Dolichol phosphate-mannose biosynthesis regulatory protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichol phosphate-mannose biosynthesis regulatory protein (DPM2), putative

Species:

Leishmania major

UniProt:

Q4QFA3_LEIMA

TriTrypDb:

LmjF.15.0815 , LMJLV39_150014500 , LMJSD75_150014700

Length:

112

Annotations

LeishMANIAdb annotations

Involved in GPI anchor biosynthesis, homologous to other Eukyrotic DPM2 proteins.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0031501	mannosyltransferase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0033185	dolichol-phosphate-mannose synthase complex	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

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Expansion

Sequence features

Q4QFA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFA3

Function

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Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	9
GO:0006486	protein glycosylation	4	9
GO:0006497	protein lipidation	5	2
GO:0006505	GPI anchor metabolic process	6	2
GO:0006506	GPI anchor biosynthetic process	6	2
GO:0006629	lipid metabolic process	3	9
GO:0006643	membrane lipid metabolic process	4	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006661	phosphatidylinositol biosynthetic process	6	2

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Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	9
GO:0098772	molecular function regulator activity	1	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	79	83	PF00917	0.527
DOC_MAPK_MEF2A_6	102	109	PF00069	0.592
DOC_PP2B_LxvP_1	41	44	PF13499	0.245
DOC_USP7_MATH_1	13	17	PF00917	0.337
DOC_USP7_MATH_1	80	84	PF00917	0.536
LIG_14-3-3_CanoR_1	84	88	PF00244	0.635
LIG_APCC_ABBA_1	28	33	PF00400	0.269
LIG_BRCT_BRCA1_1	15	19	PF00533	0.337
LIG_FHA_1	36	42	PF00498	0.266
LIG_FHA_1	55	61	PF00498	0.372

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK6	Leptomonas seymouri	81%	100%
A0A0S4JH11	Bodo saltans	47%	89%
A0A3R7MTU8	Trypanosoma rangeli	47%	96%
A0A3S5H6V0	Leishmania donovani	97%	100%
A4H853	Leishmania braziliensis	76%	98%
A4HWH8	Leishmania infantum	97%	100%
E9AQ79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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