Histidine protein methyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QFB2_LEIMA

TriTrypDb:

LmjF.15.0730 , LMJLV39_150013100 , LMJSD75_150013200

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFB2

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.764
CLV_NRD_NRD_1	156	158	PF00675	0.524
CLV_NRD_NRD_1	218	220	PF00675	0.333
CLV_PCSK_FUR_1	154	158	PF00082	0.504
CLV_PCSK_KEX2_1	153	155	PF00082	0.602
CLV_PCSK_KEX2_1	156	158	PF00082	0.524
CLV_PCSK_KEX2_1	218	220	PF00082	0.333
CLV_PCSK_KEX2_1	357	359	PF00082	0.539
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.573
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.551
CLV_PCSK_SKI1_1	189	193	PF00082	0.369
CLV_PCSK_SKI1_1	219	223	PF00082	0.333
CLV_PCSK_SKI1_1	99	103	PF00082	0.611
DEG_Nend_UBRbox_1	1	4	PF02207	0.491
DEG_SCF_FBW7_1	144	151	PF00400	0.684
DEG_SPOP_SBC_1	280	284	PF00917	0.560
DEG_SPOP_SBC_1	32	36	PF00917	0.770
DEG_SPOP_SBC_1	52	56	PF00917	0.467
DOC_CYCLIN_RxL_1	184	193	PF00134	0.435
DOC_MAPK_JIP1_4	92	98	PF00069	0.535
DOC_MAPK_MEF2A_6	364	372	PF00069	0.412
DOC_PP1_RVXF_1	216	223	PF00149	0.340
DOC_USP7_MATH_1	110	114	PF00917	0.707
DOC_USP7_MATH_1	134	138	PF00917	0.414
DOC_USP7_MATH_1	148	152	PF00917	0.579
DOC_USP7_MATH_1	244	248	PF00917	0.565
DOC_USP7_MATH_1	280	284	PF00917	0.629
DOC_USP7_MATH_1	31	35	PF00917	0.723
DOC_USP7_MATH_1	52	56	PF00917	0.543
DOC_USP7_MATH_1	60	64	PF00917	0.545
DOC_USP7_MATH_1	79	83	PF00917	0.479
DOC_WW_Pin1_4	126	131	PF00397	0.558
DOC_WW_Pin1_4	140	145	PF00397	0.686
DOC_WW_Pin1_4	255	260	PF00397	0.568
DOC_WW_Pin1_4	42	47	PF00397	0.651
LIG_APCC_ABBAyCdc20_2	218	224	PF00400	0.309
LIG_CSL_BTD_1	48	51	PF09270	0.601
LIG_deltaCOP1_diTrp_1	269	275	PF00928	0.341
LIG_FHA_1	255	261	PF00498	0.558
LIG_FHA_1	321	327	PF00498	0.467
LIG_FHA_1	89	95	PF00498	0.599
LIG_FHA_2	126	132	PF00498	0.543
LIG_FHA_2	25	31	PF00498	0.713
LIG_FHA_2	66	72	PF00498	0.486
LIG_GBD_Chelix_1	309	317	PF00786	0.323
LIG_HP1_1	60	64	PF01393	0.514
LIG_LIR_Gen_1	269	276	PF02991	0.369
LIG_LIR_Gen_1	288	295	PF02991	0.479
LIG_LIR_Gen_1	58	69	PF02991	0.543
LIG_LIR_Nem_3	269	273	PF02991	0.369
LIG_LIR_Nem_3	288	293	PF02991	0.497
LIG_LIR_Nem_3	56	62	PF02991	0.507
LIG_Pex14_1	316	320	PF04695	0.403
LIG_Pex14_1	72	76	PF04695	0.375
LIG_Pex14_2	10	14	PF04695	0.587
LIG_SH2_CRK	165	169	PF00017	0.297
LIG_SH2_CRK	188	192	PF00017	0.433
LIG_SH2_STAT5	180	183	PF00017	0.324
LIG_SH2_STAT5	320	323	PF00017	0.389
LIG_SH2_STAT5	332	335	PF00017	0.365
LIG_SH2_STAT5	339	342	PF00017	0.289
LIG_SH2_STAT5	76	79	PF00017	0.493
LIG_SH3_3	113	119	PF00018	0.640
LIG_SH3_3	40	46	PF00018	0.657
LIG_TRAF2_1	68	71	PF00917	0.343
LIG_WRC_WIRS_1	11	16	PF05994	0.665
MOD_CK1_1	13	19	PF00069	0.715
MOD_CK1_1	274	280	PF00069	0.602
MOD_CK1_1	297	303	PF00069	0.349
MOD_CK1_1	34	40	PF00069	0.629
MOD_CK1_1	55	61	PF00069	0.510
MOD_CK1_1	63	69	PF00069	0.463
MOD_CK1_1	88	94	PF00069	0.587
MOD_CK2_1	125	131	PF00069	0.552
MOD_CK2_1	187	193	PF00069	0.452
MOD_CK2_1	65	71	PF00069	0.455
MOD_GlcNHglycan	104	107	PF01048	0.669
MOD_GlcNHglycan	112	115	PF01048	0.686
MOD_GlcNHglycan	150	153	PF01048	0.628
MOD_GlcNHglycan	344	347	PF01048	0.448
MOD_GlcNHglycan	4	8	PF01048	0.696
MOD_GSK3_1	10	17	PF00069	0.679
MOD_GSK3_1	134	141	PF00069	0.521
MOD_GSK3_1	144	151	PF00069	0.676
MOD_GSK3_1	244	251	PF00069	0.572
MOD_GSK3_1	31	38	PF00069	0.676
MOD_GSK3_1	51	58	PF00069	0.423
MOD_N-GLC_1	244	249	PF02516	0.566
MOD_N-GLC_2	231	233	PF02516	0.320
MOD_NEK2_1	10	15	PF00069	0.675
MOD_NEK2_1	248	253	PF00069	0.574
MOD_NEK2_1	3	8	PF00069	0.698
MOD_NEK2_1	340	345	PF00069	0.451
MOD_NEK2_1	370	375	PF00069	0.452
MOD_PIKK_1	138	144	PF00454	0.685
MOD_PIKK_1	274	280	PF00454	0.561
MOD_PKA_2	370	376	PF00069	0.505
MOD_Plk_1	244	250	PF00069	0.475
MOD_Plk_1	271	277	PF00069	0.439
MOD_Plk_1	297	303	PF00069	0.333
MOD_Plk_2-3	65	71	PF00069	0.455
MOD_ProDKin_1	126	132	PF00069	0.559
MOD_ProDKin_1	140	146	PF00069	0.689
MOD_ProDKin_1	255	261	PF00069	0.545
MOD_ProDKin_1	42	48	PF00069	0.652
MOD_SUMO_for_1	152	155	PF00179	0.602
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.511
TRG_ENDOCYTIC_2	165	168	PF00928	0.365
TRG_ENDOCYTIC_2	188	191	PF00928	0.433
TRG_ENDOCYTIC_2	339	342	PF00928	0.485
TRG_ER_diArg_1	218	220	PF00400	0.333
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G2	Leptomonas seymouri	58%	100%
A0A0S4JZQ6	Bodo saltans	40%	100%
A0A1X0NU45	Trypanosomatidae	37%	100%
A0A3S7WTG3	Leishmania donovani	92%	79%
A0A422NRE8	Trypanosoma rangeli	40%	100%
A4H852	Leishmania braziliensis	83%	100%
A4HWH0	Leishmania infantum	92%	78%
C9ZXY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	67%
V5B4I9	Trypanosoma cruzi	40%	100%