Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFA7_LEIMA

TriTrypDb:

LmjF.15.0780 , LMJLV39_150014000 , LMJSD75_150014200

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFA7

PDB structure(s): 7ane_ae

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.512
CLV_NRD_NRD_1	169	171	PF00675	0.377
CLV_NRD_NRD_1	181	183	PF00675	0.422
CLV_NRD_NRD_1	210	212	PF00675	0.443
CLV_NRD_NRD_1	222	224	PF00675	0.352
CLV_NRD_NRD_1	454	456	PF00675	0.502
CLV_NRD_NRD_1	494	496	PF00675	0.416
CLV_PCSK_FUR_1	452	456	PF00082	0.504
CLV_PCSK_KEX2_1	169	171	PF00082	0.377
CLV_PCSK_KEX2_1	181	183	PF00082	0.422
CLV_PCSK_KEX2_1	210	212	PF00082	0.445
CLV_PCSK_KEX2_1	222	224	PF00082	0.371
CLV_PCSK_KEX2_1	454	456	PF00082	0.537
CLV_PCSK_SKI1_1	222	226	PF00082	0.383
CLV_PCSK_SKI1_1	234	238	PF00082	0.337
CLV_PCSK_SKI1_1	436	440	PF00082	0.481
DOC_CKS1_1	102	107	PF01111	0.388
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.398
DOC_MAPK_DCC_7	100	108	PF00069	0.397
DOC_MAPK_DCC_7	188	196	PF00069	0.556
DOC_MAPK_DCC_7	222	232	PF00069	0.364
DOC_MAPK_gen_1	185	194	PF00069	0.584
DOC_MAPK_gen_1	279	286	PF00069	0.370
DOC_MAPK_gen_1	312	320	PF00069	0.495
DOC_MAPK_MEF2A_6	188	196	PF00069	0.581
DOC_MAPK_MEF2A_6	223	232	PF00069	0.349
DOC_MAPK_MEF2A_6	90	97	PF00069	0.423
DOC_PP1_RVXF_1	283	289	PF00149	0.343
DOC_PP1_RVXF_1	505	511	PF00149	0.398
DOC_USP7_MATH_1	577	581	PF00917	0.573
DOC_USP7_MATH_1	589	593	PF00917	0.736
DOC_USP7_MATH_1	644	648	PF00917	0.653
DOC_WW_Pin1_4	101	106	PF00397	0.404
DOC_WW_Pin1_4	562	567	PF00397	0.593
DOC_WW_Pin1_4	629	634	PF00397	0.713
LIG_14-3-3_CanoR_1	116	122	PF00244	0.379
LIG_14-3-3_CanoR_1	222	228	PF00244	0.368
LIG_14-3-3_CanoR_1	234	242	PF00244	0.337
LIG_14-3-3_CanoR_1	314	319	PF00244	0.452
LIG_14-3-3_CanoR_1	452	461	PF00244	0.421
LIG_Actin_WH2_2	199	217	PF00022	0.368
LIG_Actin_WH2_2	346	364	PF00022	0.483
LIG_APCC_ABBA_1	250	255	PF00400	0.340
LIG_BIR_II_1	1	5	PF00653	0.460
LIG_BIR_III_4	410	414	PF00653	0.651
LIG_BRCT_BRCA1_1	257	261	PF00533	0.446
LIG_CaM_NSCaTE_8	475	482	PF13499	0.471
LIG_CSL_BTD_1	509	512	PF09270	0.484
LIG_FHA_1	116	122	PF00498	0.471
LIG_FHA_1	364	370	PF00498	0.504
LIG_FHA_1	534	540	PF00498	0.476
LIG_FHA_1	563	569	PF00498	0.489
LIG_FHA_1	614	620	PF00498	0.697
LIG_FHA_1	632	638	PF00498	0.740
LIG_FHA_1	70	76	PF00498	0.480
LIG_FHA_1	77	83	PF00498	0.476
LIG_FHA_2	142	148	PF00498	0.473
LIG_FHA_2	332	338	PF00498	0.465
LIG_FHA_2	399	405	PF00498	0.539
LIG_FHA_2	420	426	PF00498	0.495
LIG_FHA_2	483	489	PF00498	0.595
LIG_LIR_Gen_1	334	344	PF02991	0.452
LIG_LIR_Nem_3	124	128	PF02991	0.487
LIG_LIR_Nem_3	162	168	PF02991	0.548
LIG_LIR_Nem_3	219	224	PF02991	0.384
LIG_LIR_Nem_3	231	236	PF02991	0.329
LIG_LIR_Nem_3	334	339	PF02991	0.440
LIG_NRBOX	319	325	PF00104	0.327
LIG_PDZ_Class_1	650	655	PF00595	0.639
LIG_SH2_CRK	221	225	PF00017	0.389
LIG_SH2_CRK	233	237	PF00017	0.319
LIG_SH2_CRK	336	340	PF00017	0.370
LIG_SH2_CRK	531	535	PF00017	0.534
LIG_SH2_GRB2like	298	301	PF00017	0.376
LIG_SH2_SRC	298	301	PF00017	0.376
LIG_SH2_STAP1	298	302	PF00017	0.383
LIG_SH2_STAP1	336	340	PF00017	0.396
LIG_SH2_STAP1	395	399	PF00017	0.496
LIG_SH2_STAT3	554	557	PF00017	0.610
LIG_SH2_STAT5	128	131	PF00017	0.503
LIG_SH2_STAT5	179	182	PF00017	0.396
LIG_SH2_STAT5	24	27	PF00017	0.425
LIG_SH2_STAT5	262	265	PF00017	0.329
LIG_SH2_STAT5	322	325	PF00017	0.354
LIG_SH2_STAT5	338	341	PF00017	0.381
LIG_SH2_STAT5	398	401	PF00017	0.515
LIG_SH2_STAT5	468	471	PF00017	0.386
LIG_SH2_STAT5	493	496	PF00017	0.541
LIG_SH2_STAT5	554	557	PF00017	0.561
LIG_SH3_2	31	36	PF14604	0.453
LIG_SH3_3	142	148	PF00018	0.426
LIG_SH3_3	28	34	PF00018	0.446
LIG_SH3_3	583	589	PF00018	0.693
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.399
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.491
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.313
LIG_SUMO_SIM_anti_2	76	84	PF11976	0.538
LIG_SUMO_SIM_par_1	104	110	PF11976	0.396
LIG_SUMO_SIM_par_1	192	198	PF11976	0.525
LIG_TRAF2_1	217	220	PF00917	0.364
LIG_TRAF2_1	328	331	PF00917	0.484
LIG_TRAF2_1	401	404	PF00917	0.576
LIG_TRAF2_1	485	488	PF00917	0.519
MOD_CK1_1	107	113	PF00069	0.443
MOD_CK1_1	17	23	PF00069	0.530
MOD_CK1_1	497	503	PF00069	0.488
MOD_CK1_1	580	586	PF00069	0.724
MOD_CK1_1	611	617	PF00069	0.684
MOD_CK1_1	639	645	PF00069	0.662
MOD_CK1_1	65	71	PF00069	0.489
MOD_CK1_1	78	84	PF00069	0.465
MOD_CK1_1	96	102	PF00069	0.575
MOD_CK2_1	192	198	PF00069	0.525
MOD_CK2_1	398	404	PF00069	0.444
MOD_CK2_1	482	488	PF00069	0.546
MOD_GlcNHglycan	109	112	PF01048	0.401
MOD_GlcNHglycan	480	483	PF01048	0.588
MOD_GlcNHglycan	580	583	PF01048	0.661
MOD_GlcNHglycan	591	594	PF01048	0.655
MOD_GlcNHglycan	611	614	PF01048	0.511
MOD_GlcNHglycan	620	623	PF01048	0.768
MOD_GlcNHglycan	625	628	PF01048	0.718
MOD_GlcNHglycan	64	67	PF01048	0.470
MOD_GlcNHglycan	642	645	PF01048	0.535
MOD_GlcNHglycan	646	649	PF01048	0.628
MOD_GSK3_1	10	17	PF00069	0.494
MOD_GSK3_1	419	426	PF00069	0.514
MOD_GSK3_1	478	485	PF00069	0.563
MOD_GSK3_1	604	611	PF00069	0.695
MOD_GSK3_1	614	621	PF00069	0.669
MOD_GSK3_1	62	69	PF00069	0.437
MOD_GSK3_1	631	638	PF00069	0.667
MOD_GSK3_1	639	646	PF00069	0.673
MOD_N-GLC_1	141	146	PF02516	0.462
MOD_N-GLC_1	608	613	PF02516	0.651
MOD_N-GLC_1	623	628	PF02516	0.641
MOD_NEK2_1	180	185	PF00069	0.448
MOD_NEK2_1	323	328	PF00069	0.465
MOD_NEK2_1	377	382	PF00069	0.435
MOD_NEK2_1	453	458	PF00069	0.615
MOD_NEK2_1	478	483	PF00069	0.470
MOD_NEK2_1	494	499	PF00069	0.349
MOD_NEK2_1	50	55	PF00069	0.466
MOD_NEK2_1	598	603	PF00069	0.592
MOD_NEK2_1	604	609	PF00069	0.620
MOD_NEK2_1	650	655	PF00069	0.639
MOD_NEK2_1	75	80	PF00069	0.493
MOD_NEK2_2	615	620	PF00069	0.630
MOD_PIKK_1	377	383	PF00454	0.556
MOD_PK_1	223	229	PF00069	0.429
MOD_PKA_1	181	187	PF00069	0.545
MOD_PKA_1	222	228	PF00069	0.357
MOD_PKA_1	454	460	PF00069	0.523
MOD_PKA_2	10	16	PF00069	0.550
MOD_PKA_2	115	121	PF00069	0.374
MOD_PKA_2	180	186	PF00069	0.437
MOD_PKA_2	222	228	PF00069	0.403
MOD_PKA_2	453	459	PF00069	0.551
MOD_PKA_2	494	500	PF00069	0.420
MOD_PKA_2	639	645	PF00069	0.707
MOD_PKB_1	312	320	PF00069	0.450
MOD_PKB_1	452	460	PF00069	0.514
MOD_Plk_1	141	147	PF00069	0.454
MOD_Plk_1	539	545	PF00069	0.476
MOD_Plk_1	546	552	PF00069	0.554
MOD_Plk_1	75	81	PF00069	0.458
MOD_Plk_1	93	99	PF00069	0.396
MOD_Plk_2-3	141	147	PF00069	0.454
MOD_Plk_2-3	331	337	PF00069	0.468
MOD_Plk_4	104	110	PF00069	0.411
MOD_Plk_4	14	20	PF00069	0.446
MOD_Plk_4	489	495	PF00069	0.502
MOD_Plk_4	598	604	PF00069	0.617
MOD_Plk_4	78	84	PF00069	0.399
MOD_ProDKin_1	101	107	PF00069	0.409
MOD_ProDKin_1	562	568	PF00069	0.588
MOD_ProDKin_1	629	635	PF00069	0.714
MOD_SUMO_for_1	84	87	PF00179	0.428
TRG_DiLeu_BaEn_2	86	92	PF01217	0.535
TRG_ENDOCYTIC_2	165	168	PF00928	0.367
TRG_ENDOCYTIC_2	221	224	PF00928	0.388
TRG_ENDOCYTIC_2	233	236	PF00928	0.322
TRG_ENDOCYTIC_2	290	293	PF00928	0.410
TRG_ENDOCYTIC_2	298	301	PF00928	0.376
TRG_ENDOCYTIC_2	336	339	PF00928	0.344
TRG_ER_diArg_1	161	164	PF00400	0.382
TRG_ER_diArg_1	168	170	PF00400	0.396
TRG_ER_diArg_1	180	182	PF00400	0.406
TRG_ER_diArg_1	221	223	PF00400	0.426
TRG_ER_diArg_1	26	29	PF00400	0.429
TRG_ER_diArg_1	283	286	PF00400	0.368
TRG_ER_diArg_1	453	455	PF00400	0.505
TRG_NLS_MonoExtC_3	494	499	PF00514	0.412
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.501
TRG_PTS1	652	655	PF00515	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I655	Leptomonas seymouri	76%	99%
A0A0S4JKP6	Bodo saltans	54%	100%
A0A1X0NU53	Trypanosomatidae	66%	95%
A0A3R7NKZ5	Trypanosoma rangeli	61%	96%
A0A3S7WTG4	Leishmania donovani	96%	100%
A4H846	Leishmania braziliensis	90%	100%
A4HWH4	Leishmania infantum	96%	100%
C9ZXX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	98%
E9AQ76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%