Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GDP dissociation inhibitor, putative

Species:

Leishmania major

UniProt:

Q4QFA2_LEIMA

TriTrypDb:

LmjF.15.0820 , LMJLV39_150014600 , LMJSD75_150014800

Length:

1033

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFA2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007165	signal transduction	2	10
GO:0007264	small GTPase mediated signal transduction	4	10
GO:0009987	cellular process	1	10
GO:0016192	vesicle-mediated transport	4	2
GO:0035556	intracellular signal transduction	3	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0065007	biological regulation	1	10
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0005092	GDP-dissociation inhibitor activity	3	10
GO:0005093	Rab GDP-dissociation inhibitor activity	4	2
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	823	827	PF00656	0.573
CLV_NRD_NRD_1	287	289	PF00675	0.466
CLV_NRD_NRD_1	324	326	PF00675	0.430
CLV_NRD_NRD_1	419	421	PF00675	0.325
CLV_NRD_NRD_1	500	502	PF00675	0.247
CLV_NRD_NRD_1	658	660	PF00675	0.247
CLV_NRD_NRD_1	84	86	PF00675	0.221
CLV_NRD_NRD_1	892	894	PF00675	0.408
CLV_PCSK_FUR_1	417	421	PF00082	0.302
CLV_PCSK_FUR_1	82	86	PF00082	0.286
CLV_PCSK_KEX2_1	102	104	PF00082	0.284
CLV_PCSK_KEX2_1	170	172	PF00082	0.579
CLV_PCSK_KEX2_1	287	289	PF00082	0.466
CLV_PCSK_KEX2_1	324	326	PF00082	0.446
CLV_PCSK_KEX2_1	417	419	PF00082	0.328
CLV_PCSK_KEX2_1	499	501	PF00082	0.248
CLV_PCSK_KEX2_1	658	660	PF00082	0.247
CLV_PCSK_KEX2_1	84	86	PF00082	0.286
CLV_PCSK_KEX2_1	892	894	PF00082	0.408
CLV_PCSK_KEX2_1	995	997	PF00082	0.510
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.284
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.428
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.247
CLV_PCSK_PC1ET2_1	995	997	PF00082	0.454
CLV_PCSK_PC7_1	80	86	PF00082	0.360
CLV_PCSK_PC7_1	888	894	PF00082	0.310
CLV_PCSK_SKI1_1	29	33	PF00082	0.474
CLV_PCSK_SKI1_1	420	424	PF00082	0.267
CLV_PCSK_SKI1_1	456	460	PF00082	0.339
CLV_PCSK_SKI1_1	504	508	PF00082	0.254
CLV_PCSK_SKI1_1	615	619	PF00082	0.357
CLV_PCSK_SKI1_1	756	760	PF00082	0.419
CLV_PCSK_SKI1_1	995	999	PF00082	0.510
DEG_APCC_DBOX_1	358	366	PF00400	0.515
DEG_APCC_DBOX_1	418	426	PF00400	0.486
DEG_APCC_DBOX_1	65	73	PF00400	0.480
DEG_APCC_DBOX_1	657	665	PF00400	0.477
DEG_APCC_DBOX_1	718	726	PF00400	0.655
DEG_SCF_FBW7_1	946	953	PF00400	0.588
DEG_SPOP_SBC_1	394	398	PF00917	0.429
DEG_SPOP_SBC_1	463	467	PF00917	0.544
DEG_SPOP_SBC_1	473	477	PF00917	0.482
DEG_SPOP_SBC_1	588	592	PF00917	0.550
DOC_CDC14_PxL_1	970	978	PF14671	0.393
DOC_CKS1_1	688	693	PF01111	0.532
DOC_CYCLIN_RxL_1	417	424	PF00134	0.450
DOC_CYCLIN_RxL_1	453	464	PF00134	0.509
DOC_MAPK_DCC_7	71	79	PF00069	0.482
DOC_MAPK_DCC_7	892	902	PF00069	0.456
DOC_MAPK_gen_1	112	119	PF00069	0.284
DOC_MAPK_gen_1	499	505	PF00069	0.447
DOC_MAPK_gen_1	64	72	PF00069	0.423
DOC_MAPK_gen_1	658	666	PF00069	0.530
DOC_MAPK_gen_1	995	1003	PF00069	0.463
DOC_MAPK_MEF2A_6	71	79	PF00069	0.493
DOC_PP1_RVXF_1	801	808	PF00149	0.445
DOC_PP2B_LxvP_1	1001	1004	PF13499	0.482
DOC_PP2B_LxvP_1	123	126	PF13499	0.284
DOC_PP2B_LxvP_1	72	75	PF13499	0.501
DOC_PP4_FxxP_1	1027	1030	PF00568	0.509
DOC_USP7_MATH_1	392	396	PF00917	0.490
DOC_USP7_MATH_1	531	535	PF00917	0.607
DOC_USP7_MATH_1	588	592	PF00917	0.596
DOC_USP7_MATH_1	742	746	PF00917	0.662
DOC_USP7_MATH_1	941	945	PF00917	0.594
DOC_USP7_MATH_1	950	954	PF00917	0.545
DOC_USP7_MATH_2	899	905	PF00917	0.506
DOC_USP7_UBL2_3	731	735	PF12436	0.673
DOC_USP7_UBL2_3	98	102	PF12436	0.308
DOC_WW_Pin1_4	390	395	PF00397	0.511
DOC_WW_Pin1_4	40	45	PF00397	0.435
DOC_WW_Pin1_4	625	630	PF00397	0.447
DOC_WW_Pin1_4	687	692	PF00397	0.529
DOC_WW_Pin1_4	717	722	PF00397	0.611
DOC_WW_Pin1_4	744	749	PF00397	0.674
DOC_WW_Pin1_4	939	944	PF00397	0.661
DOC_WW_Pin1_4	946	951	PF00397	0.671
LIG_14-3-3_CanoR_1	112	117	PF00244	0.308
LIG_14-3-3_CanoR_1	485	489	PF00244	0.492
LIG_14-3-3_CanoR_1	646	654	PF00244	0.504
LIG_14-3-3_CanoR_1	658	662	PF00244	0.414
LIG_14-3-3_CanoR_1	84	89	PF00244	0.286
LIG_14-3-3_CanoR_1	907	911	PF00244	0.546
LIG_14-3-3_CanoR_1	963	971	PF00244	0.520
LIG_Actin_WH2_2	643	660	PF00022	0.447
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_BIR_III_2	940	944	PF00653	0.662
LIG_BIR_III_4	3	7	PF00653	0.572
LIG_BIR_III_4	327	331	PF00653	0.355
LIG_BIR_III_4	826	830	PF00653	0.564
LIG_BIR_III_4	999	1003	PF00653	0.478
LIG_BRCT_BRCA1_1	335	339	PF00533	0.523
LIG_BRCT_BRCA1_1	395	399	PF00533	0.398
LIG_BRCT_BRCA1_1	401	405	PF00533	0.415
LIG_BRCT_BRCA1_1	964	968	PF00533	0.535
LIG_deltaCOP1_diTrp_1	706	711	PF00928	0.522
LIG_deltaCOP1_diTrp_1	905	914	PF00928	0.524
LIG_eIF4E_1	143	149	PF01652	0.308
LIG_eIF4E_1	20	26	PF01652	0.354
LIG_FHA_1	144	150	PF00498	0.462
LIG_FHA_1	22	28	PF00498	0.437
LIG_FHA_1	344	350	PF00498	0.440
LIG_FHA_1	491	497	PF00498	0.467
LIG_FHA_1	559	565	PF00498	0.492
LIG_FHA_1	591	597	PF00498	0.662
LIG_FHA_1	60	66	PF00498	0.578
LIG_FHA_1	718	724	PF00498	0.710
LIG_FHA_1	761	767	PF00498	0.407
LIG_FHA_1	800	806	PF00498	0.528
LIG_FHA_2	35	41	PF00498	0.406
LIG_FHA_2	475	481	PF00498	0.524
LIG_FHA_2	55	61	PF00498	0.401
LIG_FHA_2	571	577	PF00498	0.396
LIG_FHA_2	688	694	PF00498	0.533
LIG_GBD_Chelix_1	247	255	PF00786	0.342
LIG_IRF3_LxIS_1	21	28	PF10401	0.440
LIG_LIR_Apic_2	201	207	PF02991	0.389
LIG_LIR_Apic_2	905	911	PF02991	0.495
LIG_LIR_Gen_1	236	247	PF02991	0.340
LIG_LIR_Gen_1	278	286	PF02991	0.441
LIG_LIR_Gen_1	336	343	PF02991	0.316
LIG_LIR_Gen_1	47	56	PF02991	0.483
LIG_LIR_Gen_1	628	635	PF02991	0.467
LIG_LIR_Gen_1	706	716	PF02991	0.512
LIG_LIR_Gen_1	965	976	PF02991	0.523
LIG_LIR_Nem_3	236	242	PF02991	0.345
LIG_LIR_Nem_3	278	282	PF02991	0.392
LIG_LIR_Nem_3	336	342	PF02991	0.316
LIG_LIR_Nem_3	40	45	PF02991	0.469
LIG_LIR_Nem_3	47	52	PF02991	0.439
LIG_LIR_Nem_3	648	654	PF02991	0.530
LIG_LIR_Nem_3	671	677	PF02991	0.530
LIG_LIR_Nem_3	706	712	PF02991	0.511
LIG_LIR_Nem_3	9	14	PF02991	0.593
LIG_LIR_Nem_3	965	971	PF02991	0.475
LIG_LIR_Nem_3	991	997	PF02991	0.469
LIG_LYPXL_SIV_4	993	1001	PF13949	0.393
LIG_LYPXL_yS_3	300	303	PF13949	0.385
LIG_MAD2	996	1004	PF02301	0.466
LIG_MYND_1	974	978	PF01753	0.489
LIG_NRBOX	250	256	PF00104	0.377
LIG_NRBOX	559	565	PF00104	0.428
LIG_Pex14_1	651	655	PF04695	0.447
LIG_Pex14_1	707	711	PF04695	0.476
LIG_Pex14_1	908	912	PF04695	0.558
LIG_PTB_Apo_2	976	983	PF02174	0.492
LIG_PTB_Phospho_1	976	982	PF10480	0.495
LIG_REV1ctd_RIR_1	279	288	PF16727	0.344
LIG_SH2_CRK	1025	1029	PF00017	0.469
LIG_SH2_CRK	229	233	PF00017	0.414
LIG_SH2_CRK	273	277	PF00017	0.431
LIG_SH2_CRK	709	713	PF00017	0.498
LIG_SH2_CRK	870	874	PF00017	0.424
LIG_SH2_CRK	994	998	PF00017	0.477
LIG_SH2_GRB2like	924	927	PF00017	0.475
LIG_SH2_NCK_1	326	330	PF00017	0.470
LIG_SH2_NCK_1	786	790	PF00017	0.499
LIG_SH2_PTP2	204	207	PF00017	0.388
LIG_SH2_SRC	204	207	PF00017	0.388
LIG_SH2_SRC	229	232	PF00017	0.416
LIG_SH2_SRC	874	877	PF00017	0.309
LIG_SH2_STAP1	229	233	PF00017	0.414
LIG_SH2_STAP1	373	377	PF00017	0.515
LIG_SH2_STAP1	786	790	PF00017	0.499
LIG_SH2_STAP1	860	864	PF00017	0.382
LIG_SH2_STAP1	874	878	PF00017	0.360
LIG_SH2_STAT3	20	23	PF00017	0.443
LIG_SH2_STAT3	388	391	PF00017	0.530
LIG_SH2_STAT5	204	207	PF00017	0.526
LIG_SH2_STAT5	222	225	PF00017	0.307
LIG_SH2_STAT5	264	267	PF00017	0.303
LIG_SH2_STAT5	388	391	PF00017	0.447
LIG_SH2_STAT5	421	424	PF00017	0.454
LIG_SH2_STAT5	630	633	PF00017	0.530
LIG_SH2_STAT5	699	702	PF00017	0.499
LIG_SH2_STAT5	786	789	PF00017	0.508
LIG_SH2_STAT5	855	858	PF00017	0.477
LIG_SH2_STAT5	860	863	PF00017	0.482
LIG_SH2_STAT5	870	873	PF00017	0.243
LIG_SH2_STAT5	986	989	PF00017	0.352
LIG_SH2_STAT5	99	102	PF00017	0.308
LIG_SH3_3	15	21	PF00018	0.476
LIG_SH3_3	310	316	PF00018	0.482
LIG_SH3_3	718	724	PF00018	0.651
LIG_SH3_3	893	899	PF00018	0.576
LIG_SH3_3	968	974	PF00018	0.351
LIG_SUMO_SIM_anti_2	145	153	PF11976	0.259
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.300
LIG_SUMO_SIM_anti_2	573	579	PF11976	0.383
LIG_SUMO_SIM_par_1	145	153	PF11976	0.241
LIG_SUMO_SIM_par_1	23	28	PF11976	0.446
LIG_SUMO_SIM_par_1	230	236	PF11976	0.300
LIG_SUMO_SIM_par_1	573	579	PF11976	0.464
LIG_SUMO_SIM_par_1	776	782	PF11976	0.509
LIG_SUMO_SIM_par_1	898	906	PF11976	0.508
LIG_SUMO_SIM_par_1	969	975	PF11976	0.443
LIG_TRAF2_1	57	60	PF00917	0.433
LIG_TYR_ITIM	290	295	PF00017	0.394
LIG_TYR_ITIM	872	877	PF00017	0.379
LIG_WRC_WIRS_1	377	382	PF05994	0.400
MOD_CK1_1	351	357	PF00069	0.332
MOD_CK1_1	393	399	PF00069	0.436
MOD_CK1_1	54	60	PF00069	0.483
MOD_CK1_1	556	562	PF00069	0.327
MOD_CK1_1	591	597	PF00069	0.575
MOD_CK1_1	765	771	PF00069	0.377
MOD_CK1_1	812	818	PF00069	0.370
MOD_CK2_1	112	118	PF00069	0.308
MOD_CK2_1	188	194	PF00069	0.561
MOD_CK2_1	474	480	PF00069	0.379
MOD_CK2_1	509	515	PF00069	0.451
MOD_CK2_1	54	60	PF00069	0.472
MOD_CK2_1	563	569	PF00069	0.394
MOD_CK2_1	687	693	PF00069	0.401
MOD_CK2_1	919	925	PF00069	0.648
MOD_CK2_1	941	947	PF00069	0.594
MOD_Cter_Amidation	210	213	PF01082	0.457
MOD_GlcNHglycan	1010	1013	PF01048	0.660
MOD_GlcNHglycan	190	193	PF01048	0.566
MOD_GlcNHglycan	353	356	PF01048	0.314
MOD_GlcNHglycan	399	402	PF01048	0.453
MOD_GlcNHglycan	442	445	PF01048	0.416
MOD_GlcNHglycan	470	473	PF01048	0.294
MOD_GlcNHglycan	53	56	PF01048	0.537
MOD_GlcNHglycan	569	573	PF01048	0.494
MOD_GlcNHglycan	647	650	PF01048	0.417
MOD_GlcNHglycan	822	825	PF01048	0.553
MOD_GlcNHglycan	921	924	PF01048	0.453
MOD_GlcNHglycan	952	955	PF01048	0.569
MOD_GSK3_1	21	28	PF00069	0.460
MOD_GSK3_1	390	397	PF00069	0.373
MOD_GSK3_1	435	442	PF00069	0.350
MOD_GSK3_1	464	471	PF00069	0.387
MOD_GSK3_1	50	57	PF00069	0.610
MOD_GSK3_1	526	533	PF00069	0.624
MOD_GSK3_1	587	594	PF00069	0.601
MOD_GSK3_1	625	632	PF00069	0.402
MOD_GSK3_1	740	747	PF00069	0.705
MOD_GSK3_1	758	765	PF00069	0.266
MOD_GSK3_1	838	845	PF00069	0.527
MOD_GSK3_1	942	949	PF00069	0.786
MOD_N-GLC_1	490	495	PF02516	0.379
MOD_N-GLC_1	50	55	PF02516	0.498
MOD_N-GLC_1	531	536	PF02516	0.619
MOD_N-GLC_2	643	645	PF02516	0.308
MOD_NEK2_1	220	225	PF00069	0.366
MOD_NEK2_1	247	252	PF00069	0.314
MOD_NEK2_1	25	30	PF00069	0.423
MOD_NEK2_1	333	338	PF00069	0.429
MOD_NEK2_1	343	348	PF00069	0.268
MOD_NEK2_1	399	404	PF00069	0.223
MOD_NEK2_1	440	445	PF00069	0.405
MOD_NEK2_1	489	494	PF00069	0.312
MOD_NEK2_1	563	568	PF00069	0.428
MOD_NEK2_1	570	575	PF00069	0.373
MOD_NEK2_1	617	622	PF00069	0.364
MOD_NEK2_1	631	636	PF00069	0.337
MOD_NEK2_1	657	662	PF00069	0.323
MOD_NEK2_1	809	814	PF00069	0.421
MOD_NEK2_2	914	919	PF00069	0.485
MOD_PIKK_1	669	675	PF00454	0.400
MOD_PIKK_1	842	848	PF00454	0.427
MOD_PK_1	112	118	PF00069	0.360
MOD_PKA_1	84	90	PF00069	0.284
MOD_PKA_2	484	490	PF00069	0.352
MOD_PKA_2	645	651	PF00069	0.382
MOD_PKA_2	657	663	PF00069	0.265
MOD_PKA_2	752	758	PF00069	0.369
MOD_PKA_2	820	826	PF00069	0.549
MOD_PKA_2	84	90	PF00069	0.284
MOD_PKA_2	906	912	PF00069	0.536
MOD_PKA_2	962	968	PF00069	0.535
MOD_PKB_1	82	90	PF00069	0.215
MOD_Plk_1	333	339	PF00069	0.462
MOD_Plk_1	490	496	PF00069	0.379
MOD_Plk_1	509	515	PF00069	0.451
MOD_Plk_1	531	537	PF00069	0.567
MOD_Plk_1	842	848	PF00069	0.375
MOD_Plk_1	914	920	PF00069	0.438
MOD_Plk_4	112	118	PF00069	0.308
MOD_Plk_4	21	27	PF00069	0.464
MOD_Plk_4	348	354	PF00069	0.308
MOD_Plk_4	484	490	PF00069	0.327
MOD_Plk_4	570	576	PF00069	0.408
MOD_Plk_4	591	597	PF00069	0.561
MOD_Plk_4	762	768	PF00069	0.369
MOD_Plk_4	84	90	PF00069	0.284
MOD_Plk_4	972	978	PF00069	0.372
MOD_ProDKin_1	390	396	PF00069	0.373
MOD_ProDKin_1	40	46	PF00069	0.428
MOD_ProDKin_1	625	631	PF00069	0.284
MOD_ProDKin_1	687	693	PF00069	0.401
MOD_ProDKin_1	717	723	PF00069	0.617
MOD_ProDKin_1	744	750	PF00069	0.666
MOD_ProDKin_1	939	945	PF00069	0.663
MOD_ProDKin_1	946	952	PF00069	0.663
MOD_SUMO_for_1	169	172	PF00179	0.527
MOD_SUMO_rev_2	620	629	PF00179	0.312
MOD_SUMO_rev_2	667	672	PF00179	0.400
TRG_DiLeu_BaEn_1	966	971	PF01217	0.467
TRG_DiLeu_BaEn_1	972	977	PF01217	0.376
TRG_DiLeu_BaEn_3	297	303	PF01217	0.329
TRG_DiLeu_BaEn_4	915	921	PF01217	0.443
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.340
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.506
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.400
TRG_DiLeu_BaLyEn_6	718	723	PF01217	0.643
TRG_ENDOCYTIC_2	1025	1028	PF00928	0.391
TRG_ENDOCYTIC_2	229	232	PF00928	0.416
TRG_ENDOCYTIC_2	264	267	PF00928	0.332
TRG_ENDOCYTIC_2	273	276	PF00928	0.386
TRG_ENDOCYTIC_2	292	295	PF00928	0.353
TRG_ENDOCYTIC_2	300	303	PF00928	0.363
TRG_ENDOCYTIC_2	630	633	PF00928	0.312
TRG_ENDOCYTIC_2	708	711	PF00928	0.518
TRG_ENDOCYTIC_2	874	877	PF00928	0.382
TRG_ENDOCYTIC_2	994	997	PF00928	0.367
TRG_ER_diArg_1	199	202	PF00400	0.314
TRG_ER_diArg_1	286	288	PF00400	0.461
TRG_ER_diArg_1	324	326	PF00400	0.449
TRG_ER_diArg_1	417	420	PF00400	0.348
TRG_ER_diArg_1	500	502	PF00400	0.284
TRG_ER_diArg_1	65	68	PF00400	0.487
TRG_ER_diArg_1	657	659	PF00400	0.284
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	447	452	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXX4	Leptomonas seymouri	65%	100%
A0A1X0NTW1	Trypanosomatidae	38%	100%
A0A3R7KR10	Trypanosoma rangeli	41%	100%
A0A3S7WTI0	Leishmania donovani	92%	99%
A4H854	Leishmania braziliensis	81%	98%
A4HWH9	Leishmania infantum	92%	99%
C9ZXW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQ80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%