Dolichol phosphate-mannose biosynthesis regulatory protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichol phosphate-mannose biosynthesis regulatory protein (DPM2), putative

Species:

Leishmania major

UniProt:

Q4QFA3_LEIMA

TriTrypDb:

LmjF.15.0815 , LMJLV39_150014500 , LMJSD75_150014700

Length:

112

Annotations

LeishMANIAdb annotations

Involved in GPI anchor biosynthesis, homologous to other Eukyrotic DPM2 proteins.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0031501	mannosyltransferase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0033185	dolichol-phosphate-mannose synthase complex	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4QFA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFA3

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	9
GO:0006486	protein glycosylation	4	9
GO:0006497	protein lipidation	5	2
GO:0006505	GPI anchor metabolic process	6	2
GO:0006506	GPI anchor biosynthetic process	6	2
GO:0006629	lipid metabolic process	3	9
GO:0006643	membrane lipid metabolic process	4	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006661	phosphatidylinositol biosynthetic process	6	2
GO:0006664	glycolipid metabolic process	5	2
GO:0006720	isoprenoid metabolic process	4	9
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009247	glycolipid biosynthetic process	5	2
GO:0009987	cellular process	1	9
GO:0016093	polyprenol metabolic process	4	9
GO:0019348	dolichol metabolic process	5	9
GO:0019538	protein metabolic process	3	9
GO:0019637	organophosphate metabolic process	3	2
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0043413	macromolecule glycosylation	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	9
GO:0044281	small molecule metabolic process	2	9
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046467	membrane lipid biosynthetic process	4	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046488	phosphatidylinositol metabolic process	6	2
GO:0070085	glycosylation	2	9
GO:0071704	organic substance metabolic process	2	9
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901576	organic substance biosynthetic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	9
GO:1903509	liposaccharide metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	9
GO:0098772	molecular function regulator activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	79	83	PF00917	0.527
DOC_MAPK_MEF2A_6	102	109	PF00069	0.592
DOC_PP2B_LxvP_1	41	44	PF13499	0.245
DOC_USP7_MATH_1	13	17	PF00917	0.337
DOC_USP7_MATH_1	80	84	PF00917	0.536
LIG_14-3-3_CanoR_1	84	88	PF00244	0.635
LIG_APCC_ABBA_1	28	33	PF00400	0.269
LIG_BRCT_BRCA1_1	15	19	PF00533	0.337
LIG_FHA_1	36	42	PF00498	0.266
LIG_FHA_1	55	61	PF00498	0.372
LIG_FHA_1	7	13	PF00498	0.466
LIG_FHA_1	73	79	PF00498	0.585
LIG_FHA_1	98	104	PF00498	0.674
LIG_LIR_Apic_2	75	80	PF02991	0.624
LIG_LIR_Nem_3	16	22	PF02991	0.279
LIG_LIR_Nem_3	46	50	PF02991	0.270
LIG_MLH1_MIPbox_1	15	19	PF16413	0.337
LIG_NRBOX	6	12	PF00104	0.372
LIG_Pex14_1	73	77	PF04695	0.611
LIG_SH2_CRK	47	51	PF00017	0.312
LIG_SH2_PTP2	77	80	PF00017	0.633
LIG_SH2_SRC	77	80	PF00017	0.608
LIG_SH2_STAT5	22	25	PF00017	0.418
LIG_SH2_STAT5	77	80	PF00017	0.653
MOD_CK1_1	35	41	PF00069	0.256
MOD_CK1_1	68	74	PF00069	0.409
MOD_CK1_1	82	88	PF00069	0.608
MOD_CK1_1	96	102	PF00069	0.610
MOD_GSK3_1	68	75	PF00069	0.413
MOD_GSK3_1	78	85	PF00069	0.626
MOD_GSK3_1	89	96	PF00069	0.697
MOD_N-GLC_1	14	19	PF02516	0.372
MOD_NEK2_1	54	59	PF00069	0.383
MOD_NEK2_1	65	70	PF00069	0.409
MOD_NEK2_2	14	19	PF00069	0.372
MOD_PIKK_1	35	41	PF00454	0.245
MOD_PKA_2	83	89	PF00069	0.639
MOD_Plk_1	14	20	PF00069	0.364
MOD_Plk_1	32	38	PF00069	0.215
MOD_Plk_1	89	95	PF00069	0.570
MOD_Plk_4	14	20	PF00069	0.281
MOD_Plk_4	6	12	PF00069	0.372
MOD_Plk_4	68	74	PF00069	0.492
MOD_Plk_4	89	95	PF00069	0.641
TRG_DiLeu_BaEn_1	46	51	PF01217	0.269
TRG_ENDOCYTIC_2	21	24	PF00928	0.279
TRG_ENDOCYTIC_2	47	50	PF00928	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK6	Leptomonas seymouri	81%	100%
A0A0S4JH11	Bodo saltans	47%	89%
A0A3R7MTU8	Trypanosoma rangeli	47%	96%
A0A3S5H6V0	Leishmania donovani	97%	100%
A4H853	Leishmania braziliensis	76%	98%
A4HWH8	Leishmania infantum	97%	100%
E9AQ79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%