Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFA0_LEIMA

TriTrypDb:

LmjF.15.0830 , LMJLV39_150014900 , LMJSD75_150015100

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.475
CLV_C14_Caspase3-7	570	574	PF00656	0.432
CLV_C14_Caspase3-7	648	652	PF00656	0.656
CLV_NRD_NRD_1	174	176	PF00675	0.494
CLV_NRD_NRD_1	198	200	PF00675	0.522
CLV_NRD_NRD_1	206	208	PF00675	0.445
CLV_NRD_NRD_1	214	216	PF00675	0.465
CLV_NRD_NRD_1	478	480	PF00675	0.532
CLV_NRD_NRD_1	53	55	PF00675	0.637
CLV_NRD_NRD_1	542	544	PF00675	0.450
CLV_PCSK_KEX2_1	174	176	PF00082	0.489
CLV_PCSK_KEX2_1	206	208	PF00082	0.462
CLV_PCSK_KEX2_1	478	480	PF00082	0.532
CLV_PCSK_KEX2_1	52	54	PF00082	0.632
CLV_PCSK_KEX2_1	542	544	PF00082	0.450
CLV_PCSK_PC7_1	474	480	PF00082	0.384
CLV_PCSK_SKI1_1	199	203	PF00082	0.473
CLV_PCSK_SKI1_1	338	342	PF00082	0.605
CLV_PCSK_SKI1_1	354	358	PF00082	0.518
CLV_PCSK_SKI1_1	469	473	PF00082	0.528
CLV_PCSK_SKI1_1	593	597	PF00082	0.567
CLV_PCSK_SKI1_1	624	628	PF00082	0.602
CLV_PCSK_SKI1_1	690	694	PF00082	0.587
CLV_PCSK_SKI1_1	817	821	PF00082	0.527
DEG_APCC_DBOX_1	198	206	PF00400	0.553
DEG_APCC_DBOX_1	337	345	PF00400	0.551
DEG_SCF_FBW7_1	245	251	PF00400	0.655
DEG_SPOP_SBC_1	236	240	PF00917	0.604
DEG_SPOP_SBC_1	398	402	PF00917	0.555
DEG_SPOP_SBC_1	638	642	PF00917	0.560
DEG_SPOP_SBC_1	7	11	PF00917	0.678
DOC_CKS1_1	245	250	PF01111	0.657
DOC_CKS1_1	802	807	PF01111	0.590
DOC_CYCLIN_RxL_1	196	203	PF00134	0.472
DOC_MAPK_gen_1	769	776	PF00069	0.655
DOC_PP1_RVXF_1	644	650	PF00149	0.654
DOC_PP2B_LxvP_1	30	33	PF13499	0.552
DOC_PP2B_LxvP_1	633	636	PF13499	0.623
DOC_PP4_FxxP_1	666	669	PF00568	0.652
DOC_USP7_MATH_1	108	112	PF00917	0.593
DOC_USP7_MATH_1	178	182	PF00917	0.459
DOC_USP7_MATH_1	190	194	PF00917	0.620
DOC_USP7_MATH_1	248	252	PF00917	0.685
DOC_USP7_MATH_1	314	318	PF00917	0.553
DOC_USP7_MATH_1	399	403	PF00917	0.642
DOC_USP7_MATH_1	409	413	PF00917	0.522
DOC_USP7_MATH_1	481	485	PF00917	0.467
DOC_USP7_MATH_1	58	62	PF00917	0.673
DOC_USP7_MATH_1	64	68	PF00917	0.595
DOC_USP7_MATH_1	667	671	PF00917	0.660
DOC_USP7_MATH_1	676	680	PF00917	0.589
DOC_USP7_MATH_1	684	688	PF00917	0.553
DOC_USP7_MATH_1	7	11	PF00917	0.655
DOC_USP7_MATH_2	113	119	PF00917	0.644
DOC_USP7_UBL2_3	200	204	PF12436	0.550
DOC_WW_Pin1_4	239	244	PF00397	0.693
DOC_WW_Pin1_4	291	296	PF00397	0.704
DOC_WW_Pin1_4	60	65	PF00397	0.720
DOC_WW_Pin1_4	672	677	PF00397	0.616
DOC_WW_Pin1_4	680	685	PF00397	0.621
DOC_WW_Pin1_4	70	75	PF00397	0.523
DOC_WW_Pin1_4	729	734	PF00397	0.563
DOC_WW_Pin1_4	801	806	PF00397	0.580
LIG_14-3-3_CanoR_1	230	236	PF00244	0.629
LIG_14-3-3_CanoR_1	326	330	PF00244	0.615
LIG_14-3-3_CanoR_1	457	465	PF00244	0.542
LIG_14-3-3_CanoR_1	528	534	PF00244	0.477
LIG_14-3-3_CanoR_1	59	64	PF00244	0.717
LIG_14-3-3_CanoR_1	593	601	PF00244	0.493
LIG_14-3-3_CanoR_1	646	650	PF00244	0.657
LIG_14-3-3_CanoR_1	678	683	PF00244	0.631
LIG_14-3-3_CanoR_1	68	74	PF00244	0.538
LIG_14-3-3_CanoR_1	794	802	PF00244	0.626
LIG_APCC_ABBA_1	470	475	PF00400	0.387
LIG_APCC_ABBAyCdc20_2	469	475	PF00400	0.536
LIG_BIR_III_4	20	24	PF00653	0.699
LIG_BIR_III_4	694	698	PF00653	0.561
LIG_EVH1_2	32	36	PF00568	0.572
LIG_FHA_1	196	202	PF00498	0.479
LIG_FHA_1	240	246	PF00498	0.656
LIG_FHA_1	260	266	PF00498	0.631
LIG_FHA_1	269	275	PF00498	0.579
LIG_FHA_1	376	382	PF00498	0.578
LIG_FHA_1	797	803	PF00498	0.529
LIG_FHA_1	93	99	PF00498	0.541
LIG_FHA_2	245	251	PF00498	0.658
LIG_FHA_2	457	463	PF00498	0.587
LIG_FHA_2	582	588	PF00498	0.416
LIG_FHA_2	594	600	PF00498	0.619
LIG_FHA_2	646	652	PF00498	0.659
LIG_LIR_Apic_2	664	669	PF02991	0.727
LIG_LIR_Apic_2	787	792	PF02991	0.646
LIG_LIR_Gen_1	147	154	PF02991	0.461
LIG_LIR_Nem_3	147	152	PF02991	0.471
LIG_LIR_Nem_3	813	819	PF02991	0.502
LIG_Pex14_1	183	187	PF04695	0.564
LIG_Pex14_1	812	816	PF04695	0.549
LIG_RPA_C_Fungi	177	189	PF08784	0.506
LIG_SH2_STAT3	160	163	PF00017	0.428
LIG_SH2_STAT3	473	476	PF00017	0.385
LIG_SH3_3	26	32	PF00018	0.622
LIG_SH3_3	271	277	PF00018	0.606
LIG_SH3_3	370	376	PF00018	0.611
LIG_SH3_3	720	726	PF00018	0.644
LIG_SH3_3	727	733	PF00018	0.599
LIG_SH3_3	799	805	PF00018	0.593
LIG_SH3_3	96	102	PF00018	0.648
LIG_SUMO_SIM_anti_2	584	590	PF11976	0.465
LIG_SUMO_SIM_par_1	150	156	PF11976	0.427
LIG_TRAF2_1	518	521	PF00917	0.460
LIG_TRAF2_1	811	814	PF00917	0.497
LIG_UBA3_1	201	210	PF00899	0.543
MOD_CDC14_SPxK_1	675	678	PF00782	0.697
MOD_CDK_SPxK_1	672	678	PF00069	0.619
MOD_CDK_SPxxK_3	291	298	PF00069	0.512
MOD_CDK_SPxxK_3	801	808	PF00069	0.571
MOD_CK1_1	107	113	PF00069	0.706
MOD_CK1_1	193	199	PF00069	0.573
MOD_CK1_1	229	235	PF00069	0.692
MOD_CK1_1	238	244	PF00069	0.595
MOD_CK1_1	259	265	PF00069	0.700
MOD_CK1_1	279	285	PF00069	0.477
MOD_CK1_1	317	323	PF00069	0.649
MOD_CK1_1	325	331	PF00069	0.550
MOD_CK1_1	345	351	PF00069	0.561
MOD_CK1_1	362	368	PF00069	0.500
MOD_CK1_1	433	439	PF00069	0.722
MOD_CK1_1	6	12	PF00069	0.644
MOD_CK1_1	66	72	PF00069	0.730
MOD_CK1_1	685	691	PF00069	0.625
MOD_CK1_1	713	719	PF00069	0.611
MOD_CK1_1	73	79	PF00069	0.608
MOD_CK1_1	790	796	PF00069	0.629
MOD_CK2_1	178	184	PF00069	0.428
MOD_CK2_1	409	415	PF00069	0.642
MOD_CK2_1	456	462	PF00069	0.603
MOD_CK2_1	542	548	PF00069	0.486
MOD_CK2_1	581	587	PF00069	0.428
MOD_CK2_1	593	599	PF00069	0.602
MOD_GlcNHglycan	10	13	PF01048	0.735
MOD_GlcNHglycan	106	109	PF01048	0.545
MOD_GlcNHglycan	110	113	PF01048	0.569
MOD_GlcNHglycan	142	145	PF01048	0.518
MOD_GlcNHglycan	232	235	PF01048	0.753
MOD_GlcNHglycan	250	253	PF01048	0.683
MOD_GlcNHglycan	309	312	PF01048	0.663
MOD_GlcNHglycan	389	392	PF01048	0.670
MOD_GlcNHglycan	411	414	PF01048	0.608
MOD_GlcNHglycan	432	435	PF01048	0.684
MOD_GlcNHglycan	439	442	PF01048	0.719
MOD_GlcNHglycan	483	486	PF01048	0.643
MOD_GlcNHglycan	5	8	PF01048	0.690
MOD_GlcNHglycan	544	547	PF01048	0.480
MOD_GlcNHglycan	642	645	PF01048	0.600
MOD_GlcNHglycan	663	666	PF01048	0.700
MOD_GlcNHglycan	713	716	PF01048	0.668
MOD_GlcNHglycan	719	722	PF01048	0.649
MOD_GlcNHglycan	765	768	PF01048	0.680
MOD_GlcNHglycan	77	80	PF01048	0.777
MOD_GlcNHglycan	789	792	PF01048	0.573
MOD_GSK3_1	1	8	PF00069	0.654
MOD_GSK3_1	104	111	PF00069	0.732
MOD_GSK3_1	191	198	PF00069	0.551
MOD_GSK3_1	226	233	PF00069	0.694
MOD_GSK3_1	235	242	PF00069	0.612
MOD_GSK3_1	244	251	PF00069	0.563
MOD_GSK3_1	268	275	PF00069	0.631
MOD_GSK3_1	314	321	PF00069	0.619
MOD_GSK3_1	399	406	PF00069	0.612
MOD_GSK3_1	416	423	PF00069	0.411
MOD_GSK3_1	429	436	PF00069	0.536
MOD_GSK3_1	538	545	PF00069	0.545
MOD_GSK3_1	556	563	PF00069	0.410
MOD_GSK3_1	59	66	PF00069	0.700
MOD_GSK3_1	668	675	PF00069	0.632
MOD_GSK3_1	676	683	PF00069	0.607
MOD_GSK3_1	709	716	PF00069	0.746
MOD_GSK3_1	724	731	PF00069	0.534
MOD_GSK3_1	790	797	PF00069	0.618
MOD_LATS_1	57	63	PF00433	0.674
MOD_N-GLC_1	272	277	PF02516	0.550
MOD_N-GLC_1	359	364	PF02516	0.582
MOD_N-GLC_1	593	598	PF02516	0.607
MOD_N-GLC_1	92	97	PF02516	0.622
MOD_NEK2_1	305	310	PF00069	0.535
MOD_NEK2_1	386	391	PF00069	0.577
MOD_NEK2_1	403	408	PF00069	0.566
MOD_NEK2_1	430	435	PF00069	0.594
MOD_NEK2_1	526	531	PF00069	0.552
MOD_NEK2_1	581	586	PF00069	0.465
MOD_NEK2_1	711	716	PF00069	0.665
MOD_NEK2_2	23	28	PF00069	0.569
MOD_PIKK_1	279	285	PF00454	0.564
MOD_PIKK_1	581	587	PF00454	0.428
MOD_PK_1	724	730	PF00069	0.541
MOD_PKA_1	542	548	PF00069	0.453
MOD_PKA_2	229	235	PF00069	0.674
MOD_PKA_2	325	331	PF00069	0.556
MOD_PKA_2	345	351	PF00069	0.561
MOD_PKA_2	456	462	PF00069	0.573
MOD_PKA_2	529	535	PF00069	0.479
MOD_PKA_2	542	548	PF00069	0.473
MOD_PKA_2	556	562	PF00069	0.454
MOD_PKA_2	571	577	PF00069	0.350
MOD_PKA_2	58	64	PF00069	0.674
MOD_PKA_2	645	651	PF00069	0.687
MOD_PKA_2	655	661	PF00069	0.573
MOD_PKA_2	67	73	PF00069	0.547
MOD_PKA_2	709	715	PF00069	0.605
MOD_Plk_1	272	278	PF00069	0.586
MOD_Plk_1	700	706	PF00069	0.563
MOD_Plk_4	416	422	PF00069	0.595
MOD_Plk_4	548	554	PF00069	0.579
MOD_Plk_4	724	730	PF00069	0.667
MOD_Plk_4	737	743	PF00069	0.577
MOD_ProDKin_1	239	245	PF00069	0.695
MOD_ProDKin_1	291	297	PF00069	0.699
MOD_ProDKin_1	60	66	PF00069	0.721
MOD_ProDKin_1	672	678	PF00069	0.619
MOD_ProDKin_1	680	686	PF00069	0.618
MOD_ProDKin_1	70	76	PF00069	0.526
MOD_ProDKin_1	729	735	PF00069	0.563
MOD_ProDKin_1	801	807	PF00069	0.574
MOD_SUMO_for_1	507	510	PF00179	0.520
MOD_SUMO_for_1	568	571	PF00179	0.459
MOD_SUMO_rev_2	619	626	PF00179	0.623
TRG_DiLeu_BaEn_1	286	291	PF01217	0.625
TRG_ENDOCYTIC_2	149	152	PF00928	0.444
TRG_ER_diArg_1	161	164	PF00400	0.440
TRG_ER_diArg_1	173	175	PF00400	0.458
TRG_ER_diArg_1	205	207	PF00400	0.468
TRG_ER_diArg_1	52	54	PF00400	0.623
TRG_NLS_Bipartite_1	199	219	PF00514	0.529
TRG_NLS_MonoExtN_4	214	219	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C2	Leptomonas seymouri	31%	89%
A0A3Q8IIQ6	Leishmania donovani	87%	100%
A4H856	Leishmania braziliensis	54%	96%
A4HWI1	Leishmania infantum	87%	100%
E9AQ82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%