Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF94_LEIMA

TriTrypDb:

LmjF.15.0900 , LMJLV39_150015900 , LMJSD75_150015900

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QF94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.556
CLV_C14_Caspase3-7	393	397	PF00656	0.428
CLV_NRD_NRD_1	135	137	PF00675	0.437
CLV_NRD_NRD_1	143	145	PF00675	0.436
CLV_NRD_NRD_1	289	291	PF00675	0.443
CLV_NRD_NRD_1	362	364	PF00675	0.515
CLV_NRD_NRD_1	398	400	PF00675	0.458
CLV_NRD_NRD_1	489	491	PF00675	0.483
CLV_NRD_NRD_1	519	521	PF00675	0.484
CLV_PCSK_FUR_1	359	363	PF00082	0.540
CLV_PCSK_KEX2_1	108	110	PF00082	0.610
CLV_PCSK_KEX2_1	142	144	PF00082	0.467
CLV_PCSK_KEX2_1	288	290	PF00082	0.454
CLV_PCSK_KEX2_1	359	361	PF00082	0.495
CLV_PCSK_KEX2_1	362	364	PF00082	0.502
CLV_PCSK_KEX2_1	489	491	PF00082	0.446
CLV_PCSK_KEX2_1	519	521	PF00082	0.517
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.602
CLV_PCSK_SKI1_1	144	148	PF00082	0.504
CLV_PCSK_SKI1_1	162	166	PF00082	0.330
CLV_PCSK_SKI1_1	249	253	PF00082	0.549
CLV_PCSK_SKI1_1	381	385	PF00082	0.568
DEG_APCC_DBOX_1	287	295	PF00400	0.507
DEG_Nend_UBRbox_4	1	3	PF02207	0.540
DEG_ODPH_VHL_1	167	178	PF01847	0.497
DEG_SCF_FBW7_1	23	29	PF00400	0.545
DEG_SCF_FBW7_1	452	457	PF00400	0.557
DEG_SPOP_SBC_1	199	203	PF00917	0.749
DEG_SPOP_SBC_1	40	44	PF00917	0.745
DOC_CDC14_PxL_1	165	173	PF14671	0.549
DOC_CDC14_PxL_1	24	32	PF14671	0.547
DOC_CKS1_1	23	28	PF01111	0.546
DOC_CYCLIN_RxL_1	246	255	PF00134	0.575
DOC_CYCLIN_RxL_1	260	271	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.513
DOC_MAPK_FxFP_2	443	446	PF00069	0.573
DOC_MAPK_gen_1	399	407	PF00069	0.443
DOC_PP1_RVXF_1	237	243	PF00149	0.502
DOC_PP1_RVXF_1	330	336	PF00149	0.390
DOC_PP1_RVXF_1	512	519	PF00149	0.420
DOC_PP1_RVXF_1	71	77	PF00149	0.526
DOC_PP2B_LxvP_1	171	174	PF13499	0.560
DOC_PP2B_LxvP_1	20	23	PF13499	0.523
DOC_PP2B_LxvP_1	500	503	PF13499	0.507
DOC_PP4_FxxP_1	443	446	PF00568	0.573
DOC_USP7_MATH_1	198	202	PF00917	0.735
DOC_USP7_MATH_1	26	30	PF00917	0.717
DOC_USP7_MATH_1	297	301	PF00917	0.548
DOC_USP7_MATH_1	308	312	PF00917	0.518
DOC_USP7_MATH_1	39	43	PF00917	0.651
DOC_USP7_MATH_1	439	443	PF00917	0.518
DOC_USP7_MATH_1	482	486	PF00917	0.621
DOC_USP7_MATH_1	537	541	PF00917	0.704
DOC_USP7_MATH_2	388	394	PF00917	0.457
DOC_WW_Pin1_4	15	20	PF00397	0.756
DOC_WW_Pin1_4	186	191	PF00397	0.708
DOC_WW_Pin1_4	22	27	PF00397	0.699
DOC_WW_Pin1_4	232	237	PF00397	0.498
DOC_WW_Pin1_4	306	311	PF00397	0.545
DOC_WW_Pin1_4	319	324	PF00397	0.515
DOC_WW_Pin1_4	434	439	PF00397	0.503
DOC_WW_Pin1_4	450	455	PF00397	0.505
LIG_14-3-3_CanoR_1	128	132	PF00244	0.493
LIG_14-3-3_CanoR_1	148	156	PF00244	0.242
LIG_14-3-3_CanoR_1	239	248	PF00244	0.492
LIG_14-3-3_CanoR_1	263	268	PF00244	0.430
LIG_14-3-3_CanoR_1	31	39	PF00244	0.629
LIG_14-3-3_CanoR_1	421	427	PF00244	0.468
LIG_APCC_ABBA_1	265	270	PF00400	0.504
LIG_APCC_ABBA_1	408	413	PF00400	0.489
LIG_APCC_ABBAyCdc20_2	249	255	PF00400	0.456
LIG_EVH1_1	171	175	PF00568	0.610
LIG_FHA_1	274	280	PF00498	0.439
LIG_FHA_1	362	368	PF00498	0.649
LIG_FHA_1	389	395	PF00498	0.484
LIG_FHA_1	62	68	PF00498	0.426
LIG_FHA_1	76	82	PF00498	0.516
LIG_FHA_2	148	154	PF00498	0.490
LIG_FHA_2	252	258	PF00498	0.443
LIG_FXI_DFP_1	253	257	PF00024	0.576
LIG_Integrin_isoDGR_2	330	332	PF01839	0.395
LIG_LIR_Apic_2	442	446	PF02991	0.561
LIG_LIR_Gen_1	102	110	PF02991	0.531
LIG_LIR_Gen_1	222	233	PF02991	0.522
LIG_LIR_Gen_1	254	264	PF02991	0.457
LIG_LIR_Gen_1	382	388	PF02991	0.478
LIG_LIR_Nem_3	102	107	PF02991	0.513
LIG_LIR_Nem_3	222	228	PF02991	0.520
LIG_LIR_Nem_3	243	248	PF02991	0.418
LIG_LIR_Nem_3	382	386	PF02991	0.473
LIG_LIR_Nem_3	442	448	PF02991	0.543
LIG_LIR_Nem_3	457	462	PF02991	0.530
LIG_LYPXL_yS_3	445	448	PF13949	0.712
LIG_MYND_1	169	173	PF01753	0.597
LIG_MYND_1	524	528	PF01753	0.702
LIG_PCNA_PIPBox_1	417	426	PF02747	0.524
LIG_Pex14_1	76	80	PF04695	0.433
LIG_Pex14_2	379	383	PF04695	0.439
LIG_Pex14_2	443	447	PF04695	0.598
LIG_SH2_CRK	225	229	PF00017	0.557
LIG_SH2_SRC	170	173	PF00017	0.475
LIG_SH2_SRC	499	502	PF00017	0.460
LIG_SH2_SRC	80	83	PF00017	0.428
LIG_SH2_STAP1	275	279	PF00017	0.483
LIG_SH2_STAT3	214	217	PF00017	0.576
LIG_SH2_STAT5	123	126	PF00017	0.437
LIG_SH2_STAT5	170	173	PF00017	0.551
LIG_SH2_STAT5	268	271	PF00017	0.502
LIG_SH2_STAT5	275	278	PF00017	0.417
LIG_SH2_STAT5	286	289	PF00017	0.249
LIG_SH2_STAT5	492	495	PF00017	0.459
LIG_SH2_STAT5	499	502	PF00017	0.405
LIG_SH2_STAT5	80	83	PF00017	0.410
LIG_SH3_3	166	172	PF00018	0.522
LIG_SH3_3	185	191	PF00018	0.710
LIG_SH3_3	20	26	PF00018	0.637
LIG_SH3_3	230	236	PF00018	0.494
LIG_SH3_3	347	353	PF00018	0.466
LIG_SH3_3	518	524	PF00018	0.572
LIG_SUMO_SIM_par_1	174	180	PF11976	0.624
LIG_SUMO_SIM_par_1	390	396	PF11976	0.532
LIG_SxIP_EBH_1	20	33	PF03271	0.554
LIG_TRAF2_1	206	209	PF00917	0.730
LIG_TRAF2_1	221	224	PF00917	0.541
LIG_TRFH_1	165	169	PF08558	0.520
LIG_WRC_WIRS_1	315	320	PF05994	0.580
LIG_WRC_WIRS_1	440	445	PF05994	0.540
LIG_WRC_WIRS_1	447	452	PF05994	0.525
MOD_CDK_SPxxK_3	232	239	PF00069	0.505
MOD_CK1_1	121	127	PF00069	0.505
MOD_CK1_1	18	24	PF00069	0.713
MOD_CK1_1	183	189	PF00069	0.648
MOD_CK1_1	201	207	PF00069	0.727
MOD_CK1_1	319	325	PF00069	0.426
MOD_CK1_1	34	40	PF00069	0.604
MOD_CK1_1	44	50	PF00069	0.721
MOD_CK1_1	540	546	PF00069	0.712
MOD_CK2_1	203	209	PF00069	0.706
MOD_CK2_1	422	428	PF00069	0.449
MOD_CK2_1	536	542	PF00069	0.728
MOD_GlcNHglycan	194	197	PF01048	0.755
MOD_GlcNHglycan	20	23	PF01048	0.562
MOD_GlcNHglycan	203	206	PF01048	0.636
MOD_GlcNHglycan	319	322	PF01048	0.484
MOD_GlcNHglycan	339	342	PF01048	0.459
MOD_GlcNHglycan	46	49	PF01048	0.630
MOD_GlcNHglycan	494	499	PF01048	0.423
MOD_GlcNHglycan	529	532	PF01048	0.680
MOD_GlcNHglycan	83	86	PF01048	0.485
MOD_GSK3_1	176	183	PF00069	0.641
MOD_GSK3_1	18	25	PF00069	0.777
MOD_GSK3_1	199	206	PF00069	0.692
MOD_GSK3_1	2	9	PF00069	0.658
MOD_GSK3_1	251	258	PF00069	0.482
MOD_GSK3_1	40	47	PF00069	0.754
MOD_GSK3_1	446	453	PF00069	0.547
MOD_GSK3_1	532	539	PF00069	0.737
MOD_N-GLC_1	337	342	PF02516	0.409
MOD_N-GLC_2	127	129	PF02516	0.497
MOD_N-GLC_2	504	506	PF02516	0.462
MOD_NEK2_1	192	197	PF00069	0.754
MOD_NEK2_1	337	342	PF00069	0.469
MOD_NEK2_1	379	384	PF00069	0.545
MOD_NEK2_2	422	427	PF00069	0.482
MOD_PIKK_1	219	225	PF00454	0.513
MOD_PIKK_1	482	488	PF00454	0.599
MOD_PIKK_1	61	67	PF00454	0.491
MOD_PKA_1	361	367	PF00069	0.615
MOD_PKA_2	127	133	PF00069	0.486
MOD_PKA_2	147	153	PF00069	0.238
MOD_PKA_2	361	367	PF00069	0.615
MOD_PKB_1	142	150	PF00069	0.460
MOD_PKB_1	359	367	PF00069	0.586
MOD_Plk_1	121	127	PF00069	0.430
MOD_Plk_1	297	303	PF00069	0.538
MOD_Plk_1	494	500	PF00069	0.434
MOD_Plk_2-3	390	396	PF00069	0.432
MOD_Plk_4	121	127	PF00069	0.430
MOD_Plk_4	263	269	PF00069	0.429
MOD_Plk_4	297	303	PF00069	0.581
MOD_Plk_4	455	461	PF00069	0.536
MOD_ProDKin_1	15	21	PF00069	0.754
MOD_ProDKin_1	186	192	PF00069	0.710
MOD_ProDKin_1	22	28	PF00069	0.698
MOD_ProDKin_1	232	238	PF00069	0.495
MOD_ProDKin_1	306	312	PF00069	0.549
MOD_ProDKin_1	319	325	PF00069	0.507
MOD_ProDKin_1	434	440	PF00069	0.508
MOD_ProDKin_1	450	456	PF00069	0.516
TRG_ENDOCYTIC_2	104	107	PF00928	0.481
TRG_ENDOCYTIC_2	213	216	PF00928	0.531
TRG_ENDOCYTIC_2	225	228	PF00928	0.468
TRG_ENDOCYTIC_2	423	426	PF00928	0.509
TRG_ENDOCYTIC_2	445	448	PF00928	0.712
TRG_ER_diArg_1	142	144	PF00400	0.471
TRG_ER_diArg_1	185	188	PF00400	0.638
TRG_ER_diArg_1	287	290	PF00400	0.397
TRG_ER_diArg_1	30	33	PF00400	0.558
TRG_ER_diArg_1	359	362	PF00400	0.550
TRG_ER_diArg_1	488	490	PF00400	0.539
TRG_ER_diArg_1	518	520	PF00400	0.472
TRG_NES_CRM1_1	257	271	PF08389	0.467
TRG_NLS_MonoExtC_3	398	403	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J4	Leptomonas seymouri	71%	100%
A0A1X0NTX1	Trypanosomatidae	49%	100%
A0A3Q8IA36	Leishmania donovani	96%	100%
A4H863	Leishmania braziliensis	84%	100%
A4HWI8	Leishmania infantum	96%	91%
C9ZXV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AQ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AMI4	Trypanosoma cruzi	50%	100%