Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF99_LEIMA

TriTrypDb:

LmjF.15.0850 , LMJLV39_150015100 , LMJSD75_150015300

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.498
CLV_NRD_NRD_1	24	26	PF00675	0.511
CLV_NRD_NRD_1	453	455	PF00675	0.539
CLV_NRD_NRD_1	46	48	PF00675	0.547
CLV_NRD_NRD_1	477	479	PF00675	0.515
CLV_NRD_NRD_1	52	54	PF00675	0.510
CLV_NRD_NRD_1	596	598	PF00675	0.502
CLV_NRD_NRD_1	604	606	PF00675	0.310
CLV_NRD_NRD_1	649	651	PF00675	0.534
CLV_NRD_NRD_1	655	657	PF00675	0.497
CLV_NRD_NRD_1	658	660	PF00675	0.473
CLV_NRD_NRD_1	717	719	PF00675	0.476
CLV_NRD_NRD_1	948	950	PF00675	0.619
CLV_PCSK_FUR_1	656	660	PF00082	0.513
CLV_PCSK_KEX2_1	162	164	PF00082	0.498
CLV_PCSK_KEX2_1	274	276	PF00082	0.507
CLV_PCSK_KEX2_1	37	39	PF00082	0.527
CLV_PCSK_KEX2_1	41	43	PF00082	0.557
CLV_PCSK_KEX2_1	46	48	PF00082	0.578
CLV_PCSK_KEX2_1	51	53	PF00082	0.490
CLV_PCSK_KEX2_1	596	598	PF00082	0.502
CLV_PCSK_KEX2_1	604	606	PF00082	0.310
CLV_PCSK_KEX2_1	649	651	PF00082	0.535
CLV_PCSK_KEX2_1	655	657	PF00082	0.499
CLV_PCSK_KEX2_1	658	660	PF00082	0.475
CLV_PCSK_KEX2_1	717	719	PF00082	0.439
CLV_PCSK_KEX2_1	948	950	PF00082	0.619
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.471
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.527
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.560
CLV_PCSK_PC7_1	270	276	PF00082	0.514
CLV_PCSK_PC7_1	42	48	PF00082	0.564
CLV_PCSK_SKI1_1	165	169	PF00082	0.498
CLV_PCSK_SKI1_1	228	232	PF00082	0.552
CLV_PCSK_SKI1_1	31	35	PF00082	0.542
CLV_PCSK_SKI1_1	46	50	PF00082	0.488
CLV_PCSK_SKI1_1	633	637	PF00082	0.325
CLV_PCSK_SKI1_1	688	692	PF00082	0.431
CLV_PCSK_SKI1_1	700	704	PF00082	0.433
CLV_PCSK_SKI1_1	717	721	PF00082	0.375
CLV_PCSK_SKI1_1	824	828	PF00082	0.475
CLV_PCSK_SKI1_1	949	953	PF00082	0.515
DEG_APCC_DBOX_1	164	172	PF00400	0.698
DEG_SCF_FBW7_1	581	587	PF00400	0.601
DEG_SPOP_SBC_1	465	469	PF00917	0.707
DOC_CKS1_1	581	586	PF01111	0.602
DOC_CYCLIN_RxL_1	633	642	PF00134	0.345
DOC_CYCLIN_RxL_1	697	707	PF00134	0.651
DOC_MAPK_gen_1	604	611	PF00069	0.535
DOC_MAPK_MEF2A_6	604	613	PF00069	0.490
DOC_PP1_RVXF_1	268	274	PF00149	0.722
DOC_PP1_RVXF_1	7	13	PF00149	0.687
DOC_PP2B_LxvP_1	897	900	PF13499	0.665
DOC_PP2B_PxIxI_1	814	820	PF00149	0.614
DOC_PP4_FxxP_1	327	330	PF00568	0.602
DOC_USP7_MATH_1	303	307	PF00917	0.642
DOC_USP7_MATH_1	345	349	PF00917	0.628
DOC_USP7_MATH_1	405	409	PF00917	0.680
DOC_USP7_MATH_1	57	61	PF00917	0.765
DOC_USP7_MATH_1	582	586	PF00917	0.681
DOC_USP7_MATH_1	708	712	PF00917	0.690
DOC_USP7_MATH_1	845	849	PF00917	0.691
DOC_USP7_MATH_1	855	859	PF00917	0.617
DOC_USP7_MATH_1	900	904	PF00917	0.746
DOC_USP7_MATH_1	917	921	PF00917	0.631
DOC_USP7_UBL2_3	31	35	PF12436	0.760
DOC_USP7_UBL2_3	37	41	PF12436	0.739
DOC_WW_Pin1_4	119	124	PF00397	0.707
DOC_WW_Pin1_4	135	140	PF00397	0.752
DOC_WW_Pin1_4	172	177	PF00397	0.796
DOC_WW_Pin1_4	332	337	PF00397	0.712
DOC_WW_Pin1_4	431	436	PF00397	0.704
DOC_WW_Pin1_4	53	58	PF00397	0.730
DOC_WW_Pin1_4	580	585	PF00397	0.606
DOC_WW_Pin1_4	781	786	PF00397	0.715
DOC_WW_Pin1_4	848	853	PF00397	0.669
DOC_WW_Pin1_4	941	946	PF00397	0.675
LIG_14-3-3_CanoR_1	162	168	PF00244	0.704
LIG_14-3-3_CanoR_1	284	288	PF00244	0.694
LIG_14-3-3_CanoR_1	3	10	PF00244	0.726
LIG_14-3-3_CanoR_1	310	320	PF00244	0.666
LIG_14-3-3_CanoR_1	478	487	PF00244	0.644
LIG_14-3-3_CanoR_1	615	620	PF00244	0.365
LIG_14-3-3_CanoR_1	621	627	PF00244	0.510
LIG_Actin_WH2_2	819	834	PF00022	0.668
LIG_BRCT_BRCA1_1	181	185	PF00533	0.715
LIG_BRCT_BRCA1_1	279	283	PF00533	0.695
LIG_BRCT_BRCA1_1	323	327	PF00533	0.695
LIG_CaM_IQ_9	157	172	PF13499	0.702
LIG_DCNL_PONY_1	1	4	PF03556	0.682
LIG_deltaCOP1_diTrp_1	318	327	PF00928	0.643
LIG_FHA_1	581	587	PF00498	0.736
LIG_FHA_1	79	85	PF00498	0.764
LIG_FHA_1	804	810	PF00498	0.706
LIG_FHA_1	855	861	PF00498	0.587
LIG_FHA_1	99	105	PF00498	0.594
LIG_FHA_2	108	114	PF00498	0.664
LIG_FHA_2	380	386	PF00498	0.604
LIG_FHA_2	411	417	PF00498	0.755
LIG_FHA_2	734	740	PF00498	0.737
LIG_FHA_2	782	788	PF00498	0.617
LIG_FHA_2	859	865	PF00498	0.643
LIG_Integrin_isoDGR_2	653	655	PF01839	0.400
LIG_LIR_Apic_2	324	330	PF02991	0.603
LIG_LIR_Gen_1	318	327	PF02991	0.643
LIG_LIR_Gen_1	422	432	PF02991	0.732
LIG_LIR_Gen_1	571	582	PF02991	0.722
LIG_LIR_Gen_1	813	822	PF02991	0.632
LIG_LIR_Gen_1	836	846	PF02991	0.612
LIG_LIR_Gen_1	882	890	PF02991	0.629
LIG_LIR_Nem_3	182	188	PF02991	0.657
LIG_LIR_Nem_3	318	323	PF02991	0.646
LIG_LIR_Nem_3	342	346	PF02991	0.694
LIG_LIR_Nem_3	422	428	PF02991	0.733
LIG_LIR_Nem_3	634	639	PF02991	0.315
LIG_LIR_Nem_3	698	702	PF02991	0.678
LIG_LIR_Nem_3	766	770	PF02991	0.647
LIG_LIR_Nem_3	813	819	PF02991	0.620
LIG_LIR_Nem_3	836	841	PF02991	0.605
LIG_LIR_Nem_3	882	888	PF02991	0.621
LIG_LYPXL_yS_3	343	346	PF13949	0.636
LIG_PCNA_yPIPBox_3	159	168	PF02747	0.693
LIG_Pex14_1	871	875	PF04695	0.614
LIG_Pex14_1	935	939	PF04695	0.706
LIG_PROFILIN_1	139	145	PF00235	0.725
LIG_REV1ctd_RIR_1	633	641	PF16727	0.345
LIG_SH2_PTP2	816	819	PF00017	0.618
LIG_SH2_SRC	210	213	PF00017	0.705
LIG_SH2_SRC	694	697	PF00017	0.657
LIG_SH2_STAP1	367	371	PF00017	0.624
LIG_SH2_STAT3	367	370	PF00017	0.622
LIG_SH2_STAT5	394	397	PF00017	0.699
LIG_SH2_STAT5	444	447	PF00017	0.676
LIG_SH2_STAT5	816	819	PF00017	0.618
LIG_SH2_STAT5	838	841	PF00017	0.659
LIG_SH3_3	136	142	PF00018	0.772
LIG_SH3_3	175	181	PF00018	0.656
LIG_SH3_3	306	312	PF00018	0.679
LIG_SH3_3	338	344	PF00018	0.646
LIG_SH3_3	404	410	PF00018	0.728
LIG_SH3_3	899	905	PF00018	0.694
LIG_SUMO_SIM_par_1	170	175	PF11976	0.790
LIG_SUMO_SIM_par_1	503	510	PF11976	0.673
LIG_TRAF2_1	784	787	PF00917	0.627
LIG_TRAF2_1	811	814	PF00917	0.703
LIG_TYR_ITIM	341	346	PF00017	0.541
LIG_WRC_WIRS_1	380	385	PF05994	0.494
LIG_WRC_WIRS_1	632	637	PF05994	0.395
LIG_WW_3	898	902	PF00397	0.628
MOD_CDK_SPxxK_3	941	948	PF00069	0.596
MOD_CK1_1	119	125	PF00069	0.793
MOD_CK1_1	255	261	PF00069	0.704
MOD_CK1_1	335	341	PF00069	0.567
MOD_CK1_1	396	402	PF00069	0.608
MOD_CK1_1	448	454	PF00069	0.645
MOD_CK1_1	464	470	PF00069	0.551
MOD_CK1_1	5	11	PF00069	0.657
MOD_CK1_1	504	510	PF00069	0.640
MOD_CK1_1	56	62	PF00069	0.695
MOD_CK1_1	563	569	PF00069	0.520
MOD_CK1_1	755	761	PF00069	0.658
MOD_CK1_1	848	854	PF00069	0.602
MOD_CK1_1	858	864	PF00069	0.464
MOD_CK2_1	107	113	PF00069	0.576
MOD_CK2_1	229	235	PF00069	0.705
MOD_CK2_1	325	331	PF00069	0.614
MOD_CK2_1	379	385	PF00069	0.491
MOD_CK2_1	410	416	PF00069	0.642
MOD_CK2_1	56	62	PF00069	0.694
MOD_CK2_1	703	709	PF00069	0.602
MOD_CK2_1	733	739	PF00069	0.700
MOD_CK2_1	781	787	PF00069	0.513
MOD_CK2_1	808	814	PF00069	0.553
MOD_CK2_1	858	864	PF00069	0.552
MOD_Cter_Amidation	23	26	PF01082	0.692
MOD_Cter_Amidation	553	556	PF01082	0.652
MOD_Cter_Amidation	653	656	PF01082	0.600
MOD_GlcNHglycan	104	107	PF01048	0.695
MOD_GlcNHglycan	118	121	PF01048	0.573
MOD_GlcNHglycan	181	184	PF01048	0.560
MOD_GlcNHglycan	189	192	PF01048	0.538
MOD_GlcNHglycan	260	263	PF01048	0.667
MOD_GlcNHglycan	299	302	PF01048	0.773
MOD_GlcNHglycan	337	340	PF01048	0.574
MOD_GlcNHglycan	395	398	PF01048	0.628
MOD_GlcNHglycan	4	7	PF01048	0.618
MOD_GlcNHglycan	42	45	PF01048	0.735
MOD_GlcNHglycan	447	450	PF01048	0.714
MOD_GlcNHglycan	463	466	PF01048	0.532
MOD_GlcNHglycan	468	471	PF01048	0.592
MOD_GlcNHglycan	481	484	PF01048	0.486
MOD_GlcNHglycan	490	493	PF01048	0.471
MOD_GlcNHglycan	524	527	PF01048	0.662
MOD_GlcNHglycan	586	589	PF01048	0.560
MOD_GlcNHglycan	706	709	PF01048	0.641
MOD_GlcNHglycan	710	713	PF01048	0.656
MOD_GlcNHglycan	754	757	PF01048	0.610
MOD_GlcNHglycan	801	804	PF01048	0.566
MOD_GlcNHglycan	847	850	PF01048	0.568
MOD_GlcNHglycan	902	905	PF01048	0.683
MOD_GlcNHglycan	927	930	PF01048	0.612
MOD_GSK3_1	115	122	PF00069	0.644
MOD_GSK3_1	129	136	PF00069	0.657
MOD_GSK3_1	151	158	PF00069	0.730
MOD_GSK3_1	179	186	PF00069	0.518
MOD_GSK3_1	242	249	PF00069	0.746
MOD_GSK3_1	252	259	PF00069	0.617
MOD_GSK3_1	321	328	PF00069	0.567
MOD_GSK3_1	335	342	PF00069	0.496
MOD_GSK3_1	379	386	PF00069	0.541
MOD_GSK3_1	42	49	PF00069	0.689
MOD_GSK3_1	431	438	PF00069	0.584
MOD_GSK3_1	457	464	PF00069	0.648
MOD_GSK3_1	465	472	PF00069	0.674
MOD_GSK3_1	500	507	PF00069	0.598
MOD_GSK3_1	53	60	PF00069	0.624
MOD_GSK3_1	580	587	PF00069	0.640
MOD_GSK3_1	704	711	PF00069	0.679
MOD_GSK3_1	777	784	PF00069	0.517
MOD_GSK3_1	799	806	PF00069	0.584
MOD_GSK3_1	854	861	PF00069	0.529
MOD_GSK3_1	913	920	PF00069	0.698
MOD_GSK3_1	921	928	PF00069	0.591
MOD_GSK3_1	98	105	PF00069	0.610
MOD_N-GLC_1	622	627	PF02516	0.536
MOD_N-GLC_1	703	708	PF02516	0.538
MOD_N-GLC_2	151	153	PF02516	0.605
MOD_N-GLC_2	421	423	PF02516	0.603
MOD_NEK2_1	2	7	PF00069	0.673
MOD_NEK2_1	283	288	PF00069	0.618
MOD_NEK2_1	290	295	PF00069	0.563
MOD_NEK2_1	321	326	PF00069	0.539
MOD_NEK2_1	383	388	PF00069	0.617
MOD_NEK2_1	395	400	PF00069	0.612
MOD_NEK2_1	445	450	PF00069	0.714
MOD_NEK2_1	457	462	PF00069	0.572
MOD_NEK2_1	477	482	PF00069	0.511
MOD_NEK2_1	487	492	PF00069	0.517
MOD_NEK2_1	500	505	PF00069	0.592
MOD_NEK2_1	573	578	PF00069	0.593
MOD_NEK2_1	624	629	PF00069	0.559
MOD_NEK2_1	639	644	PF00069	0.311
MOD_NEK2_1	702	707	PF00069	0.606
MOD_NEK2_1	763	768	PF00069	0.577
MOD_NEK2_2	631	636	PF00069	0.343
MOD_PIKK_1	277	283	PF00454	0.597
MOD_PIKK_1	855	861	PF00454	0.469
MOD_PK_1	25	31	PF00069	0.706
MOD_PKA_1	25	31	PF00069	0.706
MOD_PKA_1	46	52	PF00069	0.702
MOD_PKA_1	555	561	PF00069	0.640
MOD_PKA_2	107	113	PF00069	0.670
MOD_PKA_2	2	8	PF00069	0.668
MOD_PKA_2	283	289	PF00069	0.539
MOD_PKA_2	297	303	PF00069	0.597
MOD_PKA_2	46	52	PF00069	0.717
MOD_PKA_2	477	483	PF00069	0.647
MOD_PKA_2	614	620	PF00069	0.320
MOD_PKA_2	752	758	PF00069	0.679
MOD_PKA_2	900	906	PF00069	0.648
MOD_Plk_1	303	309	PF00069	0.671
MOD_Plk_1	457	463	PF00069	0.649
MOD_Plk_1	622	628	PF00069	0.531
MOD_Plk_2-3	229	235	PF00069	0.655
MOD_Plk_4	129	135	PF00069	0.619
MOD_Plk_4	283	289	PF00069	0.620
MOD_Plk_4	303	309	PF00069	0.769
MOD_Plk_4	321	327	PF00069	0.518
MOD_Plk_4	345	351	PF00069	0.615
MOD_Plk_4	501	507	PF00069	0.648
MOD_Plk_4	573	579	PF00069	0.747
MOD_Plk_4	615	621	PF00069	0.294
MOD_Plk_4	733	739	PF00069	0.608
MOD_Plk_4	866	872	PF00069	0.480
MOD_ProDKin_1	119	125	PF00069	0.634
MOD_ProDKin_1	135	141	PF00069	0.702
MOD_ProDKin_1	172	178	PF00069	0.762
MOD_ProDKin_1	332	338	PF00069	0.645
MOD_ProDKin_1	431	437	PF00069	0.635
MOD_ProDKin_1	53	59	PF00069	0.670
MOD_ProDKin_1	580	586	PF00069	0.492
MOD_ProDKin_1	781	787	PF00069	0.650
MOD_ProDKin_1	848	854	PF00069	0.584
MOD_ProDKin_1	941	947	PF00069	0.594
TRG_DiLeu_BaEn_1	814	819	PF01217	0.514
TRG_DiLeu_BaEn_2	317	323	PF01217	0.628
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.596
TRG_ENDOCYTIC_2	343	346	PF00928	0.537
TRG_ENDOCYTIC_2	380	383	PF00928	0.642
TRG_ENDOCYTIC_2	632	635	PF00928	0.310
TRG_ENDOCYTIC_2	816	819	PF00928	0.512
TRG_ENDOCYTIC_2	838	841	PF00928	0.569
TRG_ER_diArg_1	162	165	PF00400	0.628
TRG_ER_diArg_1	46	48	PF00400	0.697
TRG_ER_diArg_1	51	53	PF00400	0.682
TRG_ER_diArg_1	596	598	PF00400	0.600
TRG_ER_diArg_1	603	605	PF00400	0.545
TRG_ER_diArg_1	648	650	PF00400	0.605
TRG_ER_diArg_1	655	658	PF00400	0.582
TRG_ER_diArg_1	716	718	PF00400	0.596
TRG_ER_diArg_1	830	833	PF00400	0.582
TRG_ER_diArg_1	947	949	PF00400	0.636
TRG_NLS_MonoExtC_3	33	38	PF00514	0.576
TRG_NLS_MonoExtN_4	31	38	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	718	723	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL01	Leptomonas seymouri	36%	100%
A0A3S5H6V1	Leishmania donovani	87%	99%
A4H857	Leishmania braziliensis	72%	100%
A4HWI3	Leishmania infantum	87%	99%
E9AQ84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%