Putative myo-inositol-1 phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myo-inositol-1 phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QF96_LEIMA

TriTrypDb:

LmjF.15.0880 , LMJLV39_150015600 , LMJSD75_150015700

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF96

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0006020	inositol metabolic process	4	2
GO:0006066	alcohol metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019751	polyol metabolic process	4	7
GO:0043647	inositol phosphate metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044262	obsolete cellular carbohydrate metabolic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	7
GO:0046164	alcohol catabolic process	4	7
GO:0046174	polyol catabolic process	5	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	7
GO:0046855	obsolete inositol phosphate dephosphorylation	5	7
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071545	inositol phosphate catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7
GO:1901615	organic hydroxy compound metabolic process	3	7
GO:1901616	organic hydroxy compound catabolic process	4	7
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006661	phosphatidylinositol biosynthetic process	6	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0046488	phosphatidylinositol metabolic process	6	4
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008934	inositol monophosphate 1-phosphatase activity	8	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0052745	inositol phosphate phosphatase activity	6	6
GO:0052832	inositol monophosphate 3-phosphatase activity	8	5
GO:0052833	inositol monophosphate 4-phosphatase activity	8	5
GO:0052834	inositol monophosphate phosphatase activity	7	6
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.310
CLV_NRD_NRD_1	350	352	PF00675	0.356
CLV_PCSK_KEX2_1	47	49	PF00082	0.426
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.426
CLV_PCSK_SKI1_1	114	118	PF00082	0.383
CLV_Separin_Metazoa	366	370	PF03568	0.383
DEG_APCC_DBOX_1	363	371	PF00400	0.404
DEG_Kelch_Keap1_1	15	20	PF01344	0.544
DEG_SCF_FBW7_1	168	175	PF00400	0.383
DEG_SPOP_SBC_1	11	15	PF00917	0.629
DEG_SPOP_SBC_1	319	323	PF00917	0.308
DOC_CKS1_1	124	129	PF01111	0.299
DOC_CKS1_1	169	174	PF01111	0.310
DOC_CKS1_1	252	257	PF01111	0.662
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.383
DOC_MAPK_gen_1	108	115	PF00069	0.277
DOC_MAPK_gen_1	161	168	PF00069	0.310
DOC_MAPK_HePTP_8	158	170	PF00069	0.310
DOC_MAPK_MEF2A_6	108	115	PF00069	0.310
DOC_MAPK_MEF2A_6	161	170	PF00069	0.310
DOC_MAPK_MEF2A_6	364	372	PF00069	0.383
DOC_PP1_RVXF_1	37	43	PF00149	0.443
DOC_PP2B_LxvP_1	368	371	PF13499	0.383
DOC_PP4_FxxP_1	327	330	PF00568	0.383
DOC_USP7_MATH_1	11	15	PF00917	0.629
DOC_USP7_MATH_1	259	263	PF00917	0.645
DOC_USP7_MATH_1	269	273	PF00917	0.552
DOC_USP7_MATH_1	320	324	PF00917	0.319
DOC_WW_Pin1_4	123	128	PF00397	0.299
DOC_WW_Pin1_4	168	173	PF00397	0.310
DOC_WW_Pin1_4	202	207	PF00397	0.634
DOC_WW_Pin1_4	226	231	PF00397	0.593
DOC_WW_Pin1_4	251	256	PF00397	0.679
DOC_WW_Pin1_4	271	276	PF00397	0.627
DOC_WW_Pin1_4	282	287	PF00397	0.718
DOC_WW_Pin1_4	339	344	PF00397	0.306
DOC_WW_Pin1_4	5	10	PF00397	0.661
LIG_14-3-3_CanoR_1	179	183	PF00244	0.344
LIG_14-3-3_CanoR_1	369	378	PF00244	0.302
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_EVH1_1	251	255	PF00568	0.750
LIG_FHA_1	101	107	PF00498	0.318
LIG_FHA_1	117	123	PF00498	0.285
LIG_FHA_1	131	137	PF00498	0.409
LIG_FHA_1	141	147	PF00498	0.363
LIG_FHA_1	16	22	PF00498	0.446
LIG_FHA_1	169	175	PF00498	0.310
LIG_FHA_1	205	211	PF00498	0.707
LIG_FHA_1	233	239	PF00498	0.663
LIG_FHA_1	246	252	PF00498	0.565
LIG_FHA_1	283	289	PF00498	0.641
LIG_FHA_1	319	325	PF00498	0.322
LIG_FHA_1	432	438	PF00498	0.297
LIG_FHA_1	79	85	PF00498	0.296
LIG_FHA_2	227	233	PF00498	0.717
LIG_Integrin_isoDGR_2	308	310	PF01839	0.310
LIG_LIR_Apic_2	394	399	PF02991	0.310
LIG_LIR_Gen_1	129	139	PF02991	0.310
LIG_LIR_Gen_1	295	305	PF02991	0.346
LIG_LIR_Nem_3	129	135	PF02991	0.310
LIG_LIR_Nem_3	257	263	PF02991	0.637
LIG_LIR_Nem_3	295	300	PF02991	0.325
LIG_Pex14_2	457	461	PF04695	0.375
LIG_SH2_SRC	396	399	PF00017	0.310
LIG_SH2_STAP1	102	106	PF00017	0.383
LIG_SH2_STAP1	132	136	PF00017	0.310
LIG_SH2_STAT3	160	163	PF00017	0.383
LIG_SH2_STAT3	197	200	PF00017	0.320
LIG_SH2_STAT5	102	105	PF00017	0.236
LIG_SH2_STAT5	132	135	PF00017	0.340
LIG_SH2_STAT5	396	399	PF00017	0.310
LIG_SH3_3	121	127	PF00018	0.304
LIG_SH3_3	132	138	PF00018	0.322
LIG_SH3_3	166	172	PF00018	0.310
LIG_SH3_3	200	206	PF00018	0.592
LIG_SH3_3	207	213	PF00018	0.686
LIG_SH3_3	249	255	PF00018	0.664
LIG_Sin3_3	184	191	PF02671	0.320
LIG_SUMO_SIM_par_1	205	211	PF11976	0.606
LIG_TRAF2_1	440	443	PF00917	0.294
LIG_UBA3_1	296	301	PF00899	0.383
MOD_CK1_1	15	21	PF00069	0.465
MOD_CK1_1	4	10	PF00069	0.662
MOD_CK1_1	76	82	PF00069	0.298
MOD_CK2_1	19	25	PF00069	0.459
MOD_CK2_1	333	339	PF00069	0.299
MOD_GlcNHglycan	14	17	PF01048	0.607
MOD_GlcNHglycan	175	178	PF01048	0.310
MOD_GlcNHglycan	215	218	PF01048	0.625
MOD_GlcNHglycan	271	274	PF01048	0.611
MOD_GlcNHglycan	61	64	PF01048	0.356
MOD_GlcNHglycan	78	81	PF01048	0.374
MOD_GSK3_1	1	8	PF00069	0.663
MOD_GSK3_1	11	18	PF00069	0.542
MOD_GSK3_1	126	133	PF00069	0.328
MOD_GSK3_1	152	159	PF00069	0.310
MOD_GSK3_1	168	175	PF00069	0.310
MOD_GSK3_1	202	209	PF00069	0.606
MOD_GSK3_1	215	222	PF00069	0.517
MOD_GSK3_1	335	342	PF00069	0.456
MOD_GSK3_1	377	384	PF00069	0.314
MOD_GSK3_1	407	414	PF00069	0.294
MOD_GSK3_1	54	61	PF00069	0.301
MOD_GSK3_1	78	85	PF00069	0.326
MOD_N-GLC_2	405	407	PF02516	0.283
MOD_NEK2_1	1	6	PF00069	0.664
MOD_NEK2_1	173	178	PF00069	0.310
MOD_NEK2_1	208	213	PF00069	0.587
MOD_NEK2_1	219	224	PF00069	0.662
MOD_NEK2_1	58	63	PF00069	0.320
MOD_NEK2_2	54	59	PF00069	0.282
MOD_PIKK_1	438	444	PF00454	0.345
MOD_PIKK_1	82	88	PF00454	0.311
MOD_PKA_2	178	184	PF00069	0.344
MOD_PKA_2	91	97	PF00069	0.411
MOD_Plk_1	130	136	PF00069	0.310
MOD_Plk_1	19	25	PF00069	0.459
MOD_Plk_1	357	363	PF00069	0.495
MOD_Plk_1	432	438	PF00069	0.311
MOD_Plk_4	130	136	PF00069	0.306
MOD_Plk_4	141	147	PF00069	0.299
MOD_Plk_4	284	290	PF00069	0.574
MOD_Plk_4	320	326	PF00069	0.312
MOD_Plk_4	407	413	PF00069	0.310
MOD_Plk_4	432	438	PF00069	0.314
MOD_Plk_4	91	97	PF00069	0.320
MOD_ProDKin_1	123	129	PF00069	0.299
MOD_ProDKin_1	168	174	PF00069	0.310
MOD_ProDKin_1	202	208	PF00069	0.636
MOD_ProDKin_1	226	232	PF00069	0.594
MOD_ProDKin_1	251	257	PF00069	0.677
MOD_ProDKin_1	271	277	PF00069	0.629
MOD_ProDKin_1	282	288	PF00069	0.716
MOD_ProDKin_1	339	345	PF00069	0.306
MOD_ProDKin_1	5	11	PF00069	0.658
MOD_SUMO_rev_2	227	235	PF00179	0.538
MOD_SUMO_rev_2	71	79	PF00179	0.319
TRG_DiLeu_BaEn_1	443	448	PF01217	0.383
TRG_DiLeu_BaEn_4	365	371	PF01217	0.299
TRG_ENDOCYTIC_2	132	135	PF00928	0.310
TRG_ENDOCYTIC_2	460	463	PF00928	0.467
TRG_ER_diArg_1	348	351	PF00400	0.343
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI7	Leptomonas seymouri	57%	100%
A0A3Q8IA90	Leishmania donovani	90%	99%
A4H860	Leishmania braziliensis	76%	100%
A4HWI6	Leishmania infantum	90%	99%
E9AQ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%