDKin_1	475	481	PF00069	0.656
MOD_ProDKin_1	55	61	PF00069	0.556
MOD_ProDKin_1	582	588	PF00069	0.528
MOD_ProDKin_1	90	96	PF00069	0.518
MOD_SUMO_for_1	99	102	PF00179	0.583
MOD_SUMO_rev_2	343	352	PF00179	0.576
TRG_DiLeu_BaEn_2	482	488	PF01217	0.569
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.446
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.619
TRG_ENDOCYTIC_2	183	186	PF00928	0.497
TRG_ENDOCYTIC_2	191	194	PF00928	0.406
TRG_ENDOCYTIC_2	276	279	PF00928	0.489
TRG_ENDOCYTIC_2	358	361	PF00928	0.379
TRG_ENDOCYTIC_2	494	497	PF00928	0.439
TRG_ENDOCYTIC_2	503	506	PF00928	0.396
TRG_ENDOCYTIC_2	551	554	PF00928	0.404
TRG_ENDOCYTIC_2	594	597	PF00928	0.484
TRG_ENDOCYTIC_2	6	9	PF00928	0.693
TRG_ER_diArg_1	140	142	PF00400	0.664
TRG_ER_diArg_1	2	4	PF00400	0.626
TRG_ER_diArg_1	207	210	PF00400	0.353
TRG_ER_diArg_1	255	257	PF00400	0.484
TRG_ER_diArg_1	332	334	PF00400	0.675
TRG_ER_diArg_1	409	411	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.717
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTW3	Leptomonas seymouri	73%	100%
A0A0S4JRA1	Bodo saltans	47%	100%
A0A1X0NTX5	Trypanosomatidae	56%	100%
A0A3S5H6U9	Leishmania donovani	96%	100%
A4HWG9	Leishmania infantum	96%	100%
C9ZXY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AQ70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5DL32	Trypanosoma cruzi	54%	100%