Sulfhydryl oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sulfhydryl oxidase

Gene product:

ERV/ALR sulfhydryl oxidase domain-containing protein

Species:

Leishmania major

UniProt:

Q4QF88_LEIMA

TriTrypDb:

LmjF.15.0960 , LMJLV39_150016600 , LMJSD75_150016600

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF88

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	2
GO:0015035	protein-disulfide reductase activity	3	9
GO:0015036	disulfide oxidoreductase activity	4	9
GO:0016491	oxidoreductase activity	2	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	9
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	9
GO:0016971	flavin-linked sulfhydryl oxidase activity	4	9
GO:0016972	thiol oxidase activity	5	9
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.601
CLV_C14_Caspase3-7	288	292	PF00656	0.615
CLV_NRD_NRD_1	116	118	PF00675	0.501
CLV_NRD_NRD_1	158	160	PF00675	0.596
CLV_NRD_NRD_1	199	201	PF00675	0.677
CLV_PCSK_KEX2_1	116	118	PF00082	0.489
CLV_PCSK_KEX2_1	158	160	PF00082	0.610
CLV_PCSK_KEX2_1	295	297	PF00082	0.563
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.563
CLV_PCSK_SKI1_1	104	108	PF00082	0.560
CLV_PCSK_SKI1_1	147	151	PF00082	0.671
CLV_PCSK_SKI1_1	201	205	PF00082	0.754
CLV_PCSK_SKI1_1	295	299	PF00082	0.601
DEG_MDM2_SWIB_1	53	60	PF02201	0.325
DEG_SCF_FBW7_2	126	133	PF00400	0.417
DOC_CKS1_1	238	243	PF01111	0.673
DOC_CKS1_1	262	267	PF01111	0.598
DOC_MAPK_gen_1	158	165	PF00069	0.505
DOC_PP4_FxxP_1	199	202	PF00568	0.676
DOC_PP4_FxxP_1	273	276	PF00568	0.721
DOC_USP7_MATH_1	208	212	PF00917	0.704
DOC_USP7_MATH_1	258	262	PF00917	0.667
DOC_USP7_MATH_1	269	273	PF00917	0.749
DOC_USP7_MATH_1	276	280	PF00917	0.695
DOC_USP7_UBL2_3	143	147	PF12436	0.631
DOC_WW_Pin1_4	107	112	PF00397	0.334
DOC_WW_Pin1_4	126	131	PF00397	0.646
DOC_WW_Pin1_4	16	21	PF00397	0.496
DOC_WW_Pin1_4	217	222	PF00397	0.680
DOC_WW_Pin1_4	237	242	PF00397	0.799
DOC_WW_Pin1_4	261	266	PF00397	0.755
DOC_WW_Pin1_4	75	80	PF00397	0.231
LIG_14-3-3_CanoR_1	259	265	PF00244	0.686
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_CtBP_PxDLS_1	20	24	PF00389	0.540
LIG_FHA_1	127	133	PF00498	0.426
LIG_FHA_1	241	247	PF00498	0.788
LIG_FHA_2	129	135	PF00498	0.521
LIG_FHA_2	143	149	PF00498	0.544
LIG_FHA_2	17	23	PF00498	0.465
LIG_FHA_2	286	292	PF00498	0.624
LIG_LIR_Apic_2	261	265	PF02991	0.601
LIG_LIR_Apic_2	272	276	PF02991	0.638
LIG_LIR_Gen_1	157	167	PF02991	0.512
LIG_LIR_Gen_1	26	36	PF02991	0.327
LIG_LIR_Gen_1	55	62	PF02991	0.327
LIG_LIR_Nem_3	157	163	PF02991	0.515
LIG_LIR_Nem_3	195	199	PF02991	0.632
LIG_LIR_Nem_3	26	31	PF02991	0.327
LIG_LIR_Nem_3	55	60	PF02991	0.317
LIG_LIR_Nem_3	64	68	PF02991	0.333
LIG_PCNA_yPIPBox_3	41	54	PF02747	0.360
LIG_PDZ_Class_2	307	312	PF00595	0.498
LIG_Pex14_1	118	122	PF04695	0.449
LIG_Pex14_1	57	61	PF04695	0.301
LIG_Pex14_2	53	57	PF04695	0.301
LIG_SH2_STAP1	61	65	PF00017	0.360
LIG_SH2_STAT5	303	306	PF00017	0.573
LIG_SH2_STAT5	73	76	PF00017	0.301
LIG_SH2_STAT5	90	93	PF00017	0.301
LIG_SH3_1	117	123	PF00018	0.374
LIG_SH3_2	120	125	PF14604	0.568
LIG_SH3_3	117	123	PF00018	0.374
LIG_SH3_3	218	224	PF00018	0.560
LIG_SH3_3	299	305	PF00018	0.566
LIG_SH3_3	36	42	PF00018	0.301
LIG_TRAF2_1	131	134	PF00917	0.526
MOD_CDK_SPxxK_3	75	82	PF00069	0.231
MOD_CK1_1	231	237	PF00069	0.659
MOD_CK1_1	261	267	PF00069	0.682
MOD_CK2_1	128	134	PF00069	0.519
MOD_CK2_1	136	142	PF00069	0.524
MOD_CK2_1	16	22	PF00069	0.515
MOD_GlcNHglycan	25	28	PF01048	0.378
MOD_GlcNHglycan	33	36	PF01048	0.482
MOD_GlcNHglycan	42	45	PF01048	0.362
MOD_GSK3_1	179	186	PF00069	0.681
MOD_GSK3_1	228	235	PF00069	0.743
MOD_GSK3_1	260	267	PF00069	0.727
MOD_LATS_1	7	13	PF00433	0.584
MOD_N-GLC_1	217	222	PF02516	0.715
MOD_NEK2_1	23	28	PF00069	0.507
MOD_NEK2_1	31	36	PF00069	0.360
MOD_NEK2_1	53	58	PF00069	0.325
MOD_NEK2_1	85	90	PF00069	0.380
MOD_PIKK_1	223	229	PF00454	0.807
MOD_PKA_1	158	164	PF00069	0.577
MOD_PKA_2	158	164	PF00069	0.581
MOD_PKA_2	258	264	PF00069	0.684
MOD_PKA_2	8	14	PF00069	0.699
MOD_Plk_2-3	128	134	PF00069	0.521
MOD_Plk_2-3	285	291	PF00069	0.589
MOD_Plk_4	109	115	PF00069	0.342
MOD_Plk_4	269	275	PF00069	0.803
MOD_ProDKin_1	107	113	PF00069	0.334
MOD_ProDKin_1	126	132	PF00069	0.651
MOD_ProDKin_1	16	22	PF00069	0.491
MOD_ProDKin_1	217	223	PF00069	0.676
MOD_ProDKin_1	237	243	PF00069	0.801
MOD_ProDKin_1	261	267	PF00069	0.752
MOD_ProDKin_1	75	81	PF00069	0.231
MOD_SUMO_rev_2	306	312	PF00179	0.524
TRG_ER_diArg_1	115	117	PF00400	0.301
TRG_ER_diArg_1	158	160	PF00400	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T9	Leptomonas seymouri	52%	99%
A0A3Q8ICB2	Leishmania donovani	91%	100%
A4H869	Leishmania braziliensis	76%	99%
A4HWJ4	Leishmania infantum	90%	100%
C9ZXU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQ95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DL65	Trypanosoma cruzi	37%	92%