Serine/threonine-protein phosphatase 4 regulatory subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania major

UniProt:

Q4QF92_LEIMA

TriTrypDb:

LmjF.15.0920 , LMJLV39_150016100 , LMJSD75_150016100

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	2
GO:0005737	cytoplasm	2	2
GO:0008287	protein serine/threonine phosphatase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1903293	phosphatase complex	3	2

Expansion

Sequence features

Q4QF92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF92

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	2
GO:0019888	protein phosphatase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	270	276	PF00089	0.444
CLV_NRD_NRD_1	103	105	PF00675	0.639
CLV_NRD_NRD_1	156	158	PF00675	0.442
CLV_NRD_NRD_1	480	482	PF00675	0.477
CLV_NRD_NRD_1	567	569	PF00675	0.701
CLV_NRD_NRD_1	614	616	PF00675	0.555
CLV_NRD_NRD_1	745	747	PF00675	0.473
CLV_PCSK_KEX2_1	103	105	PF00082	0.639
CLV_PCSK_KEX2_1	156	158	PF00082	0.419
CLV_PCSK_KEX2_1	480	482	PF00082	0.477
CLV_PCSK_KEX2_1	567	569	PF00082	0.701
CLV_PCSK_KEX2_1	616	618	PF00082	0.481
CLV_PCSK_KEX2_1	745	747	PF00082	0.474
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.522
CLV_PCSK_SKI1_1	243	247	PF00082	0.481
CLV_PCSK_SKI1_1	366	370	PF00082	0.395
CLV_PCSK_SKI1_1	387	391	PF00082	0.345
CLV_PCSK_SKI1_1	661	665	PF00082	0.471
CLV_PCSK_SKI1_1	684	688	PF00082	0.505
CLV_Separin_Metazoa	496	500	PF03568	0.486
DEG_APCC_DBOX_1	341	349	PF00400	0.453
DEG_Nend_UBRbox_3	1	3	PF02207	0.774
DEG_SPOP_SBC_1	244	248	PF00917	0.491
DEG_SPOP_SBC_1	382	386	PF00917	0.522
DOC_CYCLIN_RxL_1	363	372	PF00134	0.413
DOC_CYCLIN_RxL_1	383	392	PF00134	0.191
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.404
DOC_MAPK_gen_1	639	647	PF00069	0.404
DOC_MAPK_MEF2A_6	115	124	PF00069	0.748
DOC_MAPK_MEF2A_6	764	772	PF00069	0.529
DOC_PP1_RVXF_1	271	277	PF00149	0.488
DOC_PP2B_LxvP_1	264	267	PF13499	0.375
DOC_USP7_MATH_1	102	106	PF00917	0.616
DOC_USP7_MATH_1	313	317	PF00917	0.462
DOC_USP7_MATH_1	520	524	PF00917	0.466
DOC_USP7_MATH_1	543	547	PF00917	0.656
DOC_USP7_MATH_1	571	575	PF00917	0.650
DOC_USP7_MATH_1	598	602	PF00917	0.653
DOC_USP7_MATH_1	734	738	PF00917	0.434
DOC_USP7_MATH_1	816	820	PF00917	0.397
DOC_USP7_MATH_1	96	100	PF00917	0.750
DOC_USP7_UBL2_3	383	387	PF12436	0.486
DOC_WW_Pin1_4	110	115	PF00397	0.620
DOC_WW_Pin1_4	33	38	PF00397	0.721
DOC_WW_Pin1_4	4	9	PF00397	0.742
DOC_WW_Pin1_4	583	588	PF00397	0.692
DOC_WW_Pin1_4	653	658	PF00397	0.481
DOC_WW_Pin1_4	737	742	PF00397	0.466
DOC_WW_Pin1_4	85	90	PF00397	0.718
LIG_14-3-3_CanoR_1	103	107	PF00244	0.596
LIG_14-3-3_CanoR_1	156	160	PF00244	0.447
LIG_14-3-3_CanoR_1	218	226	PF00244	0.515
LIG_14-3-3_CanoR_1	273	277	PF00244	0.495
LIG_14-3-3_CanoR_1	342	346	PF00244	0.502
LIG_14-3-3_CanoR_1	403	412	PF00244	0.398
LIG_14-3-3_CanoR_1	480	487	PF00244	0.476
LIG_14-3-3_CanoR_1	59	64	PF00244	0.691
LIG_14-3-3_CanoR_1	623	632	PF00244	0.487
LIG_14-3-3_CanoR_1	715	720	PF00244	0.512
LIG_Actin_WH2_2	671	689	PF00022	0.466
LIG_BIR_III_2	474	478	PF00653	0.549
LIG_BRCT_BRCA1_1	131	135	PF00533	0.585
LIG_EH1_1	224	232	PF00400	0.427
LIG_FHA_1	171	177	PF00498	0.420
LIG_FHA_1	218	224	PF00498	0.466
LIG_FHA_1	244	250	PF00498	0.489
LIG_FHA_1	269	275	PF00498	0.466
LIG_FHA_1	356	362	PF00498	0.482
LIG_FHA_1	625	631	PF00498	0.513
LIG_FHA_1	662	668	PF00498	0.434
LIG_FHA_1	701	707	PF00498	0.417
LIG_FHA_1	712	718	PF00498	0.397
LIG_FHA_1	751	757	PF00498	0.459
LIG_FHA_1	760	766	PF00498	0.434
LIG_FHA_2	114	120	PF00498	0.703
LIG_FHA_2	184	190	PF00498	0.466
LIG_FHA_2	342	348	PF00498	0.537
LIG_FHA_2	5	11	PF00498	0.707
LIG_FHA_2	683	689	PF00498	0.531
LIG_FHA_2	699	705	PF00498	0.363
LIG_FHA_2	784	790	PF00498	0.531
LIG_GBD_Chelix_1	241	249	PF00786	0.453
LIG_GBD_Chelix_1	283	291	PF00786	0.430
LIG_LIR_Apic_2	275	280	PF02991	0.376
LIG_LIR_Apic_2	46	51	PF02991	0.697
LIG_LIR_Apic_2	582	587	PF02991	0.515
LIG_LIR_Gen_1	333	340	PF02991	0.458
LIG_LIR_Gen_1	364	374	PF02991	0.448
LIG_LIR_Gen_1	42	51	PF02991	0.540
LIG_LIR_Nem_3	224	229	PF02991	0.383
LIG_LIR_Nem_3	263	268	PF02991	0.499
LIG_LIR_Nem_3	275	279	PF02991	0.327
LIG_LIR_Nem_3	28	33	PF02991	0.559
LIG_LIR_Nem_3	306	312	PF02991	0.463
LIG_LIR_Nem_3	333	337	PF02991	0.445
LIG_LIR_Nem_3	364	370	PF02991	0.449
LIG_LIR_Nem_3	42	47	PF02991	0.460
LIG_LIR_Nem_3	658	663	PF02991	0.381
LIG_LIR_Nem_3	718	724	PF02991	0.467
LIG_LIR_Nem_3	781	785	PF02991	0.411
LIG_LYPXL_SIV_4	792	800	PF13949	0.495
LIG_MYND_3	528	532	PF01753	0.437
LIG_Pex14_1	402	406	PF04695	0.322
LIG_Pex14_1	779	783	PF04695	0.466
LIG_Pex3_1	177	188	PF04882	0.525
LIG_SH2_CRK	584	588	PF00017	0.514
LIG_SH2_NCK_1	406	410	PF00017	0.421
LIG_SH2_STAP1	126	130	PF00017	0.471
LIG_SH2_STAT5	225	228	PF00017	0.398
LIG_SH2_STAT5	290	293	PF00017	0.494
LIG_SH2_STAT5	367	370	PF00017	0.373
LIG_SH2_STAT5	388	391	PF00017	0.373
LIG_SH2_STAT5	406	409	PF00017	0.212
LIG_SH2_STAT5	760	763	PF00017	0.469
LIG_SH3_3	651	657	PF00018	0.486
LIG_SH3_3	728	734	PF00018	0.449
LIG_SUMO_SIM_anti_2	423	431	PF11976	0.481
LIG_SUMO_SIM_anti_2	805	810	PF11976	0.467
LIG_SUMO_SIM_par_1	31	36	PF11976	0.707
LIG_TRAF2_1	152	155	PF00917	0.535
LIG_TRAF2_1	515	518	PF00917	0.482
LIG_TRFH_1	110	114	PF08558	0.641
LIG_TYR_ITIM	288	293	PF00017	0.284
LIG_TYR_ITIM	365	370	PF00017	0.369
LIG_WRC_WIRS_1	390	395	PF05994	0.463
LIG_WRC_WIRS_1	622	627	PF05994	0.545
MOD_CDK_SPK_2	110	115	PF00069	0.613
MOD_CDK_SPK_2	737	742	PF00069	0.493
MOD_CK1_1	113	119	PF00069	0.699
MOD_CK1_1	16	22	PF00069	0.580
MOD_CK1_1	275	281	PF00069	0.372
MOD_CK1_1	3	9	PF00069	0.727
MOD_CK1_1	301	307	PF00069	0.415
MOD_CK1_1	317	323	PF00069	0.410
MOD_CK1_1	355	361	PF00069	0.512
MOD_CK1_1	36	42	PF00069	0.654
MOD_CK1_1	557	563	PF00069	0.781
MOD_CK1_1	576	582	PF00069	0.655
MOD_CK1_1	624	630	PF00069	0.515
MOD_CK1_1	737	743	PF00069	0.432
MOD_CK1_1	819	825	PF00069	0.689
MOD_CK1_1	83	89	PF00069	0.723
MOD_CK1_1	92	98	PF00069	0.678
MOD_CK2_1	115	121	PF00069	0.712
MOD_CK2_1	149	155	PF00069	0.539
MOD_CK2_1	183	189	PF00069	0.453
MOD_CK2_1	20	26	PF00069	0.735
MOD_CK2_1	341	347	PF00069	0.446
MOD_CK2_1	4	10	PF00069	0.699
MOD_CK2_1	512	518	PF00069	0.415
MOD_CK2_1	682	688	PF00069	0.486
MOD_CK2_1	698	704	PF00069	0.359
MOD_CK2_1	737	743	PF00069	0.522
MOD_CK2_1	783	789	PF00069	0.441
MOD_CMANNOS	779	782	PF00535	0.427
MOD_GlcNHglycan	2	5	PF01048	0.695
MOD_GlcNHglycan	235	238	PF01048	0.464
MOD_GlcNHglycan	300	303	PF01048	0.414
MOD_GlcNHglycan	318	322	PF01048	0.427
MOD_GlcNHglycan	481	484	PF01048	0.468
MOD_GlcNHglycan	52	56	PF01048	0.789
MOD_GlcNHglycan	545	548	PF01048	0.608
MOD_GlcNHglycan	550	553	PF01048	0.627
MOD_GlcNHglycan	563	566	PF01048	0.664
MOD_GlcNHglycan	573	576	PF01048	0.590
MOD_GlcNHglycan	594	597	PF01048	0.736
MOD_GlcNHglycan	600	603	PF01048	0.621
MOD_GlcNHglycan	66	69	PF01048	0.700
MOD_GlcNHglycan	818	821	PF01048	0.583
MOD_GlcNHglycan	82	85	PF01048	0.742
MOD_GlcNHglycan	94	97	PF01048	0.635
MOD_GlcNHglycan	98	101	PF01048	0.625
MOD_GSK3_1	12	19	PF00069	0.791
MOD_GSK3_1	21	28	PF00069	0.637
MOD_GSK3_1	217	224	PF00069	0.461
MOD_GSK3_1	268	275	PF00069	0.364
MOD_GSK3_1	313	320	PF00069	0.479
MOD_GSK3_1	33	40	PF00069	0.679
MOD_GSK3_1	355	362	PF00069	0.408
MOD_GSK3_1	554	561	PF00069	0.696
MOD_GSK3_1	569	576	PF00069	0.610
MOD_GSK3_1	579	586	PF00069	0.660
MOD_GSK3_1	588	595	PF00069	0.493
MOD_GSK3_1	673	680	PF00069	0.456
MOD_GSK3_1	707	714	PF00069	0.545
MOD_GSK3_1	80	87	PF00069	0.688
MOD_GSK3_1	88	95	PF00069	0.682
MOD_N-GLC_1	221	226	PF02516	0.470
MOD_N-GLC_1	558	563	PF02516	0.700
MOD_N-GLC_1	71	76	PF02516	0.769
MOD_N-GLC_1	809	814	PF02516	0.535
MOD_NEK2_1	20	25	PF00069	0.719
MOD_NEK2_1	268	273	PF00069	0.356
MOD_NEK2_1	298	303	PF00069	0.486
MOD_NEK2_1	352	357	PF00069	0.492
MOD_NEK2_1	361	366	PF00069	0.437
MOD_NEK2_1	389	394	PF00069	0.351
MOD_NEK2_1	531	536	PF00069	0.503
MOD_NEK2_1	58	63	PF00069	0.705
MOD_NEK2_1	632	637	PF00069	0.470
MOD_NEK2_1	749	754	PF00069	0.483
MOD_NEK2_1	809	814	PF00069	0.493
MOD_NEK2_2	674	679	PF00069	0.516
MOD_NEK2_2	682	687	PF00069	0.452
MOD_PIKK_1	170	176	PF00454	0.442
MOD_PIKK_1	469	475	PF00454	0.548
MOD_PIKK_1	677	683	PF00454	0.476
MOD_PKA_2	102	108	PF00069	0.627
MOD_PKA_2	155	161	PF00069	0.489
MOD_PKA_2	217	223	PF00069	0.520
MOD_PKA_2	272	278	PF00069	0.482
MOD_PKA_2	341	347	PF00069	0.485
MOD_PKA_2	404	410	PF00069	0.373
MOD_PKA_2	479	485	PF00069	0.433
MOD_PKA_2	561	567	PF00069	0.644
MOD_PKA_2	579	585	PF00069	0.644
MOD_PKA_2	58	64	PF00069	0.657
MOD_Plk_1	128	134	PF00069	0.636
MOD_Plk_1	16	22	PF00069	0.780
MOD_Plk_1	221	227	PF00069	0.398
MOD_Plk_1	317	323	PF00069	0.475
MOD_Plk_1	71	77	PF00069	0.769
MOD_Plk_4	221	227	PF00069	0.424
MOD_Plk_4	272	278	PF00069	0.400
MOD_Plk_4	389	395	PF00069	0.349
MOD_Plk_4	43	49	PF00069	0.560
MOD_Plk_4	715	721	PF00069	0.505
MOD_Plk_4	778	784	PF00069	0.453
MOD_ProDKin_1	110	116	PF00069	0.621
MOD_ProDKin_1	33	39	PF00069	0.718
MOD_ProDKin_1	4	10	PF00069	0.743
MOD_ProDKin_1	583	589	PF00069	0.689
MOD_ProDKin_1	653	659	PF00069	0.481
MOD_ProDKin_1	737	743	PF00069	0.464
MOD_ProDKin_1	85	91	PF00069	0.719
TRG_DiLeu_BaEn_1	257	262	PF01217	0.430
TRG_DiLeu_BaEn_3	154	160	PF01217	0.517
TRG_DiLeu_BaEn_4	371	377	PF01217	0.451
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.692
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.471
TRG_DiLeu_BaLyEn_6	752	757	PF01217	0.487
TRG_ENDOCYTIC_2	290	293	PF00928	0.482
TRG_ENDOCYTIC_2	367	370	PF00928	0.390
TRG_ENDOCYTIC_2	487	490	PF00928	0.435
TRG_ENDOCYTIC_2	780	783	PF00928	0.513
TRG_ER_diArg_1	102	104	PF00400	0.654
TRG_ER_diArg_1	402	405	PF00400	0.315
TRG_ER_diArg_1	479	481	PF00400	0.473
TRG_ER_diArg_1	638	641	PF00400	0.386
TRG_ER_diArg_1	744	746	PF00400	0.473
TRG_NES_CRM1_1	250	263	PF08389	0.442
TRG_NES_CRM1_1	359	372	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA72	Leptomonas seymouri	66%	84%
A0A3Q8IDF8	Leishmania donovani	96%	100%
A0A3R7N5C8	Trypanosoma rangeli	37%	100%
A4H865	Leishmania braziliensis	84%	94%
A4HWJ0	Leishmania infantum	96%	100%
C9ZXV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQ91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	88%
Q9UT08	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
V5DL61	Trypanosoma cruzi	38%	100%