DUF4149 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2871), putative

Species:

Leishmania major

UniProt:

Q4QFB1_LEIMA

TriTrypDb:

LmjF.15.0740

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 2
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QFB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	107	111	PF00082	0.277
CLV_PCSK_SKI1_1	228	232	PF00082	0.631
DOC_PP1_RVXF_1	188	195	PF00149	0.478
DOC_USP7_MATH_1	132	136	PF00917	0.309
DOC_USP7_UBL2_3	154	158	PF12436	0.277
DOC_USP7_UBL2_3	224	228	PF12436	0.412
DOC_WW_Pin1_4	44	49	PF00397	0.602
LIG_14-3-3_CanoR_1	124	133	PF00244	0.478
LIG_14-3-3_CanoR_1	190	195	PF00244	0.513
LIG_14-3-3_CanoR_1	90	94	PF00244	0.309
LIG_BRCT_BRCA1_1	134	138	PF00533	0.309
LIG_BRCT_BRCA1_1	203	207	PF00533	0.309
LIG_EH1_1	82	90	PF00400	0.277
LIG_eIF4E_1	209	215	PF01652	0.309
LIG_eIF4E_1	5	11	PF01652	0.433
LIG_FHA_1	108	114	PF00498	0.478
LIG_FHA_1	118	124	PF00498	0.439
LIG_FHA_1	160	166	PF00498	0.309
LIG_FHA_1	168	174	PF00498	0.265
LIG_FHA_1	177	183	PF00498	0.216
LIG_FHA_1	193	199	PF00498	0.415
LIG_FHA_1	68	74	PF00498	0.398
LIG_LIR_Gen_1	135	144	PF02991	0.309
LIG_LIR_Gen_1	92	101	PF02991	0.309
LIG_LIR_Nem_3	135	141	PF02991	0.309
LIG_LIR_Nem_3	204	210	PF02991	0.309
LIG_LIR_Nem_3	92	98	PF02991	0.252
LIG_LYPXL_L_2	4	13	PF13949	0.435
LIG_MLH1_MIPbox_1	134	138	PF16413	0.309
LIG_NRBOX	138	144	PF00104	0.309
LIG_Pex14_2	136	140	PF04695	0.309
LIG_SH2_CRK	211	215	PF00017	0.309
LIG_SH2_STAT5	160	163	PF00017	0.309
LIG_SH2_STAT5	209	212	PF00017	0.309
LIG_SH2_STAT5	95	98	PF00017	0.309
LIG_SH3_3	11	17	PF00018	0.457
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.309
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.441
LIG_SUMO_SIM_par_1	140	145	PF11976	0.309
LIG_SUMO_SIM_par_1	8	15	PF11976	0.441
LIG_UBA3_1	139	146	PF00899	0.309
LIG_UBA3_1	72	78	PF00899	0.340
LIG_WRC_WIRS_1	133	138	PF05994	0.309
MOD_CK1_1	117	123	PF00069	0.478
MOD_CK1_1	62	68	PF00069	0.373
MOD_Cter_Amidation	225	228	PF01082	0.614
MOD_GlcNHglycan	101	104	PF01048	0.309
MOD_GlcNHglycan	18	21	PF01048	0.580
MOD_GlcNHglycan	215	218	PF01048	0.589
MOD_GlcNHglycan	220	223	PF01048	0.622
MOD_GSK3_1	114	121	PF00069	0.478
MOD_GSK3_1	12	19	PF00069	0.561
MOD_GSK3_1	186	193	PF00069	0.604
MOD_GSK3_1	226	233	PF00069	0.434
MOD_GSK3_1	40	47	PF00069	0.502
MOD_GSK3_1	89	96	PF00069	0.293
MOD_LATS_1	112	118	PF00433	0.478
MOD_N-GLC_1	117	122	PF02516	0.277
MOD_N-GLC_1	93	98	PF02516	0.309
MOD_NEK2_1	12	17	PF00069	0.577
MOD_NEK2_1	148	153	PF00069	0.320
MOD_NEK2_1	159	164	PF00069	0.354
MOD_NEK2_1	167	172	PF00069	0.352
MOD_NEK2_1	93	98	PF00069	0.244
MOD_NEK2_2	132	137	PF00069	0.309
MOD_OFUCOSY	18	25	PF10250	0.580
MOD_PIKK_1	118	124	PF00454	0.478
MOD_PKA_2	218	224	PF00069	0.424
MOD_PKA_2	59	65	PF00069	0.397
MOD_PKA_2	89	95	PF00069	0.309
MOD_Plk_1	93	99	PF00069	0.309
MOD_Plk_4	132	138	PF00069	0.309
MOD_Plk_4	178	184	PF00069	0.309
MOD_Plk_4	6	12	PF00069	0.461
MOD_Plk_4	93	99	PF00069	0.391
MOD_ProDKin_1	44	50	PF00069	0.599
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.478
TRG_ENDOCYTIC_2	156	159	PF00928	0.277
TRG_ENDOCYTIC_2	211	214	PF00928	0.309
TRG_ENDOCYTIC_2	95	98	PF00928	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTG8	Leishmania donovani	87%	98%
A4HWH1	Leishmania infantum	86%	98%