Ubiquitin-like modifier-activating enzyme 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

E1-like ubiquitin-activating enzyme, putative

Species:

Leishmania major

UniProt:

Q4QF87_LEIMA

TriTrypDb:

LmjF.15.0970 , LMJLV39_150016700 , LMJSD75_150016700

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QF87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF87

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071569	protein ufmylation	7	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	11
GO:0005515	protein binding	2	2
GO:0008641	ubiquitin-like modifier activating enzyme activity	2	12
GO:0016874	ligase activity	2	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	12
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.674
CLV_C14_Caspase3-7	378	382	PF00656	0.722
CLV_NRD_NRD_1	299	301	PF00675	0.463
CLV_PCSK_KEX2_1	10	12	PF00082	0.569
CLV_PCSK_KEX2_1	212	214	PF00082	0.310
CLV_PCSK_KEX2_1	277	279	PF00082	0.382
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.569
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.310
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.311
CLV_PCSK_SKI1_1	271	275	PF00082	0.469

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F3	Leptomonas seymouri	77%	96%
A0A0N0P8E8	Leptomonas seymouri	25%	90%
A0A0S4JGN9	Bodo saltans	71%	98%
A0A1X0NTY2	Trypanosomatidae	69%	100%
A0A3R7JZ58	Trypanosoma rangeli	70%	100%
A0A3S5H6V3	Leishmania donovani	94%	100%
A0A422NC72	Trypanosoma rangeli	29%	83%
A1A4L8	Bos taurus	27%	90%
A4H870	Leishmania braziliensis	89%	100%
A4HWJ5	Leishmania infantum	94%	100%

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